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Mono-and dioleyl p-coumarate phenolipids and their antioxidant activity in a muscle food model system

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Food Production, Processing and Nutrition 2022年第1期4卷 72-84页

作者： Jiankang Wang Xiaojia Hu Yan Huang Ye Zou Linxiao han.Daoying Wang Fereidoon shahidi school of Food and Biological Engineering Shaanxi University of Science and TechnologyXi’an710021People’s Republic of China Institute of Agricultural Products Processing Jiangsu Academy of Agricultural SciencesNanjing210014People’s Republic of China Department of Biochemistry Memorial University of NewfoundlandSt.John’sNLA1C 5S7Canada

Response surface methodology (RsM) was used to optimize the degree of esterification of p-coumaric acid to triolein via lipase-catalyzed acidolysis, and enzyme load, reaction time and mole ratio of substrates were selected as variables in the experimental design. The results showed that the model employed was highly sufficient for determining the effectiveness and interaction of three selected variables, enzyme load, reaction time and the mole ratio of substrates, on the dependent variable, the degree of esterification. Although the optimization point was not found in the selected range of the three variables, the steepest ascent analysis suggested that an increase of these three variables might lead to a stationary point. However, based on the limitations on increasing the range of tested variables, including possible oxidation of synthesized lipids and increased cost, the degree of esterification so yielded in the designed central composite design should be the one closest to the possible ideal optimized degree. The p-coumarates so produced exhibited varying antioxidant performance in the tested muscle food model, which could be explained by their different lipophilicity. Moreover, the potential health benefits of synthesized phenolic lipids have been discussed.

关键词： Response surface methodology Acidolysis P-coumaric acid Monooleyl p-coumarates Dioleyl p-coumarates Antioxidant activity

Concordant Atrioventricular Connection to L-Looped Ventricles with the Left Ventricle on Top of the Right Ventricle in situs solitus:A Case Report with 3D Modelling and Printing

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Congenital Heart Disease 2022年第4期17卷 393-398页

作者： Mi Kyoung song Gi Beom Kim Woong han.Kim Whal Lee Eun-Jung Bae Department of Pediatrics Seoul National University Children’s HospitalSeoul National University College of MedicineSeoulKorea Department of Thoracic and Cardiovascular surgery Seoul National University Children’s HospitalSeoulKorea Department of Radiology and the Institute of Radiation Medicine Seoul National University HospitalSeoulKorea

We report the case of a rare complex cardiac anomaly involving situs solitus,concordant atrioventricular connection with left-han. ventricular topology,and L-looped *** ventricles had a superior-inferior relationship with an inferiorly located right ventricle,which had a double outlet with far posteriorly located great *** left atrium was elongated,with juxta-positioned atrial appendages on the right *** 3D-printed model using a computed tomography scan taken on the fourth day of birth demonstrated the anatomy clearly and helped us decide on the surgical management.

关键词： Double outlet right ventricle superior-inferior ventricle L-looped ventricles 3D printing

DCE-MRI定量参数对类风湿性关节炎的诊断价值及与凝血功能状态的关系探究

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医学影像学杂志 2024年第2期34卷 98-103页

作者：杨靖泽尹劲胡清杨海青张涵易炜云南省昆明市第一人民医院骨科云南昆明650000 中国人民解放军联勤保障部队九二〇医院骨科云南昆明650000 云南省第三人民医院放射医学影像科云南昆明650000

目的探讨动态增强磁共振成像(DCE-MRI)定量参数对类风湿性关节炎的诊断价值及与凝血功能状态的关系。方法选取我院类风湿性关节炎患者80例为观察组,另选取排除类风湿性关节炎诊断的正常关节受检者60例为对照组。比较两组DCE-MRI定量参数... 详细信息

