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Ensemble projections of climate and streamflow in a typical basin of semi-arid steppes in Mongolian Plateau of 2021-2100

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Advances in Climate Change Research 2024年第2期15卷 230-243页

作者： hang pan Jian-Ping TANG Liang CHENG Man-Chun LI Jiangsu Provincial Key Laboratory of Geographic Information Science and Technology Nanjing UniversityNanjing 210023China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Key Laboratory of Mesoscale Severe Weather/Ministry of Education Nanjing UniversityNanjing 210023China School of Atmospheric Sciences Nanjing UniversityNanjing 210023China

The Kherlen River is the main water source for Hulun Lake,the largest lake in northern China.Due to reduced inflow from the Kherlen River,Hulun Lake experienced rapid shrinkage at the beginning of the 21st century,posing a serious threat to the ecological security of northern China.However,there is still a significant lack of projections regarding future climate change and its hydrological response in the Kherlen River basin.This study analyzed the projected climate and streamflow changes in the Kherlen River basin,a vital yet vulnerable international semi-arid steppes type basin.A combination of multi-model ensemble projection techniques,and the soil and water assessment tool(SWAT)model was employed to examine the spatio-temporal changes in precipitation,temperature,streamflow,and the associated uncertainties in the basin.The temperature(an increase of 1.84-6.42℃)and the precipitation(an increase of 15.0-46.0 mm)of Kherlen River basin are projected to increase by 2100,leading to a rise in streamflow(1.08-4.78 m^(3) s^(-1)).The upstream of the Kherlen River exhibits remarkable increasing trends in precipitation,which has a dominant influence on streamflow of Kherlen River.Noteworthy increases in streamflow are observed in April,August,September,and October compared to the reference period(1971-2000).These findings suggest a partial alleviation of water scarcity in the Kherlen River,but also an increased likelihood of hydrological extreme events.The projected temperature increase in the Kherlen River basin exhibits the smallest uncertainty,while more pronounced uncertainties are found in precipitation and streamflow.The spread among the results of CMIP6 models is greater than that of CMIP5 models,with lower signal-to-noise ratio(SNR)values for temperature,precipitation,and streamflow.

关键词： Climate change Flow projection Uncertainty SWAT Mongolian Plateau

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Polycystic ovary syndrome: pathogenic mechanisms and nutritional therapeutic strategies

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Food Science and Human Wellness 2024年

作者： Yanyan Zhao Bin Liu Junying Zhao Yanpin Liu hang pan Yuying Yuan Xiaoyan Tian Weicang Qiao Zhenzhen Zhang Lijun Chen School of Public Health Shandong Second Medical University National Engineering Research Center of Dairy Health for Maternal and Child Beijing Sanyuan Foods Co.Ltd. Beijing Engineering Research Center of Dairy Beijing Technical Innovation Center of Human Milk Research Beijing Sanyuan Foods Co.Ltd. Key Laboratory of Dairy Science Ministry of Education Food Science College Northeast Agricultural University

Polycystic ovary syndrome (PCOS) is the most common endocrine disease afflicting women of childbearing age. It is characterized by irregular menstruation， clinical or biochemical hyperandrogenemia， and polycystic ovary morphology. As a complex endocrine-metabolic syndrome， PCOS shares several endocrine-metabolic features with the metabolic syndrome (MS)， with insulin resistance at the core of their pathogenic mechanisms. PCOS and MS are interrelated and thus have similarities in treatment. Currently， the common treatment modalities for both are lifestyle intervention， medication， and surgery. More studies have shown that lifestyle intervention and regulation of intestinal flora are more effective and sustainable. However， progress towards treatment and cure is hampered by unclear etiology and mechanisms. This review aimed to summarize the relationship between PCOS and MS， the pathogenesis of metabolic disorders， and the current nutritional therapeutic strategies， especially lifestyle modifications and modulation of intestinal flora. Lifestyle interventions combined with the regulation of gut flora can be a new perspective for treatment. This perspective has a positive significance in the early diagnosis， adoption of personalized treatment plans， and prevention of complications in PCOS and MS. The need to prevent the occurrence of MS in patients with PCOS should be emphasized.

