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Effect of radical surgery combined with pre- or postoperative radiotherapy in treatment of resectable rectal cancer

The Chinese-German Journal of Clinical Oncology 2012年第7期11卷 384-390页

作者： Ehab Atif hanem sakr Saleh Teama Dalia Zayed Surgical Gastroenterology Center Mansoura UniversityMansouraEgypt Clinical Oncology and Nuclear Medicine Department Mansoura UniversityMansouraEgypt

Objective： This study was done to compare between the effect of preoperative radiotherapy and postoperative radiotherapy in treatment of resectable rectal carcinoma. The primary endpoints are local recurrence rate, overall survival （OS） and disease free survival （DFS）. The secondary endpoints are to evaluate down-staging, treatment toxicity, and ability to do sphincter preservation, aiming at choosing the optimal treatment modality. Methods： This study included 100 patients with resectable rectal carcinoma who presented to Surgical Gastro Entrology Center and Clinical Oncology and Nuclear Medicine Department, Mansoura University during the period between January 2007 and September 2009. The included patients were randomized in two groups; group h 50 patients received preoperative radiotherapy and group Ih 50 patients received post- operative radiotherapy. Concurrent 5-fluorouracil-based chemotherapy was given to all patients. Two major types of surgery were done： abdomino-perineal resection with a permanent colostomy and low anterior resection with colorectal or coloanal anastomosis. Results： Preoperative radiotherapy resulted in pathologic complete response in 3 patients. T down-staging occurred in 18 out of 50 patients （36%） with statistically significant difference （P = 0.008）. N down-staging occurred in 10 out of 24 patients. Sphincter preservation was more in group I. Delayed wound healing was the most common postoperative complication in group I with no significant difference. After a median follow up of 18 months, local recurrence rate and distant metastasis were higher in group I1. The 2-year disease free survival was 72% and 60% in group I and II respectively with no statistically significant difference between both groups. Conclusion： This study concluded that preoperative radiotherapy is better than postoperative radiotherapy as regard local control, sphincter preservation with higher disease free survival and overall survival. No difference in treatment

关键词： resectable rectal cancer preoperative radiotherapy postoperative radiotherapy

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Efficient Relational Techniques for Processing Graph Queries

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Journal of Computer Science & Technology 2010年第6期25卷 1237-1255页

作者： Sherif sakr Ghazi Al-Naymat School of Computer Science and Engineering University of New South Wales Managing Complexity Group National ICT Australia (NICTA)

Graphs are widely used for modeling complicated data such as social networks,chemical compounds,protein interactions and semantic *** effiectively understand and utilize any collection of graphs,a graph database that efficiently supports elementary querying mechanisms is crucially *** example,Subgraph and Supergraph queries are important types of graph queries which have many applications in practice.A primary challenge in computing the answers of graph queries is that pair-wise comparisons of graphs are usually hard *** database management systems（RDBMSs） have repeatedly been shown to be able to efficiently host different types of data such as complex objects and XML *** derive much of their performance from sophisticated optimizer components which make use of physical properties that are specific to the relational model such as sortedness,proper join ordering and powerful indexing *** this article,we study the problem of indexing and querying graph databases using the relational *** present a purely relational framework for processing graph *** framework relies on building a layer of graph features knowledge which capture metadata and summary features of the underlying graph *** describe different querying mechanisms which make use of the layer of graph features knowledge to achieve scalable performance for processing graph ***,we conduct an extensive set of experiments on real and synthetic datasets to demonstrate the efficiency and the scalability of our techniques.

关键词： graph database graph query subgraph query supergraph query

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Novel Framework for Generating Criminals Images Based on Textual Data Using Identity GANs

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Computers, Materials & Continua 2023年第7期76卷 383-396页

作者： Mohamed Fathallah Mohamed sakr Sherif Eletriby Department of Computer Science Faculty of Computers and InformationKafrelsheikh UniversityKafrelsheikhEgypt Department of Computer Science Faculty of Computers and InformationMenoufia UniversityMenoufiaEgypt

Text-to-image generation is a vital task in different fields,such as combating crime and terrorism and quickly arresting *** several years,due to a lack of deep learning and machine learning resources,police officials required artists to draw the face of a *** methods of identifying criminals are inefficient and *** paper presented a new proposed hybrid model for converting the text into the nearest images,then ranking the produced images according to the available *** framework contains two main steps:generation of the image using an Identity Generative Adversarial Network(IGAN)and ranking of the images according to the available data using multi-criteria decision-making based on neutrosophic *** IGAN has the same architecture as the classical Generative Adversarial Networks(GANs),but with different modifications,such as adding a non-linear identity block,smoothing the standard GAN loss function by using a modified loss function and label smoothing,and using mini-batch *** model achieves efficient results in Inception Distance(FID)and inception score(IS)when compared with other architectures of GANs for generating images from *** IGAN achieves 42.16 as FID and 14.96 as *** it comes to ranking the generated images using Neutrosophic,the framework also performs well in the case of missing information and missing data.

