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Plant Diversity 2021年第4期43卷 292-298页

作者： Yu-hang chang Gang Yao Jens Neilsen De-Tuan Liu Lu Zhang Yong-Peng Ma Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Key Laboratory for Plant Diversity and Biogeography of East Asia Chinese Academy of SciencesKunmingYunnan 650201China Dobbies Garden Centre UK-DD2 PerthScotlandUK Flower Research Institute Yunnan Academy of Agricultural SciencesKunmingYunnan 650051China

Rhododendron kuomeianum ***,***&***,a new species of Rhododendron(Ericaceae)within *** in *** from Yiliang County,NE Yunnan,China,is described and *** new species is similar to ***,but it can be easily distinguished by its sparse scales on the abaxial surface of the leaf blade,fewer flowers per inflorescence and white corolla with pale red *** are also differences in the widths of calyx lobes,leaf blade shape and indumentum characteristics of the petiole between the new species and Rhododendron *** confirmed that *** is a new species closely related to *** and *** with phylogenomic studies of 10 species within this subsection based on restriction site-associated DNA sequencing(RADseq)*** phylogenomic analyses also clarified additional taxonomic problems in this subsection previously raised by morphological *** findings make a strong case for using next-generation sequencing to explore phylogenetic relationships and identify new species,especially in plants groups with complicated taxonomic problems.

关键词： Rhododendron New species RAD-seq Phylogenetic position

Does the critically endangered Rhododendron amesiae deserve top priority for conservation?

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Plant Diversity 2022年第6期44卷 625-628页

作者： Yi-Shan Ao Yu-hang chang De-Tuan Liu Yong-Bo Liu Yong-Peng Ma Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Populations Kunming Institute of BotanyChinese Academy of SciencesKunming650201China University of the Chinese Academy of Sciences Beijing100049China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing100012China

The genus Rhododendron is the largest genus of woody plants in China,having extremely important horticultural value(Chamberlain et al.,1996).However,efforts have only recently been made to assess the conservation status of the *** to conservation category assessments on the Red List of Rhododendrons(Gibbs et al.,2011)and the Threatened Species List of China's Higher Plants(Qin et al.,2017),32.03%and 17.13%of rhododendrons are evaluated to be threatened.

关键词： Rhododendron endangered Species

He-Wei Granule enhances anti-tumor activity of cyclophosphamide by changing tumor microenvironment

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Chinese Herbal Medicines 2022年第1期14卷 79-89页

作者： Jianxiu Zhai Zehai Song hang chang Yuwei Wang Na Han Zhihui Liu Jun Yin Key Laboratory of Northeast Plant Materials Department of Pharmacognosy and UtilizationSchool of Traditional Chinese MedicineShenyang Pharmaceutical UniversityShenyang 110016China

Objective:He-Wei Granule(HWKL)is a modern product derived from the modified formulation of traditional Chinese medicine Banxia Xiexin Decoction(BXD),which remarkedly enhanced the anti-proliferation activity of cyclophosphamide(CTX)on HepG2 and SGC-7901 cell lines in vitro in our previous *** aim of the study was to investigate the synergistic effects of HWKL and CTX using a transplanted H22 hepatocellular carcinoma mouse ***:The CTX-toxic-reducing efficacy of HWKL was evaluated by hematology indexes,organ indexes and marrow DNA *** investigate the underlying mechanisms,histopathology test,immunohistochemistry test and TUNEL staining were *** efficacy of HWKL on the micro-vessel density(MVD)in tumor tissue was also evaluated by measuring CD34 ***:High dose HWKL(6.75 g/kg)markedly attenuated CTX-induced hepatotoxicity and myelosuppression while significantly enhanced CTX anticancer efficacy in *** mechanism investigation suggested that high dose HWKL significantly increased cleaved Caspase 3 level and promoted apoptosis in tumor tissue by up-regulating Bax expression and down-regulating Bcl-2 and FasL *** with CTX alone group,the decrease in LC-3B and Beclin 1 levels suggested that the autophagy in H22 carcinoma was significantly inhibited with addition of high dose *** assay results indicated that the autophagy inhibition was achieved by decreasing p53 expression,blocking PI3K/AKT/mTOR pathway and recovering Th1/Th2 cytokine *** addition,CD34 and EGFR immunohistochemistry assay suggest that high dose HWKL could significantly decrease micro-vessel density(MVD)and inhibit angiogenesis in H22 ***:It can be concluded that high-dose HWKL enhanced CTX efficacy by promoting apoptosis,inhibiting autophagy and angiogenesis in tumor tissue while significantly alleviated CTX-induced toxicity,and could be applied along with CTX in clinical treatment as a supplement agent.

