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Effective use of the Japan Narrow Band Imaging Expert Team classification based on diagnostic performance and confidence level

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World Journal of Clinical Cases 2019年第18期7卷 2658-2665页

作者： Daizen Hirata Hiroshi kashida Mineo Iwatate Tomomasa Tochio Akira Teramoto Yasushi sano Masatoshi kudo Gastrointestinal Center and Institute of Minimally-invasive Endoscopic Care Sano HospitalKobe 6550031Japan Department of Gastroenterology and Hepatology Kindai UniversityOsaka 5895811Japan

Five years have passed since the Japan Narrow Band Imaging Expert Team (JNET) classification was proposed in 2014. However, the diagnostic performance of this classification has not yet been established. We conducted a retrospective study and a systematic search of Medical Literature Analysis and Retrieval System On-Line. There were three retrospective single center studies about the diagnostic performance of this classification. In order to clarify this issue, we reviewed our study and three previous studies. This review revealed the diagnostic performance in regards to three important differentiations.(1) Neoplasia from non-neoplasia;(2) malignant neoplasia from benign neoplasia;and (3) deep submucosal invasive cancer (D-SMC) from other neoplasia. The sensitivity in differentiating neoplasia from non-neoplasia was 98.1%-99.8%. The specificity in differentiating malignant neoplasia from benign neoplasia was 84.7%-98.2% and the specificity in the differentiation D-SMC from other neoplasia was 99.8%-100.0%. This classification would enable endoscopists to identify almost all neoplasia, to appropriately determine whether to perform en bloc resection or not, and to avoid unnecessary surgery. This article is the first review about the diagnostic performance of the JNET classification. Previous reports about the diagnostic performance have all been retrospective single center studies. A large-scale prospective multicenter evaluation study is awaited for the validation.

关键词： Japan Narrow Band Imaging Expert Team Classification Magnifying endoscopy Narrow-band imaging Validation Diagnostic performance Colonoscopy Colorectal neoplasms

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Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma

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Protein & Cell 2010年第8期1卷 711-717页

作者： Takuma Hayashi Akiko Horiuchi kenji sano Nobuyoshi Hiraoka Yae kanai Tanri Shiozawa Susumu Tonegawa Ikuo konishi Department of Immunology and Infectious Disease Shinshu University Graduate School of MedicineMatsumotoNagano 390-8621Japan Department of Obstetrics and Gynecology Shinshu University School of MedicineMatsumotoNagano 390-8621Japan Department of Laboratory Medicine Shinshu University HospitalMatsumotoNagano 390-8621Japan Pathology Division National Cancer Center Research InstituteTokyo 104-0045Japan Picower Institution and Department of Biology Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Department of Obstetrics and Gynecology Kyoto University Graduate School of MedicineSakyo-kuKyoto 606-8501Japan Promoting Business using Advanced Technology Japan Science and Technology Agency(JST)Kawaguchi-shiSaitama 332-0012Japan

Uterine tumors are the most common type of gynecologic *** leiomyosarcoma(LMS)is rare,accounting for 2%to 5%of tumors of the uterine *** LMS develops more often in the muscle tissue layer of the uterine body than in the uterine *** development of gynecologic tumors is often correlated with female hormone secretion;however,the development of uterine LMS is not substantially correlated with hormonal conditions,and the risk factors are not yet *** evaluation combined with PET/CT can be useless in the diagnosis and surveillance of uterine ***,a diagnostic biomarker,which distinguishes malignant LMS and benign tumor leiomyoma(LMA)is yet to be ***,it is necessary to analyze risk factors associated with uterine LMS in order to establish a method of ***2-deficient mice spontaneously develop uterine LMS,with a disease prevalence of~40%by 14 months of *** is therefore of interest whether human uterine LMS shows a loss of LMP2 *** found LMP2 expression is absent in human LMS,but present in human ***,defective LMP2 expression may be one of the risk factors for ***2 is potentially a diagnostic biomarker for uterine LMS,and gene therapy with LMP2-encording DNA may be a new therapeutic approach.

