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Preface to Special Issue: Cancer epidemiology, risk factors and screening

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Chinese Journal of Cancer Research 2023年第6期35卷 563-564页

作者： Binghe xu hangcheng xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Cancer continues to be one of the leading causes of morbidity and mortality worldwide, posing significant challenges to public health systems. The International Agency for Research on Cancer(IARC) revealed an increase... 详细信息

关键词： Cancer epidemiology mortality

Docetaxel plus S-1 versus docetaxel plus capecitabine as first-line treatment for advanced breast cancer patients:a prospective randomized phase II study

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Journal of the National Cancer Center 2023年第2期3卷 115-120页

作者： Nilupai Abudureheiyimu Yun Wu Qing Li Pin Zhang Fei Ma Peng Yuan Yang Luo Ying Fan Shanshan Chen Ruigang Cai Qiao Li Yiqun Han hangcheng xu Yan Wang Jiayu Wang Binghe xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background:This study was conducted to evaluate the efficacy and safety of docetaxel/S-1(TS)compared with docetaxel/capecitabine(TX)as a first-line treatment for advanced breast ***:Patients with advanced metastatic breast cancer were randomly divided into the TS group(n=54)and the TX group(n=57)for first-line chemotherapy from August 2015 to April 2019(*** registration ***02947061).Following the completion of combination therapy,patients without progression received S-1 or capecitabine maintenance *** primary end point was progression-free survival(PFS).Results:Among 111 enrolled patients,the median PFS did not differ significantly between the TS group and the TX group(TS ***,9.0 vs.7.4 months,P=0.365,95%confidence interval[CI]:0.50-1.11,hazard ratio[HR]:0.75).There was also no statistically significant difference in median overall survival(OS)between the two groups(TS ***,40.2 vs.41.3 months,P=0.976).In addition,visceral metastasis and metastasis sites,such as the liver or lung,did not lead to a significant effect on PFS and *** two regimens showed no significant difference in adverse events,except hand-foot syndrome,which predominated in the TX group(38.6%vs.7.4%,P=0.001),and diarrhea(24.1%vs.3.6%,P=0.003)and elevation of aspartate aminotransferase(AST)/alanine aminotransferase(ALT)levels(14.8%vs.3.5%,P=0.049),which were more frequent in the TS ***:The TS and TX regimens demonstrated similar efficacy and safety for the first-line treatment of advanced breast *** TS regimen had fewer cases of severe hand-foot syndrome than the TX regimen,representing an effective alternative option to the TX *** studies are warranted to define the efficacy and safety of this strategy in real-world settings.

关键词： Advanced breast cancer Maintenance therapy Docetaxel Capecitabine S-1

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HER2低表达乳腺癌研究进展

国际肿瘤学杂志 2022年第9期49卷 513-516页

作者：徐航程吴云王佳玉国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院内科北京100021

人表皮生长因子受体2(HER2)低表达乳腺癌具有较为独特的生物学行为,与HER2零表达乳腺癌相比,在分子分型与基因表达方面存在显著差异。以T-DXd为代表的新型抗体药物偶联物为HER2低表达乳腺癌患者提供了新的治疗选择,相关临床试验在持续... 详细信息

人表皮生长因子受体2(HER2)低表达乳腺癌具有较为独特的生物学行为,与HER2零表达乳腺癌相比,在分子分型与基因表达方面存在显著差异。以T-DXd为代表的新型抗体药物偶联物为HER2低表达乳腺癌患者提供了新的治疗选择,相关临床试验在持续开展中。目前,HER2低表达与乳腺癌患者预后的关系尚存争议。对HER2低表达乳腺癌的深入研究将有助于进一步改善该类乳腺癌患者的临床结局。

关键词：乳腺肿瘤预后治疗学人表皮生长因子受体2低表达

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乳腺癌免疫治疗研究进展

国际肿瘤学杂志 2024年第4期51卷 227-234页

作者：萨蔷徐航程王佳玉国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院内科北京100021

世界卫生组织国际癌症研究机构发布的2020年全球最新癌症负担数据显示,乳腺癌已经成为全世界范围内发病率最高的恶性肿瘤,在现有的化疗、靶向治疗及内分泌治疗等内科治疗手段的基础上,免疫治疗的发展为乳腺癌治疗提供了全新思路。目前,... 详细信息

世界卫生组织国际癌症研究机构发布的2020年全球最新癌症负担数据显示,乳腺癌已经成为全世界范围内发病率最高的恶性肿瘤,在现有的化疗、靶向治疗及内分泌治疗等内科治疗手段的基础上,免疫治疗的发展为乳腺癌治疗提供了全新思路。目前,免疫治疗在不同分子分型、不同阶段乳腺癌中的临床研究均取得了一定的成果。此外,对免疫治疗与其他疗法联合应用、疗效预测标志物以及免疫相关不良反应的探索也在不断进行。乳腺癌免疫治疗领域未来的研究和发展仍存在很大的空间,这些研究进展将有助于推动免疫治疗在乳腺癌中的进一步应用。

