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Gastric Mucosal Atrophy Might Be Associated with the Efficacy of First-Line Therapy Using Vonoprazan for <i>Helicobacter pylori</i>

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Open Journal of Gastroenterology 2017年第9期7卷 243-259页

作者： Mika Miura Masahiko Ohtaka Mitsuhiko hanawa naoki Shimura Yoshioki Yoda Sho Suzuki Yamanashi Koseiren Health Care Center Yamanashi Japan Division of Gastroenterology and Hepatology Department of Medicine Nihon University School of Medicine Tokyo Japan

Aim: To investigate the factors related to the effect of eradication therapy with vonoprazan for Helicobacter pylori (H. pylori). Methods: We retrospectively reviewed medical records of H. pylori-positive patients who received first-line (40 mg vonoprazan/60 mg lansoprazole or 20 mg rabeprazole, 1500 mg amoxicillin, 400 mg clarithromycin, all 2/day for 7 days) (n = 4118). H. pylori eradication was assessed by the 13C-urea breath test with success defined as a result of H. pylori eradication therapy using vonoprazan was more effective than standard triple therapy with proton pump inhibitor. Gastric mucosal atrophy was associated with treatment success.

关键词： Vonoprazan Eradication Helicobacter pylori Propensity Score Matching Gastric Mucosal Atrophy

Estimation of Physiologic Ability and Surgical Stress Scoring System Appraises Laparoscopy-Assisted and Open Distal Gastrectomy in Treatment of Early Gastric Cancer

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Journal of Cancer Therapy 2013年第9期4卷 1-5页

作者： Hideki Bou Hideyuki Suzuki Kentaro Maejima Hidetsugu hanawa Masanori Watanabe Eiji Uchida Department of Surgery Nippon Medical School Tokyo Japan Institute of Gastroenterology Nippon Medical School Musashi-kosugi Hospital Kawasaki Japan

Laparoscopy-assisted distal gastrectomy (LADG) has been widely used to treat early gastric cancer (EGC). The Estimation of Physiologic Ability and Surgical Stress (E-PASS) scoring system predicts the risk of fatal postoperative complications by quantifying the patient’s reserve and degree of surgical stress, but there have been a few reports of use of the E-PASS scoring system to assess the risk of mortality following special types of surgical procedures such as LADG. In this study we assessed the feasibility of LADG versus open distal gastrectomy (ODG) by the E-PASS scoring system. The subjects of this study consisted of 69 stage IA gastric cancer patients who underwent LADG (LADG group) and 69 stage IA gastric cancer patients who underwent ODG (ODG group). The mean age of the patients in the LADG group was 68.6 years, which was significantly higher than the mean age of 63.4 years in the ODG group. There were no statistically significant differences between the groups in operation time or preoperative risk score, but there were statistically significant differences in blood loss, surgical stress score, comprehensive risk score, and duration of postoperative hospital stay. We conclude that using the E-PASS scoring system, LADG appreciates a more beneficial procedure for the treatment of EGC than ODG.

关键词： E-PASS LADG ODG

纯二氧化硅芯单模光纤的拉制条件对其光学特性的影响

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电线电缆 1988年第4期 27-28+22页

作者： Fumiaki hanawa 徐乃英

研究了纯二氧化硅芯/掺氟二氧化硅包层单模光纤的拉制条件对其光学特性的影响。因为拉制张力使折射率差减小,随着拉制张力的增加,截止波长向较短的波长移动。

关键词：单模光纤光纤拉丝折射率影响

Efficacy and Tolerability of Second-Line Metronidazole Triple Therapy Using Vonoprazan for Helicobacter pylori Eradication in Japan—Comparative Study: Vonoprazan vs. Proton Pump Inhibitors

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Open Journal of Gastroenterology 2018年第1期8卷 27-38页

作者： Masahiko Ohtaka Mika Miura Mitsuhiko hanawa Yuichi Hirose Atsuko Kitahashi naoki Imamura Ikko Watanabe Kazuhiko Takaso naoki Shimura Yoshioki Yoda Ichiro Takayama Mitsuharu Fukasawa nobuyuki Enomoto Yamanashi Koseiren Health Care Center Yamanashi Japan First Department of Internal Medicine Graduate School of Medical and Engineering Science University of Yamanashi Yamanashi Japan Health Care Center University of Yamanashi Yamanashi Japan

