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海绵Dysideidae sp.中的两个溴代酚类化合物

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天然产物研究与开发 2007年第4期19卷 603-604页

作者：李想 Mirko Bayer 林文翰 peter Proksch 杜塞尔多夫大学药学生物技术研究所北京大学天然药物与仿生药物国家重点实验室北京100083 北京大学天然药物与仿生药物国家重点实验室

利用各种层析手段,从海绵Dysideidae sp.的正丁醇部分纯化了两个溴代酚类化合物,通过各种波谱数据鉴定为3,4,5-三溴-2-(2,′4′-二溴-苯氧基)-苯酚(1)和3,4,5,6-四溴-2-(2,′4′-二溴-苯氧基)-苯酚(2)。

关键词：海绵 Dysideidae sp. 溴代酚

Nature, Society and the Spirit: peter Matthiessen’s Ecological Ideas

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Journal of Geoscience and Environment Protection 2020年第11期8卷 176-182页

作者： Jie han.Liming Zhan. Foreign Languages Department Baoding University Baoding China

peter Matthiessen is widely regarded as a serious, disciplined author who wrote about wild nature, vanishing cultures, and human society. He was a dedicated naturalist from early on, and the concern for nature informed his work from the beginning of his career. This paper analyses Matthiessen’s major works from the perspective of ecocriticism, revealing his ecological ideas on natural ecology, social ecology and spiritual ecology respectively. For Matthiessen, the modern environmental crisis is inseparable from social and spiritual problems. He criticizes the anthropocentric and imperial points of view, sparing no effort to pursue justice, harmony and wholeness both in his literary imagination and real life.

关键词： Nature Society Spirit peter Matthiessen Ecology

Validation of Treatment Planning Dose Calculations: Experience Working with Medical Physics Practice Guideline 5.a.

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第1期6卷 57-72页

作者： Jinyu Xue Jared D. Ohrt James Fan peter Balter Joo han.Park Leonard Kim Steven M. Kirsner Geoffrey S. Ibbott Department of Radiation Oncology NYU Langone Medical Center New York NY USA Department of Radiation Physics UT MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology Fox Chase Cancer Center Philadelphia PA USA Department of Radiation Oncology MD Anderson Cancer Center at Cooper Camden NJ USA

Recently published Medical Physics Practice Guideline 5.a. (MPPG 5.a.) by American Association of Physicists in Medicine (AAPM) sets the minimum requirements for treatment planning system (TPS) dose algorithm commissioning and quality assurance (QA). The guideline recommends some validation tests and tolerances based primarily on published AAPM task group reports and the criteria used by IROC Houston. We performed the commissioning and validation of the dose algorithms for both megavoltage photon and electron beams on three linacs following MPPG 5.a. We designed the validation experiments in an attempt to highlight the evaluation method and tolerance criteria recommended by the guideline. It seems that comparison of dose profiles using in-water scan is an effective technique for basic photon and electron validation. IMRT/VMAT dose calculation is recommended to be tested with some TG-119 and clinical cases, but no consensus of the tolerance exists. Extensive validation tests have provided the better understanding of the accuracy and limitation of a specific dose calculation algorithm. We believe that some tests and evaluation criteria given in the guideline can be further refined.

关键词： Dose Calculation Algorithm Treatment Planning System Beam Data Modeling Validation Test MPPG 5.a.

Coronary artery disease in congenital single coronary artery in adults:A Dutch case series

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World Journal of Cardiology 2014年第4期6卷 196-204页

作者： Salah AM Said Willem G de Voogt Suat Bulut Jacques han.peter Polak Rogier LG Nijhuis Jeroen W op den Akker Andries Slootweg Department of Cardiology Hospital Group Twente Almelo-Hengelo Department of Cardiology St.LucasAndreas Hospital Department of Cardiology Gelre Hospital Zutphen Department of Cardiology Hospital De Sionsberg Department of Cardiology St.Anna Hospital Department of Radiodiagnostics Hospital Group Twente Almelo-Hengelo

AIM:To assess the current diagnostic and therapeutic management and the clinical implications of congenital single coronary artery(SCA) in ***:We identified 15 patients with a SCA detected from four Dutch angiography centers in the period between 2010 and *** patients who underwent routine diagnostic coronary angiography(CAG) for suspected coronary artery disease and who incidentally were found to have isolated SCA were ***:Fifteen(7 females) with a mean age of 58.5 ± 13.78 years(range 43-86) had a *** demonstrated congenital isolated SCA originating as a single ostium from the right sinus of Valsalva in 6 patients and originating from the left in 9 *** to moderate coronary atherosclerotic chan.es were found in 4,and severe stenotic lesions in another 4 *** patients were free of coronary *** of non-sustained ventricular tachycardia were documented in 2 patients,one of whom demonstrated transmural ischemic chan.es on *** perfusion scintigraphic evidence of transmural myocardial ischemia was found in 1 patient due to kinking and squeezing of the SCA with an interarterial course between the aorta and pulmonary ***-slice computed tomography(MSCT) was helpful to delineate the course of the anomalous artery relative to the aorta and pulmonary *** coronary intervention was successfully performed in 3 *** patients were managed *** bypass graft was performed in 4 patients with the squeezed ***:SCA may be associated with transient transmural myocardial ischemia and aborted sudden death in the absence of coronary *** availability and sophistication of MSCT facilitates the delineation of the course of a *** present a Dutch case series and review of the literature.

