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Data-driven Wasserstein distributionally robust chance-constrained optimization for crude oil scheduling under uncertainty

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Chinese Journal of Chemical Engineering 2024年第5期69卷 152-166页

作者： Xin Dai liang Zhao Renchu He Wenli Du Weimin Zhong Zhi Li feng Qian Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Process System Engineering Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

Crude oil scheduling optimization is an effective method to enhance the economic benefits of oil *** uncertainties,including uncertain demands of crude distillation units(CDUs),might make the production plans made by the traditional deterministic optimization models infeasible.A data-driven Wasserstein distributionally robust chance-constrained(WDRCC)optimization approach is proposed in this paper to deal with demand uncertainty in crude oil ***,a new deterministic crude oil scheduling optimization model is developed as the basis of this *** Wasserstein distance is then used to build ambiguity sets from historical data to describe the possible realizations of probability distributions of uncertain demands.A cross-validation method is advanced to choose suitable radii for these ambiguity *** deterministic model is reformulated as a WDRCC optimization model for crude oil scheduling to guarantee the demand constraints hold with a desired high probability even in the worst situation in ambiguity *** proposed WDRCC model is transferred into an equivalent conditional value-at-risk representation and further derived as a mixed-integer nonlinear programming *** case studies from a real-world refinery are conducted to show the effectiveness of the proposed ***-of-sample tests demonstrate that the solution of the WDRCC model is more robust than those of the deterministic model and the chance-constrained model.

关键词： Distributions Model Optimization Crude oil scheduling Wasserstein distance Distributionally robust chance constraints

A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance

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Journal of Genetics and Genomics 2024年第8期51卷 836-843页

作者： Shibo Hou Jingheng Chen Ruobing feng Xuejiao Xu Nan liang Jackson Champer Center for Bioinformatics Center for Life SciencesSchool of Life SciencesPeking UniversityBeijing 100871China

CRISPR homing gene drives have considerable potential for managing populations of medically and agriculturally significant *** operate by Cas9 cleavage followed by homology-directed repair,copying the drive allele to the wild-type chromosome and thus increasing in frequency and spreading throughout a ***,resistance alleles formed by end-joining repair pose a significant *** address this,we create a homing drive targeting the essential hairy gene in Drosophila *** resistance alleles are recessive lethal,while drive carriers have a recoded“rescue”version of *** drive inheritance rate is moderate,and multigenerational cage studies show drive spread to 96%–97%of the ***,the drive does not reach 100%due to the formation of functional resistance alleles despite using four *** alleles have a large deletion but likely utilize an alternate start ***,revised designs targeting more essential regions of a gene may be necessary to avoid such functional *** of the rescue element’s native 3'UTR with a homolog from another species increases drive inheritance by 13%–24%.This was possibly because of reduced homology between the rescue element and surrounding genomic DNA,which could also be an important design consideration for rescue gene drives.

关键词： Genedrive Homing drive Rescueelement Population modification Multiplexed gRNAs Resistance alleles Cage study

Electrospun PCL/gelatin/arbutin nanofiber membranes as potent reactive oxygen species scavengers to accelerate cutaneous wound healing

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Regenerative Biomaterials 2024年第3期3卷 43-55页

作者： Mindong Du Shuhan Liu Nihan Lan Ruiming liang Shengde liang Maoqiang Lan Disen feng Li Zheng Qingjun Wei Ke Ma Department of Orthopaedics Trauma and Hand Surgery The First Affliated Hospital of Guangxi Medical UniversityGuangxi Medical UniversityNanning 530521China Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affliated Hospital of Guangxi Medical UniversityGuangxi Medicar UniversityNanning530021China Guangxi Collaborative Innovation Center for Biomedicine The First Affliated Hospital of Guangxi Medical UniversityGuangxi Medical UniversityNanning 530021China Department of Plastic&Cosmetic Surgery.The First Affliated Hospital of Guangxi Medical University Guangxi Medical UniversityNanning 530021China Pharmaceutical College Guangxi Medical UniversityNanning530021China

The presence of excessive reactive oxygen species(Ros)at a skin wound site is an important factor affecting wound *** scavenging,which regulates the ROS microenvironment,is essential for wound *** this study,we used novel electrospun PCL/gelatin/arbutin(PCL/G/A)nanofibrous membranes as wound dressings,with PCL/gelatin(PCL/G)as the backbone,and plantderived arbutin(hydroquinone-β-D-glucopyranoside,ARB)as an effective antioxidant that scavenges ROos and inhibits bacterial infection in *** loading of ARB increased the mechanical strength of the nanofibres,with a water vapour transmission rate of more than 2500g/(m^(2)×24h),and the water contact angle decreased,indicating that hydrophilicity and air permeability were significantly *** release and degradation experiments showed that the nanofibre membrane controlled the drug release and exhibited favourable *** experiments showed that the PCL/G/A nanofibre membranes were biocompatible,and DPPH and ABTS+radical scavenging experiments indicated that PCL/G/A could effectively scavenge ROS to reflect the antioxidant *** addition,haemostasis experiments showed that PCL/G/A had good haemostatic effects in vitro and in *** vivo animal wound closure and histological staining experiments demonstrated that PCL/G/A increased collagen deposition and remodelled epithelial tissue regeneration while showing good in vivo biocompatibility and *** conclusion,we successfully prepared a multifunctional wound dressing,PCL/G/A,for skin wound healing and investigated its potential role in wound healing,which is beneficial for the clinical translational application of phytomedicines.

