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Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential

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World Journal of Stem Cells 2024年第5期16卷 512-524页

作者： hang Zhang Ling-Zi Wu Zhen-Yu Liu Zi-Bing jin Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Human induced pluripotent stem cell(hiPSC)technology is a valuable tool for generating patient-specific stem cells,facilitating disease modeling,and invest-igating disease mechanisms.However,iPSCs carrying specific mutations may limit their clinical applications due to certain inherent characteristics.AIM To investigate the impact of MERTK mutations on hiPSCs and determine whether hiPSC-derived extracellular vesicles(EVs)influence anomalous cell junction and differentiation potential.METHODS We employed a non-integrating reprogramming technique to generate peripheral blood-derived hiPSCs with and hiPSCs without a MERTK mutation.Chromo-somal karyotype analysis,flow cytometry,and immunofluorescent staining were utilized for hiPSC identification.Transcriptomics and proteomics were employed to elucidate the expression patterns associated with cell junction abnormalities and cellular differentiation potential.Additionally,EVs were isolated from the supernatant,and their RNA and protein cargos were examined to investigate the involvement of hiPSC-derived EVs in stem cell junction and differentiation.RESULTS The generated hiPSCs,both with and without a MERTK mutation,exhibited normal karyotype and expressed pluripotency markers;however,hiPSCs with a MERTK mutation demonstrated anomalous adhesion capability and differentiation potential,as confirmed by transcriptomic and proteomic profiling.Furthermore,hiPSC-derived EVs were involved in various biological processes,including cell junction and differentiation.CONCLUSION HiPSCs with a MERTK mutation displayed altered junction characteristics and aberrant differentiation potential.Furthermore,hiPSC-derived EVs played a regulatory role in various biological processes,including cell junction and differentiation.

关键词： Cell junction Cellular differentiation Extracellular vesicle Human induced pluripotent stem cells Transcriptomics Proteomics

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FeNi Prussian blue analogues on highly graphitized carbon nanosheets as efficient glucose sensors

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Rare Metals 2024年第6期43卷 2730-2738页

作者： jin-hang Xue Qiu-Hong Sun Cheng Han Yuan-Dong Yang Shao-Jie Xu Qi-Peng Li jin-Jie Qian College of Life and Environmental Science Wenzhou University College of Chemistry and Materials Engineering Wenzhou University College of Chemistry and Chemical Engineering Zhaotong University

Meeting the continuous glucose monitoring requirements of individuals necessitates the research and development of sensors with high sensitivity and stability.In this study,a straightforward strategy was proposed for synthesizing ultra-thin oxygen-rich graphitized carbon nanosheets（denoted as GCS-O）.These nanosheets are obtained by calcining a topologically two-dimensional indium-based coordination polymer.Subsequently,the growth of FeNi Prussian blue analogue（PBA） on GCS-O effectively introduces active sites and increases the nitrogen content within the carbonaceous matrix.The resulting FeNi-PBA/GCS-O composite exhibits excellent glucose sensing performance with a broad linear range of 1 to 1300μmol·L-1.Meanwhile,it also achieves a high sensitivity of 2496 μA·mmol-1·L·cm-2,a limit of detection of 100nmol·L-1（S/N=3）,and commendable long-term durability.The relatively simple synthesis process,exceptional sensitivity,and satisfactory electrochemical sensing performance of FeNi-PBA/GCS-O open up new directions for biosensor applications.

关键词： Coordination polymer Carbon nanosheet Prussian blue analogue Surface reconstruction Glucose oxidation

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Exploring precursor effect in in-situ reconstruction of Bi metal organic-frameworks during CO_(2)electroreduction reaction to tailor formate selectivity towards 100%

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Science China Chemistry 2024年第7期67卷 2190-2198页

