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The pathogenic mechanism of syndactyly type V identified in aHoxd13Q50R knock-in mice

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Bone Research 2024年第2期12卷 349-360页

作者： han Wang Xiumin Chen Xiaolu Meng Yixuan Cao Shirui han Keqiang Liu Ximeng zhao Xiuli zhao Xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Complex Severe and Rare DiseasesDepartment of Medical GeneticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Orthopedics State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifthmetacarpals. In the previous publication, we first identified a heterozygous missense mutation Q50R in homeobox domain (HD) ofHOXD13 in a large Chinese family with SDTY5. In order to substantiate the pathogenicity of the variant and elucidate the underlyingpathogenic mechanism causing limb malformation, transcription-activator-like effector nucleases (TALEN) was employed togenerate a Hoxd13Q50R mutant mouse. The mutant mice exhibited obvious limb malformations including slight brachydactyly andpartial syndactyly between digits 2-4 in the heterozygotes, and severe syndactyly, brachydactyly and polydactyly in *** on BMP2 and SHH/GREM1/AER-FGF epithelial mesenchymal (e-m) feedback, a crucial signal pathway for limbdevelopment, we found the ectopically expressed Shh, Grem1 and Fgf8 and down-regulated Bmp2 in the embryonic limb bud atE10.5 to E12.5. A transcriptome sequencing analysis was conducted on limb buds (LBs) at E11.5, revealing 31 genes that exhibitednotable disparities in mRNA level between the Hoxd13Q50R homozygotes and the wild-type. These genes are known to be involvedin various processes such as limb development, cell proliferation, migration, and apoptosis. Our findings indicate that the ectopicexpression of Shh and Fgf8, in conjunction with the down-regulation of Bmp2, results in a failure of patterning along both theanterior-posterior and proximal-distal axes, as well as a decrease in interdigital programmed cell death (PCD). This cascadeultimately leads to the development of syndactyly and brachydactyly in heterozygous mice, and severe limb malformations inhomozygous mice. These findings suggest that abnormal expression of SHH, FGF8, and BMP2 induced by HOXD13Q50R may beresponsible for the manifestation of human SDTY5.

关键词： BMP2 mechanism finding

Reinforcement of High Impact Polystyrene by Aramid Nanoparticle Fillers Prepared via an In situ Bottom-up Approach

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Chinese Journal of Polymer Science 2024年第8期42卷 1167-1176页

作者： Xiang-Jun Gong Zhi-Ping zhao Chang-Mei Sun ying Zhang Rong-Jun Qu ying Wang School of Chemistry and Materials Science Ludong UniversityYantai 264025China

In this work,aramid nanoparticles(ANPs)were prepared in dimethyl formamide(DMF)solution containing high impact polystyrene(HIPS)via a bottom-up *** electron microscopy(TEM)images showed that the obtained ANPs were evenly distributed in the HIPS matrix without any *** composition of the ANPs,i.e.,poly(p-phenyl-p-phenylenediamine)(PPTA),was confirmed by Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and X-ray diffractometer(XRD).The ANP/HIPS composites,obtained after ethanol precipitation,were added to neat HIPS as fillers to fabricate ANP/HIPS composite *** surface roughness and the glass transition temperature(T_g)of the sheets were characterized by atomic force microscope(AFM)and differential scanning calorimetry(DSC),*** with neat HIPS,the mechanical properties of the composite sheet were significantly improved,and the Young's modulus increased from 246.55 MPa to 2025.12 MPa,the tensile strength increased from 3.07 MPa to 29.76 MPa,and the toughness increased from 0.32 N/mm^2 to 3.92 N/mm^2,with an increase rate of 721%,869%and 1125%,***,the thermal stability of the composites improved with the increase in ANP content.

关键词： High impact polystyrene PPTA nanoparticle Reinforce Mechanical property

Copper-Free Click Chemistry-Mediated Assembly of Single Quantum Dot Nanosensor for Accurately Monitoring Locus-Specific m^(6)A in Cancer Cells

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Chinese Journal of Chemistry 2024年第5期42卷 499-504页

作者： Yue-ying Li Ning-Ning zhao Yi-Xuan Geng Qian han Jian-Ge Qiu Bing-Hua Jiang Zi-Yue Wang Chun-Yang Zhang Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityThe Academy of Medical SciencesHenan Institute of Medical and Pharmaceutical Sciences BGI CollegeZhengzhou UniversityZhengzhouHenan450052 China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandong250014 China School of Chemistry and Chemical Engineering Southeast UniversityNanjingJiangsu211189 China