关键词： Congenital heart disease Coronary artery anomaly Coronary angiography Single coronary artery Coronary artery disease Multi-slice computed tomography

Pax7基因在C 2C12细胞内的表达及诱导失活(简报)

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实验生物学报 1996年第2期29卷 185-189页

作者：夏顺汉姚鑫 Ahmed MANSOURI peter GRUSS 中科院上海细胞生物学研究所 Max-Planck Institute of Biophysical Chemistry 37077 GottingenGermany

配对框(Paired box)首先是在果蝇的分节基因中发现的一段DNA保守序列,编码能与DNA特异结合的一个蛋白质结构域。这些序列在进化中有一定的保守性,在许多种生物基因组内存在,其中包括小鼠和人。至今为止,在小鼠中分离到九个含配对框的Pa... 详细信息

配对框(Paired box)首先是在果蝇的分节基因中发现的一段DNA保守序列,编码能与DNA特异结合的一个蛋白质结构域。这些序列在进化中有一定的保守性,在许多种生物基因组内存在,其中包括小鼠和人。至今为止,在小鼠中分离到九个含配对框的Pax基因,按基因发现时序,分别定名为Pax 1至Pax 9。Pax 7是其中的一个成员,它不但含有配对框,还含有八肽结构(Octapeptide)

关键词：基因细胞配对框 Pax7基因表达失活

Revisiting ovarian cancer microenvironment： a friend or a foe？

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Protein & Cell 2018年第8期9卷 674-692页

作者： Boyi Zhan. Fei Chen Qixia Xu Liu han.Jiaqian Xu Libin Gao Xiaochen Sun Yiwen Li Yan Li Min Qian Yu Sun Key Laboratory of Stem Cell Biology Institute of Health Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine University of Chinese Academy of Sciences Shanghai 200031 China Institute of Health Sciences Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Department of Medicine and VAPSHCS Univers"ity of Washington Seattle WA 98195 USA

Development of ovarian cancer involves the co-evolu- tion of neoplastic cells together with the adjacent microenvironment. Steps of malignant progression including primary tumor outgrowth, therapeutic resis- tance, and distant metastasis are not determined solely by genetic alterations in ovarian cancer cells, but con- siderably shaped by the fitness advantage conferred by benign components in the ovarian stroma. As the dynamic cancer topography varies drastically during disease progression, heterologous cell types within the tumor microenvironment （TME） can actively determine the pathological track of ovarian cancer. Resembling many other solid tumor types, ovarian malignancy is nurtured by a TME whose dark side may have been overlooked, rather than.overestimated. Further, har- nessing breakthrough and targeting cures in human ovarian cancer requires insightful understanding of the merits and drawbacks of current treatment modalities, which mainly target transformed cells. Thus, designing novel and precise strategies that both eliminate cancer cells and manipulate the TME is increasingly recognized as a rational avenue to improve therapeutic outcome and prevent disease deterioration of ovarian cancer patients.

关键词： ovarian cancer stromal cells tumormicroenvironment therapeutic resistance ectopicmetastasis combinational treatment patient stratification

Development of a Consolidated Anaerobic Digester and Microbial Fuel Cell to Produce Biomethan. and Electricity from Cellulosic Biomass Using Bovine Rumen Microorganisms

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Journal of Sustainable Bioenergy Systems 2019年第2期9卷 17-28页

作者： Rebecca Chung Eunice Yujin Kang Yun Jae Shin Justin Jong Park peter Sang Park Chan. Hyun han.Byungjun Kim Seog In Moon Jooheon Park Paul Sung Chung Centreville High School Clifton VA USA West Springfield High School Springfield VA USA Department of Biological Science University of Southern California Los Angeles CA USA Biology College of Arts & Science Cornell University Ithaca NY USA Biological Science Mellon College of Science Carnegie Mellon University Pittsburgh PA USA Department of Biology Amherst College Amherst MA USA Biology Science Program University of Alberta Edmonton Canada Fuzbien Technology Institute (FTI) Rockville USA

