检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

液相沉淀法制备高纯超细阻燃型氢氧化镁

塑料科技 2024年第2期52卷 94-99页

作者：曾书航杜莹陈婷李智力裴丰郭忠何东升唐远杨晶晶武汉工程大学资源与安全工程学院湖北武汉430073 湖北宜化化工科技研发有限公司湖北宜昌443300

以硫酸镁为原料,氢氧化钠为沉淀剂,加入适量硬脂酸钠(NaSt)和聚乙二醇(PEG2000)作为表面活性剂,采用液相沉淀法制备高纯超细阻燃型氢氧化镁粉体。考察沉淀方式、反应物配比、反应温度、搅拌速率、反应时间、表面活性剂配比、表面活性剂... 详细信息

以硫酸镁为原料,氢氧化钠为沉淀剂,加入适量硬脂酸钠(NaSt)和聚乙二醇(PEG2000)作为表面活性剂,采用液相沉淀法制备高纯超细阻燃型氢氧化镁粉体。考察沉淀方式、反应物配比、反应温度、搅拌速率、反应时间、表面活性剂配比、表面活性剂用量和洗涤方式等对氢氧化镁粉体粒径的影响。测试了产物形貌、晶相结构、粒径及粒径分布、纯度、分散效果和润湿性。结果表明:制备超细氢氧化镁的适宜的工艺条件包括,沉淀方式为双向沉淀,n(NaOH)∶n(MgSO4)=2.5∶1.0,反应温度为60℃,搅拌速率为400 r/min,反应时间为50 min,NaSt/PEG2000的配比为4∶1、添加量为4 g/mol MgSO4,洗涤方式为纯水洗涤3次。所得的氢氧化镁表面呈疏水性,接触角达123.50°,分散性好,纯度高达99.50%,平均粒径为3.83μm,粒度分布均匀并呈六方片状晶体。样品白度、纯度和粒径满足阻燃剂用氢氧化镁指标。

关键词：超细氢氧化镁表面改性表面活性剂阻燃剂

Huge pelvi-abdominal malignant inflammatory myofibroblastic tumor with rapid recurrence in a 14-year-old boy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第21期16卷 2698-2701页

作者： Chia-Hsun Lu Hsuan-Ying Huang Han-Koo Chen Jiin-Haur Chuang shu-hang Ng Sheung-Fat Ko Department of Radiology Chang Gung Memorial Hospital-Kaohsiung Medical CenterChang Gung University College of MedicineKaohsiung Hsien833TaiwanChina Department of Pathology Chang Gung Memorial Hospital-Kaohsiung Medical CenterChang Gung University College of MedicineKaohsiung Hsien833TaiwanChina Department of Pediatric Surgery Chang Gung Memorial Hospital-Kaohsiung Medical CenterChang Gung University College of MedicineKaohsiung Hsien833TaiwanChina

Inflammatory myofibroblastic tumor(IMT) is an uncommon benign neoplasm with locally aggressive behavior but malignant change is *** report an unusual case of pelvic-abdominal inflammatory myofibroblastic tumor with malignant transformation in a 14-year-old boy presenting with abdominal pain and 9 kg body weight loss in one *** tomography revealed a huge pelvi-abdominal mass(30 cm),possibly originating from the pelvic extraperitoneal space,protruding into the abdomen leading to upward displacement of the bowel loops,downward displacement of the urinary bladder,massive central necrosis,a well-enhanced peripheral solid component with prominent peritumoral *** examination confirmed the computed tomographic *** examination revealed proliferative epitheloid and spindle cells,inflammatory cell infiltration and high mitotic *** was strongly positive for anaplastic lymphoma kinase and revealed a high proliferative index(ki-67 = 40%).DNA sequencing and electronic microscopy further confirmed the primitive fibroblastic cell phenotype of the tumor and a final diagnosis of inflammatory myofibroblastic tumor with malignant transformation was *** tumor recurrence was noted 20 d after radical tumor *** our knowledge,this is the largest documented case of IMT in a pediatric patient and the first report of IMT with malignant transformation originating from the pelvic extraperitoneal space.