目的探讨动态增强磁共振成像(DCE-MRI)定量参数对类风湿性关节炎的诊断价值及与凝血功能状态的关系。方法选取我院类风湿性关节炎患者80例为观察组,另选取排除类风湿性关节炎诊断的正常关节受检者60例为对照组。比较两组DCE-MRI定量参数[相对增强(RE)、曲线下面积(AUC)、最大相对增强(MRE)、最大强化斜率(slope_(max))、最大增强(ME)],评价DCE-MRI定量参数对类风湿性关节炎的诊断价值,比较不同预后患者临床资料、DCE-MRI定量参数及凝血功能指标[D-二聚体(D-D)、纤维蛋白原(FBG)、凝血酶原时间(PT)、部分凝血酶原时间(APTT)],分析DCE-MRI定量参数及凝血功能指标与临床资料的相关性,DCE-MRI定量参数及凝血功能指标与类风湿性关节炎患者预后的关系,DCE-MRI定量参数与凝血功能指标相关性。结果观察组RE、MRE、ME、slope_(max)、AUC均高于对照组,差异有统计学意义(Pslope_(max)、AUC诊断类风湿性关节炎的AUC值分别为0.719、0.767、0.800、0.834、0.814,联合预测AUC值最大为0.928;预后不良患者病程、关节压痛与肿胀指数、疾病活动度、RE、MRE、ME、slope_(max)、AUC、FBG、D-D、PT、APTT与预后良好患者比较,差异有统计学意义(Pslope_(max)、AUC、FBG、D-D、PT、APTT均与类风湿性关节炎患者病程,关节压痛指数,关节肿胀指数,疾病活动度及预后情况显著相关(Pslope_(max)、AUC均与类风湿性关节炎患者FBG、D-D、PT、APTT呈正相关关系(P<0.05)。结论DCE-MRI定量参数与类风湿性关节炎凝血功能状态有关,可作为临床诊断类风湿性关节炎诊断、病情评估及预后预测的可靠手段,为临床提供参考依据。

关键词：类风湿性关节炎动态增强磁共振成像定量参数凝血功能

1,2-二氯乙烷降解菌群的富集及关键降解菌Ancylobacter sp. BL0的分离鉴定

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生物技术通报 2024年第8期40卷 288-298页

作者：张志梅张彦猛谢东明杨秀云王浪左梓涵吴志国天津乐金渤海化学有限公司天津300452 天津市丹晟环安科技有限公司天津300457 天津科技大学天津300457

【目的】1,2-二氯乙烷(1,2-DCA)的污染会危害到人体的生命健康和环境生态安全。为获得高效的1,2-DCA生物降解种质资源,研究菌群特征并探索从中分离筛选高效1,2-DCA降解菌株的规律和方法。【方法】从受1,2-DCA污染的土壤中富集培养能以1,... 详细信息

【目的】1,2-二氯乙烷(1,2-DCA)的污染会危害到人体的生命健康和环境生态安全。为获得高效的1,2-DCA生物降解种质资源,研究菌群特征并探索从中分离筛选高效1,2-DCA降解菌株的规律和方法。【方法】从受1,2-DCA污染的土壤中富集培养能以1,2-DCA为唯一碳源和能源的降解菌群,通过气相色谱、紫外分光光度仪考察了不同批次菌群的生长和对1,2-DCA的降解情况,利用高通量测序分析不同批次富集液的物种多样性和相对丰度。通过16s rDNA基因序列分析鉴定菌株,利用气相色谱-质谱联用测定降解产物,分析菌株的降解途径。【结果】得到了降解菌群BG1,且实验结果显示第6-11批和15批富集菌群在24 h内对12.5 mg/L 1,2-DCA的降解率呈先增加后降低趋势,菌群生物量(OD_(600))可从0.03增长至0.095,但菌群中Ancylobacter sp.的相对丰度随着持续富集而降低。从第9批富集液中筛选出一株菌命名为BL0,鉴定为Ancylobacter sp.,能在6 h内降解120 mg/L 1,2-DCA,推测BL0降解1,2-DCA的途径为1,2-DCA水解为2-氯乙醇,2-氯乙醇再被氧化为氯乙酸,然后被彻底降解利用。【结论】本研究得到了高效降解1,2-DCA的菌群BG1和菌株Ancylobacter ***0,同时发现1,2-DCA降解菌株的筛选分离需要的样品富集过程周期较长且微生物生长量较低,不适于过度富集。菌株Ancylobacter ***0与富集菌群中的其他菌株之间以竞争关系为主。

关键词： 1 2-二氯乙烷生物降解菌群富集降解菌群 Ancylobacter 群落互作代谢途径

硫铁矿沸腾焙烧炉多相流动反应特性的数值模拟

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材料与冶金学报 2024年第3期23卷 218-225页

作者：穆玺文缪海山薛绍秀韩志明曾伟焦璐璐张浩余艾冰东北大学多金属共生矿生态化冶金教育部重点实验室沈阳110819 东北大学冶金学院沈阳110819 瓮福(集团)有限责任公司瓮福化工公司贵州福泉550500 东南大学能源与环境学院南京210096 江苏集萃工业过程模拟与优化研究所有限公司江苏苏州215000