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Hematopoietic aging: Cellular, molecular, and related mechanisms

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中华医学杂志(英文版) 2024年第11期137卷 2023 Oct 27页

作者： Ye Li Tian Chuan Li Ye pan hang Hu Jinxiu Shu Liping pan Xinghua The Stem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province Kunming Key Laboratory of Stem Cell and Regenerative Medicine Basic Medical Laboratoryth Hospital of Joint Logistics Support Force PLA Kunming Yunnan China Department of Immunology of School of Basic Medicine of Guizhou Medical University National and Local Joint Engineering Laboratory of Cell Engineering Biomedical Technology Key Laboratory of Regenerative Medicine of Guizhou Province State Key Laboratory of Efficacy and Utilization of Medicinal Plants Co-constructed by Province and Ministry Key Laboratory of Translational Research of Adult Stem Cell of Chinese Academy of Medical Sciences Guiyang Guizhou China

Aging is accompanied by significant inhibition of hematopoietic and immune system function and disruption of bone marrow structure. Aging-related alterations in the inflammatory response, immunity, and stem cell niches are at the root of hematopoietic aging. Understanding the molecular mechanisms underlying hematopoietic and bone marrow aging can aid the clinical treatment of aging-related diseases. In particular, it is unknown how the niche reprograms hematopoietic stem cells (HSCs) in an age-dependent manner to maintain normal hematopoiesis in elderly individuals. Recently, specific inhibitors and blood exchange methods have been shown to reshape the hematopoietic niche and reverse hematopoietic aging. Here, we present the latest scientific discoveries related to hematopoietic aging and hematopoietic system rejuvenation, discuss the relationships between hematopoietic niche aging and HSC aging, and describe related studies on stem cell-mediated regulation of hematopoietic aging, aiming to provide new ideas for further study.

关键词： Stem cells Hematopoietic stem cell Niche Hematopoietic aging

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Long-term surface water changes and driving cause in Xiong'an,China:from dense Landsat time series images and synthetic analysis

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Science Bulletin 2018年第11期63卷 708-716页

作者： Chunqiao Song Linghong Ke hang pan Shengan Zhan Kai Liu Ronghua Ma Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China Department of Geography University of CaliforniaLos AngelesLos AngelesCA 90095United States School of Earth Sciences and Engineering Hohai UniversityNanjing 211100China Department of Geographic Information Science Nanjing UniversityNanjing 210023China

China's government statement recently reported the plan of constructing Xiong'an New Area, which aims to phase out some extra capital functions from Beijing and to explore an innovative urban development mode with the priority in eco-environmental protection. The New Area is located in the semi-arid North China Plain(NCP) and is home to NCP's largest natural freshwater wetland, Baiyangdian Lake. A comprehensive realization of surface water dynamics would be crucial for policy-makers to outline a sustainable environment development strategy for New Area. In this study, we used a total of 245 time slices of cloud-free Landsat images to document the continuous changes of water bodies within Xiong'an City during 1984-2016 and to provide detailed evidence of water presence and persistency states and changes under the influences of climate change and human actions. Our results reveal that the New Area water body areas varied dramatically during the past 33 years, ranging from 0.44 km^2 in April 1988 to317.85 km^2 in February 1989. The change of surface water area was not characterized by a monotonically decreasing tendency. The evolution processes can be divided into four sub-stages: the first extreme desiccation in mid-1980 s, the wet stage with the most extensive inundation areas and strong inter-annual fluctuations from late-1988 to late 1999, another desiccation stage in early 2000 s, and the overall recovering stage between 2007 and 2016. We also mapped the maximum water inundation extents and frequencies of all-season, pre-wet season(February-May) and post-wet season(September-December) for the 33 years and different sub-periods. Although there is good agreement between time series of surface water area evolution in the New Area and station-based precipitation and evaporation variations, multiple lines of evidences reviewed in previous research indicate that the degraded Baiyangdian Lake was also tightly associated with human activities from various aspects, including dam construction, groundwater extraction, agr

