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MEASURING OF COMPLEX STRUCTURE TRANSFER FUNCTION AND CALCULATING OF INNER SOUND FIELD

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Chinese Journal of Mechanical Engineering 2005年第4期18卷 582-585页

作者： Chen Yuan Huang Qibai Shi hanmin School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

In order to measure complex structure transfer function and calculate inner sound field, transfer function of integration is mentioned. By establishing virtual system, transfer function of integration can be measured and the inner sound field can also be calculated. In the experiment, automobile body transfer function of integration is measured and experimental method of establishing virtual system is very valid.

关键词： Complex structure Virtual system Transfer function of integration

Iron-Catalyzed Aminomethyloxygenative Cyclization of Hydroxy-α-diazoesters with N,O-Aminals

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Chinese Journal of Chemistry 2020年第4期38卷 389-393页

作者： Suchen Zou Tianze Zhang Siyuan Wang hanmin Huang Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry Center for Excellence in Molecular SynthesisUniversity of Science and Technology of ChinaChinese Academy of SciencesHefeiAnhui 230026China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhouGonsu 730000China

Summary of main observation and conclusion A new and eficient cyclization reaction has bleen developed to synthesize cyclic a,a-disubstituted B-amino esters via iron-catalyzed intramolecular aminomethyloxygenative cyclization of diazo compounds with N,O-aminal under mild reaction condi-tions.A broad range of hydroxy-a diazoesters with different substituents and various N,O-aminals were compatible with this protocol,affording the corresponding a,a-disubstitutedβ-amino esters bearing a five-to eight-membered oxacycle in good yields.

关键词： esters substituted cyclization

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG LUJI HUANG FU CHENG XINDAN sheng XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

Positive effect of Mo on mechanical properties of a Ni-42W-10Co-x Mo medium heavy alloy

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China Foundry 2025年

作者： Guo-xin Cao Jian-xin Dong Yong-sheng He He Jiang Fang Hao Zhi-hua Nie Teng-fei Ma Bao-quan Fu School of Materials Science and Engineering University of Science and Technology Beijing Xi'an Superalloy Technology Co. Ltd. School of Materials Science and Engineering Beijing Institute of Technology Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou University

In this study,a novel Ni-W-Co-Mo medium heavy alloy (MHA) was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-xM o alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypoeutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-xM o alloys is Mo-induced solid solution strengthening and precipitation strengthening.

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Comparative study of VOF, LS, and VOSET on pore-scale immiscible waterflooding modeling

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Petroleum 2021年第3期7卷 314-324页

作者： Jiajun Peng Rui Song Yao Wang hanmin Xiao School of Geoscience and Technology Southwest Petroleum UniversityChengdu610500China School of Civil Engineering and Architecture Southwest University of Science and TechnologyMianyang621010China Research Institute of Petroleum Exploration&Development PetroChina Company LimitedBeijing100083China

The pore-scale mechanism of the waterflooding contributes to enhancing oil recovery,which has been widely emphasized in the petroleum *** this paper,the performances and accuracy of three tracking interface algorithms,including VOF,LS,and VOSET,are compared and analyzed through twophase flow in the conceptual model of *** results show that the VOSET method combines the advantages of the other two methods,which not only satisfies the mass conservation but also improves the continuity of the physical quantities near the ***,based on the binary image of the pore,the two-dimensional micro pore model is reconstructed by extracting image *** grid independence of the reconstructed pore model is verified by the single-phase flow *** waterflooding process in the reconstructed pore model is simulated using the VOSET method,and the effects of displacement speed and wettability on the oil recovery are *** morphologies of residual oil under different conditions of wettability are investigated and *** study provides a basic theory for modeling the pore-scale oil-water flow and optimizing the scheme of the water injection.

关键词： Waterflooding Oil recovery VOSET Displacement speed Wettability

Discussion on Performance Evaluation Method of Distributed Combined Cooling, Heating, and Power System

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Journal of Thermal Science 2019年第6期28卷 1212-1220页

作者： SHAO Youyuan CHEN Baiman XIAO hanmin QIN Frank G.F. Guangdong Provincial Key Laboratory of Distributed Energy System School of Chemical Engineering and Energy Technology Dongguan University of Technology

This paper briefly analyzed some problems and limitations of existing evaluation indicators for distributed energy system performance. Based on the diversity and difference of the energy form and grade of cooling, heating and power in the distributed combined cooling, heating, and power(CCHP) system, this paper proposed three-index evaluation system composed of key indicators including relative energy saving rate, exergy efficiency and thermoelectric ratio. In order to further prove the reasonableness and scientificity of the evaluation index system applied in performance evaluation of distributed CCHP system, it enumerated, calculated, and evaluated the energy conservation of three engineering cases. The evaluation results showed that the high energy-saving rate of the system did not mean good energy-saving, but also the efficiency of the system should be examined. Only when the energy saving rate and exergy efficiency were both high, can the energy saving performance of the system be demonstrated. When the energy-saving rate was high and the efficiency was not high, it is shown that the energy-saving of the system had great room for improvement.