Aim: To investigate the efficacy and tolerability of second-line metronidazole triple therapy with vonoprazan (VPZ) for Helicobacter pylori (H. pylori). Methods: We retrospectively reviewed medical records of patients who experienced clarithromycin triple therapy failure and were treated with second-line (20 mg VPZ (n = 274)/30 mg lansoprazole (n = 323) or 10 mg rabeprazole (n = 141) twice daily, 750 mg amoxicillin twice daily, 250 mg metronidazole twice daily for 7 days) eradication therapies. Successful eradication rates were compared between two groups: those receiving VPZ and those receiving a proton pump inhibitor (PPI). Adverse events were also investigated. Results: Successful second-line eradication rates according to ITT analysis and PP analysis, respectively, were 79.9% and 92.4% for VPZ therapy and 83.6% and 93.3% for PPI therapy. There were no significant differences between treatment groups. The eradication rates in those who had received first-line VPZ therapy previously according to ITT and PP analysis were 75.2% and 88.1%, respectively;in contrast, values were 82.5% and 95.4%, respectively, for those who had received first-line PPI therapy previously. In second-line therapy, the overall adverse event rate for VPZ therapy was the same as for PPI therapy. Conclusions: The efficacy and tolerability of metronidazole-containing second-line triple therapy with VPZ or a PPI were equivalent.

关键词： Vonoprazan Metronidazole Proton Pump Inhibitor Second-Line Eradication Helicobacter pylori

A prospective randomized trial of lafutidine vs rabeprazole on post-ESD gastric ulcers

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World Journal of Gastrointestinal Endoscopy 2010年第1期2卷 36-40页

作者： Tomohiko Richard Ohya Hiroki Endo Kei Kawagoe Tatsuro Yanagawa Katsuhiro hanawa Ken Ohata Masako Asayama Kantaro Hisatomi Takuma Teratani Toshiaki Gunji Hajime Sato nobuyuki Matsuhashi Department of Gastroenterology Kanto Medical CenterNTT East5-9-22 Higashi-gotandaShinagawa-kuTokyo 141-8625Japan Department of Public Health Graduate School of MedicineUniversity of TokyoTokyo 108-0075Japan

AIM:To compare the effects of rabeprazole and lafutidine on post-endoscopic submucosal dissection(ESD) gastric ***:Patients with gastric tumors indicated for ESD were prospectively *** ESD,all patients were treated with intravenous omeprazole for the first 3 *** were then randomly assigned to oral lafutidine or *** size,ulcer size reduction rate,and ulcer stage were evaluated 4 wk *** of complication was monitored throughout the 4-wk ***:Sixty five patients were enrolled in the study,and 60 patients were subjected to the final *** the lafutidine group(30 lesions in 29 patients),initial and 4-wk post-ESD ulcer sizes were 33.3 ± 9.2 and 10.5 ± 4.8 mm,*** the rabeprazole group(34 lesions in 31 patients),the values were 34.7 ± 11.3 and 11.8 ± 6.7 mm,*** size reduction rates in lafutidine and rabeprazole groups were 32.3% and 33.5%,respectively(P=0.974).Ulcer stage 4 wk post-ESD did not differ significantly between the two groups(P=0.868).Two cases in the rabeprazole group and no cases in the lafutidine group developed ulcer bleeding during the oral dose period,although the difference of bleeding rate between the two groups was not statistically significant(P=0.157).COnCLUSIOn:Lafutidine and rabeprazole have equivalent therapeutic effects on post-ESD gastric ulcers.

关键词： Cytoprotection Endoscopic submucosal dissection Gastric ulcer Histamine H2 receptor antagonists Lafutidine Proton pump inhibitors Rabeprazole

三辛基氧膦涂层玻璃碳电极伏安法及其在海水中预富集后微量铀酰离子的测定

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世界核地质科学 1986年第2期 67-71页

作者： Kosuke Izutsu Toshio nakamura Ritsuo Takizawa Hiroshi hanawa 李万山保定市化工研究所

本文叙述了三辛基氧膦（TOPO）涂层玻璃碳电极（GC）的伏安特性和它在测定微量铀酰离子的应用。在已试验的各种物质中,对Ag/AgCl电极为0V时只有铀酰离子有效地被富集到GC电极上的TOPO层中,并且在电极电位负向扫描时给出还原波。有些物... 详细信息