关键词： LMP2 uterine leiomyosarcoma uterine leiomyoma diagnostic biomarker

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A kind of Sustainable Craft Making： Equal and Flexible Participation in Piecing Acehnese Hat

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Journal of Literature and Art Studies 2016年第9期6卷 1013-1026页

作者： Toshiyuki sano Nara Women's University Nara Japan

Terms of sustainable and sustainability have been employed in various sectors and fields since around 1990. To make a society sustainable needs to find ways of having sustainable local activities. The ways may be to find and revitalize local resources, or to support new life styles by accepting outsider＇s new ideas. I see those ways often taken from a perspective that the ways require a structure or institutional organization. To explore in-between ways, it would be better to have an alternative perspective and useful to learn from Southeast Asian cases of managing diversity while accepting new ways （cf. Reid, 2015）. In this essay, I focus on a sustainable craft making of a men＇s hat kopiah meuketob in Aceh, Sumatra, which is traditional item for marriage but has been used in various imaginative ways and has been shaping a regional ＂craft-scape.＂ I examine such ways and various facets of making the hat and conclude that a lesson from the case for making things sustainable is equal and flexible ways of participating in production processes.

关键词： Aceh Sumatra craft sustainability flexible participation women's work men's hat

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Development and Application of Laser Peening in Japan

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航空制造技术 2006年第1期49卷 73-77页

作者： Yuji sano Toshiba Corporation Yokohama/Japan

This paper reviews the current status of research and development on laser peening without protective coating(LPPC) in Japan. LPPC is an innovative process since it does not require any surface coating that is formed prior to laser irradiation in conventional laser peening for preventing the surface from melting. Surface residual stress of various metal materials was converted from tensile to compressive by LPPC. High cycle fatigue property was remarkably improved for steels, aluminum alloys and titanium alloys. Accelerating stress corrosion cracking (SCC) tests showed that LPPC completely prevents SCC of sensitized austenitic stainless steels, nickel-based alloys and their weld metals. LPPC has been utilized to combat against SCC in Japanese nuclear power reactors since 1999.

关键词：激光敲击应力疲劳腐蚀裂化金属处理结构力学

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Isolated ileal perforation due to cytomegalovirus reactivation during management of terbinafine hypersensitivity

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World Journal of Gastroenterology 2010年第26期16卷 3339-3342页

作者： Soichi sano Hiroki Ueno keiko Yamagami Yosuke Yakushiji Yoshihiro Isaka Isao kawasaki Masashi Takemura Takeshi Inoue Masayuki Hosoi Department of Internal Medicine Osaka City General Hospital Osaka 534-0021 Japan Department of Metabolism and Endocrinology Osaka City General Hospital Osaka 534-0021 Japan Department of Gastrointestinal Surgery Osaka City General Hospital Osaka 534-0021 Japan Department of Pathology Osaka City General Hospital Osaka 534-0021 Japan

We report a case of 71-year-old man who developed a hypersensitivity syndrome associated with terbinafine. He was placed on terbinafine (250 mg/d) for the treatment of tinea pedis due to diabetes mellitus. Following the treatment with terbinafine, he developed druginduced hypersensitivity syndrome (DIHS). Systemic corticosteroid led to transient improvement of his clinical manifestations. Three months after disease onset, he presented with panperitonitis due to ileal perforation, and underwent an emergency operation. The affected ileum was resected and ileostomy was performed in the terminal ileum. Cytomegalovirus (CMV)-specific IgG antibodies were significantly increased, high-titer CMV antigenemia was detected, and pathological examination of the resected ileum confirmed CMV infection. Based onthese observations, we strongly recommend that physicians monitor reactivation of the family of herpesvirus other than herpesvirus 6, to manage DIHS properly.

