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Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 389-396页

作者： Aisha Hussein Abou Zeid mohamed Ali Farag Manal Abdel Aziz Hamed Zeinab Abdel Aziz Kandil Radwa Hassan el-Akad hanaa mohamed el-rafie Pharmacognosy Department National Research Centre Pharmacognosy Department College of PharmacyCairo University Therapeutic Chemistry Department National Research Centre

Objective:To evaluate Brachychiton acerifolius leaf extracts as antidiabetic potential agent and to identify the main active constituents using bioactivity guided ***:In vitro antioxidant activity was evaluated for *** different extracts using DPPH assay and vitamin C as *** activity was then determined using STZ-induced rats treated daily with ethyl acetate and 70% ethanol leaf extracts for4 weeks at a dose of 200 g/kg body weight against gliclazide reference *** glucose,a-amylase,lipid profile,liver function enzymes and oxidative stress markers were assessed along with histopathological study for liver and pancreatic *** and structural elucidation of active compounds were made using Diaion and Sephadex followed by spectral ***:The results indicated that ethyl acetate and ethanol leaf extracts exhibited the strongest antioxidant activity compared to that of vitamin C(IC500.05,0.03 and 12 mg/m L,respectively).Both extracts showed potent anti-hyperglycemic activity evidenced by a significant decrease in serum glucose levels by 82.5% and 80.9% and a-amylase by45.2% and 53.6%,as compared with gliclazide 68% and 59.4%,*** of ethanol extract resulted in the isolation of 9 flavonoids including apigenin-7-O-arhamnosyl(1/2)-b-D-glucuronide,apigenin-7-O-b-D-glucuronide,apigenin-7-O-b-Dglucoside and ***:This study highlights the potential use of *** leaf extract enriched in flavones for the treatment of diabetes that would warrant further clinical trials investigation.

关键词： STZ-induced diabetes Diaion fractionation Flavonoid glucuronides Brachychiton acerifolius

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Primmorph extracts and mesohyls of marine sponges inhibit proliferation and migration of hepatocellular carcinoma cells in vitro

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Journal of Pharmaceutical Analysis 2019年第4期9卷 284-291页

作者： hanaa Rady Sohair Salem mohamed Ez el-Arab Chemistry of Natural Compound Department National Research Centre Cairo Egypt Molecular Genetics and Enzymology Department National Research Centre Cairo Egypt National Institute of Oceanography and Fisheries (NIOF) Hurghada Egypt

Cancer recurrence and severe side effects of currently being used chemotherapeutic agents reduce their clinical efficacy. Thus, there is a constant need to develop alternative anticancer drugs. Sustainable supply is an important challenge facing marine-based drug discovery. Primmorph, a 3D cell culture system, could provide a sustainable source to produce metabolites for anticancer drugs from marine sponges. In the present work, the anticancer activity of primmorph extracts and mesohyls of Negombata magnifica, Hemimycle arabica, Crella spinulata, and Stylissa carteri sponges was evaluated. Antiproliferative activity was studied in terms of cytotoxicity, colony formation, cell cycle, and apoptosis. Migration was assessed by migration assay and matrix metalloproteinase activity. The expression of proliferation and migration-related genes was analyzed using real time PCR. Migration and proliferation activities of HepG2 cells were inhibited by treatment with primmorph extracts and mesohyls of N. magnifica, H. arabica, and C. spinulata. The mesohyl of S. carteri did not show any anticancer activity although the primmorph extract led to cell cycle arrest. Among the selected sponge species, the primmorph extract of C. spinulata was the most promising anticancer agent regarding antiproliferative and antimigratory activities. In addition, primmorph extracts have the advantage of working under welldefined and controlled conditions, which allows the easy application as a bioreactor.