N6-methyladenosine(m^(6)A)plays an important role in embryogenesis,nuclear export,transcription splicing,and protein translation ***,we demonstrate a copper-free click chemistry-mediated assembly of single quantum dot(QD)nanosensor for accurately monitoring locus-specific m^(6)A in cancer *** m^(6)A-sensitive endoribonuclease MazF can digest the unmethylated A-RNA,and the intact m^(6)A-RNA then hybridizes with DNA probes a and b to produce a sandwich hybrid,initiating the click chemistry to generate probe a–b ligation product via first tandem ligation detection reaction(LDR)***,DNA probes c and d can hybridize with the probe a–b ligation product to generate the probe c–d ligation product via second LDR *** LDR cycles can be repeated through denaturation and annealing reaction to generate abundant biotin-/fluorophore-modified probe c–d ligation products that can easily assemble on the QD surface to induce distinct fluorescence resonance energy transfer(FRET)between QD and *** assay can be homogenously performed without the involvement of copper catalyst,m^(6)A-specific antibody,radioactive labeling,ligase enzyme,enzymatic reverse transcription,and next-generation ***,it can discriminate even 0.01% m^(6)A level in complex samples and accurately measure cellular m^(6)A-RNA expression,providing a promising avenue for clinical diagnostics and biomedical research.

关键词： RNA methylation Click chemistry Förster resonance energy transfer Biosensor Cancer

Human-Machine Shared Lateral Control Strategy for Intelligent Vehicles Based on Human Driver Risk Perception Reliability

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Automotive Innovation 2024年第1期7卷 102-120页

作者： Dongjian Song Bing Zhu Jian zhao Jiayi han State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130022China

Intelligent vehicle(Ⅳ)technology has developed rapidly in recent ***,achieving fully unmanned driving still presents numerous challenges,which means that human drivers will continue to play a vital role in vehicle operation for the foreseeable ***-machine shared driving,involving cooperation between a human driver and an automated driving system(AVS),has been widely regarded as a necessary stage for the development of *** onⅣdriving safety,this study proposed a human-machine shared lateral control strategy(HSLCS)based on the reliability of driver risk *** HSLCS starts by identifying the effective areas of driver risk perception based on eye *** establishes an anisotropic driving risk field,which serves as the foundation for the AVS to assess risk *** upon the cumulative and diminishing effects of risk perception,the proposed approach leverages the driver's risk perception effective area and converts the risk field into a representation aligned with the driver's ***,it quantifies the reliability of the driver's risk perception by using area-matching ***,based on the driver’s risk perception reliability and dif-ferences in lateral driving operation between the human driver and the AVS,the dynamic distribution of driving authority is achieved through a fuzzy rule-based system,and the human-machine shared lateral control is completed by using model predictive *** HSLCS was tested across various scenarios on a driver-in-the-loop test *** results show that the HSLCS can realize the synergy and complementarity of human and machine intelligence,effectively ensuring the safety ofⅣoperation.

关键词： Intelligent vehicle Human-machine shared driving Risk perception Driving authority distribution

Understanding Discrepancy of Power System Dynamic Security Assessment with Unknown Faults: A Reliable Transfer Learning-based Method

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 427-431页

作者： Chao Ren han Yu Yan Xu zhao Yang Dong School of Computer Science and Engineering Nanyang Technological UniversitySingapore School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore

This letter proposes a reliable transfer learning(RTL)method for pre-fault dynamic security assessment(DSA)in power systems to improve DSA performance in the presence of potentially related unknown *** takes individual discrepancies into consideration and can handle unknown faults with incomplete *** experiment results demonstrate high DSA accuracy and computational efficiency of the proposed RTL *** analysis shows RTL can guarantee system performance.

关键词： Adversarial training dynamic security assessment maximum classifier discrepancy missing data transfer learning

Multilevel carbon architecture of subnanoscopic silicon for fast‐charging high‐energy‐density lithium‐ion batteries

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Carbon Energy 2024年第4期6卷 256-268页

作者： Meisheng han Yongbiao Mu Lei Wei Lin Zeng Tianshou zhao Shenzhen Key Laboratory of Advanced Energy Storage Southern University of Science and TechnologyShenzhenChina SUSTech Energy Institute for Carbon Neutrality Southern University of Science and TechnologyShenzhenChina Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhenChina

Silicon(Si)is widely used as a lithium‐ion‐battery anode owing to its high capacity and abundant crustal ***,large volume change upon cycling and poor conductivity of Si cause rapid capacity decay and poor fast‐charging capability limiting its commercial ***,we propose a multilevel carbon architecture with vertical graphene sheets(VGSs)grown on surfaces of subnanoscopically and homogeneously dispersed Si–C composite nanospheres,which are subsequently embedded into a carbon matrix(C/VGSs@Si–C).Subnanoscopic C in the Si–C nanospheres,VGSs,and carbon matrix form a three‐dimensional conductive and robust network,which significantly improves the conductivity and suppresses the volume expansion of Si,thereby boosting charge transport and improving electrode *** VGSs with vast exposed edges considerably increase the contact area with the carbon matrix and supply directional transport channels through the entire material,which boosts charge *** carbon matrix encapsulates VGSs@Si–C to decrease the specific surface area and increase tap density,thus yielding high first Coulombic efficiency and electrode compaction ***,C/VGSs@Si–C delivers excellent Li‐ion storage performances under industrial electrode *** particular,the full cells show high energy densities of 603.5 Wh kg^(−1)and 1685.5 Wh L^(−1)at 0.1 C and maintain 80.7%of the energy density at 3 C.