作者： Zhida Liu Qikui Fan hang Huo Fanglei Yao Xiaoping Gao jin Wang College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Key Laboratory of Functional Molecular Solids Ministry of EducationCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Bi-based metal-organic frameworks(Bi-MOFs)as efficient catalysts for the CO_(2)electroreduction reaction(CRR)have been extensively investigated.It has been established that Bi-MOFs usually undergo in-situ transformation during the CRR,ultimately converting into Bi nanostructures.However,the effect of the MOF precursors on the structure of the derived Bi catalysts and consequently on their electrocatalytic properties has not been clearly elucidated.In this work,we prepared four variants of a novel Bi-MOF with different morphologies and dimensions,and explored the effects of the precursors on the resulting Bi catalysts and their CRR performance.A precursor-dependent in-situ transformation and its profound impact on tuning the CO_(2)-formate FE towards~100%have been revealed.Among the four examined variants,Bi-MOF with nanocube-like morphology(BiMOF-NC)is transformed into thin and flat Bi nanosheets capable of successfully enveloping the fibers of carbon paper(working electrode),while the other three variants with increased size and dodecahedral/octahedral geometry have been transformed into Bi nanoflowers,exposing a fair portion of the carbon fibers in the working electrode.Furthermore,the transformation rate was found to be dependent on the precursors and BiMOF-NC exhibited the highest rate of reconstruction compared with other samples.Consequently,the Bi catalyst derived from BiMOF-NC delivered a selectivity for the formate product of nearly 100%at-1.2 V(vs.reversible hydrogen electrode(RHE))and of over 95%in a wide potential range due to efficient suppression of the competing hydrogen evolution reaction(HER)over carbon fibers.The in-situ transformed BiMOFNC also demonstrated equivalently high formate selectivity at large current densities(≥100 mA cm^(-2))in flow cell reactors as that in H-type reactors,underscoring its potential for industrial applications.This work highlights the necessity of finely tuning the structural features of MOF precursors to achieve optimized electrocatalytic performance.

关键词： Bi-MOFs precursor effect in-situ transformation Bi nanosheets CO2-to-formate

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Fe/S oxidation-coupled arsenic speciation transformation mediated by AMD enrichment culture under different pH conditions

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Journal of Environmental Sciences 2024年第3期137卷 681-700页

作者： Yu-hang Zhou Wei-xi Huang Zhen-yuan Nie Hong-chang Liu Yue Liu Can Wang jin-lan Xia Wen-sheng Shu Key Lab of Biometallurgy of Ministry of Education of China School of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China School of Life Sciences South China Normal UniversityGuangzhou 510631China

Arsenic(As)speciation transformation in acid mine drainage(AMD)is comprehensively affected by biological and abiotic factors,such as microbially mediated Fe/S redox reactions and changes in environmental conditions(pH and oxidation-reduction potential).However,their combined impacts on arsenic speciation transformation remain poorly studied.Therefore,we explored arsenic transformation and immobilization during pyrite dissolution mediated by AMD enrichment culture under different acidic pH conditions.The results for incubation and mineralogical transformation of solid residues show that in the presence of AMD enrichment culture,pH 2.0,2.5,and 3.0 are more conducive to the formation of jarosites and ferric arsenate,which could immobilize high quantities of dissolved arsenic by adsorption and coprecipitation.The pH conditions significantly affect the initial adsorption of microbial cells to the minerals and the evolution of microbial community structure,further infuencing the biodissolution of pyrite and the release and oxidation process of Fe/S.The results of Fe/S/As speciation transformation of the solid residues show that the transformation of Fe,S,and As in solution is mainly regulated by pH and potential values,which imposed significantly different effects on the formation of secondary minerals and thus arsenic oxidation and immobilization.The above results indicated that arsenic transformation is closely related to the Fe/S oxidation associated with pyrite bio-oxidation,and this correlation is critically regulated by the pH conditions of the system.

关键词： Acid mine drainage(AMD) pH conditions Fe/S/As speciation transformation Microbial community structure

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Tunable magneto-Seebeck effect in Co_(2)FeSi/MgO/Co_(2)FeSi heterostructure via optimized interfacial engineering

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 128-135页

作者： jingyu Li Xianbiao Shi Yurong jin Le Ma Liuming Wei Chi Zhang hang Li Peng-Fei Liu International Joint Research Laboratory of New Energy Materials and Devices of Henan Province School of Physics and ElectronicsHenan UniversityKaifeng 475004China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Defence Industry Secrecy Examination and Certification Center Beijing 100089China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Department of Network Security Henan Police CollegeZhengzhou 450046China College of Electrical Engineering Henan University of TechnologyZhengzhou 450001China

Enhancing the tunneling magneto-Seebeck(TMS) ratio and uncovering its underlying mechanism are greatly demanded in spin caloritronics.The magnitude and sign of the TMS effect depend on the type of atom and the stacking order of atoms at the interfaces.Herein,we demonstrate that TMS ratios can be effectively manipulated by altering heterogonous or homogeneous interface through decoration on the CoFeSi(001) surface inserted on the MgO insulating layers.The maximum TMS ratio of pure Co_(2)/O termination is 4565% at 800 K.Notably,the TMS ratio of the FeSi/O termination has two peak values,of which the maximum could reach up to-3290% at 650 K.By comparing two different atom arrangements at the interface,we reveal that the sign and symbol of the TMS ratio can be controlled by the temperature and different atomic configurations at the Co_(2)FeSi/MgO interface.Furthermore,the spin-Seebeck coefficient up to ~150 μV/K is also possible when we select suitable terminations and temperatures.These findings will provide useful insights into how to control the sign and symbol of the TMS ratio and accordingly stimulate the development field of magneto-thermoelectric power and spin caloritronic devices based on the magneto-Seebeck effect in Heusler-based metallic multilayers.

