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Cobalt protoporphyrin-induced nano-self-assembly for CT imaging,magnetic-guidance,and antioxidative protection of stem cells in pulmonary fibrosis treatment

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Bioactive Materials 2023年第3期21卷 129-141页

作者： Yimeng Shu Ming Ma Xiaoxia Pan Muhammad Shafiq Huizhu Yu hangrong chen State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai200050PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049PR China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-laneXiangshanHangzhou310024PR China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438PR China Department of Biotechnology Faculty of Science and TechnologyUniversity of Central Punjab(UCP)Lahore54000Pakistan

Mesenchymal stem cells(MSCs)transplantation is a promising approach for pulmonary fibrosis(PF),however it is impeded by several persistent challenges,including the lack of long-term tracking,low retention,and poor survival of MSCs,as well as the low labeling efficiency of ***,a cobalt protoporphyrin IX(CoPP)aggregation-induced strategy is applied to develop a multifunctional nano-self-assembly(ASCP)by combining gold nanoparticle(AuNPs),superparamagnetic iron oxide nanoparticles(SPIONs),and CoPP through a facile solvent evaporation-driven *** no additional carrier materials are employed during the synthesis,high loading efficiency of active ingredients and excellent biocompatibility are ***,facile modification of the ASCPs with bicyclo[6.1.0]nonyne(BCN)groups(named as ASCP-BCN)enables them to effectively label MSCs through bioorthogonal *** obtained ASCP-BCN could not only help to track MSCs with AuNP-based computed tomography(CT)imaging,but also achieve an SPIONs-assisted magnetic field based improvement in the MSCs retention in lungs as well as promoted the survival of MSCs via the sustained release of *** in vivo results demonstrated that the labeled MSCs improved the lung functions and alle-viated the fibrosis symptoms in a bleomycin–induced PF mouse ***,a novel ASCP-BCN multi-functional nanoagent was developed to bioorthogonally-label MSCs with a high efficiency,presenting a promising potential in the high-efficient MSC therapy for PF.

关键词： Self-assembly Pulmonary fibrosis Cell labeling Stem cell therapy Theranostic

In situ forming oxygen/ROS-responsive niche-like hydrogel enabling gelation-triggered chemotherapy and inhibition of metastasis

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Bioactive Materials 2023年第3期21卷 86-96页

作者： Shi-Xiong chen Ji Zhang Fengfeng Xue Wei Liu Yichen Kuang Bingxin Gu Shaoli Song hangrong chen State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049PR China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesSub-lane Xiangshan Road 1Hangzhou310024PR China Department of Nuclear Medicine Fudan University Shanghai Cancer CenterShanghai200032PR China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai200032PR China Center for Biomedical Imaging Fudan UniversityShanghai200032PR China Shanghai Engineering Research Center of Molecular Imaging Probes Shanghai200032PR China

Though the development of the diverse hypoxia-activated prodrugs(HAPs)has made great progresses in the last several decades,current cancer therapy based on HAPs still suffers many obstacles,e.g.,poor therapeutic outcome owing to hard deep reaching to hypoxic region,and the occurrence of metastasis due to *** by engineered niches,a novel functional chitosan polymer(CS-FTP)is synthesized for construction of a hydrogel-based bio-niche(CS-FTP-gel)in aiming at remodeling tumor hypoxic *** CS-FTP polymers are crosslinked to form a niche-like hydrogel via enzyme-mediated oxygen-consumable dimerization after injected into tumor,in which a HAP(i.e.,AQ4N)could be physically encapsulated,resulting in enhanced tumor hypoxia to facilitate AQ4N-AQ4 toxic transformation for maximizing efficacy of ***,Pazopanib(PAZ)conjugated onto the CS backbone via ROS-sensitive linker undergoes a stimuli-responsive release behavior to promote antiangiogenesis for tumor starvation,eventually contributing to the inhibition of lung metastasis and synergistic action with AQ4N-based chemotherapy for an orthotopic 4T1 breast tumor *** study provides a promising strategy for hypoxia-based chemotherapy and demonstrates an encouraging clinical potential for multifunctional hydrogel applicable for antitumor treatment.

关键词： Hypoxia-activated prodrugs Bio-niches Hypoxia-inducible hydrogels Antimetastases

Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3837-3848页

作者： Xinyue Wang Qian chen Yefei Zhu Kairuo Wang Yongliang Chang Xiawei Wu Weichao Bao Tongcheng Cao hangrong chen Yang Zhang Huanlong Qin Nanomedicine and Intestinal Microecology Research Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072PR China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsShanghai 200050China Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji University1239 Siping RoadShanghai 200092China Precision Medicine Center Taizhou Central Hospital999 Donghai RoadTaizhou 318000 ZhejiangChina

