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Massively parallel sequencing of 231 autosomal SNPs with a custom panel:a SNP typing assay developed for human identification with Ion Torrent PGM

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Forensic Sciences Research 2017年第1期2卷 26-33页

作者： Suhua Zhang Yingnan Bian Anqi Chen hancheng zheng Yuzhen Gao Yiping Hou Chengtao Li Shanghai Key Laboratory of Forensic Medicine Shanghai Forensic Service PlatformInstitute of Forensic SciencesMinistry of JusticePRCShanghaiChina State Key Laboratory of Genetic Engineering Institute of GeneticsSchool of Life SciencesFudan UniversityShanghaiChina Department of Forensic Medicine Medical College of Soochow UniversitySuzhouChina Department of Forensic Genetics West China School of Preclinical and Forensic MedicineSichuan UniversityChengduChina

The custom-designed single nucleotide polymorphism(SNP)panel amplified 231 autosomal SNPs in one PCR reaction and subsequently sequenced with massively parallel sequencing(MPS)technology and Ion Torrent personal genome machine(PGM).SNPs were chosen from SNPforID,IISNP,HapMap,dbSNP,and related published *** concordance was obtained between available MPS calling and Sanger sequencing with 9947A and 9948 *** SNPs(rs4606077,rs334355,rs430046,rs2920816,rs4530059,rs1478829,rs1498553,rs7141285,rs12714757 and rs2189011)with low coverage or heterozygote imbalance should be optimized or excluded from the *** data had sufficiently high coverage and gave reliable SNP calling for the remaining 221 loci with the custom MPS-SNP panel.A default DNA input amount of 10 ng per reaction was recommended by Ampliseq technology but sensitivity testing revealed positive results from as little as 1 ng input *** testing with this panel is possible through analysis of the F MAR(frequency of major allele reads)values at most loci with enough high coverage depth and low level of sequencing *** results indicate the potential advantage of the custom MPS-SNP assays and Ion Torrent PGM platform for forensic study.

关键词： Forensic science forensic genetics single nucleotide polymorphism(SNP) massively parallel sequencing(MPS) Ion Torrent personal genome machine(Ion Torrent PGM)

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Approaching high oxygen evolution reaction performance by synergetic dual-ion leaching

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Nano Research 2024年第9期17卷 7975-7983页

作者： hancheng Ma Yao Ding Jianqi Li Wei Peng Liqiang Mai School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Self-reconstruction of catalysts during oxygen evolution reaction(OER)is crucial for the development of energy conversion ***,the relationship between the specific atomic structure of pre-catalysts and their electrocatalytic behavior after reconstruction via dual-ion leaching has not been extensively *** this work,we design a highly effective non-noble metal OER catalyst with heterointerface through continuous self-reconstruction of Co_(2)(OH)_(3)Cl@NiMoO_(4)as pre-catalyst by a straightforward dual-ion(***_(4)^(2-)and Cl^(-))***-situ Raman and in-situ Fourier transform infrared(FT-IR)spectroscopy have precisely identified the progressive phase transformation of the pre-catalyst during self-reconstruction,which results in a stable heterojunction of CoOOH and NiOOH(CoOOH@NiOOH).Further calculations based on density functional theory(DFT)of CoOOH@NiOOH evident that more electrons will be aggregated in the Fermi level of ***,Gibbs free energy(ΔG)for different OER steps of CoOOH@NiOOH exhibit lower energy costs of all intermediates,implying the well catalytic ***,the catalyst derived from dual-ion leaching displays outstanding OER performance,characterized by an overpotential of 275 mV at a current density of 10 mA·cm^(-2)and exceptional stability over 12 h *** work successfully paves a way of finding high-performance OER catalysts based on non-noble metal through dual-ion leaching during self-reconstruction.

关键词： dual-ion leaching oxygen evolution reaction chemical reconstruction NiMoO_(4) Co_(2)(OH)_(3)Cl

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人工智能在2型糖尿病精准分型中的应用

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中华糖尿病杂志 2020年第5期12卷 348-352页

作者：纪英杰刘颖王俊郑汉城王健深圳数字生命研究院 518110

随着海量多维度生物医学数据的积累,包括基因组、代谢组、脂质组、微生物组、电子医疗病历、医学影像和可穿戴设备数据以及包括深度学习在内的多模态人工智能(AI)模型算法取得的突破,使得对糖尿病精准分型和精准治疗的探索成为可能。通... 详细信息

随着海量多维度生物医学数据的积累,包括基因组、代谢组、脂质组、微生物组、电子医疗病历、医学影像和可穿戴设备数据以及包括深度学习在内的多模态人工智能(AI)模型算法取得的突破,使得对糖尿病精准分型和精准治疗的探索成为可能。通过对应用传统AI算法在2型糖尿病分型上取得的进展进行回顾,借鉴多模态AI模型在其他精准医学领域所得的成功经验,展望2型糖尿病精准分型中应用多模态AI模型整合多维度数据的前景。

关键词：糖尿病,2型人工智能

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Plate tectonics in the Archean:Observations versus interpretations

