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Midnight Salivary Cortisol and Other Effective Factors in the Graduation of Clinical Suspect of Cushing Syndrome: Is There Any Reasonable Clinical Score?

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Open Journal of Endocrine and Metabolic Diseases 2013年第1期3卷 52-54页

作者： Meral Mert Refik Tanakol hande karpuzoglu Semra Abbasoglu Sema Yarman Harika Boztepe Faruk Alagol Istanbul University Istanbul Medical Faculty Department of Biochemistry Istanbul Turkey Istanbul University Istanbul Medical Faculty Department of Internal Medicine Division of Endocrinology and Metabolism Istanbul Turkey

Background: Diagnosis of Cushing’s Syndrome (CS) at the right time and with the right method is getting more important for the patients and clinicians due to high mortality rate. The most appropriate laboratory test will provide great benefits in terms of cost-effectiveness in the well-chosen group of patients. Selection of the high risk group is of crucial importance for the true diagnosis and treatment on time. Aim: The aim of this study was to evaluate the worth of the midnight salivary cortisol and to establish other effective factors in the graduation of clinical suspect of CS. Material and Methods: 115 patients were evaluated in weight, height, body mass index (BMI), waist/hip ratio, systolic, diastolic blood pressures, hirsutism, weight gain, purple-stria, plethore, buffalo-hump, supraclavicular fullness, temporal fat cushion, acnea, moonface, proximal muscle weakness, lower limb edema, ecchymosis, loss of libido, depression, diabetes mellitus, hypertension, allopecia of all patients were noted in the evaluation forms (23 findings). Patients were grouped according to clinical scores, low (16). Results: When we compare the groups in terms of midnight salivary cortisol, morning salivary cortisol after overnight dexamethasone suppression test, we found statistically significant relationship between the low and high clinical score groups, as well as between medium and high score groups (p: 0.0001). Urinary free cortisol was statistically significant only between low and high clinical score groups (p: 0.0001). Conclusion: This clinical scoring system which includes clinical signs and laboratory findings both, can be used for selection of the high risk group.

关键词： Salivary Cortsiol Clinical Suspect Clinical Score Cushing’s Syndrome

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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

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LightAD: 基于自适应采样的自动去偏框架加速方法

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中国科学技术大学学报 2024年第4期54卷 46-54,45,67页

作者：邱阳董汉德陈佳伟何向南中国科学技术大学信息科学技术学院安徽合肥230027

在推荐系统中,由于数据是从用户行为中收集而来而不是通过合理的实验得到,因此偏差问题是普遍存在的。自动去偏框架(AutoDebias)通过采用元学习寻找适当地去偏置配置(即伪标签和置信权重),已被证明是应对各种偏差的一种通用和有效的解... 详细信息

在推荐系统中,由于数据是从用户行为中收集而来而不是通过合理的实验得到,因此偏差问题是普遍存在的。自动去偏框架(AutoDebias)通过采用元学习寻找适当地去偏置配置(即伪标签和置信权重),已被证明是应对各种偏差的一种通用和有效的解决方案。然而,为每个用户-物品对设置伪标签和权重是一个极度耗时的过程。因此,自动去偏框架面临巨大的计算成本,这使其在实际应用中的适用性较差。虽然使用带有均匀采样器的随机梯度下降可以加速模型训练,但这会显著恶化模型的收敛性和稳定性。为了解决这个问题,我们提出了LightAutoDebias (简称LightAD),它为自动去偏框架配备了一种专门的权重采样策略。该采样器可以自适应地和动态地获取信息量更大的训练样本,这带来的收敛性和稳定性比标准的均匀采样器更好。在三个基准数据集上的广泛实验证明,我们的LightAD可以加速自动去偏框架的训练达几个数量级,同时保持几乎相同的精度。

关键词：推荐系统偏差去偏采样

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Thermal Behaviour of Some New Polyoxometalate Complexes of Ciprofloxacin with Keggin-type Heteropoly Acids

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Chemical Research in Chinese Universities 2005年第3期21卷 258-263页

作者： WANGDun-jia FANGZheng-dong hande-yan DepartmentofChemistryandEnvironmentalEngineering HubeiNormalUniversityHuangshi435002P.R.China

Four polyoxometalate complexes, (CPFX·HCl)_3H_4SiW_~12 O_~40 , (CPFX·HCl)_3H_3PW_~12 O_~40 , (CPFX·HCl)_3H_3PMo_~12 O_~40 and (CPFX·HCl)_4H_4SiMo_~12 O_~40 , were prepared from ciprofloxacin hydrochloride(CPFX·HCl) reacting with H_nXM_~12 O_~40 ·nH_2O(X=P,Si; M=W,Mo) in an aqueous solution, and characterized by elemental analysis, IR spectrometry and TG-DTA. The IR spectrum confirms the presence of Keggin-type anions of heteropoly acids and the characteristic functional groups of ciprofloxacin. The TG/DTA curves show that their thermal decomposition is a multi-step process including simultaneous collapse of the Keggin-type structure. At first, these compounds had a mass loss of water molecules, then several other mass losses occured due to the decomposition of ciprofloxacin hydrochloride and its fragments with the degradation of Keggin anions. The end product of decomposition is the mixture of WO_3(or MoO_3) and SiO_2(or P_2O_5), identified by X-ray diffraction and IR spectroscopy. The possible thermal decomposition mechanisms of these complexes are proposed. This study exemplified that the thermal stability of the complexes containing tungsten is much better than that of the complexes containing molybdenum.