关键词： distributed energy systems(DES) energy efficiency performance index exergy analysis

Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma： a systematic review with meta-analysis

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Frontiers of Medicine 2017年第2期11卷 191-202页

作者： Li Ma Bin Wang Yuanxiong Long hanmin Li Hubei University of Chinese Medicine Wuhan 430065 China Hepatopathy Institute Affiliated Hospital of Hubei University of Chinese Medicine (Chinese Medicine Hospital in Hubei Province) Wuhan 430061 China

Primary hepatic carcinoma （PHC） is a common malignant tumor in China. Cancer is comprehensively treated with various therapeutic regimes, including traditional Chinese medicine （TCM）. TCM has been widely used to improve the quality of fife, delay the time of cancer progression, and prolong the median survival time. This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma. A comprehensive literature search was conducted in six databases, including CNKI, VIP, Wan-Fang Database, CBM, PubMed, and Cochrane library. A total of 44 randomized controlled trials （RCTs） involving 3429 participants suffering from PHC were selected. Meta-analysis results indicated that the overall effect of TCM and Western integrative treatment on PHC was higher than that of Western intervention alone, which can postpone tumor recurrence and metastasis and prolong the overall survival time of patients with PHC. Although the obtained evidence remained weak because of the poor methodological quality of the included studies, this review provided relevant data supporting the efficacy and safety of TCM combined with Western therapies. In future research, individual RCT studies should incorporate accepted standards for trial design and reporting, proper outcome indicators according to international standards, blinding in allocation concealment, and valid follow-up periods.

关键词： traditional Chinese medicine primary hepatic carcinoma meta-analysis

Sequence-stratigraphic frameworks and their palaeogeographic patterns for the Permian Lopingian of the Dianqiangui Basin and its adjacent areas of Southwestern China

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Science China Earth Sciences 2007年第6期50卷 869-885页

作者： MEI MingXiang MA Yongsheng DENG Jun CHU hanmin ZHENG KuanBing State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 100083China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China

The Permian Lopingian in the Dianqiangui Basin and its adjacent areas is marked by the coal measures of the Wuchiapingian and the carbonate strata of the Changhsingian stages. For the Lopingian of the Dianqiangui Basin and its adjacent areas,the diversity of sedimentary facies and the obviousness of facies change provide an advantaged condition on a study of sequence stratigraphy. Approximately,the Wuchiapingian stage constitutes a third-order sequence and the Changhsingian stage forms an-other. For the Wuchiapingian stage in the study area,coal-measures were developed on the attached platform and,in addition,a special coal-measure that is composed of both limestone beds and coal beds was also developed in the central part of some isolated platforms. Grain-bank grainstones and packstones were formed on the margin of the attached platform as well as in the windward part of iso-lated platforms. For the Changhsingian stage in the study area,open-platform limestones were formed on the attached platform,while sponge-reef limestones were developed both on the margin of the at-tached platform and on the isolated platforms. The Lopingian Series is a set of basin-facies muddy shales with interbeds of silicalites in the inter-platform basin,which appears a set of the large-thick coarse clastic strata of molasses covering direct the deep-water strata from the Devonian to the Per-mian Yangsingian in the Qinzhou-Fangcheng region in the southern part of the study area. All of these features indicate the complexity of temporal-spatial facies-changes. Sequence-stratigraphic frame-works could be established,which would illustrate two types of facies-changing surfaces and dia-chronisms in the stratigraphic records,based on the combination of both biostratigraphic and chronostratigraphic materials and the regularity reflected by temporal evolutionary succession of sediments as well as spatial distributional patterns of sedimentary facies. Ultimately,features of sedi-mentary succession

关键词： sequence-stratigraphic frameworks palaeogeographical patterns the Permian Lopingian the Dianqiangui Basin and its adjacent areas

A stretchable, ionic conductive, and adhesive patch electrode with ultra-low on-skin impedance for electrophysiological signal recording

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Science China(Information Sciences) 2025年

作者： Yang LI Yuzhe GU sheng QIAN Yuncong PANG Aoxi YU Shuwen ZHENG Wenjie XIA Yuan LIAO Baoguang LIU Shujuan LIU Qiang ZHAO College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications (NJUPT) State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications (NJUPT)

Flexible electrodes have significant potential in fields such as healthcare and neuroscience, as they enable comprehensive recording and analysis of human electrical signals, providing deeper insights into physiological conditions and the state of internal organs and tissues [1, 2]. However, commercial Ag/AgCl wet electrodes face issues such as dehydration,poor comfort, and insufficient mechanical strength, while other types of electrodes, like dry and semi-dry electrodes,also have their own limitations, including the higher contact impedance. In contrast, ionically conductive electrodes offer potential advantages such as transparency, stability, and low impedance, making them a promising alternative to existing electrically conductive electrodes [3]. Acrylic acid (AA)and 2-acrylamido-2-methylpropanesulfonic acid (AMPS) are commonly used in the synthesis of ionic gels, as they ionize in water to produce a large number of ions, helping to maintain moisture balance and reduce impedance caused by dehydration [4]. However, the presence of freely moving ions in the gel network can interfere with conductivity, highlighting the need to introduce new conductive networks to enhance performance [5].

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