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Science China Earth Sciences 2024年第1期67卷 1-30页

作者： YongFei zheng School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Key Laboratory of Crust-Mantle Materials and Environment Chinese Academy of SciencesHefei 230026China Center of Excellence for Comparative Planetology Chinese Academy of SciencesHefei 230026China

Plate tectonics theory,established in the 1960s,has been successful in explaining many geological phenomena,processes and events that occurred in the ***,the theory has often struggled to provide a coherent framework in interpreting geological records in continental interior and Precambrian *** dealing with the relationship between plate tectonics and continental geology,continental interior tectonics was often separated from continental margin tectonics in the inheritance and development of their structure and *** separation led to the illusion that the plate tectonics theory is not applicable to Precambrian geology,particularly in explaining the fundamental geological characteristics of Archean *** this illusion does not mean that the Archean continental crust did not originate from a regime of plate tectonics,it led to the development of alternative tectonic models,often involving vertical movements under a regime of stagnant lid tectonics,including not only endogenous processes such as gravitational sagduction,mantle plumes and heat pipes but also exogenous processes such as bolide *** vertical processes were not unique to the Archean but persisted into the *** result from mantle poloidal convection at different depths,not specific to any particular *** the plate tectonics theory from the traditional kinematic model in the 20th century to a holistic kinematic-dynamic model in the 21st century and systematically examining the vertical transport of matter and energy at plate margins,it is evident that plate tectonics can explain the common geological characteristics of Archean cratons,such as lithological associations,structural patterns and metamorphic *** deciphering the structure and composition of convergent plate margins as well as their dynamics,the formation and evolution of continental crust since the Archean can be divided into ancient plate tectonics in the Preca

关键词： Plate tectonics Archean geology Continental origin Crustal reworking Plate interior Plate margin

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Safe Motion Planning and Control Framework for Automated Vehicles with Zonotopic TRMPC

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Engineering 2024年第2期33卷 146-159页

作者： Hao zheng Yinong Li Ling zheng Ehsan Hashemi State Key Laboratory of Mechanical Transmissions College of Mechanical and Vehicle EngineeringChongqing UniversityChongqing 400044China Department of Mechanical Engineering University of AlbertaEdmontonAB T6G 2H5Canada

Model mismatches can cause multi-dimensional uncertainties for the receding horizon control strategies of automated vehicles(AVs).The uncertainties may lead to potentially hazardous behaviors when the AV tracks ideal trajectories that are individually optimized by the AV's planning *** address this issue,this study proposes a safe motion planning and control(SMPAC)framework for *** the control layer,a dynamic model including multi-dimensional uncertainties is established.A zonotopic tube-based robust model predictive control scheme is proposed to constrain the uncertain system in a bounded minimum robust positive invariant set.A flexible tube with varying cross-sections is constructed to reduce the controller *** the planning layer,a concept of safety sets,representing the geometric boundaries of the ego vehicle and obstacles under uncertainties,is *** safety sets provide the basis for the subsequent evaluation and ranking of the generated *** efficient collision avoidance algorithm decides the desired trajectory through the intersection detection of the safety sets between the ego vehicle and obstacles.A numerical simulation and hardware-in-the-loop experiment validate the effectiveness and real-time performance of the *** result of two driving scenarios indicates that the SMPAC can guarantee the safety of automated driving under multi-dimensional uncertainties.

关键词： Automated vehicles Automated driving Motion planning Motion control Tube MPC Zonotope

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Discovery of the Significant Impacts of Swell Propagation on Global Wave Climate Change

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Journal of Ocean University of China 2024年第3期23卷 594-604页

作者： zheng Chongwei Dalian Naval Academy Dalian 116018China Marine Resources and Environment Research Group on the Maritime Silk Road Dalian 116018China

This study compared the differences in the wave climate in the South China Sea and North Indian Ocean under these two datasets:ERA-40 wave reanalysis and Mei’s hindcast wave *** the numerical calculation of regional ocean waves,the wave climate characteristics exhibited significant bias if the influence of external swells(swells from afar)was not fully considered,which may provide an incorrect basis for global climate change analysis.1)The trends of the significant wave height(SWH)obtained from the two datasets showed significant differences,such as those of the Bay of Bengal and the Java Sea in *** the past 45 years,SWH from ERA-40(SWH-ERA)exhibited a significant annual increase in low-latitude waters of the North Indian Ocean(0.2-0.6 cm yr^(-1))and South China Sea(0.2-0.8 cm yr^(-1)).2)In the Bay of Bengal,the SWH-ERA in each month was generally 0.5 m higher than the SWH from Mei’s hindcast wave data(SWH-Mei)and can reach 1.0 m higher in some months.3)In the Bay of Bengal,SWH-ERA and SWH-Mei increased significantly at annual rates of 0.13 and 0.27 cm yr^(-1),*** increasing trend was mainly reflected after ***-ERA showed a trough in 1975(1.33 m)and a crest in 1992(1.83 m),which were not reflected in SWH-Mei.