关键词： Inflammatory myofibroblastic tumor Malignant transformation Pediatric patient Pelvis Extraperitoneal space Computed tomography

Clinical outcomes of EGFR-TKI treatment and genetic heterogeneity in lung adenocarcinoma patients with EGFR mutations on exons 19 and 21

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2016年第4期35卷 171-180页

作者： Jiang-Yong Yu Si-Fan Yu shu-hang Wang Hua Bai Jun Zhao Tong-Tong An Jian-Chun Duan Jie Wang The Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Thoracic Medical Oncology Peking University School of OncologyBeijing Cancer Hospitaland Institute

Background:Epidermal growth factor receptor(EGFR) mutations,including a known exon 19 deletion(19 del) and exon 21 L858 R point mutation(L858R mutation),are strong predictors of the response to EGFR tyrosine kinase inhibitor(EGFR-TKI) treatment in lung ***,whether patients carrying EGFR 19 del and L858 R mutations exhibit different responsiveness to EGFR-TKls and what are the potential mechanism for this difference remain *** study aimed to investigate the clinical outcomes of EGFR-TKI treatment in patients with EGFR 19 del and L858 R mutations and explore the genetic heterogeneity of tumors with the two mutation ***:Of 1127 patients with advanced lung adenocarcinoma harboring EGFR 19 del or L858 R mutations,532 received EGFR-TKI treatment and were included in this *** 19 del and L858 R mutations were detected by using denaturing high-performance liquid chromatography(DHPLC).T790 M mutation,which is a common resistant mutation on exon 20 of EGFR,was detected by amplification refractory mutation system(ARMS).Next-generation sequencing(NGS) was used to explore the genetic heterogeneity of tumors with EGFR 19 del and L858 R ***:Of the 532 patients,319(60.0%) had EGFR 19 del,and 213(40.0%) had L858 R *** patients with EGFR 19 del presented a significantly higher overall response rate(ORR) for EGFR-TKI treatment(55.2%vs.43.7%,P = 0.017) and had a longer progression-free survival(PFS) after first-line EGFR-TKI treatment(14.4 vs.11.4 months,P = 0.034) compared with those with L858 R ***,no statistically significant difference in overall survival(OS) was observed between the two groups of patients.T790 M mutation status was analyzed in 88 patients before EGFR-TKI treatment and 134 after EGFR-TKI treatment,and there was no significant difference in the co-existence of T790 M mutation with EGFR 19 del and L858 R mutations before EGFR-TKI treatment(5.6%vs.8.8%,P = 0.554)or after treatme

关键词： EGFR exon 19 deletion EGFR exon 21 L858R point mutation Lung adenocarcinoma Treatment efficacy

Computed tomography findings in fatal cases of enormous hepatic portal venous gas

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第19期11卷 2953-2955页

作者： Siu-Cheung Chan Yung-Liang Wan Yun-Chung Cheung shu-hang Ng Alex Mun-Ching Wong Koon-Kwan Ng Department of Diagnostic Radiology Chang Gung Memorial Hospital Linko Medical Center and Keelung HospitalTaoyuanTaiwanChina

AIM: To assess the computed tomography (CT) findings in the patients with hepatic portal venous gas (HPVG) who presented with a short fatal clinical course in our hospital in order to demonstrate if there was any sign for ***: Between January 1997 and December 2000, CT scan of the abdomen was performed on 949 patients with acute abdominal pain in our emergency *** patients were found having HPVG. The CT images and clinical presentations of all these five patients were reviewed. RESULTS: In reviewing the CT findings of the cases, HPVG in bilateral hepatic lobes, abnormal gas in the superior mesenteric veins, small bowel intramural gas, and bowel distension were observed in all patients. Dry gas in multiple branches of the mesenteric vein was also revealed in all cases. All the patients expired due to irreversible septic shock within 48 h after their initial clinical presentation in emergency room. Two patients had acute pancreatitis with grade D and E Balthazar classification and they expired within 24 h due to progressing septic shock under aggressive medical treatment and life support. Two patients with underlying end stage renal disease expired within 48 h even though emergent surgical intervention was undertaken. The excited bowels revealed severe ischemic change. One patient expired only a few hours after the CT examination. CONCLUSION: HPVG is a diagnostic clue in patients with acute abdominal conditions, and CT is the most specific diagnostic tool for its evaluation. The dry mesenteric veins are the suggestive fatal sign, especially for the deteriorating patients, with the direct effect on gastrointestinal perfusion.

