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Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells

Genes & Diseases 2017年第4期4卷 240-246页

作者： hanan abdelmawgoud Rehab Refaat El Awady Biochemistry Department Faculty of PharmacyAl-Azhar UniversityCairoEgypt

Breast cancer is the most common invasive cancer in women *** 1(SIRT1)has recently been shown to have implications in regulating cancer cell growth and ***1 regulates Forkhead box O3a(FOXO3a)by both inhibiting FOXO3-induced apoptosis and potentiating the ability of FOXO3a to resist oxidative *** metalloproteinase 2(MMP2)participates in tumor invasion and metastasis by degrading extracellular ***1 up regulates MMP2 expression by its deacetylation *** study aimed to investigate the expression of SIRT1,FOXO3a and MMP2 in breast tissues of women with breast *** addition,the effect of SIRT1 inhibition on both FOXO3a and MMP2 expression in breast cancer(MCF-7)cells was *** expression levels of SIRT1,FOXO3a and MMP2 in the breast tissues were determined by real-time PCR in 60 patients with malignant tumor and in 24 patients with benign *** SIRT1 inhibition,protein levels of SIRT1 and FOXO3a were assessed by Western Blot and levels of MMP2 by ELISA in MCF-7 *** expression levels of SIRT1,FOXO3a and MMP2 were significantly higher in breast cancer tissues compared to in benign breast tumor and adjacent normal ***1,MMP2 and FOXO3a expression were associated directly with each ***1 inhibition suppresses MMP2 and FOXO3a expression compared to control ***(SIRT1 inhibitor)effectively induced inhibition of MMP2 and FOXO3a expression in MCF-7 cells,indicating the promising therapeutic strategy of targeting SIRT1 for breast cancer.

关键词： Breast cancer FOXO3a MMP2 SIRT1 Sirtinol

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