关键词： Marine sponge Primmorph Mesohyl Proliferation Migration Hepatocellular carcinoma cell line

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SOX9 in biliary atresia: New insight for fibrosis progression

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 154-162页

作者： hanaa Ahmed el-Araby Magdy Anwar Saber Noha mohamed Radwan Doha Maher Taie Nermin mohamed Adawy Ahmad mohamed Sira Department of Pediatric Hepatology Gastroenterologyand NutritionNational Liver InstituteMenoufia University32511 Shebin El-koomMenoufiaEgypt Department of Pathology National Liver InstituteMenoufia University32511 Shebin El-koomMenoufiaEgypt

Background:Liver fibrosis is a hallmark determinant of morbidity in biliary atresia(BA)even in successfully operated *** factors for this rapid progression of fibrosis are not completely *** expression of the transcription factor SOX9 and hepatic progenitor cells(HPCs)proliferation have roles in fibrogenesis in cholestatic ***,they were not investigated sufficiently in *** aimed to delineate the relation of SOX9 and HPCs to fibrosis and its progression in ***:Forty-eight patients with BA who underwent an initial diagnostic liver biopsy(LB)and consequent intraoperative LB were recruited and compared to 28 cases with non-BA cholestasis that had an LB in their diagnostic *** fibrosis,tissue SOX9 and HPC expressions were studied in both BA and non-BA-cholestasis *** fibrosis,SOX9,and HPCs’dynamic changes in BA cases were *** of fibrosis and its progression to SOX9 and HPCs in BA was ***:SOX9 and HPCs in ductular reaction(DR)form were expressed in 100%of BA and their grades increased significantly in the second *** rapidly progressive fibrosis in BA,represented by fibrosis grade of the intraoperative LB,correlated significantly to SOX9-DR and HPC-DR at the diagnostic(r=0.420,P=0.003 and r=0.405,P=0.004,respectively)and the intraoperative(r=0.460,P=0.001 and r=0.467,P=0.001,respectively)*** the other hand,fibrosis,SOX9-DR,and HPC-DR were significantly lower in non-BA cases at a comparable age(Pely).Conclusions:Fibrosis in BA is rapidly progressive within a short time and is significantly correlated to SOX9 and *** of targeting SOX9 and HPCs on fibrosis progression is warranted.

关键词： Biliary atresia Fibrosis Hepatic progenitor cells Immunohistochemistry Neonatal cholestasis SOX9

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Serum ferritin in neonatal cholestasis: A specific and active molecule or a non-specific bystander marker?

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 173-180页

作者： Behairy el-Sayed Behairy Hatem Abd-Alsattar Konswa hanaa Talaat Ahmed Dina Shehata el-Azab Nermin mohamed Adawy Ahmad mohamed Sira Department of Pediatric Hepatology Gastroenterology and Nutrition National Liver Institute Menofiya University Department of Pathology National Liver Institute Menofiya University

Background: Serum ferritin(SF) and consequently hepatic iron have long been considered important in liver fibrosis progression. They have been studied in different liver diseases with no previous reports in neonatal cholestasis(NC). This study aimed to measure SF in different etiologies of NC and investigate its relation to hepatic iron and fibrosis. Methods: SF was measured in 75 infants, including 50 with NC and 25 with sepsis. SF was compared between these two groups. Biochemical parameters, hepatic iron grades, and liver fibrosis and other histopathological characteristics and correlated with SF were assessed in NC group. Finally, a comparison between intrahepatic cholestasis and obstructive etiology was performed. Results: SF was elevated in NC(1598 ± 2405 ng/mL) with no significant difference from those with sepsis( P = 0.445). NC and sepsis constituted augmenting factors leading to more elevation of SF(2589 ± 3511 ng/mL). SF was significantly correlated with hepatic iron grades( r = 0.536, P ell transformation( P = 0.009) and hepatocyte swelling( P = 0.023) than those with obstructive etiology(672 ± 566 ng/mL) and their prevalent pathological findings of ductular proliferation( P = 0.003) and bile plugs( P = 0.002). SF was unrelated to the grade of liver fibrosis( P = 0.058). Conclusions: SF is non-specifically elevated in NC, with positive correlation to hepatic iron grades. SF ≥ 803.5 ng/mL can predict higher grades( ≥ grade 3) of hepatic iron. However, an active role of increased SF and hepatic iron in disease progression remains questionable.