关键词： GAN deep learning text-to-image identity GAN

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A spatiotemporal algebra in Hadoop for moving objects

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Geo-Spatial Information Science 2018年第2期21卷 102-114页

作者： Mohamed S.Bakli Mahmoud A.sakr Taysir Hassan A.Soliman Faculty of Computers and Information Assiut UniversityAssiutEgypt Faculty of Computer and Information Sciences Ain Shams UniversityCairoEgypt Universitélibre de Bruxelles BruxellesBelgium

Spatiotemporal data represent the real-world objects that move in geographic space over *** enormous numbers of mobile sensors and location tracking devices continuously produce massive amounts of such *** leads to the need for scalable spatiotemporal data management *** systems shall be capable of representing spatiotemporal data in persistent storage and in *** shall also provide a range of query processing operators that may scale out in a cloud ***,very few researches have been conducted to meet this *** paper proposes a Hadoop extension with a spatiotemporal *** algebra consists of moving object types added as Hadoop native types,and operators on top of *** Hadoop file system has been extended to support parameter passing for files that contain spatiotemporal data,and for operators that can be unary or *** the types and operators are accessible for the MapReduce *** an extension allows users to write Hadoop programs that can perform spatiotemporal *** queries may call more than one operator for different jobs and keep these operators running in *** paper describes the design and implementation of this algebra,and evaluates it using a benchmark that is specific to moving object databases.

关键词： Spatiotemporal algebra Hadoop MapReduce moving objects

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A New Hybrid Model for Segmentation of the Skin Lesion Based on Residual Attention U-Net

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Computers, Materials & Continua 2023年第6期75卷 5177-5192页

作者： Saleh Naif Almuayqil Reham Arnous Noha sakr Magdy M.Fadel Department of Information Systems College of Computer and Information SciencesJouf UniversitySakakaSaudi Arabia Department of Communications and Electronics Delta Higher Institute for Engineering and Technology(DHIET)MansouraEgypt Computers Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansouraEgypt

Skin segmentation participates significantly in various biomedical applications,such as skin cancer identification and skin lesion *** paper presents a novel framework for segmenting the *** framework contains two main stages:The first stage is for removing different types of noises from the dermoscopic images,such as hair,speckle,and impulse noise,and the second stage is for segmentation of the dermoscopic images using an attention residual U-shaped Network(U-Net).The framework uses variational Autoencoders(VAEs)for removing the hair noises,the Generative Adversarial Denoising Network(DGAN-Net),the Denoising U-shaped U-Net(D-U-NET),and Batch Renormalization U-Net(Br-U-NET)for remov-ing the speckle noise,and the Laplacian Vector Median Filter(MLVMF)for removing the impulse *** the second main stage,the residual attention u-net was used for *** framework achieves(35.11,31.26,27.01,and 26.16),(36.34,33.23,31.32,and 28.65),and(36.33,32.21,28.54,and 27.11)for removing hair,speckle,and impulse noise,respectively,based on Peak Signal Noise Ratio(PSNR)at the level of(0.1,0.25,0.5,and 0.75)of *** framework also achieves an accuracy of nearly 94.26 in the dice score in the process of segmentation before removing noise and 95.22 after removing different types of *** experiments have shown the efficiency of the used model in removing noise according to the structural similarity index measure(SSIM)and PSNR and in the segmentation process as well.

关键词： Skin tumor speckle noise impulse noise hair noise deep learning segmentation

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Novel Framework of Segmentation 3D MRI of Brain Tumors

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Computers, Materials & Continua 2023年第2期74卷 3489-3502页

作者： Ibrahim Mahmoud El-Henawy Mostafa Elbaz Zainab H.Ali Noha sakr Department of Computer Science Faculty of Computers and InformaticsZagazig UniversityZagazigEgypt Department of Computer Science Faculty of Computers and InformaticsKafrelsheikh UniversityKafrelsheikhEgypt Department of Embedded Network Sys.and Tec. Faculty of Artificial IntelligenceKafrelsheikh UniversityKafrelsheikhEgypt Computers Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansouraEgypt

Medical image segmentation is a crucial process for computer-aided diagnosis and *** image segmentation refers to portioning the images into small,disjointed parts for simplifying the processes of analysis and *** and speckle noise are different types of noise in magnetic resonance imaging(MRI)that affect the accuracy of the segmentation process ***,image enhancement has a significant role in MRI *** paper proposes a novel framework that uses 3D MRI images from Kaggle and applies different diverse models to remove Rician and speckle noise using the best possible noise-free *** proposed techniques consider the values of Peak Signal to Noise Ratio(PSNR)and the level of noise as inputs to the attention-U-Net model for segmentation of the *** framework has been divided into three stages:removing speckle and Rician noise,the segmentation stage,and the feature extraction *** framework presents solutions for each problem at a different stage of the *** the first stage,the framework uses Vibrational Mode Decomposition(VMD)along with Block-matching and 3D filtering(Bm3D)algorithms to remove the ***,the most significant Rician noise-free images are passed to the three different methods:Deep Residual Network(DeRNet),Dilated Convolution Auto-encoder Denoising Network(Di-Conv-AE-Net),andDenoising Generative Adversarial Network(DGAN-Net)for removing the speckle *** Bm3D have achieved PSNR values for levels of noise(0,0.25,0.5,0.75)for reducing the Rician noise by(35.243,32.135,28.214,24.124)and(36.11,31.212,26.215,24.123)*** framework also achieved PSNR values for removing the speckle noise process for each level as follows:(34.146,30.313,28.125,24.001),(33.112,29.103,27.110,24.194),and(32.113,28.017,26.193,23.121)forDeRNet,Di-Conv-AE-Net,and DGAN-Net,*** experiments that have been conducted have proved the efficiency of the proposed framework a

关键词： MRI Rician noise speckle noise segmentation deep learning

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Amino Acid Encryption Method Using Genetic Algorithm for Key Generation

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Computers, Materials & Continua 2022年第1期70卷 123-134页

作者： Ahmed S.sakr M.Y.Shams Amena Mahmoud Mohammed Zidan Department of Information System Faculty of Computers and InformationMenofia UniversityEgypt Department of Machine learning and Information Retrieval Faculty of Artificial IntelligenceKafrelsheikh UniversityEgypt Department of Computer Science Faculty of Computers and InformationKafrelshiekh UniversityEgypt Hurghada Faculty of Computers and Artificial Intelligence South Valley UniversityEgypt

In this new information era,the transfer of data and information has become a very important *** data must be kept secured from unauthorized persons using *** science of cryptography depends not only on complex mathematical models but also on encryption *** acid encryption is a promising model for data *** this paper,we propose an amino acid encryption model with two encryption *** first key is generated randomly using the genetic *** second key is called the protein key which is generated from converting DNA to a protein ***,the protein message and the first key are used in the modified Playfair matrix to generate the cypher *** experimental results show that the proposed model survives against known attacks such as the Brute-force attack and the Ciphertext-only *** addition,the proposed model has been tested over different types of characters including white spaces and special characters,as all the data is encoded to 8-bit *** performance of the proposed model is compared with other models using encryption time and decryption *** model also balances all three principles in the CIA triad.

关键词： Cryptography amino acid genetic algorithm playfair deep learning DNA computing

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Outcome of non surgical hepatic decompression procedures in Egyptian patients with Budd-Chiari

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World Journal of Gastroenterology 2011年第7期17卷 906-913页

作者： Ahmed Eldorry Eman Barakat Heba Abdella Sara Abdelhakam Mohamed Shaker Amr Hamed Mohammad sakr Department of Radiodi-agnosis and Interventional Radiology Faculty of Medicine AinShams University Department of Tropical Medicine Faculty of Medicine Ain Shams University

AIM: To evaluate outcome of patients with Budd-Chiari syndrome after balloon angioplasty ± stenting or transjugular intrahepatic portosystemic shunt (TIPS). METHODS: Twenty five patients with Budd-Chiari syndrome admitted to Ain Shams University Hospitals, Tropical Medicine Department were included. Twelve patients (48%) with short segment occlusion were candidates for angioplasty; with stenting in ten cases and without stenting in two. Thirteen patients (52%) had Transjugular Intrahepatic Portosystemic Shunt. Patients were followed up for 12-32 mo. RESULTS: Patency rate in patients who underwent angioplasty ± stenting was 83.3% at one year and at end of follow up. The need of revision was 41.6% with one year survival of 100%, dropped to 91.6% at end of follow up. In patients who had Transjugular Intrahepatic Portosystemic Shunt, patency rate was 92.3% at one year, dropped to 84.6% at end of follow up. The need of revision was 38.4% with one year and end of follow up survival of 100%. Patients with patent shunts showed marked improvement compared to those with occluded shunts. CONCLUSION: Morbidity and mortality following angioplasty ± stenting and TIPS are low with satisfactory outcome. Proper patient selection and management of shunt dysfunction are crucial in improvement.