关键词： cyclophosphamide He-Wei Granule H22 carcinoma synergistic effect toxicity

Thirdhand smoke: Genotoxicity and carcinogenic potential

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Chronic Diseases and Translational Medicine 2020年第1期6卷 27-34页

作者： hang Bo Wang Pin Zhao Yue chang hang Mao Jian-Hua Antoine MSnijders Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Gastroenterology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsu 210008China Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Thirdhand smoke (THS), the residual tobacco smoke remaining in the environment after tobacco has been smoked, represents a hidden and underestimated public health hazard. Evidence supports its widespread presence in indoor environments. Exposure to secondhand smoke (SHS), a precursor of THS, has been well documented as a risk factor for human cancers, especially lung cancer. However, the concept of THS as a distinct entity that poses health risks for small children has developed only recently and the associations of THS with cancer risk and other chronic diseases are poorly understood due to limited numbers of studies to date. In this perspective, we mainly summarize all published studies on the genotoxicity and carcinogenic potential of THS exposure. These studies begin to fill the knowledge gap in our understanding of cancer risk of THS. Accumulating data from existing and future studies will help reduce the tobacco-related cancer incidence through changes in lifestyle and tobacco control policies.

关键词： Tobacco Thirdhand smoke Tobacco-specific nitrosamines Genotoxicity Carcinogenesis

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Olmesartan Reduces New-onset Atrial Fibrillation and Atrial Fibrillation Burden after Dual-chamber Pacemaker Implantation in Atrioventricular Block Patients

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Chinese Medical Journal 2016年第18期129卷 2143-2148页

作者： hang Zhang chang Pan Juan Zhang Lin-Lin Zhu Kai Huang Yun Zhong Zuo-Ying Hu Department of Cardiology Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu 210006 China

Background： Atrial fibrillation （AF） is the rnost frequent tachyarrhythmia in patients with a permanent pacemaker. Angiotensin II receptor antagonists have a protective effect against the occurrence of AF in patients with heart diseases. This study aimed to assess the effectiveness of olmcsartan in the prevention of new-onset AF and AF burden in atrioventricular block （AVB） patients with dual-chamber （DDD） pacemaker implantation. Methods： This was a single-center, prospective, randomized, single-blind, controlled clinical study. A total of 116 AVB patients, who received DDD pacemakers implantation with the percentage of ventricular pacing （VP%） _〉40% from April 22, 2011 to December 24, 2012, were prospectively randomized to olrnesartan group （20 mg per day; n - 57） or control group （n = 59）. Patients were lbllowed up using pacernaker prograrnming± 12-lead electrocardiography in the intrinsic sinus rhythm, laboratory examinations, and transthoracic echocardiography at 24 months. Atrial high rate events （AHREs） were defined as 180 beats/min over a minimum of 5 min. AF burden was calculated by the number of hours with AHREs divided by the number of measurement hours. Results： Ten （17.5%） patients in the olmesartan group and 24 patients （40.7%） in the control group occurred new-onset AF, and the difference between two groups was statistically significant （P = 0.04）. AF burden was lower in olmesartan group than that in control group （8.02 ± 3.10% vs. 13.66 ± 6.14%, P = 0.04）. There were no significant differences in mean days to the first occurrence of AHREs and mean cumulative numbers of AHREs between two groups （P = 0.89 and P = 0.42, respectively）. Moreover, olmesartan group had smaller values of maximal P-wave durations and P-wave dispersion （PD） after 24 months follow-up compared with the control group （ 109.5 ± 7.4 ins vs. 113.4 ± 7.1 ms, P = 0.00; and 40.6 ± 4.5 ms vs. 43.3 ± 4.4 ins, P - 0.02, respectively）. Left ventricular end-diastolic diameter and left ventri

关键词： Angiotensin II Receptor Antagonist Atrial Fibrillation Olmesartan Pacemaker Ventricular Pacing

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叶片圆盘泵固液两相流动规律数值模拟

中国石油大学学报（自然科学版） 2010年第5期34卷 147-151,158页

作者：周昌静陈国明徐长航中国石油大学海洋油气装备与安全技术研究中心山东东营257061 中国石油大学机电工程学院山东东营257061

为研究叶片圆盘泵内流动规律,将叶片圆盘泵叶轮分为无叶区和叶片区,采用多重参考坐标系法模拟叶轮在泵体内的转动。采用Eulerian多相流模型、RNGk-ε湍流模型与SIMPLEC算法,利用Fluent软件对叶片圆盘泵内固液两相湍流进行数值模拟。在... 详细信息