关键词： Biliary atresia Liver fibrosis Hepatic iron grade Intrahepatic cholestasis Iron

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Bayesian belief-based model for reliability improvement of the digital reactor protection system

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Nuclear Science and Techniques 2020年第10期31卷 55-73页

作者： hanaa Torkey Amany S.Saber mohamed K.Shaat Ayman el-Sayed Marwa A.Shouman Faculty of electronic Engineering Menoufia UniversityCairoEgypt Nuclear Research Center Egyptian Atomic Energy AuthorityCairoEgypt

The digital reactor protection system(RPS)is one of the most important digital instrumentation and control(I&C)systems utilized in nuclear power plants(NPPs).It ensures a safe reactor trip when the safety-related parameters violate the operational limits and conditions of the *** high reliability and availability of digital RPS is essential to maintaining a high degree of reactor safety and cost *** main objective of this study is to develop a general methodology for improving the reliability of the RPS in NPP,based on a Bayesian Belief Network(BBN)*** structure of BBN models is based on the incorporation of failure probability and downtime of the RPS I&C *** architectures with dual-state nodes for the I&C components were developed for reliability-sensitive analysis and availability optimization of the RPS and to demonstrate the effect of I&C components on the failure of the entire system.A reliability framework clarified as a reliability block diagram transformed into a BBN representation was constructed for each architecture to identify which one will fit the required *** results showed that the highest availability obtained using the proposed method was *** are 120 experiments using two common component importance measures that are applied to define the impact of I&C modules,which revealed that some modules are more risky than others and have a larger effect on the failure of the digital RPS.

关键词： Nuclear power plants Reactor protection system Bayesian belief network

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Applicability and efficacy of a model for prevention of perinatal transmission of hepatitis B virus infection:Single center study in Egypt

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World Journal of Gastroenterology 2014年第45期20卷 17075-17083页

作者： hanaa M el-Karaksy Lamiaa M Mohsen Doa'a A Saleh Mona S Hamdy Noha A Yassin mohamed Farouk mohamed E Salit Mortada H el-Shabrawi Department of Pediatrics Kasr Al-Ainy School of Medicine Cairo University Department of Community Medicine Kasr AlAiny School of Medicine Cairo University Department of Clinical and Chemical Pathology Kasr Al-Ainy School of Medicine Cairo University Department of Obstetrics and Gynecology Kasr Al-Ainy School of Medicine Cairo University

AIM: To identify possible maternal risk factors for hepatitis B virus (HBV) acquisition and assess the efficacy of immunoprophylaxis given to infants born to hepatitis B virus surface antigen (HBsAg) positive mothers.

关键词： Egypt Hepatitis B virus Hepatitis B virus surface antigen positive mothers Immunoprophylaxis Perinatal transmission

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Hepatocellular carcinoma in Egypt: A single center study over a decade

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World Journal of Gastroenterology 2005年第33期11卷 5193-5198页

作者： Adbel-Rahman el-Zayadi hanaa M Badran Eman MF Barakat Mohy el-Deen Attia Sherine Shawky Mostafa K mohamed Osaima Selim Ahmed Saeid Department of Tropical Medicine Ain Shams University Cairo Egypt Department of Hepatology National Liver Institute MenoufeyaEgypt Department of Tropical Medicine Ain Shams University Cairo Egypt Department of Hepatology and Gastroenterology Theodor Bilharz Research Institute Cairo Egypt The Social Research Center The American University in Cairo Egypt Department of Community Medicine Ain Shams University CairoEgypt Department of Clinical Pathology Ain Shams University CairoEgypt Cairo Liver Center Giza Egypt