关键词： fast charging high energy densities lithium‐ion batteries multilevel carbon architecture subnanoscopic silicon anode

Tuning interface mechanism of FeCo alloy embedded N,S-codoped carbon substrate for rechargeable Zn-air battery

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Journal of Energy Chemistry 2024年第6期93卷 400-410,I0010页

作者： Hui Chang Lulu zhao Shan zhao Zong-Lin Liu Peng-Fei Wang ying Xie Ting-Feng Yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080HeilongjiangChina Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004HebeiChina

The interface mechanism between catalyst and carbon substrate has been the focus of *** this paper,the FeCo alloy embedded N,S co-doped carbon substrate bifunctional catalyst(FeCo/S-NC)is obtained by a simple one-step pyrolysis *** experimental results and density functional theory(DFT)calculation show that the formation of FeCo alloy is conducive to promoting electron transfer,and the introduction of S atom can enhance the interaction between FeCo alloy and carbon substrate,thus inhibiting the migration and agglomeration of particles on the surface of carbon *** FeCo/SNC catalysts show outstanding performance for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).FeCo/S-NC shows a high half-wave potential(E_(1/2)=0.8823 V)for ORR and a low overpotential at 10 mA cm^(-2)(E_(j=10)=299 mV)for *** addition,compared with Pt/C+RuO_(2) assembled Zn-air battery(ZAB),the FeCo/S-NC assembled ZAB exhibits a larger power density(198.8 mW cm^(-2)),a higher specific capacity(786.1 mA h g_(zn)~(-1)),and ultra-stable cycle *** results confirm that the optimized composition and the interfacial interaction between catalyst and carbon substrate synergistically enhance the electrochemical performance.

关键词： FeCo alloy N S co-doped carbon DFT calculation Zn-air batteries Interfacial interaction

Differential Operator Approach to■quantum Groups and Their Oscillator Representations

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1360-1374页

作者： zhao Bing FAN Ji Cheng GENG Shao Long han College of Mathematical Science Harbin Engineering UniversityHarbin 150001P.R.China

For a quasi-split Satake diagram,we define a modified q-Weyl algebra,and show that there is an algebra homomorphism between it and the corresponding■quantum *** other words,we provide a differential operator approach to■quantum ***,the oscillator representations of■quantum groups are *** crystal basis of the irreducible subrepresentations of these oscillator representations are constructed.

关键词： ■quantum group differential operator oscillator representation crystal basis

Promoted monolithic perovskite/organic tandem solar cells through elaborate manipulation of light transmission and carrier tunneling in interconnect junction

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Science China Chemistry 2024年第9期67卷 3131-3139页

作者： Rongbo Wang Jiawei Zhang Juntao zhao Ya Wang Yi Ding ying zhao Xiaodan Zhang Guofu Hou Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage CenterSolar Energy Conversion CenterNankai UniversityTianjin 300350China Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Tianjin 300350China Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Tianjin 300350China State Key Laboratory of Photovoltaic Materials and Solar Cells Tianjin 300350China

Monolithic perovskite/organic tandem solar cells(TSCs)have emerged as promising thin film solar *** is recognized that interconnect junction plays a pivotal role in tandem ***,wide bandgap Cs_(0.25)FA_(0.75)Pb(I_(0.6)Br_(0.4))_(3)perovskite top-cell and narrow bandgap PM6:Y6:PC_(61)BM ternary organic bottom-cell were integrated in this study with several kinds of thin metal interconnect layers,which provides feasibility to elaborately manipulate light transmission and carrier tunneling process in interconnect *** is confirmed that,in comparison with Au,employing an Ag interconnect layer elevates integrated transmittance of light in longer wavelength regions,mainly because of the alleviated screening effect with a lower free electron concentration,which offers sufficient light harvest for the ***,established energy barriers with moderate height afford convenient extraction and recombination for both holes and ***,the performance of TSCs is promoted ***,an innovative Ag/Au double interconnect layer is proposed accordingly,which can preserve exceptional conductivity and light transmission and further reduce barrier height,especially for hole tunneling,by optimizing the band alignment between the interconnect layer and ***,the monolithic perovskite/organic TSC with a striking efficiency of 23.26% is *** a word,this study can pave a general approach toward high-performance TSCs integration.

关键词： tandem solar cells band alignment perovskite organic solar cells interconnect junction

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