关键词： Landsat 表面水水变中国合成分析开车图象时间

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Review of micro-expression spotting and recognition in video sequences

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Virtual Reality & Intelligent Hardware 2021年第1期3卷 1-17页

作者： hang pan Lun XIE Zhiliang WANG Bin LIU Minghao YANG Jianhua TAO School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China

Facial micro-expressions are short and imperceptible expressions that involuntarily reveal the true emotions that a person may be attempting to suppress,hide,disguise,or conceal.Such expressions can reflect a person's real emotions and have a wide range of application in public safety and clinical diagnosis.The analysis of facial micro-expressions in video sequences through computer vision is still relatively recent.In this research,a comprehensive review on the topic of spotting and recognition used in micro expression analysis databases and methods,is conducted,and advanced technologies in this area are summarized.In addition,we discuss challenges that remain unresolved alongside future work to be completed in the field of micro-expression analysis.

关键词： Facial expression Micro-expression spotting Micro-expression recognition Database Review

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Water storage changes in the North China Plain from 2004 to 2019

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Science China(Technological Sciences) 2023年第7期66卷 2036-2046页

作者： CHEN MinLan XU YuYue pan hang WANG LuHan School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Jiangsu Provincial Key Laboratory of Geographic Information Science and Technology Nanjing UniversityNanjing 210023China Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China National Earth System Science Data Center National Science and Technology Infrastructure of ChinaBeijing 100101China

In the past few decades,the irrational use of water resources has resulted in many issues such as land subsidence in the North China Plain(NCP),hindering its socio-economic development.An accurate understanding of water resource changes is important for the allocation of water resources in the NCP.In this study,we employed Gravity Recovery and Climate Experiment(GRACE) satellite data to monitor the total water storage(TWS) change in the NCP during 2004–2019.Evapotranspiration,precipitation,and runoff during 2004–2019 were sequentially examined,using the water balance formula(WBF),to retrieve TWS change.Furthermore,the soil moisture,snow water equivalent,and canopy water storage from the Global Land Data Assimilation System were used to calculate the natural component of the TWS variations.A comparison of these results revealed the drivers of the changes in water resources.The results showed that:(1) overall TWS retrieved by GRACE decreased substantially as a consequence of human activity,while TWS obtained by WBF fluctuated periodically around zero under the impact of three natural drivers;(2) TWS in the NCP fell at a remarkable rate of-12.39 mm/y from 2004 to 2019,and the natural part of TWS experienced two significant declines,during 2004–2010 and 2013–2016;(3) variations in runoff,precipitation,and evapotranspiration from 2004 to 2019 were not significant,but human activities contributed more to the decreasing TWS than natural factors.This study provides a reference for water resource management and groundwater exploitation across the NCP under climate change.

关键词： North China Plain water storage GRACE human activities climatic factor

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Direction controllable inverse transition radiation from the spatial dispersion in a graphene-dielectric stack

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Photonics Research 2019年第10期7卷 1154-1160页

作者： SEN GONG MIN HU ZHENHUA WU hang pan HAOTIAN WANG KAICHUN Zhang RENBIN ZHONG JUN ZHOU TAO ZHAO DIWEI LIU WEI WANG CHAO Zhang SHENGGANG LIU Terahertz Research Center School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China Key Laboratory of Terahertz Technology Ministry of EducationChengdu 610054China Glasgow College University of Electronic Science and Technology of ChinaChengdu 610054China School of Physics and Institute for Superconducting and Electronic Materials University of WollongongNew South Wales 2522Australia