关键词： Terbinafi ne Drug hypersensitivity Human herpesvirus 6 Cytomegalovirus Intestinal perforation Ileum

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Non-alcoholic fatty liver disease later diagnosed as myotonic dystrophy

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World Journal of Hepatology 2020年第9期12卷 685-692页

作者： Naoki Tanaka Takefumi kimura Naoyuki Fujimori Yasuyuki Ichise kenji sano Akira Horiuchi Department of Metabolic Regulation Shinshu University School of MedicineMatsumoto 390-8621Japan Department of Gastroenterology Shinshu University School of MedicineMatsumoto 390-8621Japan Digestive Disease Center Showa Inan General HospitalKomagane 399-4117Japan Department of Pathology Iida Municipal HospitalIida 395-8502Japan

BACkGROUND Myotonic dystrophy(MD)is sometimes accompanied by metabolic/endocrine disorders,including dyslipidemia,central obesity,and *** to considerable individual differences in the severity and progression of myopathy,MD patients with minimal-to-mild muscle symptoms might be followed as having other diseases,such as non-alcoholic fatty liver disease(NAFLD).CASE SUMMARY A 40-year-old non-obese man without a history of regular ethanol consumption was referred to our hospital due to persistent liver dysfunction and *** body mass index was 23.4 kg/*** histology demonstrated macrovesicular steatosis,ballooned hepatocytes with eosinophilic inclusion bodies,and perisinusoidal fibrosis,leading to the diagnosis of nonalcoholic steatohepatitis(NASH).Although he had no discernable muscle pain or weakness,persistently high serum creatine kinase(Ck)and myoglobin levels as well as the presence of frontal baldness,a hatched face,history of cataract surgery,and grip myotonia indicated the possibility of *** blotting of the patient’s DNA revealed the presence of CTG repeats,confirming the *** When gastroenterologists encounter NAFLD/NASH patients,serum Ck should be *** hyperCkemia,frontal baldness,a hatched face,history of cataract surgery,and grip myotonia are noted,the possibility of MD may be considered.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Frontal baldness Cataract Creatine kinase

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Isolation and structural elucidation of antifungal compounds from Curcuma amada

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Asian Pacific Journal of Tropical Medicine 2019年第3期12卷 123-129页

作者： Jesmin Akter kensaku Takara Md.Zahorul Islam Md.Amzad Hossain Ayako sano De-Xing Hou The United Graduate School of Agricultural Sciences Kagoshima University Faculty of Agriculture University of the Ryukyus

Objective: To isolate and identify the antifungal compounds from Curcuma amada. Methods: The antifungal activity was measured by the diameter of colonies grown on Petri dish,microscopic observation,and CLSI microdilution methods. The antifungal compounds were isolated through bioactivity guided purification by using silica gel and high-performance liquid chromatography. Structural identification of the antifungal compounds was conducted using 1 H NMR,13 C NMR,and liquid chromatography-tandem mass spectrometry. Results: The purified antifungal compounds were zederone and furanodienone. These two compounds showed dose-dependent antifungal activity against Fusarium solani sensu lato. The concentration required for 50% growth inhibition(IC50) of FSSL ranged from 115 to 129 μM and 82 to 91 μM for zederone and furanodienone,respectively. Conclusion: This study suggested that the isolated compounds from Curcuma amada could be promising natural antifungal agents to control the diseases caused by Fusarium solani sensu lato.

关键词： Curcuma amada Fusarium solani sensu lato Antifungal compounds Zederone Furanodienone Nuclear magnetic resonance

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Determination of a Cut-Off Point of a Scale for Achievement Motive in Geriatrics That Predicts the Frequency of Undertaking Instrumental Activities of Daily Living in Community-Dwelling Elderly People

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Advances in Aging Research 2019年第6期8卷 107-118页

作者： Nobuyuki sano Hisato Nakazono Department of Occupational Therapy Fukuoka International University of Health and Welfare Fukuoka Japan