关键词： arbutin nanofiber membranes wound dressing reactive oxygen species

Progress in processing of porous titanium:a review

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Rare Metals 2024年第5期43卷 1932-1955页

作者： Xiao-Li Yang Xian-feng Du Zhi-Lin Xu Zhong-Shuai liang Li-Long Xiong Engineering Research Center of Energy Storage Materials and Devices Ministry of EducationSchool of ChemistryXi'an Jiaotong UniversityXi'an 710049China

As a novel structural and functional material,porous titanium and its alloys have been widely used in the aerospace,marine engineering and biomedical fields due to their high corrosion resistance,low density,good biocompatibility and excellent mechanical ***,in this paper,a comprehensive review of powder metallurgy(PM)(including additive manufacturing(AM)processes)for fabricating porous titanium is firstly covered in terms of their working principles,capabilities,shortcomings and ***,the influencing factors of various methods on final pore structure of porous Ti are ***,a summary of the chemical methods(CM)to obtain the porous Ti is also provided,such as dealloying method and reduction ***,the tendency and direction of preparation technology as well as application of porous titanium were prospected.

关键词： Porous titanium Powder metallurgy Chemical method Pore structure Processing process

Comparative Effectiveness of Mobile Health-Based Comprehensive Smoking Cessation Modalities and Traditional Clinic-Delivered Treatments—Beijing Municipality,China,May 2022 to April 2024

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China CDC weekly 2024年第22期6卷 516-521页

作者： Shuilian Chu hang Jing Di Zhang Yuan Cao Yunliang Qian Xiurong Liu Lin Xiao Zhaohui Tong Lirong liang Department of Research on Tobacco Dependence Therapies Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Beijing Center for Disease Prevention and Control BeijingChina Tobacco Control Office Chinese Center for Disease Control and PreventionBeijingChina Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina

What is already known about this topic?Most Chinese smokers have not accessed professional help due to a lack of sufficient smoking cessation *** health(mHealth)can mitigate obstacles related to time and transportation,thereby providing effective support for smokers seeking to *** is added by this report?This study offers real-world evidence supporting the effectiveness of mHealth-based comprehensive smoking cessation *** findings indicate that these modalities can significantly enhance abstinence rates,albeit to a lesser extent compared to traditional clinicbased *** to the intervention was identified as a critical factor influencing the effectiveness of smoking cessation *** are the implications for public health practice?The mHealth-based comprehensive smoking cessation modalities,with or without mailing cessation medications,present a promising approach to enhancing access to and utilization of smoking cessation *** strategy addresses the significant challenge of limited smoking cessation resources in China.

关键词： smoke Health thereby

A multifunctional shear apparatus for rocks subjected to true triaxial stress and high temperature in real-time

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3524-3543页

作者： Jun Zhao Xia-Ting feng Jia-Rong Wang liang Hu Yue Guo Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang110819China Key Laboratory of Liaoning Province on Deep Engineering and Intelligent Technology Northeastern UniversityShenyang110819China

Deep engineering disasters,such as rockbursts and collapses,are more related to the shear slip of rock joints.A novel multifunctional device was developed to study the shear failure mechanism in *** this device,the complete shearedeformation process and long-term shear creep tests could be performed on rocks under constant normal stiffness(CNS)or constant normal loading(CNL)conditions in real-time at high temperature and true-triaxial *** the research and development process,five key technologies were successfully broken through:(1)the ability to perform true-triaxial compressioneshear loading tests on rock samples with high stiffness;(2)a shear box with ultra-low friction throughout the entire stress space of the rock sample during loading;(3)a control system capable of maintaining high stress for a long time and responding rapidly to the brittle fracture of a rock sample as well;(4)a refined ability to measure the volumetric deformation of rock samples subjected to true triaxial shearing;and(5)a heating system capable of maintaining uniform heating of the rock sample over a long *** developing these technologies,loading under high true triaxial stress conditions was *** apparatus has a maximum normal stiffness of 1000 GPa/m and a maximum operating temperature of 300*** differences in the surface temperature of the sample are constant to within5*** types of true triaxial shear tests were conducted on homogeneous sandstone to verify that the apparatus has good performance and *** results show that temperature,lateral stress,normal stress and time influence the shear deformation,failure mode and strength of the *** novel apparatus can be reliably used to conduct true-triaxial shear tests on rocks subjected to high temperatures and stress.