采用双流体方法对硫铁矿在沸腾焙烧炉内的多相流动反应特性进行数值模拟研究,得到了不同工况下炉内温度分布、各组分分布及反应速率等关键数据,重点分析了进气速度和预热风温对反应速率的影响规律.结果表明:当进气速度由2 m/s增至2.5 m/... 详细信息

采用双流体方法对硫铁矿在沸腾焙烧炉内的多相流动反应特性进行数值模拟研究,得到了不同工况下炉内温度分布、各组分分布及反应速率等关键数据,重点分析了进气速度和预热风温对反应速率的影响规律.结果表明:当进气速度由2 m/s增至2.5 m/s时,沸腾焙烧炉内焙烧硫铁矿的反应速率由8.01 mmol/(m^(3)·s)增至13 mmol/(m^(3)·s),同时流化床层厚度会随着进气速度的增加而增大,但过高的气速有可能致使固相扰动sO2的收集工序,因此建议将进气速度调整至2.5 m/s;预热风温对提高沸腾焙烧炉内硫铁矿的反应速率起促进作用,当预热风温由25℃升至600℃时,炉内平均温度升高,反应速率由4.1 mmol/(m^(3)·s)增至6.3 mmol/(m^(3)·s),反应进行得更完全,残硫率也更低;当预热风温到达600℃时,炉内局部区域超过1000℃,极易造成安全隐患,因此建议将预热风温设置在200~300℃.

关键词：硫铁矿多相流动反应沸腾焙烧炉残硫率

A review of brain imaging biomarker genomics in Alzheimer’s disease:implementation and perspectives

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Translational Neurodegeneration 2022年第1期11卷 294-330页

作者： Lanlan Li Xianfeng Yu Can sheng Xueyan Jiang Qi Zhan. Ying han.Jiehui Jiang school of Information and Communication Engineering Shanghai UniversityShanghai 200444China school of Biomedical Engineering Hainan UniversityHaikou 570228China Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Institute of Biomedical Engineering School of Life ScienceShanghai UniversityShanghai 200444China.

Alzheimer’s disease(AD)is a progressive neurodegenerative disease with phenotypic chan.es closely associated with both genetic variants and imaging *** imaging biomarker genomics has been developed in recent years to reveal potential AD pathological mechan.sms and provide early *** technique integrates multimodal imaging phenotypes with genetic data in a noninvasive and high-throughput *** this review,we summarize the basic analytical framework of brain imaging biomarker genomics and elucidate two main implementation scenarios of this technique in AD studies:(1)exploring novel biomarkers and seeking mutual interpretability and(2)providing a diagnosis and prognosis for AD with combined use of machine learning methods and brain imaging biomarker ***,we highlight the necessity of brain imaging biomarker genomics,discuss the strengths and limitations of current methods,and propose directions for development of this research field.

关键词： Imaging biomarker genomics Alzheimer’s disease Evolving technologies Implementation

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宇航用总线型上注刷新AsIC的设计

集成电路与嵌入式系统 2024年第5期24卷 72-80页

作者：于栋刘琦韩志学王磊申一伟李阳北京空间机电研究所北京100094

当前宇航任务中,sRAM型FPGA易受到单粒子效应的影响,造成非预期的功能失效。为消减单粒子效应的影响、减小FPGA在轨维护重复开发和测试的工作量,设计了一款支持多种总线、适配多型FPGA和存储器的上注刷新AsIC芯片,用于完成FPGA的程序加... 详细信息

当前宇航任务中,sRAM型FPGA易受到单粒子效应的影响,造成非预期的功能失效。为消减单粒子效应的影响、减小FPGA在轨维护重复开发和测试的工作量,设计了一款支持多种总线、适配多型FPGA和存储器的上注刷新AsIC芯片,用于完成FPGA的程序加载、动态刷新、程序上注等操作。首先介绍了AsIC系统层级、模块层级设计、工作流程规划,并简述了AsIC抗单粒子原理。通过对通信协议的兼容设计,AsIC同时支持CAN总线、Rs485总线;通过对FPGA配置位流结构分析,AsIC支持9种FPGA的加载和刷新,并实现国产兼容;通过对存储器数据格式转换,AsIC能够在BPI Flash、sPI Flash、PROM等多种存储器中存储配置位流;对刷新的触发、sEFI检测、刷新的执行进行了论述。对影响AsIC上注速度的因素进行了分析和仿真验证;使用原型验证板、AsIC验证板配合可插拔的FPGA、存储器上浮小板完成流片前后的各项功能验证,验证结果符合预期。评估刷新的效果并与其他在轨维护方案进行对比,总线型FPGA上注刷新AsIC具有一定优势,可以高效、可靠地满足宇航FPGA的多种在轨维护需求。

