检索结果-南通市图书馆

Targeting long non-coding RNA MALAT1 alleviates retinal neurodegeneration in diabetic mice

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2020年第2期13卷 213-219页

作者： Yu-Lan Zhang han-ying hu Zhi-Peng You Bing-Yang Li Ke Shi Department of Ophthalmology the Second Affiliated HospitalNanchang UniversityNanchang 330006Jiangxi ProvinceChina

●AIM:To observe the effect of inhibiting long non-coding RNA(lncRNA)metastasis-associated lung adenocarcinoma transcript 1(MALAT1)on diabetic neurodegeneration.●METHODS:Thirty-six 8-week-old C57 BL/6 mice were randomly divided into normal control,diabetic control,diabetic scrambled small interfering RNAs(siRNAs)and diabetic MALAT1-siRNA *** diabetic induction with streptozocin intraperitoneally-injection,the diabetic M A L AT 1-s i R N A g ro u p w a s i n t r av i t r e a l l y i n j e c te d with 1μL 20μmol/L MALAT1 siRNA,and the diabetic scrambled siRNA group was injected with the same amount of scrambled *** was performed to examine photoreceptor functions 16 wk after diabetes ***1 expression was detected via real time polymerase chain *** morphological changes were examined using *** morphological changes were examined by determining outer nuclear layer(ONL)thickness.●RESULTS:The upregulation of retinal MALAT1 expression was detected in the diabetic control mice,while MALAT1 expression in the diabetic MALAT1-siRNA mice was decreased by 91.48%compared to diabetic control *** diabetic MALAT1-siRNA and diabetic control mice showed lower a-wave and b-wave amplitudes than did the normal control mice in scotopic and photopic electroretinogram,while the diabetic MALAT1-siRNA mice showed higher amplitudes than diabetic control *** examination revealed that ONL thickness in the diabetic MALAT1-siRNA and diabetic control mice was lower than normal control ***,ONL thickness was greater in the diabetic MALAT1-siRNA mice than diabetic control ***,the diabetic control mice performed a sparser cone cell arrangement and shorter outer segment morphology than diabetic MALAT1-siRNA mice.●CONCLUSION:Inhibiting retinal MALAT1 results in mitigative effects on the retinal photoreceptors,thus alleviating diabetic neurodegeneration.

关键词： long non-coding RNA MALAT1 small interfering RNA diabetic retinopathy neurodegeneration

C-Alkylation of α-acylamino ketones.A versatile synthesis of α-alkyl α-amino ketones

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1991年第3期9卷 251-257页

作者： han,ying-Lin hu,Hong-Wen Department of Chemistry,Nanjing University,Nanjing 210008 Department of Chemistry Nanjing University Nanjing 210008

C-Alkylation of some α-acylamino ketones were achieved with alkyl halides by means of sodium ethoxide in *** present paper deals with the C-alkylation of N,N-diformylamino ketones and the difference in stability of t... 详细信息

关键词： acylamino ketones.A versatile synthesis of amino ketones alkyl

Transfer force perception skills to robot‐assisted laminectomy via imitation learning from human demonstrations

在线全文

学校读者我要写书评

暂无评论

CAAI Transactions on Intelligence Technology 2024年第4期9卷 903-916页

作者： Meng Li Xiaozhi Qi Xiaoguang han ying hu Bing Li Yu Zhao Jianwei Zhang Harbin Institute of Technology ShenzhenChina Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhenChina Shenzhen Key Laboratory of Minimally Invasive Surgical Robotics and System Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina Beijing Jishuitan Hospital Capital Medical UniversityBeijingChina Department of Orthopedics Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina University of Hamburg Hamburg22527Germany

A comparative study of two force perception skill learning approaches for robot‐assisted spinal surgery,the impedance model method and the imitation learning(IL)method,is *** impedance model method develops separate models for the surgeon and patient,incorporating spring‐damper and bone‐grinding *** surgeons'feature parameters are collected and mapped using support vector regression and image navi-gation *** imitation learning approach utilises long short‐term memory networks(LSTM)and addresses accurate data labelling challenges with custom *** results demonstrate skill recognition rates of 63.61%-74.62%for the impedance model approach,relying on manual feature ***,the imitation learning approach achieves a force perception recognition rate of 91.06%,outperforming the impedance model on curved bone *** findings demonstrate the potential of imitation learning to enhance skill acquisition in robot‐assisted spinal surgery by eliminating the laborious process of manual feature extraction.