Transition radiation(TR) induced by electron–matter interaction usually demands vast accelerating voltages, and the radiation angle cannot be controlled. Here we present a mechanism of direction controllable inverse transition radiation(DCITR) in a graphene-dielectric stack excited by low-velocity electrons. The revealed mechanism shows that the induced hyperbolic-like spatial dispersion and the superposition of the individual bulk graphene plasmons(GPs) modes make the fields, which are supposed to be confined on the surface, radiate in the stack along a special radiation angle normal to the Poynting vector. By adjusting the chemical potential of the graphene sheets, the radiation angle can be controlled. And owing to the excitation of bulk GPs, only hundreds of volts for the accelerating voltage are required and the field intensity is dramatically enhanced compared with that of the normal TR. Furthermore, the presented mechanism can also be applied to the hyperbolic stack based on semiconductors in the infrared region as well as noble metals in the visible and ultraviolet region.Accordingly, the presented mechanism of DCITR is of great significance in particle detection, radiation emission,and so on.

关键词： dispersion dielectric inverse

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虚拟导航支气管镜联合EBUS-GS技术在直径≤2 cm的肺外周结节诊断中的应用

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现代生物医学进展 2024年第5期24卷 925-929页

作者：潘航程杨旸潘霞武良权杨健张秀伟南京医科大学附属江宁医院呼吸与危重症医学科江苏南京211100

目的:探究虚拟导航支气管镜联合EBUS-GS技术在直径≤2 cm的肺外周结节诊断中的诊断价值。方法:本研究采用回顾性分析的方法,选取2019年5月-2022年5月期间在我院就诊的140例直径≤2 cm的肺外周结节患者作为研究对象,随机分为对照组和实验... 详细信息

目的:探究虚拟导航支气管镜联合EBUS-GS技术在直径≤2 cm的肺外周结节诊断中的诊断价值。方法:本研究采用回顾性分析的方法,选取2019年5月-2022年5月期间在我院就诊的140例直径≤2 cm的肺外周结节患者作为研究对象,随机分为对照组和实验组,各70例。对照组使用传统支气管镜技术进行诊断,实验组使用虚拟导航支气管镜联合EBUS-GS技术进行诊断,并进行随访实验。记录并比较两组患者的可视率、操作时间、诊断率及并发症发生率等指标。结果:对照组和实验组中的病灶位置比较,两组差异无统计学意义(P>0.05)。实验组与对照组病变大小相比差异无统计学意义(P>0.05),实验组可视率高于对照组。对照组和实验组的支气管镜操作总时间比较,无明显统计学差异(P>0.05),探及病灶位置时间与对照组相比,实验组低于对照组(P<0.05)。实验组中恶性病变的诊断率为89.74%,良性肺结节的诊断率为83.87%,而对照组恶性病变的诊断率为60%,良性结节的诊断率为50%,两组间病变性质的良性和恶性诊断率相比较,差异均具有统计学意义(P<0.05)。与对照组相比,实验组不良反应发生率2.86%低于对照组不良反应发生率18.57%,差异具有统计学意义(P<0.05)。结论:虚拟导航支气管镜联合EBUS-GS技术是一种可行且有效的方法,可用于直径≤2 cm的肺外周结节的诊断。该技术既可提高诊断准确性,又可减少不必要的切除手术,对患者具有重要的临床意义。

关键词：虚拟导航支气管镜气道内超声-引导鞘管(EBUS-GS) 肺外周结节诊断

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超表达HnCYP82M3和DsTRI基因对颠茄托品烷生物碱合成的影响

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药学学报 2024年第3期59卷 775-783页

作者：穆德会刘艳红陈漂漂谭艾娟马炳南潘航张明生强玮贵州大学生命科学学院/农业生物工程研究院山地植物资源保护与种质创新教育部重点实验室贵州贵阳550025

托品烷生物碱(TAs)是一类临床上广泛应用的抗胆碱药物,颠茄是提取TAs的主要药源植物,利用代谢工程技术大量获取TAs具有重要的产业价值。本研究基于开源引流代谢工程策略,在颠茄发根中超表达TAs合成途径分支处的细胞色素氧化酶(cytochrom... 详细信息