Microbial fuel cells (MFCs) are bioelectrochemical systems that convert chemical energy contained in organic matter into electrical energy by using the catalytic (metabolic) activity of living microorganisms. Mediator-less two chamber H-type MFCs were constructed in the current study, using dairy digester microbial population as anode inocula to convert finely ground pine tree (Avicel) at 2% (w/v) to electricity. MFCs were placed at 37°C and after the circuit voltage was stabilized on d9, bovine rumen microorganisms cultured anaerobically for 48 hrs in cellulose broth media were added to treatment group of MFC at 1% v/v dosage. MFC power and current across an external resistor were measured daily for 10 d. At the end of incubation on d19 head space gas and anode chamber liquid solutions were collected and analyzed for total gas volume and composition, and volatile fatty acids, respectively. Addition of enriched rumen microorganisms to anaerobic anode chamber increased cellulose digestibility and increased both CO2 and methan. production;however, it decreased the methan. to CO2 ratio. Over the experimental period, electricity generation was increased with rumen microorganism addition, and power density normalized to anode surface area was 17.6 to 67.2 mW/m2 with average of 36.0 mW/m2 in treatment, while control group had 3.6 to 21.6 (AVE 12.0) mW/m2. These observations imply that biocatalysis in MFCs requires additional cellulolytic activities to utilize structural biomass in bioenergy production.

关键词： Microbial Fuel Cells (MFCs) Bovine Rumen Bacteria Bioenergy

Limited Knowledge of Acetaminophen in Patients with Liver Disease

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Journal of Clinical and Translational Hepatology 2016年第4期4卷 281-287页

作者： Sarnrny Saab peter G.Konyn Matthew R.Viramontes Melissa A.Jimenez Jonathan.F.Grotts Wally Hamidzadah Veronica P.Dang Negin L.Esmailzadeh Gina Choi Francisco A.Durazo Mohamed M.El-Kabany Steven-Huy B.han.Myron J.Tong Department of Medicine the University of California at Los Angeles Los Angeles CA USA Department of Surgery the University of California at Los Angeles Los Angeles CA USA Department of Surgery the University of California at Los Angeles Los Angeles CA USA Department of Biostatistics the University of California at Los Angeles Los Angeles CA USA Department of Surgery the University of California at Los Angeles Los Angeles CA USA California and Huntington Medical Research Institutes Pasadena CA USA

Background andAims:Unintentional acetaminophen overdose remains the leading cause of acute liver failure in the United *** with underlying liver disease are at higher risk of poor outcomes from acetaminophen *** knowledge of acetaminophen may be a preventable contributor to elevated rates of overdose and thus acute liver *** purpose of this study is to assess knowledge of acetaminophen dosing and presence of acetaminophen in common combination products in patients with liver ***:We performed a cross-sectional study of patients with liver disease at the Pfleger Liver Institute at the University of California,Los Angeles between June 2015 and August *** completed a demographic questionnaire and an acetaminophen knowledge *** information was obtained from the medical ***:Of 401 patients with liver disease,30 (15.7%) were able to correctly identify that people without liver disease can safely take up to 4 g/day of *** majority of patients (79.9%-86.8%) did not know that Norco(R) (hydrocone/acetaminophen),Vicodin(R) (hydrocone/acetaminophen) and Percocet(R) (oxycodone/acetaminophen) contained *** 45.3% of the patients knew that Tylenol(R) #3 contained ***:We conclude that patients with liver disease have critically low levels of knowledge of acetaminophen,putting them at risk both of acetaminophen overdose,as well as undermedication,and inadequate management of chronic *** recommend an increase in education efforts regarding acetaminophen dosage and its safety in the setting of liver *** education for those at risk of low acetaminophen knowledge is essential to minimizing acetaminophen overdose rates and optimizing pain management.

关键词： Acetaminophen Pain management Cirrhosis

《弹性城市——应对石油紧缺与气候变化》与我国城市发展模式选择

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国际城市规划 2013年第6期28卷 110-114页

作者：王量量韩洁彼得.纽曼厦门大学建筑与土木工程学院城市规划系新加坡国立大学设计与环境学院厦门大学建筑与土木工程学院建筑系澳大利亚科廷大学

本文介绍了《弹性城市——应对石油紧缺与气候变化》一书中所提出的四种城市模型,并针对城市如何应对能源短缺和全球变暖等危机和问题讨论了弹性城市的要素。与此同时根据本文作者的译后感,对"弹性城市"这一概念作了新的诠释。最后,结... 详细信息

本文介绍了《弹性城市——应对石油紧缺与气候变化》一书中所提出的四种城市模型,并针对城市如何应对能源短缺和全球变暖等危机和问题讨论了弹性城市的要素。与此同时根据本文作者的译后感,对"弹性城市"这一概念作了新的诠释。最后,结合我国国情和中国的城市发展现状与特点,论述了《弹性城市——应对石油紧缺与气候变化》一书对我国城市发展的借鉴意义,并阐述了弹性城市发展战略的必要性和重要性。

关键词：弹性城市气候变化石油峰值城市发展