关键词： Hepatic portal vein Intestines Ischemia Computed tomography

Prenatal diagnosis of choledochal cyst using magnetic resonance imaging: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第32期11卷 5082-5083页

作者： Alex Mun-Ching Wong Yun-Chung Cheung Yu-Hung Liu Koon-Kwan Ng Siu-Cheung Chan shu-hang Ng Department of Diagnostic RadiologyChang Gung Memorial Hospital Kwei-ShanTao-YuanTaiwanChina Obstetrics and GynecologyChang Gung Memorial Hospital 222Mei Chin RoadKeelungTaiwanChina

Choledochal cysts are congenital anomalies of the biliary ducts, characterized by cystic dilatation of the *** diagnosis of this anomaly using ultrasonography (US) has been well documented. Magnetic resonance imaging (MRI) has recently become an important complement to US in prenatal diagnosis of fetal anomalies. We herein report a patient in whom at 24 wk' gestation US suggested a right upper quadrant abdominal cyst and in whom at 26 wk' gestation MRI more clearly delineated the cyst and its surrounding structures and suggested a choledochal cyst, which was confirmed at postnatal surgery and histopathology.

关键词： Choledochal cyst Prenatal diagnosis MRI

A comparative analysis of the endoscopic endonasal and pterional approaches for clipping anterior communicating artery aneurysms on three-dimensional printed models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第17期134卷 2113-2115页

作者： Kun Qin Yue Wang Ge Tian Jian-Tao Zheng Hui Jiang Kai Tang hang shu Dong Zhou Guang-Zhong Chen Department of Neurosurgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Institute for Medical Device Standardization Administration National Institutes for Food and Drug ControlBeijing 100050China Department of Neurology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Anterior communicating artery(ACoA)aneurysms account for the largest proportion of intracranial aneurysms and are the most likely to rupture.[1]The main treatment methods are endovascular embolization and traditional craniotomy clipping.[2]With the rapid development of interventional materials and technologies in the last two decades,many medical centers have adopted endovascular embolization as the preferred treatment for intracranial ***,some aneurysms still require traditional craniotomy *** endoscopy technology has also developed rapidly in recent years.[3]Because intracranial aneurysms are mostly within the circle of Willis and occur on the ventral side of the skull base,a few neurosurgeons have tried to use an endoscopic endonasal approach(EEA)for clipping.[4-6]However,the number of cases reported in the literature is small and more anatomical studies are needed to deeply analyze the approach and technique.

关键词： nasal aneurysm likely

药物不良事件因果关系评估方法及实施步骤讨论

在线全文

学校读者我要写书评

暂无评论

中国临床药理学杂志 2024年第2期40卷 299-304页

作者：房虹贾硕鹏王海学裴小静刘敏于安琪周凌云石方芳卢淑杰王书航俞悦崔丹丹唐玉李宁温泽淮国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院药物临床试验研究中心北京100021 国家药品监督管理局药品审评中心北京100022 赛诺菲中国投资有限公司北京100022 辉瑞中国投资有限公司上海201210 信达生物制药有限公司江苏苏州215000 广东省中医院临床研究方法学重点研究室广州广东510120

药物不良事件评估是药物临床安全性评价及上市后风险控制的重要依据,其因果关系评估日益受到重视。现有的药物与不良事件发生之间的因果关系评估方法大致可分为全面内省法、标准化法和概率法3类。目前,国内尚没有文献对各种方法的操作... 详细信息

药物不良事件评估是药物临床安全性评价及上市后风险控制的重要依据,其因果关系评估日益受到重视。现有的药物与不良事件发生之间的因果关系评估方法大致可分为全面内省法、标准化法和概率法3类。目前,国内尚没有文献对各种方法的操作细节进行系统介绍。本文从定义及概念、方法步骤、行业评价和优缺点等方面对现有各种因果关系评估方法进行了梳理,明确了药物不良事件因果关系判断的基本流程,同时也探讨如何进一步健全药物不良事件风险管理体系,以期为中国药物研发和药物警戒工作提供参考。