关键词： magneto-Seebeck effect interface spintronics electronic structure spin-Seebeck effect

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Clinical observation of extraction-site incisional hernia after laparoscopic colorectal surgery

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 710-716页

作者： Bao-hang Fan Ke-Li Zhong Li-jin Zhu Zhao Chen Fang Li Wen-Fei Wu Second Clinical Medical College of jinan University Jinan UniversityShenzhen 518020Guangdong ProvinceChina Department of Gastrointestinal Surgery Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina Department of Radiation Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina

BACKGROUND Laparoscopic colorectal cancer surgery increases the risk of incisional hernia(IH)at the tumor extraction site.AIM To investigate the incidence of IH at extraction sites following laparoscopic colo-rectal cancer surgery and identify the risk factors for IH incidence.METHODS This study retrospectively analyzed the data of 1614 patients who underwent la-paroscopic radical colorectal cancer surgery with tumor extraction through the abdominal wall at our center between January 2017 and December 2022.Diffe-rences in the incidence of postoperative IH at different extraction sites and the risk factors for IH incidence were investigated.RESULTS Among the 1614 patients who underwent laparoscopic radical colorectal cancer surgery,303(18.8%),923(57.2%),171(10.6%),and 217(13.4%)tumors were ex-tracted through supraumbilical midline,infraumbilical midline,umbilical,and off-midline incisions.Of these,52 patients developed IH in the abdominal wall,with an incidence of 3.2%.The incidence of postoperative IH was significantly higher in the off-midline incision group(8.8%)than in the middle incision groups[the supraumbilical midline(2.6%),infraumbilical midline(2.2%),and umbilical incision(2.9%)groups](χ^(2)=24.985;P<0.05).Univariate analysis showed that IH occurrence was associated with age,obesity,sex,chronic cough,incision infection,and combined diabetes,anemia,and hypopro-teinemia(P<0.05).Similarly,multivariate analysis showed that off-midline incision,age,sex(female),obesity,incision infection,combined chronic cough,and hypoproteinemia were independent risk factors for IH at the site of laparoscopic colorectal cancer surgery(P<0.05).CONCLUSION The incidence of postoperative IH differs between extraction sites for laparoscopic colorectal cancer surgery.The infraumbilical midline incision is associated with a lower hernia rate and is thus a suitable tumor extraction site.

关键词： Incisional hernia Laparoscopy Colorectal cancer Incision infection

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Genome-wide analysis of Panonychus citrimicro RNAs witha focus on potential insecticidal activity of 4 micro RNAs toeggs and nymphs

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Insect Science 2024年第2期31卷 354-370页

作者： Chuan-Zhen Li Yu-hang Liu Deng Pan Meng-Hao Xia Qiang Zhang Yu-Chuang Li Guo-Rui Yuan jin-Jun Wang Wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwestUniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina

Panonychus citriMcGregor(Acari:Tetranychidae),a destructive citrus pest,causes considerable annual economic losses due to its short lifespan and rapid resistancedevelopment.MicroRNA(miRNA)-induced RNA interference is a promising approachfor pest control because of endogenous regulation of pest growth and development.Tosearch for miRNAs with potential insecticidal activity inP.citri,genome-wide analysis ofmiRNAs at different developmental stages was conducted,resulting in the identificationof 136 miRNAs,including 73 known and 63 novel miRNAs.A total of 17 isomiRNAsand 12 duplicated miRNAs were characterized.MiR-1 and miR-252-5p were identified asreference miRNAs forP.citriandTetranychus urticae.Based on differential expressionanalysis,treatments with miR-let-7a and miR-315 mimics and the miR-let-7a antagomirsignificantly reduced the egg hatch rate and resulted in abnormal egg development.Over-expression or downregulation of miR-34-5p and miR-305-5p through feeding significantlydecreased the adult eclosion rate and caused molting defects.The 4 miRNAs,miR-let-7a,miR-315,miR-34-5p,and miR-305-5p,had important regulatory functions and insectici-dal properties in egg hatching and adult eclosion.In general,these data advance our un-derstanding of miRNAs in mite biology,which can assist future studies on insect-specificmiRNA-based green pest control technology.