关键词：乳腺肿瘤免疫疗法免疫检查点抑制剂新辅助治疗

Combined algorithm of acquisition and anti-jamming based on SFT

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Journal of Systems Engineering and Electronics 2015年第3期26卷 431-440页

作者： Ying Ma Xiangyuan Bu hangcheng Han Qiaoxian Gong School of Information and Electronics Beijing Institute of Technology

A communication and navigation receiver is required to remove hostile jamming signals and synchronize receiving signals effectively especially for satellite communication and navigation whose resources are becoming more and more limited. This paper proposes a novel signal receiving method by combining the pro- cesses of anti-jamming and synchronization to reduce the overall computationa~ complexity at the expense of slightly affecting the detection probability, which is analyzed in detail by derivations. Furthermore, this paper introduces sparse Fourier transformation （SFT） into the proposed algorithm to replace fast Fourier transfor- mation （FFT） so as to further reduce the calculation time especially in large frequency offset environments.

关键词： acquisition anti-jamming navigation sparse Fourier transformation (SFT).

Energy Efficiency Optimization for D2D Communications Based on SCA and GP Method

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China Communications 2017年第3期14卷 66-74页

作者： Xiaozheng Gao hangcheng Han Kai Yang Jianping An School of Information and Electronics Beijing Institute of Technology Beijing 100081 China.

In this paper, we propose an energy-efficient power control scheme for device-to-device(D2D) communications underlaying cellular networks, where multiple D2D pairs reuse the same resource blocks allocated to one cellular user. Taking the maximum allowed transmit power and the minimum data rate requirement into consideration, we formulate the energy efficiency maximization problem as a non-concave fractional programming(FP) problem and then develop a two-loop iterative algorithm to solve it. In the outer loop, we adopt Dinkelbach method to equivalently transform the FP problem into a series of parametric subtractive-form problems, and in the inner loop we solve the parametric subtractive problems based on successive convex approximation and geometric programming method to obtain the solutions satisfying the KarushKuhn-Tucker conditions. Simulation results demonstrate the validity and efficiency of the proposed scheme, and illustrate the impact of different parameters on system performance.

关键词： device-to-device(D2D) communications power control energy efficiency(EE) successive convex approximation(SCA) geometric programming(GP)

Design of a(480,240)CMOS Analog Low-Density Parity-Check Decoder

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China Communications 2017年第8期14卷 41-53页

作者： Hao Zheng Zhe Zhao Xiangming Li hangcheng Han School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

Digital low-density parity-check(LDPC) decoders can hardly meet the power-limits brought by the new application scenarios. The analog LDPC decoder, which is an application of the analog computation technology, is considered to have the potential to address this issue to some extent. However, due to the lack of automation tools and analog stopping criteria, the analog LDPC decoders suffer from costly handcraft design and additional decoding delay, and are not feasible to practical applications. To address these issues, a decoder architecture using reusable building blocks is designed to lower the handcraft design, and a probability stopping criterion that is specially designed for analog decoder is further planned and implemented to reduce the decoding delay. Then, a(480,240) CMOS analog LDPC decoder is designed and fabricated in a 0.35-μm CMOS technology. Experimental results show that the decoder prototype can achieve 50 Mbps throughput when the power consumption is about 86.3m W, and the decoding delay can be reduced by at most 93% compared with using the preset maximum decoding delay in existing works.

关键词： LDPC analog decoder handcraft design reduction probability stopping criterion for analog decoding reusable building block

Adaptive suppression of passive intermodulation in digital satellite transceivers

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Chinese Journal of Aeronautics 2017年第3期30卷 1154-1160页

作者： Lu TIAN hangcheng HAN Wenhui CAO Xiangyuan BU Shuai WANG School of lnJormation Science and Electronics Beijing Institute of Technology Bering 100081 China

For the performance issues of satellite transceivers suffering passive intermodulation interference,a novel and effective digital suppression algorithm is presented in this *** contrast to analog approaches,digital passive intermodulation（PIM） suppression approaches can be easily reconfigured and therefore are highly attractive for future satellite communication systems.A simplified model of nonlinear distortion from passive microwave devices is established in consideration of the memory *** multiple high-order PIM products falling into the receiving band can be described as a bilinear predictor function.A suppression algorithm based on a bilinear polynomial decorrelated adaptive filter is proposed for baseband digital signal *** consideration of the time-varying characteristics of passive intermodulation,this algorithm can achieve the rapidness of online interference estimation and low complexity with less consumption of *** simulation results show that the algorithm can effectively compensate the passive intermodulation interference,and achieve a high signal-to-interference ratio gain.

关键词： Adaptive digital filters Intermodulation model Interference suppression Passive devices Satellite communication systems

Synthesis and Study of VATP inhibitors as Potential drugs for the Treatment of Osteoporosis

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Synthesis and Study of VATP inhibitors as Potential drugs fo...