关键词： Thermal decomposition Polyoxometalate complexes Keggin-type heteropoly acids Ciprofloxacin hydrochloride TG/DTA

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An inherent curvature-compensated voltage reference using non-linearity of gate coupling coefficient

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Journal of Semiconductors 2015年第8期36卷 113-123页

作者： Vinayak hande Maryam Shojaei Baghini Indian Institute of Technology Bombay

A novel current-mode voltage reference circuit which is capable of generating sub- 1 V output voltage is presented. The proposed architecture exhibits the inherent curvature compensation ability. The curvature com- pensation is achieved by utilizing the non-linear behavior of gate coupling coefficient to compensate non-linear temperature dependence of base-emitter voltage. We have also utilized the developments in CMOS process to re- duce power and area consumption. The proposed voltage reference is analyzed theoretically and compared with other existing methods. The circuit is designed and simulated in 180 nm mixed-mode CMOS UMC technology which gives a reference level of 246 mV. The minimum required supply voltage is 1 V with maximum current drawn of 9.24μA. A temperature coefficient of 9 ppm/℃ is achieved over -25 to 125 ℃ temperature range. The reference voltage varies by ±11 mV across process corners. The reference circuit shows the line sensitivity of 0.9 mV/V with area consumption of 100 × ll0μm2

关键词： voltage reference gate coupling coefficient temperature coefficient curvature compensation

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Comparison of topical nepafenac 0.1% with intravitreal dexamethasone implant for the treatment of Irvine-Gass syndrome

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 258-267页

作者： hande Guclu Vuslat Pelitli Gurlu Department of Opthalmology Trakya University Faculty of Medicine

AIM: To compare safety and efficacy of intravitreal dexamethasone(IVD) implant with topical nepafenac(TN) 0.1% in previously untreated Irvine-Gass syndrome(IGS) in clinical practice. METHODS: This was a retrospective study of 62 eyes with IGS after phacoemulsification with posterior chamber intraocular lens(IOL) implantation. None of the patients used treatment before IVD or TN. Best-corrected visual acuity(BCVA) with Early Treatment Diabetic Retinopathy Study chart(ETDRS), slit-lamp, intraocular pressure(IOP) measurement, fundus examination, spectral-domain optical coherence tomography(OCT) and fundus florescein angiography were performed to all subjects at baseline, 1, 3 and 6 mo. RESULTS: The mean BCVA of the IVD group was 49.3±6.8, and the mean BCVA of the TN group was 32.9±7.3 ETDRS letters in post-treatment month 6. The mean central macular thickness(CRT) of IVD group was 266.6±53.5 μm and the mean CRT of TN group was 364.9±56.3 μm in posttreatment month 6. Baseline BCVA has correlation with final BCVA in TN group however there was no correlation between baseline BCVA and final BCVA in IVD group. CONCLUSION: IVD is found to be better than TN in controlling pseudophakic macular edema and improving visual acuity. IVD group also has significantly lower CRT however IOP is not significantly different between two groups in post-treatment month 6.

关键词： intravitreal dexamethasone implant nepafenac Irvine-Gass syndrome cystoid macular edema inflammation

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Risk factors and clinical responses of pneumonia patients with colistin-resistant Acinetobacter baumannii-calcoaceticus

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World Journal of Clinical Cases 2019年第10期7卷 1111-1121页

作者： hande Aydemir hande Idil Tuz Nihal Piskin Guven Celebi Canan Kulah Furuzan Kokturk Department of Infectious Diseases and Clinical Microbiology Zonguldak Bulent Ecevit UniversityFaculty of MedicineZonguldak 67100Turkey Department of Microbiology Zonguldak Bulent Ecevit UniversityFaculty of MedicineZonguldak 67100Turkey Department of Biostatistics Zonguldak Bulent Ecevit UniversityFaculty of MedicineZonguldak 67100Turkey

