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Targeting long non-coding RNA MALAT1 alleviates retinal neurodegeneration in diabetic mice

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 213-219页

作者： Yu-Lan Zhang han-ying hu Zhi-Peng You Bing-Yang Li Ke Shi Department of Ophthalmology the Second Affiliated HospitalNanchang UniversityNanchang 330006Jiangxi ProvinceChina

●AIM:To observe the effect of inhibiting long non-coding RNA(lncRNA)metastasis-associated lung adenocarcinoma transcript 1(MALAT1)on diabetic neurodegeneration.●METHODS:Thirty-six 8-week-old C57 BL/6 mice were randomly divided into normal control,diabetic control,diabetic scrambled small interfering RNAs(siRNAs)and diabetic MALAT1-siRNA *** diabetic induction with streptozocin intraperitoneally-injection,the diabetic M A L AT 1-s i R N A g ro u p w a s i n t r av i t r e a l l y i n j e c te d with 1μL 20μmol/L MALAT1 siRNA,and the diabetic scrambled siRNA group was injected with the same amount of scrambled *** was performed to examine photoreceptor functions 16 wk after diabetes ***1 expression was detected via real time polymerase chain *** morphological changes were examined using *** morphological changes were examined by determining outer nuclear layer(ONL)thickness.●RESULTS:The upregulation of retinal MALAT1 expression was detected in the diabetic control mice,while MALAT1 expression in the diabetic MALAT1-siRNA mice was decreased by 91.48%compared to diabetic control *** diabetic MALAT1-siRNA and diabetic control mice showed lower a-wave and b-wave amplitudes than did the normal control mice in scotopic and photopic electroretinogram,while the diabetic MALAT1-siRNA mice showed higher amplitudes than diabetic control *** examination revealed that ONL thickness in the diabetic MALAT1-siRNA and diabetic control mice was lower than normal control ***,ONL thickness was greater in the diabetic MALAT1-siRNA mice than diabetic control ***,the diabetic control mice performed a sparser cone cell arrangement and shorter outer segment morphology than diabetic MALAT1-siRNA mice.●CONCLUSION:Inhibiting retinal MALAT1 results in mitigative effects on the retinal photoreceptors,thus alleviating diabetic neurodegeneration.

关键词： long non-coding RNA MALAT1 small interfering RNA diabetic retinopathy neurodegeneration

C-Alkylation of α-acylamino ketones.A versatile synthesis of α-alkyl α-amino ketones

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Chinese Journal of Chemistry 1991年第3期9卷 251-257页

作者： han,ying-Lin hu,Hong-Wen Department of Chemistry,Nanjing University,Nanjing 210008 Department of Chemistry Nanjing University Nanjing 210008

C-Alkylation of some α-acylamino ketones were achieved with alkyl halides by means of sodium ethoxide in *** present paper deals with the C-alkylation of N,N-diformylamino ketones and the difference in stability of t... 详细信息

关键词： acylamino ketones.A versatile synthesis of amino ketones alkyl

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han Tang Jianian hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo Chen Shengpeng Su Yanfang huang Bingbing Liu hu Sun Shuzhen Yang Guihong han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy

保留中央凹或标准内界膜剥除联合玻璃体切割术治疗近视牵引性黄斑病变的Meta分析

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国际眼科杂志 2023年第3期23卷 443-448页

作者：柴宛璇游志鹏胡寒英赵永吉苏晓涵南昌大学附属眼科医院眼底病科江西省南昌市330000

目的:评估玻璃体切割术中保留中央凹(FSIP)或标准内界膜剥除(CMIP)治疗近视牵引性黄斑病变(MTM)的疗效及安全性。方法:计算机检索中国知网、万方、维普、PubMed、Embase、Cochrane Library、Web of Science数据库,搜集2000-01-01/2022-0... 详细信息

目的:评估玻璃体切割术中保留中央凹(FSIP)或标准内界膜剥除(CMIP)治疗近视牵引性黄斑病变(MTM)的疗效及安全性。方法:计算机检索中国知网、万方、维普、PubMed、Embase、Cochrane Library、Web of Science数据库,搜集2000-01-01/2022-07-01玻璃体切割术中FSIP或CMIP治疗MTM的对比研究。比较两组患者术后最佳矫正视力(BCVA)的变化值和改善率、术后全层黄斑裂孔(FTMH)发生率、视网膜中央凹厚度(CFT)变化值、术后中心凹完全解剖复位率。结果:共12篇文献484眼纳入研究,其中FSIP组203眼,CMIP组281眼。Meta分析结果显示:FSIP组患者术后BCVA的变化值(SMD=0.52,95%CI:0.20~0.85,P=0.002)、BCVA改善率(RR=1.50,95%CI:1.22~1.85,P=0.0002)及术后FTMH发生率(RR=0.23,95%CI:0.10~0.54,P=0.0008)优于CMIP组,两组患者CFT变化值(SMD=0.04,95%CI:-0.19~0.26,P=0.75)及术后中心凹完全解剖复位率(RR=1.12,95%CI:0.94~1.32,P=0.20)比较均无差异。结论:现有证据表明,两种术式解剖改善结果相似,但在改善视觉效果及降低术后全层黄斑裂孔发生率方面,FSIP明显优于CMIP。