为研究叶片圆盘泵内流动规律,将叶片圆盘泵叶轮分为无叶区和叶片区,采用多重参考坐标系法模拟叶轮在泵体内的转动。采用Eulerian多相流模型、RNGk-ε湍流模型与SIMPLEC算法,利用Fluent软件对叶片圆盘泵内固液两相湍流进行数值模拟。在水力性能试验验证的基础上,得到叶轮无叶区和叶片区内压力和速度变化规律,以及固相体积分数分布规律。结果表明:旋流是叶轮无叶区内主要流动方式,无叶区内较大部分是低压区,存在叶片区高能流体流向无叶区的轴向流动;固相颗粒大部分集中于无叶区,叶片区颗粒浓度最高是在叶轮出口叶片工作面靠近无叶区处。分析认为大部分固体颗粒直接从无叶区排出而不经过叶轮叶片区是叶片圆盘泵具有良好固相通流能力而又对叶轮磨损较小的原因。

关键词：计算流体力学叶片圆盘泵无叶区叶片区固液两相湍流流动规律数值模拟

基于支持向量机和蒙特卡洛的结构可靠性分析方法及应用

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中国石油大学学报（自然科学版） 2008年第4期32卷 103-108页

作者：徐长航陈国明谢静中国石油大学机电工程学院山东东营257061

将支持向量机作为极限状态函数重构的工具引入结构可靠性分析问题中,并结合蒙特卡洛方法,分别给出了模式识别型和函数回归型两种支持向量机(SVM)模型应用于结构可靠性分析的计算流程图。结合数值算例,对两种支持向量机模型在结构可靠性... 详细信息

将支持向量机作为极限状态函数重构的工具引入结构可靠性分析问题中,并结合蒙特卡洛方法,分别给出了模式识别型和函数回归型两种支持向量机(SVM)模型应用于结构可靠性分析的计算流程图。结合数值算例,对两种支持向量机模型在结构可靠性问题的应用方面进行了对比,并研究了训练样本数目、核函数类型、模型参数的取值以及随机变量数目等因素对可靠性分析结果的影响。最后以某自升式平台为工程对象,进行了考虑多个随机变量的结构可靠性评估。结果表明:在应用支持向量机方法进行极限状态函数重构时,无论是模式识别型SVM模型还是函数回归型SVM模型均可取得良好的效果,前者对模型参数的敏感程度大于后者;支持向量机理论作为极限状态函数重构工具与蒙特卡洛方法相结合,可有效解决大型复杂工程结构可靠性分析精度和效率问题。

关键词：支持向量机蒙特卡洛方法极限状态函数重构结构可靠性分析自升式平台

Orbits quality and PPP application for Galileo

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Orbits quality and PPP application for Galileo

第九届中国卫星导航学术年会

作者： Guofeng Ji hang chang Zhiqiang Yang Xiaolin Jia Liang Zhang College of Geology Engineering and Geomantics Chang'an University National key laboratory of Geographic information Engineering Xi'an Research Institute of Surveying and Mapping

The orbit quality and PPP application of the Galileo precise products from five MGEX analysis centers(AC) are analyzed in this article, the influence of Solar Radial Pressure(SRP) model on Precise Orbit Determination(POD) is studied. The results show that: the quality of Galileo orbit from GFZ and TUM is significantly improved if the Cuboid Box-Wing(CBW) priori model is used. The SLR residual amplitudes reduced from 20 cm down to 10 cm, the STD has decreased about 50%, and the mean SLR bias is reduced from-2.06.0 cm to millimeters level;and PHMs clock-offsets daily linear fitting results also show that the periodic signature could be significantly reduced, which is consistent with the results of SLR residuals. CODE’s ECOM2 model shows slightly worse performance than CBW+ECOM1 model, but much better than classic ECOM1 model. In addition, the mean SLR bias of CODE’s and WHU’s orbits is about-2.04.0 cm, too larger than the result of other Analysis Center, so that the impact of albedo model and antenna thrust require appropriate consideration. Precise point positioning(PPP) error of Galileo-only is about 1.0 cm in horizontal, which is very close to the results of GPS-only, but larger than 3.0 cm in vertical component due to the limited number of active satellites. The convergence speed of GPS/Galileo combined solution is faster than any single system, the positioning accuracy in horizontal is improved respect to GPS-only, but a small degradation can be observed in vertical component.

关键词： Galileo system Precise Orbit determination SLR residuals Solar Radiation model PPP

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机器视觉在水松纸印刷质量检测中的应用

科学技术与工程 2013年第15期21卷 4240-4245,4251页

作者：黄杭昌厦门鑫叶包装材料有限公司厦门361022

介绍了利用机器视觉原理在高速分切机上对水松纸进行高精度印刷质量检测的方案。详细介绍了系统的硬件结构及其功能、检测算法和软件设计。系统具有检测精度高、速度快的特点。实现了对高速水松纸分切机上产品的在线质量检测。

关键词：机器视觉水松纸印刷质量检测高速

CA-CFAR in Weibull Background

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CA-CFAR in Weibull Background