The crucial role of intratumoral bacteria in the progression of cancer has been gradually recognized with the development of sequencing *** intratumoral bacteria which have been identified as pathogens of cancer that induce progression,metastasis,and poor outcome of cancer,while tumor vascular networks and immunosuppressive microenvironment provide shelters for pathogens ***,the mutually-beneficial interplay between pathogens and tumors,named“pathogentumor symbionts”,is probably a potential therapeutic site for tumor ***,we proposed a destroying pathogen-tumor symbionts strategy that kills intratumoral pathogens,***,to break the symbiont and synergize to kill colorectal cancer(CRC)*** strategy was achieved by a groundbreaking protein-supported copper single-atom nanozyme(BSA-Cu SAN)which was inspired by the structures of native enzymes that are based on protein,with metal elements as the active ***-Cu SAN can exert catalytic therapy by generating reactive oxygen species(ROS)and depleting *** in vitro and in vivo experiments demonstrate that BSA-Cu SAN passively targets tumor sites and efficiently scavenges *** in situ to destroy pathogentumor *** a result,ROS resistance of CRC through elevated autophagy mediated by *** was relieved,contributing to apoptosis of cancer cells induced by intracellular redox imbalance generated by BSA-Cu ***,BSA-Cu SAN experiences renal clearance,avoiding long-term systemic *** work provides a feasible paradigm for destroying pathogen-tumor symbionts to block intratumoral pathogens interplay with CRC for antitumor therapy and an optimized trail for the SAN catalytic therapy by the clearable protein-supported SAN.

关键词： colorectal elevated catalytic

Design strategy of optical probes for tumor hypoxia imaging

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Science China(Life Sciences) 2020年第12期63卷 1786-1797页

作者： Fengfeng Xue Jufeng chen hangrong chen State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Clinical manifestations of tumors indicate that malignant phenotypes developing in the hypoxic microenvironment lead to resistance to cancer treatment, rendering chemotherapy, radiotherapy, and photodynamic therapy less sensitive and effective in patients with tumor. Visualizing the oxygen level in the tumor environment has garnered much attention due to its implications in precision tumor therapy. Following the rapid development of biomaterials in nanotechnology, various nanomaterials have been designed to visualize the oxygen levels in tumors. Here, we review recent research on detecting oxygen levels in solid tumors for tumor hypoxia imaging. To monitor the hypoxic level of tumors, two main strategies were investigated: directly detecting oxygen levels in tumors and monitoring the hypoxia-assisted reduced microenvironment. We believe that hypoxia as a tumor-specific microenvironment can be a breakthrough in the clinical treatment of tumors.

关键词： fluorescent imaging tumor hypoxia hypoxia sensing hypoxia probes

H2O2-responsive theranostic nanomedicine

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Chinese Chemical Letters 2017年第9期28卷 1841-1850页

作者： Luodan Yu Yu chen hangrong chen State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai200050 China University of Chinese Academy of Sciences Beijing 100049 China

The fast progress of stimuli-responsive theranostic nanomedicine can achieve the specific and highperformance diagnosis and therapy of various ***,H2O2-responsive theranostic nanomedicine is recently emerging as a new stimuli-responsive modality showing the great potential for the theranostic of diseases with overexpressed H2O2 because H2O2 is associated with several kinds of human diseases as the most stable and abundant reactive oxygen *** review summarizes and discusses the very-recent developments of H2O2-responsive theranostic nanoplatforms for versatile biomedical applications,including diagnostic imaging,attenuating tumor hypoxia,enhancing the therapeutic efficiency of photodynamic therapy/radiation therapy/chemotherapy and theranostic of inflammation/*** facing challenges and future developments of H2O2-responisve theranostics are also briefly discussed to further promote the clinical translation of this new responsive theranostic *** is highly believed that H2O2-responsive theranostic nanomedicine will be extensively developed a new specific and efficient theranostic modality to benefit the personalized biomedicine in the near future.

关键词： Hydrogen peroxide (H2O2) H2O2 responsibility Stimuli-responsive Nanomedicine Theranostic

Construction of smart inorganic nanoparticle-based ultrasound contrast agents and their biomedical applications

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Science Bulletin 2015年第13期60卷 1170-1183页

作者： Ming Ma hangrong chen Jianlin Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of Sciences

Ultrasound(US) imaging in combination with US contrast agents(UCAs) is a powerful tool in the modern biomedical field because of its high spatial resolution, easy access to patients and minimum *** microbubble-based UCAs have been widely used in clinical diagnosis; however, they are only limited to the blood pool imaging and not applicable to the tissue-penetrated imaging due to their large particle size and structural instability. Inorganic nanoparticles(NPs), such as silica,gold and Fe x O y, featured with both satisfactory echogenic properties and structural stability have the potential to be used as a new generation of UCAs. In this review, we present the most recent progresses in the tailored construction of inorganic UCAs and their biomedical applications in the US imaging-involved fields. Firstly, the typical inorganic NPs with different structures including solid, hollow and multiple-layer forms will be comprehensively introduced in terms of their structure design,physicochemical property, US imaging mechanism and diverse applications; secondly, the recent progress in exploring the gas-generating inorganic NP system for US imaging purpose will be reviewed, and these intelligent UCAs are multifunctional for simultaneous US imaging and disease therapy; thirdly, several nanocomposite platforms newly constructed by combining inorganic UCAs with other functional components will be presented anddiscussed. These multifunctional NPs are capable of further enhancing the imaging resolution by providing more comprehensive anatomical information *** but not the least, the design criteria for developing promising UCAs to satisfy both clinical demands and optimized US imaging capability will be discussed and summarized in this review.