AIM： To identify the trend, possible risk factors and any pattern change of hepatocellular carcinoma （HCC） in Egypt over a decade. METHODS： All HCC patients attending Cairo Liver Center between January 1993 and December 2002, were enrolled in the study. Diagnosis of HCC was based on histopathological examination and/or detection of hepatic focal lesions by two imaging techniques plus α-fetoprotein level above 200 ng/mL. The duration of the study was divided into two periods of 5 years each; period Ⅰ （1993-1997） and period Ⅱ （1998-2002）. Trend, demographic features of patients （age, gender, and residence）, risk factors （HBsAg, HCV-Ab, schistosomiasis and others） and pattern of the focal lesions were compared between the two periods. Logistic regression model was fitted to calculate the adjusted odds ratios for the potential risk factors. The population attributable risk percentage was calculated to estimate the proportion of HCC attributed to hepatitis B and C viral infections. RESULTS： Over a decade, 1 328 HCC patients out of 22 450 chronic liver disease （CLD） patients were diagnosed with an overall proportion of 5.9%. The annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 （P = 0.000）. A significant increase in male proportion from 82.5% to 87.6% （P = 0.009）; M/F from 5：1 to 7：1 and a slight increase of the predominant age group （40-59 years） from 62.6% to 66.8% （P = 0.387）in periods Ⅰ and Ⅱ respectively, reflecting a shift to younger age group. In the bivariate analysis, HCC was significantly higher in rural residents, patients with history of schistosomiasis and/or blood transfusion. Yet, after adjustment, these variables did not have a significant risk for development of HCC. There was a significant decline of HBsAg from 38.6% to 20.5% （P = 0.000）, and a slight increase of HCV-Ab from 85.6% to 87.9% in periods I and II respectively. HBV conferred a higher risk to develop HCC more than HCV in period Ⅰ （OR 1.9 vsl.6） and pe

关键词： Hepatocellular carcinoma HCC prevalence HCCrisk factors Pattern of HCC HCV and HCC HBV and HCC

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Variant Wasserstein Generative Adversarial Network Applied on Low Dose CT Image Denoising

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Computers, Materials & Continua 2023年第5期75卷 4535-4552页

作者： Anoud A.Mahmoud hanaa A.Sayed Sara S.mohamed Department of Mathematics and Computer Science Faculty of ScienceNew Valley UniversityNew Valley72511Egypt Department of Computer Science College of Computer Science and Engineering Taibah UniversityMedina42221KSA Department of Mathematics Faculty of ScienceAssiut UniversityAssiut71516Egypt

Computed Tomography(CT)images have been extensively employed in disease diagnosis and treatment,causing a huge concern over the dose of radiation to which patients are *** the radiation dose to get a better image may lead to the development of genetic disorders and cancer in the patients;on the other hand,decreasing it by using a Low-Dose CT(LDCT)image may cause more noise and increased artifacts,which can compromise the ***,image reconstruction from LDCT image data is necessary to improve radiologists’judgment and *** study proposed three novel models for denoising LDCT images based on Wasserstein Generative Adversarial Network(WGAN).They were incorporated with different loss functions,including Visual Geometry Group(VGG),Structural Similarity Loss(SSIM),and Structurally Sensitive Loss(SSL),to reduce noise and preserve important information on LDCT images and investigate the effect of different types of loss ***,experiments have been conducted on the Graphical Processing Unit(GPU)and Central Processing Unit(CPU)to compare the performance of the proposed *** results demonstrated that images from the proposed WGAN-SSIM,WGAN-VGG-SSIM,and WGAN-VGG-SSL were denoised better than those from state-of-the-art models(WGAN,WGAN-VGG,and SMGAN)and converged to a stable equilibrium compared with WGAN and *** proposed models are effective in reducing noise,suppressing artifacts,and maintaining informative structure and texture details,especially WGAN-VGG-SSL which achieved a high peak-signalto-noise ratio(PNSR)on both GPU(26.1336)and CPU(25.8270).The average accuracy of WGAN-VGG-SSL outperformed that of the state-ofthe-art methods by 1 *** prove that theWGAN-VGG-SSL is more stable than the other models on both GPU and CPU.