本文叙述了三辛基氧膦（TOPO）涂层玻璃碳电极（GC）的伏安特性和它在测定微量铀酰离子的应用。在已试验的各种物质中,对Ag/AgCl电极为0V时只有铀酰离子有效地被富集到GC电极上的TOPO层中,并且在电极电位负向扫描时给出还原波。有些物质可通过TOPO层的GC面,并且起电化学反应,而其他某些物质不通过TOPO层。用本法在0.5 M naCl测定铀酰离子,预富集后用醋酸盐缓冲溶液调节pH到4;探测极限是2×10-9M,可以测定的铀酰离子浓度在2×10-9M和2×10-7M之间。这种方法对铀酰离子是非常有选择性的,可用于分析海水中的铀。对人工的海水初步研究表明,简单的顶处理,包括在pH2.5时煮沸（除去溶解的二氧化碳）后即可测定。

关键词：预富集 GC 伏安特性电位扫描速度 TOPO 峰电流伏安法电化学分析海水

三种新型技术制备钴铬合金机械性能的初步评价

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中国口腔医学继续教育杂志 2018年第1期21卷 1-3页

作者： Jang SH Lee DH Ha JY hanawa T Kim KH Kwon TY 黎艳珊滕伟不详中山大学光华口腔医学院·附属口腔医院广州市陵园西路56号510055

一个初期的拉伸试验用于评价三种新型技术（包括金属铣削、软金属铣削和快速成型技术）（n=6）制备钴铬合金的机械性能．铸造方法制备出3种不同金属材料作为对照组。所有组别的极限强度均高于500MPa．延展率均高于2％。软金属铣削组的... 详细信息

一个初期的拉伸试验用于评价三种新型技术（包括金属铣削、软金属铣削和快速成型技术）（n=6）制备钴铬合金的机械性能．铸造方法制备出3种不同金属材料作为对照组。所有组别的极限强度均高于500MPa．延展率均高于2％。软金属铣削组的延展率最大．而快速成型组的极限强度最高。

关键词：机械性能钴铬合金制备快速成型技术金属材料极限强度铸造方法对照组

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纯钛表面微弧氧化多孔陶瓷膜的结构特性

材料热处理学报 2009年第2期30卷 129-133页

作者：朱瑞富王志刚王爱娟肖桂勇吕宇鹏李士同墒隆夫山东大学材料科学与工程学院山东济南250061 山东建筑大学材料科学与工程学院山东济南250076 东京医科齿科大学生体材料工学研究所日本东京101-0062

采用微弧氧化处理技术和电解液成分的优化设计,在纯钛表面制备了含钙磷的多孔复合陶瓷膜,并考察了陶瓷膜的表面形貌、截面形貌、化学成分、物相构成、生物活性及其与基体的结合强度等特性。研究结果表明:纯钛表面微弧氧化后形成了凹凸... 详细信息

采用微弧氧化处理技术和电解液成分的优化设计,在纯钛表面制备了含钙磷的多孔复合陶瓷膜,并考察了陶瓷膜的表面形貌、截面形貌、化学成分、物相构成、生物活性及其与基体的结合强度等特性。研究结果表明:纯钛表面微弧氧化后形成了凹凸不平的多孔陶瓷膜,整个膜层分为表层疏松层、中间过渡层和内部致密层三个区域,总厚度为25～40μm,膜层与基体的界面呈'锯齿状'紧密结合。膜层主要由金红石相TiO2和锐钛矿相TiO2构成;膜层中含有Ca,P,O,Ti四种元素,其钙磷比ω(Ca)∶ω(P)为1.528;膜层中的Ti,Ca,P元素呈梯度分布,由表及里Ti含量逐渐增多,Ca和P含量逐渐减少,O元素分布比较均匀。含钙磷多孔复合陶瓷膜具有良好的生物活性,样品经碱液处理后再在快速钙化溶液(FCS)中浸泡4d即有羟基磷灰石(HA)形成;膜层与基体具有高的结合强度,在450V和600Hz时膜层的临界载荷值高达29.5n。

关键词：纯钛微弧氧化多孔陶瓷膜组织结构特性

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Radioactive Beam Project at HIM AC

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Radioactive Beam Project at HIM AC