BACKGROUND Nosocomial infections with carbapenem-resistant Acinetobacter baumanniicalcoaceticus complex(ABC)strains are great problem for intensive care *** strains can develop resistance to all the antibiotics *** resistance is common and colistin resistance is rare in our *** the risk factors for colistin resistance is important since colistin seems to be the only remaining therapeutic option for the patients with pneumonia due to extensively drug resistant ABC for our *** To investigate the comparison of clinical responses and outcomes between pneumonia patients with colistin-susceptible and-resistant Acinetobacter *** During the study period,108 patients with pneumonia due to colistin-susceptible strains and 16 patients with colistin-resistant strains were included *** variables were compared with the Mann-Whitney U test,and categorical variables were compared using Pearson’s chi-square test or Fisher’s Exact chi-square test for two groups.A binary logistic regression model was developed to identify the potential independent factors associated with colistin resistance in patients with colistin-resistant *** High Acute Physiology and Chronic Health Evaluation II scores(OR=1.9,95%CI:1.4-2.7;P<0.001)and prior receipt of teicoplanin(OR=8.1,95%CI:1.0-63.3;P=0.045)were found to be independent risk factors for infection with colistin-resistant Acinetobacter *** combinations of antibiotics including colistin,meropenem,ampicillin/sulbactam,amikacin and trimethoprim/sulfamethoxazole were used for the treatment of patients with colistin-resistant *** the median duration of microbiological cure(P<0.001)was longer in the colistin-resistant group,clinical(P=0.703),laboratory(P=0.277),radiological(P=0.551),microbiological response(P=1.000)and infection related mortality rates(P=0.603)did not differ between the two *** the patients with infections due to c

关键词： Acinetobacter baumannii Colistin Ventilator-associated pneumonia

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Removing the impact of wind direction on remote sensing of sea surface salinity

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Chinese Science Bulletin 2006年第11期51卷 1368-1373页

作者： YIN Xiaobin LIU Yuguang ZHANG hande Physical Oceanography Laboratory Ocean University of China Qingdao 266003 China North China Sea Branch of the State Oceanic Administration Qingdao 266033 China

Using the small-slope approximation model of microwave emission of rough sea surface, the impacts of sea surface wind on brightness tem- perature variations generated by the surface rough- ness, i.e. ?Th,v, are investigated. Here ?T denotes the brightness temperature variation, and “h” and “v” denote the horizontal and vertical polarizations re- spectively. ?Th,v has a linear relation with wind speed, sea surface temperature (SST) and sea surface sa- linity (SSS) respectively. Further more, the impact of wind direction on SSS retrieval, under small inci- dence angles, can be removed by calculating (?Th+?Tv). These characteristics provide simple new ways to develop an SSS retrieval algorithm without wind direction factor.

关键词：遥感海面温度海面盐度风向亮度温度

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Incidence of toxoplasmosis in patients with cirrhosis

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World Journal of Gastroenterology 2004年第3期10卷 452-454页

作者： Sebnem Ustun Umit Aksoy hande Dagci Galip Ersoz Department of Gastroenterology School of MedicineUniversity of Ege35100 BornovaIzmirTurkey Department of Parasitology School of MedicineUniversity of Dokuz EylulIzmirTurkey Department of Parasitology School of MedicineUniversity of EgeIzmirTurkey Department of Gastroenterology School of MedicineUniversity of EgeIzmirTurkey

AIM:It is known that toxoplasmosis rarely leads to various liver pathologies,most common of which is granulomatose hepatitis in patients having normal immune *** who have cirrhosis of the liver are subject to a variety of cellular as well as humoral immunity ***,it may be considered that toxoplasmosis can cause more frequent and more severe diseases in patients with cirrhosis and is capable of changing the course of the *** aim of this study was to investigate the frequency of toxoplasmosis in patients with cirrhosis. METHODS:Serum samples were taken from 108 patients with cirrhosis under observation in the Hepatology Polyclinic of the Gastroenterology Clinic,and a control group made up of 50 healthy blood *** and ELISA methods were used to investigate the IgG and IgM antibodies,which had developed from these sera. RESULTS:Toxoplasma IgG and IgN antibody positivity was found in 74 (68.5%) of the 108 cirrhotic patients and 24 (48%) of the 50 people in the control *** difference between them was significant (P<0.05). CONCLUSION:In conclusion,it was found that the toxopiasma sero-prevalence in the cirrhotic patients in this study was *** patients are likely to form a toxoplasma risk *** detailed studies are needed on this subject.

关键词： Adult Animals Antibodies, Protozoan Female Humans Incidence Liver Cirrhosis Male Middle Aged Toxoplasma Toxoplasmosis

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A novel mutation in the sodium channel α1 subunit gene in a child with Dravet syndrome in Turkey

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Neural Regeneration Research 2013年第10期8卷 955-958页

作者： Mutluay Arslan Ulu Yis hande aglayan Ridvan Akin Department of Pediatric Neurology Gülhane Military Medical School Department of Pediatric Neurology Dokuz Eylül University School of Medicine Department of Molecular Biology and Genetics Bogazii University

Dravet syndrome is a rare epileptic encephalopathy characterized by frequent seizures beginning in the first year of life and behavioral disorders. Mutations in the sodium channel α1 subunit gene are the main cause of this disease. We report two patients with refractory seizures and psychomotor retardation in whom the final diagnosis was Dravet syndrome with confirmed mutations in the sodium channel α1 subunit gene. The mutation identified in the second patient was a novel frame shift mutation, which resulted from the deletion of five nucleotides in exon 24.

关键词： neural regeneration clinical practice Dravet syndrome sodium channel (]1 subunit gene mutation child Turkish epilepsy refractory seizures neuroregeneration

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