关键词： Angioplasty Stenting Transjugular Intrahepatic portosystemic shunt Patency rate

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Resveratrol Modulates Bone Mineral Density and Bone Mineral Content in A Rat Model of Male Hypogonadism

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Chinese Journal of Integrative Medicine 2023年第2期29卷 146-154页

作者： Hussein F.sakr Boudaka Ammar Amira AlKharusi I Al-Lawati Mahmoud AlKhateeb Basim H Elesawy Department of Physiology College of Medicine and Health SciencesSultan Qaboos UniversityMuscat 123Oman Medical Physiology Department Faculty of MedicineMansouraUniversityMansoura 35516Egypt Basic Medical Sciences Department College of Medicine at King Saud bin Abdulaziz University for Health Sciences(KSAU-HS)Riyadh 11481Saudi Arabia Department of Clinical Laboratory Sciences College of Applied Medical SciencesTaif UniversityTaif 21944Saudi Arabia

Objective: To determine whether resveratrol(Res) can correct osteoporosis induced in a rat model of male hypogonadism. Methods: Thirty-two rats were randomly divided into 4 groups, 8 in each group;1) a control sham group: underwent a similar surgical procedure for induction of orchiectomy(ORCD) without ligation of any arteries or veins or removal of the testis and epididymis;2) a control + Res-treated group(Con+Res):underwent sham surgery similar to the control, but was then treated with Res, as described below;3) an ORCDinduced group: bilateral ORCD surgery as described above, and 4) a ORCD+Res-treated group: bilateral ORCD surgery followed by Res treatment. Res treatment began 4 weeks after ORCD and continued for 12 weeks. After 12 weeks, bone mineral density(BMD) and bone mineral content(BMC) were measured in the tibia and femur of each rat’s right hind leg. Blood levels of bone turnover indicators such as deoxypyridinoline(Dpd), N-telopeptide of type Ⅰ collagen(NTXⅠ), alkaline phosphatase(ALP), and osteocalcin(OC), as well as receptor activator of nuclear factor kappa B(RANK) and osteoprotegerin(OPG) were assessed. Results: ORCD significantly decreased BMD(P<0.01) and significantly increased bone resorption, manifested by increased RANK. In addition, it inhibited serum levels of OPG and OC. Res treatment after ORCD effectively increased serum levels of bone formation markers such as OPG and OC, compared with testisectomized rats(P<0.05). Conclusion:Res could ameliorate bone loss induced by male hypogonadism, possible via restoration of the normal balance between RANK and OPG.

关键词： osteoporosis male hypogonadism resveratrol receptor activator of nuclear factor-kappa

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The possible source of uranium mineralization in felsic volcanic rocks,Eastern Desert,Egypt of the Arabian-Nubian Shield:Constraints from whole-rock geochemistry and spectrometric prospection

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Acta Geochimica 2021年第5期40卷 819-845页

作者： Gehad.M.Saleh Bahaa.M.Emad Ibrahim.B.Abdel Kader Rania.M.sakr Nuclear Materials Authority El MaadiP.O.Box 530CairoEgypt

The present work deals with the detailed geology,mineralogy,geochemistry,and spectrometric prospection of the felsic volcanic rocks at the Eastern Desert,Egypt of the Arabian-Nubian *** volcanic rocks are an essential source for rare earth elements(REEs)and uranium occurrences in this *** are compositionally uniform with tholeiitic to calc-alkaline affinities,peraluminous and belong to the series of rhyolite with high-K *** exhibit more enrichment in high field strength elements(HFSE,***,Ta,Nd,Th,and U)and large-ion lithophile elements(LILE,*** and Rb)compared to the country rocks of the studied area,with REE ranging from 188.20 to 442.70 ppm and strong depletion in Ti,Sr,P with deep negative Eu *** felsic volcanic rocks were mostly generated from the partial melting of quartz-amphibolite facies accreted during the *** oddities of Zr-U-Th for the felsic volcanic rocks determine the involvement of crustal *** volcanic rocks are found in A-type suites of magma and represent highly fractionated rocks derived from rhyolitic magma,with insignificant interaction with continental crust in the low-pressure environment and during fractional *** volcanic rocks have higher values of radioactivity in which eU range from 0.5 to 121 ppm and eTh from 1.0 to 415.10 *** high values of eU and eTh can be ascribed to the mineralization of uranium and the presence of accessory minerals of radiogenic nature such as uranophane,uranothorite,zircon,and *** is considered as the mineral with most enriched uranium contents in the studied felsic volcanic rocks in which(UO2=87.30 wt%).Also,they are enriched with REE-bearing accessory minerals comprising allanite,titanite,and *** geological investigations of the felsic volcanic rocks in the studied areas are inappropriate to clear the feasible economic potentialities of rare earth elements and U occurrences;itemized and invaluable

关键词： Felsic volcanic rocks Geochemistry REE Uranium mineralization Egypt Arabian-Nubian Shield

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