关键词： True-triaxial shear apparatus Rocks Complete shear stressedeformation process Creep Real-time high-temperature

Multi-scale context-aware network for continuous sign language recognition

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虚拟现实与智能硬件（中英文） 2024年第4期6卷 323-337页

作者： Senhua XUE Liqing GAO liang WAN Wei feng College of Intelligence and Computing Tianjin UniversityTianjin 300354China

The hands and face are the most important parts for expressing sign language morphemes in sign language ***,we find that existing Continuous Sign Language Recognition(CSLR)methods lack the mining of hand and face information in visual backbones or use expensive and time-consuming external extractors to explore this *** addition,the signs have different lengths,whereas previous CSLR methods typically use a fixed-length window to segment the video to capture sequential features and then perform global temporal modeling,which disturbs the perception of complete *** this study,we propose a Multi-Scale Context-Aware network(MSCA-Net)to solve the aforementioned *** MSCA-Net contains two main modules:(1)Multi-Scale Motion Attention(MSMA),which uses the differences among frames to perceive information of the hands and face in multiple spatial scales,replacing the heavy feature extractors;and(2)Multi-Scale Temporal Modeling(MSTM),which explores crucial temporal information in the sign language video from different temporal *** conduct extensive experiments using three widely used sign language datasets,i.e.,RWTH-PHOENIX-Weather-2014,RWTH-PHOENIX-Weather-2014T,and *** proposed MSCA-Net achieve state-of-the-art performance,demonstrating the effectiveness of our approach.

关键词： Continuous sign language recognition Multi-scale motion attention Multi-scale temporal modeling

Strain-enhanced polarization sensitivity inβ-Ga_(2)O_(3)photodetector

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 126-137页

作者： Yonghui Zhang Huili liang Fei Xing Qiqian Gao Yu feng Yuping Sun Zengxia Mei School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China

Polarization-sensitive photodetection and imaging have great application value in fields such as polarization division multiplexing optical communication,remote sensing,near-field imaging and military *** a high polarization ratio has always been the research hotspot in polarization-sensitive *** this paper,we report a compression strain enhanced polarization ratio inβ-gallium oxide(β-Ga_(2)O_(3))single crystal flake.A rigorous crystallographic analysis confirmed its high crystalline quality and ***-resolved polarization Raman spectroscopy(ARPRS)was adopted to study the anisotropy of its optical *** ARPRS measurements and theoretical calculation consistently demonstrate the strong optical anisotropy in the high-qualityβ-Ga_(2)O_(3)flake.A polarization ratio of 0.96 was obtained in the flatβ-Ga_(2)O_(3)***,mechanical strain of±0.7%was introduced intoβ-Ga_(2)O_(3).An increased polarization ratio of 0.98 was achieved in the case of 0.7%compression strain,which is,to the best of our knowledge,the highest value for UVC polarization-sensitive *** corresponds to an improved polarization rejection ratio of *** work proposed a new path towards improving polarization sensitivity by applying strain engineering in the active material.

关键词： gallium oxide polarization photodetector anisotropy strain

Postoperative serum tumor markers-based nomogram predicting early recurrence for patients undergoing radical resections of pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3211-3223页

作者： hang He Cai-feng Zou feng Yang Yang Di Chen Jin De-liang Fu Department of Pancreatic Surgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China

BACKGROUND Early recurrence(ER)is associated with dismal outcomes in patients undergoing radical resection for pancreatic ductal adenocarcinoma(PDAC).Approaches for predicting ER will help clinicians in implementing individualized adjuvant *** serum tumor markers(STMs)are indicators of tumor progression and may improve current systems for predicting *** To establish an improved nomogram based on postoperative STMs to predict ER in *** We retrospectively enrolled 282 patients who underwent radical resection for PDAC at our institute between 2019 and *** and multivariate Cox regression analyses of variables with or without postoperative STMs,were performed to identify independent risk factors for ER.A nomogram was constructed based on the independent postoperative *** operating characteristic curve analysis was used to evaluate the area under the curve(AUC)of the *** analysis was performed using Kaplan-Meier survival plot and log-rank *** Postoperative carbohydrate antigen 19-9 and carcinoembryonic antigen levels,preoperative carbohydrate antigen 125 levels,perineural invasion,and pTNM stage III were independent risk factors for ER in *** postoperative STMs-based nomogram(AUC:0.774,95%CI:0.713-0.835)had superior accuracy in predicting ER compared with the nomogram without postoperative STMs(AUC:0.688,95%CI:0.625-0.750)(P=0.016).Patients with a recurrence nomogram score(RNS)>1.56 were at high risk for ER,and had significantly poorer recurrence-free survival[median:3.08 months,interquartile range(IQR):1.80-8.15]than those with RNS≤1.56(14.00 months,IQR:6.67-24.80),P<0.001).CONCLUSION The postoperative STMs-based nomogram improves the predictive accuracy of ER in PDAC,stratifies the risk of ER,and identifies patients at high risk of ER for tailored adjuvant therapies.

关键词： Nomogram Postoperative serum tumor markers Early recurrence Predicting accuracy Adjuvant therapy Pancreatic ductal adenocarcinoma