关键词：单粒子效应 FPGA 动态刷新程序上注 AsIC设计

Mixed ion-electron conducting Li_(3)P for efficient cathode prelithiation of all-solid-state Li-ion batteries

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smartMat 2023年第5期4卷 119-130页

作者： Jing Li Dan Liu han.sun Deyu Qu Zhizhong Xie Haolin Tang Jinping Liu Department of Chemistry School of ChemistryChemical Engineering and Life ScienceWuhan University of TechnologyWuhanChina Laboratory of the Advanced Energy science and Technology Guangdong Laboratory FoshanChina state Key Laboratory of Advanced Technology for Materials synthesis and Processing Wuhan University of TechnologyWuhanChina

All-solid-state batteries(AssBs)using sulfide electrolytes hold promise for next-generation battery *** using a pure Li metal anode is believed to maximize battery energy density,numerous recent studies have implicated that Li-ion anodes(e.g.,graphite and si)are more realistic candidates due to their interfacial compatibility with sulfide ***,those Li-ion AssBs suffer from an issue similar to liquid Li-ion batteries,which is a loss of active Li inventory owing to interfacial side reactions between electrode components,resulting in reduced available capacities and shortened cycle ***,for the first time,we explore the potential of Li_(3)P for cathode prelithiation of Li-ion *** identify that the crystallized Li_(3)P(c-Li_(3)P)has room-temperature ionic and electronic conductivities of both over 1o-4 s/*** a mixed ion-electron conduct-ing feature ensures that the neat c-LisP affords a high Li+-releasing capacity of 983 mAh/g in AssBs during the first ***,the electro-chemical delithiation of c-LisP takes place below 2 V versus Li+/Li,while its lithiation dominates below 1 V versus Lit/*** used as a cathode prelithiation regent for AssBs,c-Li_(3)P only functions as a Li+donor without lithiation activity and can adequately compensate for the Li loss with minimal dosage *** mitigating first-cycle Li loss,c-LisP prelithiation can also improve the battery cyclability by sustained release of low-dosage Li+ions in subsequent cycles,which have been embodied in several full AssBs by coupling a LiCoO2 cathode with various types of anodes(including graphite,in foil,sb,and si anode).Our work provides a universal cathode prelithiation strategy for high-efficiency Li-ion AssBs.

关键词： all-solid-state batteries cathode prelithiation Li_(3)P lithium-ion batteries mixed ion-electron conductor

Atypical Takotsubo cardiomyopathy presenting as acute coronary syndrome:A case report

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World Journal of Clinical Cases 2022年第29期10卷 10772-10778页

作者： Zi-han.Wang Jia-Rong Fan Gao-Yu Zhan. Xian-Lun Li Lin Li Beijing University of Chinese Medicine Graduate SchoolBeijing 100029Chaoyang DistrictChina Department of Integrative Cardiology China-Japan Friendship HospitalBeijing 100029Chaoyang DistrictChina

BACKGROUND Takotsubo cardiomyopathy(Ts)is a rare acute cardiac disease with clinical features,symptoms,and electrocardiographic manifestations similar to those of acute myocardial *** present the case of a patient with Ts caused by a pheochromocytoma,which was confirmed by the postoperative ***,we present the patient’s subsequent management,treatment,and *** sUMMARY A 64-year-old woman was admitted to the hospital with episodic chest pain and palpitations,electrocardiogram(ECG)findings suggestive of high lateral wall myocardial infarction,echocardiogram showing left ventricular wall segmental motion abnormalities,and elevated levels of the myocardial marker *** patient underwent coronary angiography,which revealed unobstructed blood flow without obvious *** their hospitalization,the patient had paroxysmal elevation of blood pressure accompanied by palpitations and profuse sweating,with elevated blood catecholamine levels during *** computerized tomography of the adrenal glands revealed the presence of a nodule in the right adrenal,which was resected and determined to be an adrenal ***,the diagnosis of pheochromocytoma-induced atypical Ts was *** patient had an uneventful postoperative *** Cardiologists should consider pheochromocytoma in patients with *** detection allows timely intervention,benefiting patients.

关键词： Takotsubo cardiomyopathy Acute coronary syndromes Pheochromocytoma Diagnose Prognosis Case report