关键词： growth and development microRNAs Panonychus citri referencemiRNAs regulation small RNA libraries

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Thermal safety boundary of lithium-ion battery at different state of charge

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Journal of Energy Chemistry 2024年第4期91卷 59-72页

作者： hang Wu Siqi Chen Yan Hong Chengshan Xu Yuejiu Zheng Changyong jin Kaixin Chen Yafei He Xuning Feng Xuezhe Wei Haifeng Dai Clean Energy Automotive Engineering Center Tongji UniversityShanghai 201804China College of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China

Thermal runaway(TR)is a critical issue hindering the large-scale application of lithium-ion batteries(LIBs).Understanding the thermal safety behavior of LIBs at the cell and module level under different state of charges(SOCs)has significant implications for reinforcing the thermal safety design of the lithium-ion battery module.This study first investigates the thermal safety boundary(TSB)correspondence at the cells and modules level under the guidance of a newly proposed concept,safe electric quantity boundary(SEQB).A reasonable thermal runaway propagation(TRP)judgment indicator,peak heat transfer power(PHTP),is proposed to predict whether TRP occurs.Moreover,a validated 3D model is used to quantitatively clarify the TSB at different SOCs from the perspective of PHTP,TR trigger temperature,SOC,and the full cycle life.Besides,three different TRP transfer modes are discovered.The interconversion relationship of three different TRP modes is investigated from the perspective of PHTP.This paper explores the TSB of LIBs under different SOCs at both cell and module levels for the first time,which has great significance in guiding the thermal safety design of battery systems.

关键词： Lithium-ion battery Battery safety Thermal runaway State of charge Numerical analysis

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Nanoindentation behavior and creep-induced cracking of long-term crept austenitic steel at 650℃

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Journal of Iron and Steel Research(International) 2024年第2期31卷 464-474页

作者： Zhen Zhang Yu-hang Duan Shuai Wang jin-shan Chen An-zhe Wang Xiang-yang Mao Yuan-ji Shi Jie Zhang Ming Liu Zheng-fei Hu School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing211167JiangsuChina Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing211167JiangsuChina Jiangsu Wind Power Engineering Technology Center Nanjing210023JiangsuChina Nanjing Vocational University of Industry Technology Nanjing210023JiangsuChina Baoshan Iron&Steel Co. Ltd.Shanghai201900China Fujian Provincial Key Laboratory of Terahertz Functional Devices and Intelligent Sensing School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou350116FujianChina School of Materials Science and Engineering Tongji UniversityShanghai201804China

The grain boundary(GB)damage of long-term crept HR3C(25Cr–20Ni–Nb–N)austenitic steel with solid solution state was investigated by nanoindentation test accompanied with in-situ electron back-scattered diffraction.The corresponding microstructure was characterized by scanning electron microscopy and transmission electron microscopy.Results show that the increase in nanoindentation hardness at the GBs and triple grain junctions may be related to the dislocation accumulation and carbide growth during the creep.Coarsened M23C6 and dislocations piling-up at the GB accelerate the nucleation and coalescence of creep cavity along the GB.The nanoindentation hardness in grains varies with orientation of the stress axis.The orientation difference of neighbor grains may induce local high geometrically necessary dislocation densities and strain gradients near the GB,consequently causing stress concentration and subsequent crack growth at specific GBs.

关键词： Austenitic steel Creep Nanoindentation Grain orientation Creep-induced cracking

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Tungsten chalcogenides as anodes for potassium-ion batteries

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Tungsten 2024年第2期6卷 278-292页

作者： Yu-Han Wu Wei-Hao Xia Yun-Zhuo Liu Peng-Fei Wang Yu-hang Zhang jin-Ru Huang Yang Xu De-Ping Li Li-Jie Ci School of Environmental and Chemical Engineering Shenyang University of TechnologyShenyang 110870China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China State Key Laboratory of Advanced Welding and Joining School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Department of Chemistry University College LondonLondon WC1H 0AJUnited Kingdom

Potassium-ion batteries(PIBs)by virtue of their strong cost competitiveness and similar electrochemical properties to lithiumion batteries have been deemed to be a promising electrochemical energy storage technology.To promote the application in the commercial market,developing electrode materials with high specifi c capacities,superior cycling stability,and reliable safety is of great importance.Anode materials as an important component of PIBs play a decisive role,among which twodimensional transition metal chalcogenides(2D TMCs)have attracted wide attention owing to their unique material and electrochemical properties.In the 2D TMCs’family,molybdenum chalcogenides as fl agship are the most studied materials and demonstrated the potential as anodes.With the deepening of research on 2D TMCs,another shining member that possesses similar properties to molybdenum chalcogenides,tungsten chalcogenides(WS_(2),WSe_(2),and WTe_(2)),has aroused tremendous attention.Despite many inspiring results,various challenges remain to be further addressed;meanwhile,some results are still unclear and disputed.Herein,this review fi rst introduces their material properties and electrochemical storage mechanisms.Then,we systematically overview the research progress and put forward promoting improvement strategies.Finally,challenges and opportunities that would be future research directions are discussed.

关键词： Electrochemical energy storage Potassium-ion batteries Anodes Tungsten chalcogenides

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