托品烷生物碱(TAs)是一类临床上广泛应用的抗胆碱药物,颠茄是提取TAs的主要药源植物,利用代谢工程技术大量获取TAs具有重要的产业价值。本研究基于开源引流代谢工程策略,在颠茄发根中超表达TAs合成途径分支处的细胞色素氧化酶(cytochrome oxidase,CYP82M3)HnCYP82M3(来源于天仙子)和托品酮还原酶I(tropinone reductase I,TRI)DsTRI(来源于曼陀罗)两个酶基因,以期通过CYP82M3催化合成托品酮(开源),TRI进而将托品酮引入TAs合成的代谢方向(引流),大量促进3种TAs的积累。从天仙子根中克隆了HnCYP82M3基因,其编码氨基酸与颠茄AbCYP82M3序列一致性高达91.7%。单独超表达HnCYP82M3不影响颠茄发根TAs的含量,说明CYP82M3不是TAs合成的关键酶。同时超表达HnCYP82M3和DsTRI极大促进了3种TAs的积累,莨菪碱、山莨菪和东莨菪碱含量分别是对照的4.97倍、2.83倍和2.19倍,并且提高幅度大于DsTRI单表达。本研究证明分支点处酶基因共表达的开源引流策略是有效提高颠茄TAs合成的代谢工程新方法,为工业化大量获取TAs奠定了理论和技术基础。

关键词： CYP82M3 TRI 托品烷生物碱颠茄代谢工程

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Additive manufacturing of tungsten,tungsten-based alloys,and tungsten matrix composites

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Tungsten 2023年第1期5卷 1-31页

作者： Shuai-hang pan Gong-Cheng Yao Yi-Nan Cui Fan-Shi Meng Chuan Luo Tian-Qi Zheng Gurminder Singh Department of Mechanical Engineering University of UtahSalt Lake CityUT 84112USA University of California-Los Angeles Los AngelesCA 90095USA Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China University of Grenoble Alpes CNRSGrenoble INPSIMaP38000 GrenobleFrance Department of Civil and Systems Engineering Johns Hopkins University3400 N.Charles StreetBaltimoreMD 21218USA Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China School of Mechanical and Materials Engineering University College DublinDublin 4Ireland Department of Mechanical Engineering Indian Institute of Technology BombayMumbai 400076India

Tungsten(W) materials are gaining more and more attention due to the extended applications of metallic systems in the extreme environments.Given W’s unique characteristics like room-temperature brittleness,additive manufacturing(AM)techniques could give them a higher design flexibility and manufacturability.With the growing focus and thriving development of W-faced AM techniques,since the mechanical performance of additively manufactured W parts is still unsatisfactory,a critical review to further explore the possibilities of combining W and AM processes is urgently needed.In this review,we systematically explain the fundamentals of AM processes for W materials.Following the traditional classification,we further discuss the widely used AM processes including wire arc additive manufacturing(WAAM),electron beam melting(EBM),laser powder bed fusion(LPBF),laser direct energy deposition(laser DED),and other modified yet emergent AM techniques.Accordingly,since additively manufacturing W materials is processing parameter-sensitive,we illustrated the effects of various important processing parameters on the AM process control and final parts’ quality.With this detailed understanding,various categories of AM-compatible W materials(i.e.,pure W,W alloys,and W composites) were presented,and their general mechanical performance,distinct role(particularly the role of different alloying elements and added secondary-phase particles in W),and application-oriented benefits have been summarized.After clarifying the current status,main challenges,and triumphant successes for additively manufacturing W materials,we further provide a concise prospect into the development of additively manufactured(AMed) W materials by integrating potential fabrication,measurement,alloy design,and application’s considerations.In summary,this critical review investigates the fundamental and practical problems crucially limiting the applications of AMed W materials,and the comprehensive discussion concentrates the history of the development and combinat

关键词： Tungsten Additive manufacturing Alloy design Composite design Cracking Mechanical properties

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