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Antimicrobial Activity of the Methanolic Extract and Compounds from the Stem Bark of Drypetes tessmanniana

Chinese Journal of Integrative Medicine 2010年第4期16卷 337-343页

作者： Victor Kuete Marlise D.J.Dongfack Armelle t.Mbaveng Marie-Christine Lallemand hanh t.van-dufat Jean-Duplex Wansi Elisabeth Seguin Francois tillequin Jean Wandji Department of Biochemistry Faculty of ScienceUniversity of Dschang.P.O.Box 67 DschangCameroon Department of Organic Chemistry Faculty of ScienceUniversity of Yaounde I.P.O.Box 812 YaoundeCameroon Laboratoire de Pharmacognosie de I'Universite Paris Descartes UMR/CNRS N° 8638Faculte des Sciences Biologiques et Pharmaceutiques4-Avenue de I'Observatoire75006 ParisFrance Department of Biochemistry Faculty of ScienceUniversity of Yaounde IP.O.Box 812 YaoundeCameroon Department of Chemistry University of DoualaFaculty of ScienceP.O.Box 24157 DoualaCameroon Laboratoire de Pharmacognosie UFR de Medecine Pharmacie Rouen22-Bid Gambetta76183 Rouen Cedex 1France

Objective： to evaluate the antimicrobial activity of the methanol extract from the stem bark of Drypetes tessmanniana, fractions （DtB1-5） as well as compounds [friedelin （2）, 3,7-dioxofriedelane （3）, 3,15-dioxofriedelane （4）, 313 -O-（E）-3,5-dihydroxycinnamoyl-11 -oxo-olean-12-ene （6）, and 313,6 α -dihydroxylup- 20（29）-ene （7）. Methods： Agar disc diffusion was used to determine the sensitivity of the above samples, whilst the microdilution method was used for the determination of the minimal inhibitory concentration （MIC） and the minimal microbicidal concentrations （MMC）. Results： the diffusion test showed that the crude extract was able to prevent the growth of all tested organisms. All other samples showed selective activity. the inhibitory effect of the fraction DtB2 was noted on 63.7%, that of DtB1 and DBt3 on 54.6%, whilst DtB4 and DtB5 were active on 9.1% of the 11 tested organisms. the tested compounds prevented the growth of 81.8% of the tested microbial species for compounds 3 and 4, 36.7% for compound 6, and 18.2% for compound 7. the results of the MIC determinations indicated perceptible values for DtB and compound 4 on 81.8% of the tested organisms. For other samples, MICs were detected on 0-63.7%. the lowest MIC value （78.12 μg/mL） for the crude extract and fractions （DtB2） was observed on M. audouinii. the corresponding value for isolated compounds （156.25 μg/ mL） was noted with compounds 3 on S. faecalis and 4 on M. audouinii. the results of the MMC determination suggested that the microbicidal effect of most of the tested samples on the studied microorganisms could be expected. Conclusion： the methanol extract from the stem bark of Drypetes. tessmanniana （Euphorbiaceae） as well as some of the isolated compounds might be potential sources of new antimicrobial drues.

关键词： Drypetes tessmanniana Euphorbiaceae compounds antimicrobial activity

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New flavan and unusual chalcone glycosides from Drypetes parvifolia

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Chinese Chemical Letters 2008年第8期19卷 943-946页

作者： Viviane Nadège Nenkep Jovita Chi Shirri hanh trinh van-dufat Falindor Sipepnou Philippe Vérité Elisabeth Seguin Francois tillequin Jean Wandji Department of Organic Chemistry University of Yaounde-1Faculty of ScienceP.O.Box 812YaoundeCameroon Laboratoire de Pharmacognosie de l'Université Paris Descartes UMR/CNRS N 8638Faculté des Sciences Biologiques et Pharmaceutiques4-Avenue de l'Observatoire75006 ParisFrance Laboratoire de Chimie Analytique UFR de Médecine Pharmacie Rouen22-Bid Gambetta76183 Rouen Cedex 1France Laboratoire de Pharmacognosie UFR de Médecine Pharmacie Rouen22-Bld Gambetta76183 Rouen Cedex 1France

two new compounds 7-hydroxy-5-O-（β-D-glucopyranoside） flavan （1） and （Z）-4＇,6＇-dihydroxy-2＇-O-（β-D-glucopyranoside） chalcone （2）, along with eight known compounds, were isolated from the stem bark of Drypetes parvifolia （Euphorbiaceae）. their structures were established on the basis of spectroscopic analysis and chemical evidence.

关键词： Drypetes parvifolia Flavonoid glycosides 7-Hydroxy-5-O-(β-D-glucopyranoside) flavan (Z)-4',6'-Dihydroxy-2'-O-(β-D-glucopyr-anoside) chalcone

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