关键词：内界膜保留中央凹玻璃体切割术近视牵引性黄斑病变 Meta分析

建设项目管理全目标下代建合同的激励机制研究

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施工技术 2011年第4期40卷 57-59页

作者：韩英爱胡金红长春工程学院管理学院

首先分析了我国当前采用的代建合同机制的3种形式:总价合同、单价合同和代建成本+固定酬金±工程成本偏差相关奖罚金类型各自存在的局限性,在此基础上构建了更加全面、有效的建设项目全目标下的代建合同激励机制。指出建设项目管理全目... 详细信息

首先分析了我国当前采用的代建合同机制的3种形式:总价合同、单价合同和代建成本+固定酬金±工程成本偏差相关奖罚金类型各自存在的局限性,在此基础上构建了更加全面、有效的建设项目全目标下的代建合同激励机制。指出建设项目管理全目标下代建合同激励机制的具体设计步骤,并结合实例进行设计计算,有效促进了代建市场的良性发展。

关键词：代建工程项目管理全目标激励机制

Synthesis of a New Isoflavone: 7,8,4′-Trihydroxyisoflavone

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Synthesis of a New Isoflavone: 7,8,4′-Trihydroxyisoflavone

Femtosecond laser in refractive and cataract surgeries

第三届全国有机化学学术会议

作者： WU, Fu-Li WANG, han-ying YAN, Xi hu, Wen Xiang Xu, Ming ( Institute of Military Medicine , Headquarter of General Equipment, Beijing 100101) ( Department of Chemistry , Beijing Normal University , Beijing 100875 )

＜正＞ Isoflavones have been found a wide range of applications as natural antioxidants being suggested in diet as a-gents responsible for the prevention of coronary diseases, breast and prostate cancer. Most of the isoflavones have been isolated from natural sources and their simple structural features lead to the development of many synthetic methods. Here we synthesized a new trihydroxyisoflavone.

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 419-426页

作者： han-han Liu ying hu Hong-Ping Cui Department of Ophthalmology Shanghai East Hospital Affiliated to Tongji University

In the past few years, 9 unique laser platforms have been brought to the market. As femtosecond(FS) laserassisted ophthalmic surgery potentially improves patient safety and visual outcomes, this new technology indeed provides ophthalmologists a reliable new option. But this new technology also poses a range of new clinical and financial challenges for surgeons. We provide an overview of the evolution of FS laser technology for use in refractive and cataract surgeries. This review describes the available laser platforms and mainly focuses on discussing the development of ophthalmic surgery technologies.

关键词： femtosecond refractive surgery cataract surgery

Advances in longitudinal studies of amnestic mild cognitive impairment and Alzheimer's disease based on multi-modal MRI techniques

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Neuroscience Bulletin 2014年第2期30卷 198-206页

作者： Zhongjie hu Liyong Wu Jianping Jia ying han Department of Neurology Xuan Wu Hospital Capital Medical University Postgraduates Institute Capital Medical University Alzheimer's Disease Center Beijing Institute for Brain Disorders

Amnestic mild cognitive impairment （aMCI） is a prodromal stage of Alzheimer＇s disease （AD）, and 75%-80% of aMCI patients finally develop AD. So, early identification of patients with aMCI or AD is of great significance for prevention and intervention. According to cross-sectional studies, it is known that the hippocampus, posterior cingulate cortex, and corpus callosum are key areas in studies based on structural MRI （sMRI）, functional MRI （fMRI）, and diffusion tensor imaging （DTI） respectively. Recently, longitudinal studies using each MRI modality have demonstrated that the neuroimaging abnormalities generally involve the posterior brain regions at the very beginning and then gradually affect the anterior areas during the progression of aMCI to AD. However, it is not known whether follow-up studies based on multi-modal neuroimaging techniques （e.g., sMRI, fMRI, and DTI） can help build effective MRI models that can be directly applied to the screening and diagnosis of aMCI and AD. Thus, in the future, large-scale multi-center follow-up studies are urgently needed, not only to build an MRI diagnostic model that can be used on a single person, but also to evaluate the variability and stability of the model in the general population. In this review, we present longitudinal studies using each MRI modality separately, and then discuss the future directions in this field.

关键词： magnetic resonance imaging amnestic mild cognitive impairment Alzheimer's disease multi-modality longitudinal studies