关键词： Inorganic nanoparticle .Ultrasoundimaging . Theranostic . Contrast agent

Sodium carbonate-assisted synthesis of hierarchically porous single-crystalline nanosized zeolites

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Science Bulletin 2017年第14期62卷 1018-1024页

作者： Xiaoxia Zhou Yu chen Tongguang Ge Zile Hua hangrong chen Jianlin Shi State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences

Hierarchically porous single-crystalline nanosized zeolites as heterogeneous catalysts show great poten- tial in fine chemistry because they offer more rich hierarchically porous channels for the mass transfer and molecular diffusion. However, the synthesis of hierarchically porous nanosized zeolites generally requires the assistance of templates acting as the mesoporogens, which limits its popularity. Herein, we report a one-pot and template-free synthesis of hierarchically porous single-crystalline nanosized zeolite beta only by introducing sodium carbonate in precursor solution. The resulted sample features the extraordinary properties, including the uniform nanocrystal （200-300 nm）, high pore volume （0.65 cm3g 1） and the hierarchical pore-size distribution （e.g., 2-8 and 90-150 nm）. After slicing pro- cessing, it is interestingly found that a large number of interconnected mesopores penetrate throughout whole material, which enables the hierarchically porous nanosized zeolite beta remarkably superior cat- alytic activity than the conventional zeolite beta in condensation of henzaldehyde with ethanol at room temperature. More importantly, this one-pot sodium carbonate-assisted synthetic strategy is highly ver- satile, which has also been successfully developed to synthesize hierarchically porous nanosized single- crystalline zeolites ZSM-5 and TS.

关键词： Hierarchically porous Single-crystalline Beta/ZSM-5/TS Sodium carbonate Template-free Condensation of benzaldehyde

Simultaneous Al2O3 Doping and Sulfation in Hierarchically Porous ZrO2 Solid Acids by an One-pot Synthesis for Enhanced Recycling Catalytic Performances

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Chinese Journal of Chemistry 2011年第3期29卷 483-488页

作者： Wang, Nan chen, Yu Ye, Zhengqing chen, hangrong Shi, Jianlin State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

Alumina doping and sulfation in hierarchically porous zirconia solid acids have been achieved simultaneously via one-pot and bi-surfactant-assisted self-assembly process, using aluminum sulfate as both Al and SO^2- sources. The prepared composite solid acids showed much enhanced acidity and recycling catalytic activity for an esterification reaction compared with sulfated zirconia without alumina doping and Al-doped sulfated zirconia without hierarchically porous structure.

关键词： one-pot synthesis doping Al-promoted sulfated zirconia hierarchical porous structure material science self-assembly

普鲁士蓝基HClO荧光纳米探针及其对肿瘤细胞的特异性检测

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无机材料学报 2023年第1期38卷 55-61,I0001页

作者：杜邱静刘天智陈菊锋陈航榕中国科学院上海硅酸盐研究所上海200050 中国科学院大学北京100049

次氯酸(HClO)是一种活性氧(ROS),在许多生理和病理过程中起着至关重要的作用。然而,过量的HClO会导致组织损伤、动脉粥样硬化、神经退行性疾病甚至癌症。因此,实时检测肿瘤细胞中HClO对于探索HClO在肿瘤进展以及免疫治疗中的作用具有重... 详细信息

次氯酸(HClO)是一种活性氧(ROS),在许多生理和病理过程中起着至关重要的作用。然而,过量的HClO会导致组织损伤、动脉粥样硬化、神经退行性疾病甚至癌症。因此,实时检测肿瘤细胞中HClO对于探索HClO在肿瘤进展以及免疫治疗中的作用具有重要意义。与目前常用的工艺复杂、水溶性差的有机分子探针不同,本工作简单地将异硫氰酸荧光素(FITC)与中空介孔普鲁士蓝纳米粒子(HMPB)相结合,构建了一种新型的无机亲水荧光纳米探针。由于内滤光效应,HMPB中FITC的荧光有一定程度的猝灭,但通过Fe^(2+)-ClO^(–)氧化还原反应可恢复荧光。体外条件下,加入HClO后,FITC在发射峰(520 nm)处荧光逐渐增强,HClO在5×10^(–6)~50×10^(–6)mol/L范围内呈良好的线性关系,检出限为2.01×10^(–6)mol/L。此外,在细胞水平上,该纳米探针对癌细胞中的HClO显示出良好的特异检测能力,且灵敏度高。

关键词：普鲁士蓝荧光探针 HClO检测