关键词： Machine learning deep learning image denoising low dose CT loss function

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Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children

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World Journal of Gastroenterology 2014年第16期20卷 4681-4691页

作者： Suzan el Naghi Tawhida Y Abdel-Ghaffar hanaa el-Karaksy elham F Abdel-Aty Mona S el-Raziky Aleef A Allam Heba Helmy hanaa A el-Araby Behairy E Behairy mohamed A el-Guindi Hatem el-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M el-Hennawy Mostafa M Sira Pediatric Department National Hepatology and Tropical Medicine Research Institute11441 CairoEgypt Yassin Abdel Ghaffar Charity Center for Liver Disease and Research 2851 CairoEgypt Pediatric Department Ain Shams University11566 CairoEgypt Department of Pediatrics Cairo University Pediatric Hospital11562 CairoEgypt Pediatric Hepatology Department National Liver InstituteMenofiya UniversityShebin El-koom32511 MenofiyaEgypt Biochemistry Department National Liver Institute32511 MenofiyaEgypt Clinical Pathology Department Ain Shams University11566 CairoEgypt Pathology Department National Liver InstituteMenofiya UniversityShebin El-koom32511 MenofiyaEgypt Pathology Department Cairo UniversityFaculty of MedicineKasr El-Aini11562 CairoEgypt

AIM: To investigate the safety and efficacy of a Hansenula-derived PEGylated (polyethylene glycol) interferon (IFN)-alpha-2a (Reiferon Retard) plus ribavirin customized regimen in treatment-naïve and previously treate... 详细信息

关键词： Children Chronic hepatitis C Hansenula polymorpha PEGylated interferon Response rate Ribavirin Treatment

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Influence of bioactive sulphated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1175-1186页

作者： Azza A.Matloub Hadeer A.Aglan Sahar Salah mohamed el Souda Mona elsayed Aboutabl Amany Sayed Maghraby hanaa H.Ahmed Pharmacognosy Department National Research Centre Hormones Department National Research Centre Chemistry of Natural Compounds Department National Research Centre Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group) National Research Centre Therapeutical Chemistry Department National Research Centre Laboratory of Immune and Biomarkers for Infection the Center of Excellence for Advanced SciencesNational Research Centre

Objective:To explore the in vivo anticancer,anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens(JCEM) and Pterocladia capillacea(PCEM) as well as hot aqueous extract of Enteromorpha intestinalis(EHEM) against hepatocellular carcinoma rat model(HCC) and to study their chemical ***:The sugars and amino acids composition of the bioactive polysaccharides of JCEM,PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer,*** polysaccharide extracts(20 mg/kg *** 5 weeks) were assessed on hepatocarcinogenesis in rats and α-fetoprotein(AFP),carcinoembryonic antigen(CEA),glypican-3(GPC-3),hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) and Ig G levels were ***:The GLC analysis of JCEM,PCEM and EHEM polysaccharide revealed the presence of 10,9 and10 sugars,in addition the amino acid analyser enable identification of 16,15 and 15 amino acids,*** polysaccharide extracts of JCEM,PCEM and EHEM produced significant decrease in serum AFP,CEA,GPC-3,HGF and VEGF compared with untreated HCC ***,PCEM and EHEM had an immunostimulatory responses by increasing the IgG levels as compared by naive value(1.23,1.53 and 1.17 folds),*** bioactive polysaccharides in HCC induced rats improved the humoral immune *** photomicrographs of liver tissue sections of the groups of HCC treated with polysaccharide extracts of Jania rubens and Enteromorpha intestinalis showed intact histological ***,fractions HE1,HE4,HE7 obtained from polysaccharide of EHEM showed moderate cytotoxic activity against Hep G2 in vitro with IC_(50) 73.1,42.6,76.2 μg/***,fractions of PCEM and JCEM show no or weak cytotoxicity against Hep G2 in vitro where the cytotoxic activity of their crude polysaccharide extract proved synergetic ***:The pronounced antitumor activi

关键词： Jania rubens Pterocladia capillacea Enteromorpha intestinalis Polysaccharide-protein complexes Anti-tumor activity Anti-angiogenesis

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