关键词：不良事件个例评价因果关系评估评价方法药物警戒

Bladder preservation in complicated invasive urothelial carcinoma following treatment with cisplatin/gemcitabine plus tislelizumab:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第5期11卷 1165-1174页

作者： Rui Yang Jun-Xing Chen shu-hang Luo Ting-Ting Chen Ling-Wu Chen Bin Huang Department of Urology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina The Medical Department 3D Medicines Inc.Shanghai 200120China

BACKGROUND Invasive urothelial carcinoma(UC)with squamous and glandular differentiation is a highly malignant and complicated pathological subtype,and the standard care is radical cystectomy(RC).However,urinary diversion after RC significantly reduces patient quality of life,thus bladder-sparing therapy has become a research hotspot in this ***,five immune checkpoint inhibitors have been approved for systemic therapy of locally advanced or metastatic bladder cancer by the Food and Drug Administration,but the efficacy of immunotherapy combined with chemotherapy for invasive UC is still unknown,especially for pathological subtypes with squamous and glandular *** SUMMARY We report the case of a 60-year-old male who complained of repetitive painless gross hematuria and was diagnosed with muscle-invasive bladder cancer with squamous and glandular differentiation,defined as cT3N1M0 according to the American Joint Committee on Cancer,who had a strong desire to preserve the *** staining revealed that programmed cell deathligand 1(PD-L1)expression in the tumor was ***,a transurethral resection to maximize removal of the bladder tumor was performed under cystoscopy,and the patient subsequently received a combination of chemotherapy(cisplatin/gemcitabine)and immunotherapy(tislelizumab)*** tumor recurrence in the bladder was observed following pathological and imaging examination after 2 cycles and 4 cycles of treatment,*** patient achieved bladder preservation and has been tumor-free for more than two *** This case shows that the combination of chemotherapy and immunotherapy might be an effective and safe treatment strategy for PD-L1 expression positive UC with divergent histologic differentiation.

关键词： Invasive urothelial carcinoma Immunotherapy Chemotherapy Squamous and glandular differentiation Tislelizumab Case report

Understand the Temperature Sensing Behavior of Solid-state Polymerized PEDOT Hybrid Based on X-ray Scattering Studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第1期42卷 105-112,I0010页

作者： Zhen-hang He Guang-Feng Liu Ze-Kun Zhou Zhen Liu Yi-shu Zeng Peng Zhang School of Materials Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China Shanghai Advanced Research Institute(Zhangjiang Laboratory) Chinese Academy of SciencesShanghai 201204China

Poly(3,4-ethylenedioxythiophene)(PEDOT) is one of the most successful conductive polymers that recently has been used in wearable sensors for human health monitoring. In this work, we prepared a series of PEDOT hybrids consisting of PEDOT, sodium poly(styrene sulfonate)(PSSNa) and polyethylene oxide(PEO), and their preparation could be scaled-up via an adapted solid-state polymerization process. The resistance of the as-prepared PEDOT:PSS/PEO hybrid shows clear temperature response, i.e., it decreases almost linearly with the temperature increase. To understand this phenomenon, the in situ synchrotron radiation wide-and small-angle X-ray scattering(WAXS/SAXS) characterizations were undertaken to study the temperature-dependent microstructure change of the PEDOT:PSS/PEO hybrid. It demonstrated that PEDOT formed conductive paths in the hybrids, which were not destroyed by the PEO crystallization. As temperature increased, the PEO crystals' melting and the accompanying reorganization of PEDOT chains endowed the hybrid sample temperature responsiveness. Based on these fundamental knowledges, the hybrid materials were used to fabricate flexible wearable sensor that showing temperature sensing performance with an accuracy of 1 ℃. These findings shed lights on the scalable manufacturing of wearable sensors for body temperature monitoring.

关键词： Solid-state polymerization PEDOT hybrid Structure-property correlation X-ray scattering