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Impact of school reopening on pandemic spread: A case study using an agent-based model for COVID-19

Infectious Disease Modelling 2021年第1期6卷 839-847页

作者： hanisha tatapudi Tapas K.Das Department of Industrial and Management System Engineering University of South FloridaTampaFLUSA

This article examines the impact of partial/full reopening of school/college campuses on the spread of a pandemic using COVID-19 as a case study.The study uses an agent-based simulation model that replicates community spread in an urban region of U.S.A.via daily social mixing of susceptible and infected individuals.Data representing population demographics,SARS-CoV-2 epidemiology,and social interventions guides the model's behavior,which is calibrated and validated using data reported by the government.The model indicates a modest but significant increase(8.15%)in the total number of reported cases in the region for a complete(100%)reopening compared to keeping schools and colleges fully virtual.For partial returns of 75%and 50%,the percent increases in the number of reported cases are shown to be small(2.87%and 1.26%,respectively)and statistically insignificant.The AB model also predicts that relaxing the stringency of the school safety protocol for sanitizing,use of mask,social distancing,testing,and quarantining and thus allowing the school transmission coefficient to double may result in a small increase in the number of reported infected cases(2.14%).Hence for pandemic outbreaks from viruses with similar characteristics as for SARS-CoV-2,keeping the schools and colleges open with a modest campus safety protocol and in-person attendance below a certain threshold may be advisable.

关键词： COVID-19 SARS-CoV-2 Agent-based simulation model School reopening School transmission rate Age-specific impact

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Pregnancy outcomes following supplementation of single dose GnRH agonist to sustain the luteal phase in antagonist fresh embryo transfer cycles:A multicentric prospective cohort study

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Asian pacific Journal of Reproduction 2023年第4期12卷 162-169页

作者： tatapudi S V Parvathi Devi Alka Gahlot Sangita Sharma Manisha Choudhary Ravikant Soni Meeta Sharma Department of Reproductive Medicine&Surgery Mahatma Gandhi Medical College&HospitalJaipurIndia Department of Biochemistry Senior EmbryologistMahatma Gandhi Medical College&HospitalJaipurIndia Department of Reproductive Medicine&Surgery Senior EmbryologistMahatma Gandhi Medical College&HospitalJaipurIndia

Objective:To determine whether a single dose of gonadotropin-releasing hormone(GnRH)agonist administered subcutaneously in addition to the regular progesterone supplementation could provide a better luteal support in antagonist protocol fresh embryo transfer cycles.Methods:This prospective,multicentric,cohort study included total 140 women,70 in each group.Controlled ovarian stimulation was carried out as per fixed GnRH antagonist protocol.The trigger was given with hCG.In vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)was performed and day-3 embryos were transferred.Patients were divided into groups 1 and 2 based on computer generated randomization sheet.Six days following oocyte retrieval,group 1 received 0.2 mg decapeptyl subcutaneously in addition to regular progesterone support while group 2 received progesterone only.Luteal support was given for 14 days to both groups;if pregnancy was confirmed luteal support was continued till 12 weeks of gestation.The clinical pregnancy rate was the primary outcome.The implantation rate,miscarriage rate,live birth delivery rate,and multiple pregnancy rates were the secondary outcomes.Results:A total of 140 patients were analysed,70 in each group.Clinical pregnancy rates(47.1%vs.35.7%;P=0.17),implantation rates(23.4%vs.18.1%,P=0.24),live birth delivery rates(41.4%vs.27.1%,P=0.08),and multiple pregnancy rates(21.2%vs.16.0%,P=0.74)were higher in group 1 than in group 2.Group 1 had a lower miscarriage rate than group 2(5.7%vs.8.6%;P=0.75).However,these differences were not statistically significant between the two groups.Conclusions:Administration of a single dose of GnRH agonist in addition to regular natural micronized vaginal progesterone as luteal support in GnRH antagonist protocol cycles marginally improves implantation rates,clinical pregnancy rates,and live birth delivery rates.However,more studies with higher sample sizes are needed before any conclusive statements about GnRH agonist as luteal phase support can be made.

关键词： GnRH agonist Triptorelin IVF Ovum pick up Luteal phase support Antagonist protocol Cleavage stage Fresh embryo transfer Live birth delivery rate

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