关键词： wave climate climatic trend monthly variation annual variation external swell

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A positive trend in the stability of global offshore wind energy

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Acta Oceanologica Sinica 2024年第1期43卷 123-134页

作者： Chongwei zheng Dalian Naval Academy Dalian 116018China Marine Resources and Environment Research Group on the Maritime Silk Road Dalian 116018China Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China

The recognition on the trend of wind energy stability is still extremely rare,although it is closely related to acquisition efficiency,grid connection,equipment lifetime,and costs of wind energy *** the 40-year(1979–2018)ERA-Interim data from the European Center for Medium-Range Weather Forecasts,this study presented the spatial-temporal distribution and climatic trend of the stability of global offshore wind energy as well as the abrupt phenomenon of wind energy stability in key regions over the past 40 years with the climatic analysis method and Mann-Kendall(M-K)*** results show the following 5 points.(1)According to the coefficient of variation(C_(v))of the wind power density,there are six permanent stable zones of global offshore wind energy:the southeast and northeast trade wind zones in the Indian,Pacific and Atlantic oceans,the Southern Hemisphere westerly,and a semi-permanent stable zone(North Indian Ocean).(2)There are six lowvalue zones for both seasonal variability index(S_(v))and monthly variability index(M_(v))globally,with a similar spatial distribution as that of the six permanent stable zones.M_(v) and S_(v) in the Arabian Sea are the highest in the world.(3)After C_(v),M_(v) and S_(v) are comprehensively considered,the six permanent stable zones have an obvious advantage in the stability of wind energy over other sea areas,with C_(v) below 0.8,M_(v) within 1.0,and S_(v) within 0.7 all the year round.(4)The global stability of offshore wind energy shows a positive climatic trend for the past four decades.C_(v),M_(v) and S_(v) have not changed significantly or decreased in most of the global ocean during 1979 *** is,wind energy is flat or more stable,while the monthly and seasonal variabilities tend to shrink/smooth,which is beneficial for wind energy utilization.(5)C_(v) in the low-latitude Pacific and M_(v) and S_(v) in both the North Indian Ocean and the low-latitude Pacific have an obvious abrupt phenomenon at the end of

关键词： global oceans wind energy stability spatial-temporal distribution climatic trend

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Wind power and sand/dust storms

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 175-176页

作者： XiaoJing zheng Center for Particle-Laden Turbulence Lanzhou UniversityLanzhou 730000China

Sand/dust storms,a globally prevalent catastrophic weather phenomenon,can cause significant erosion to the climate and ecological *** high concentration of sand particles they carry not only impacts atmospheric qualit... 详细信息

关键词： Wind power and sand/dust storms

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Damping Characteristic Analysis and Optimization of Wind-thermal-bundled Power Transmission by LCC-HVDC Systems

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 299-312页

作者： Liwen zheng Shiying Ma the Power System Department China Electric Power Research InstituteBeijing 100192China

With the rapid development of renewable energy,wind-thermal-bundled power transmission by line-commutated converter based high-voltage direct current(LCC-HVDC)systems has been widely *** dynamic interaction mechanisms among permanent magnet synchronous generators(PMSGs),synchronous generators(SGs),and LCC-HVDC system become *** deal with this issue,a path analysis method(PAM)is proposed to study the dynamic interaction mechanism,and the damping reconstruction is used to analyze the damping characteristic of the ***,based on the modular modeling,linearized models for the PMSG subsystem,the LCC-HVDC subsystem,and the SG subsystem are ***,based on the closed-loop transfer function diagram of the system,the disturbance transfer path and coupling relationship among subsystems are analyzed by the PAM,and the damping characteristic analysis of the SG-dominated oscillation mode is studied based on the damping *** with the PAM,the small-signal model of the system is obtained and eigenvalue analysis results are ***,the effect of the control parameters on the damping characteristic is analyzed and the conclusions are verified by time-domain ***,the penalty functions of the oscillation modes and decay modes are taken as the objective function,and an optimization strategy based on the Monte Carlo method is proposed to solve the parameter optimization *** simulation results are presented to validate the effectiveness of the proposed strategy.

关键词： Wind-thermal-bundled power transmission line-commutated converter based high-voltage direct current(LCC-HVDC) path analysis method(PAM) damping characteristic analysis Monte Carlo method

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A Minimum Residual Based Gradient Iterative Method for a Class of Matrix Equations

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 17-34页

作者： Qing-qing zheng Department of Mathematics College of ScienceChina University of Petroleum-BeijingBeijing102249China

In this paper, we present a minimum residual based gradient iterative method for solving a class of matrix equations including Sylvester matrix equations and general coupled matrix equations. The iterative method uses a negative gradient as steepest direction and seeks for an optimal step size to minimize the residual norm of next iterate. It is shown that the iterative sequence converges unconditionally to the exact solution for any initial guess and that the norm of the residual matrix and error matrix decrease monotonically. Numerical tests are presented to show the efficiency of the proposed method and confirm the theoretical results.

关键词： Sylvester matrix equation coupled matrix equation minimum residual gradient descent convergence analysis

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