Background: Among elderly people, rehabilitation is important for reducing the risk of falls and hospitalization and to maintain an independent life for longer. Motivation is a factor for elderly people to lead an active daily life and leave home more frequently. Purpose: The purposes of this study were to determine the optimal cut-off point in the Scale for Achievement Motive in Geriatrics (SAMG) that could identify individuals as inactive or active, based on the Frenchay Activities Index (FAI), and to compare characteristics between active and inactive groups classified by the cut-off point. Methods: A cross-sectional study of 285 community-dwelling elderly people measured SAMG and FAI and physical function. Receiver operating characteristic (ROC) analysis was used to calculate the area under the curve (AUC) that was the optimal cut-off point for the SAMG total score, with the associated sensitivity and 1-specificity when compared with the FAI results. Demographic parameters and physical function were compared between two groups defined by cut-off point. Results: The AUC was 0.78, the optimal cut-off for SAMG total score for indicating inactivity was ≤48, the sensitivity was 77.98% and the 1-specificity was 75.00%. The group with SAMG score >48 was characterized by a significantly higher proportion of women, fewer people sharing a house, and participation in more hobbies. Discussion: A cut-off point of 48 in the SAMG could be a predictive index of motivation toward goals for individuals with inactive daily activities. The group with score higher than the cut-off was characterized by more women, fewer people living together, and more hobbies than the group with lower scores.

关键词： Achievement Motive Instrumental Activities of Daily Living Cut-Off Point Preventive Care Community-Dwelling Elderly People

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RESEARCH ON SUPERPLASTICITY IN SiCp/2024Al AND SiCp/8090Al-Li COMPOSITES

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Chinese Journal of Mechanical Engineering 2001年第4期14卷 370-372页

作者： Zhang Libin, Wang Zongren (School of Materials Science and Engineering，Harbin Institute of Technology) Hai Jintao (China Academy of Machinery Science and Technology) sano T Murakoshi Y Takahashi M Hanada k Mechanical Engineering Laboratory,AIST,MITI,J 哈尔滨工业大学黑龙江机械部机械科学研究院北京 Mechanical Engineering Laboratory 日本

The superplasticity in SiCp/Al alloy and SiCp/Al Li Composites is introduced The composites are prepared by powder metallurgy and cast methods The superplastic parameters are measured Superplastic treatment proc... 详细信息

关键词： Composites Metal matrix composites Superplasticity Extrusion

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Preliminary prospective study of real-time post-gastrectomy glycemic fluctuations during dumping symptoms using continuous glucose monitoring

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World Journal of Gastroenterology 2021年第23期27卷 3386-3395页

作者： Motonari Ri Souya Nunobe Satoshi Ida Naoki Ishizuka Shinichiro Atsumi Rie Makuuchi koshi kumagai Manabu Ohashi Takeshi sano Department of Gastroenterological Surgery Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan Clinical Trial Planning and Management Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

BACkGROUND Although dumping symptoms constitute the most common post-gastrectomy syndromes impairing patient quality of life,the causes,including blood sugar fluctuations,are difficult to elucidate due to limitations in examining dumping symptoms as they *** To investigate relationships between glucose fluctuations and the occurrence of dumping symptoms in patients undergoing gastrectomy for gastric *** Patients receiving distal gastrectomy with Billroth-I(DG-BI)or Roux-en-Y reconstruction(DG-RY)and total gastrectomy with RY(TG-RY)for gastric cancer(March 2018-January 2020)were prospectively *** tissue glycemic profiles were measured every 15 min,up to 14 d,by continuous glucose *** episodes were recorded on 5 patient-selected days by *** 3 h postprandially,dumping-associated glycemic changes were defined as a dumping profile,those without symptoms as a control *** profiles were *** Thirty patients were enrolled(10 DG-BI,10 DG-RY,10 TG-RY).The 47 early dumping profiles of DG-BI showed immediately sharp rises after a meal,which 47 control profiles did not(P<0.05).Curves of the 15 late dumping profiles of DG-BI were similar to those of early dumping profiles,with lower glycemic *** and TG-RY late dumping profiles(7 and 13,respectively)showed rapid glycemic decreases from a high glycemic state postprandially to hypoglycemia,with a steeper drop in TG-RY than in *** Postprandial glycemic changes suggest dumping symptoms after standard gastrectomy for gastric ***,glycemic profiles during dumping may differ depending on reconstruction methods after gastrectomy.

关键词： Gastric cancer Gastrectomy Billroth-I reconstruction Roux-en-Y reconstruction Dumping syndrome Continuous glucose monitoring

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