关键词： learning(artificial intelligence) medical applications medical signal processing robotics

The regulation of ferrocene-based catalysts on heat transfer in highpressure combustion of ammonium perchlorate/hydroxyl-terminated polybutadiene/aluminum composite propellants

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第5期35卷 174-186页

作者： Jinchao han Songqi hu Linlin Liu Science and Technology on Combustion Internal Flow and Thermo-Structure LaboratoryNorthwestern Polytechnical UniversityXi'an 710072ShaanxiChina

The regulation of the burning rate pressure exponent for the ammonium perchlorate/hydroxylterminated polybutadiene/aluminum(AP/HTPB/Al)composite propellants under high pressures is a crucial step for its application in high-pressure solid rocket *** this work,the combustion characteristics of AP/HTPB/Al composite propellants containing ferrocene-based catalysts were investigated,including the burning rate,thermal behavior,the local heat transfer,and temperature profile in the range of 7-28 *** results showed that the exponent breaks were still observed in the propellants after the addition of positive catalysts(Ce-Fc-MOF),the burning rate inhibitor((Ferrocenylmethyl)trimethylammonium bromide,Fc Br)and the mixture of Fc Br/catocene(GFP).However,the characteristic pressure has increased,and the exponent decreased from 1.14 to 0.66,0.55,and 0.48 when the addition of Ce-FcMOF,Fc Br and Fc Br/GFP in the *** addition,the temperature in the first decomposition stage was increased by 7.50℃ and 11.40℃ for the AP/Fc Br mixture and the AP/Fc Br/GFP mixture,respectively,compared to the pure *** the other hand,the temperature in the second decomposition stage decreased by 48.30℃ and 81.70℃ for AP/Fc Br and AP/Fc Br/GFP mixtures,*** was also found that Fc Br might generate ammonia to cover the AP *** this case,a reaction between the methyl in Fc Br and perchloric acid caused more ammonia to appear at the AP surface,resulting in the suppression of ammonia *** addition,the coarse AP particles on the quenched surface were of a concave shape relative to the binder matrix under low and high pressures when the catalysts were *** the process,the decline at the AP/HTPB interface was only exhibited in the propellant with the addition of *** ratio of the gas-phase temperature gradient of the propellants containing catalysts was reduced significantly below and above the characteristic pressure,rather than 3.6 times of the di

关键词： AP/HTPB/Al propellants Heat transfer High-pressure combustion Ferrocene-based catalysts Pressure exponent

Advanced Sensors Towards Ubiquitous Power Internet of Things

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第3期10卷 871-890页

作者： Jinliang He Zhifei han Jun hu Department of Electrical Engineering Tsinghua UniversityBeijing 100084China IEEE CSEE

The ubiquitous power Internet of Things(UPIoT)uses modern information technology and advanced communication technologies to realize interconnection and human-computer interaction in all aspects of the power *** has the characteristics of comprehensive state perception and efficient information processing,and has broad application prospects for transformation of the energy *** fundamental facility of the UPIoT is the sensor-based information *** using advanced sensors,Wireless Sensor Networks(WSNs),and advanced data processing technologies,Internet of Things can be realized in the power *** this paper,a framework of WSNs based on advanced sensors towards UPIoT is *** addition,the most advanced sensors for UPIoT purposes are reviewed,along with an explanation of how the sensor data obtained in UPIoT is utilized in various scenarios.

关键词： Advanced sensors ubiquitous power Internet of Things wireless sensor networks

Cloud-Type-Dependent 1DVAR Algorithm for Retrieving Hydrometeors and Precipitation in Tropical Cyclone Nanmadol from GMI Data

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第3期41卷 407-419页

作者： Linjun han Fuzhong WENG Hao hu Xiuqing hu School of the Environment China University of Geosciences(Wuhan)Wuhan 430074China Chinese Academy of Meteorological Sciences Beijing 100081China CMA Earth System Modeling and Prediction Centre Beijing 100081China Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites National Satellite Meteorological Center(National Center for Space Weather)of CMABeijing 100081China

Understanding the structure of tropical cyclone(TC)hydrometeors is crucial for detecting the changes in the distribution and intensity of *** this study,the GMI brightness temperature and cloud-dependent 1DVAR algorithm were used to retrieve the hydrometeor profiles and surface rain rate of TC Nanmadol(2022).The Advanced Radiative Transfer Modeling System(ARMS)was used to calculate the Jacobian and degrees of freedom(△DOF)of cloud water,rainwater,and graupel for different channels of GMI in convective *** retrieval results were compared with the Dual-frequency Precipitation Radar(DPR),GMI 2A,and IMERG *** is shown that from all channels of GMI,rain water has the highest△DOF,at *** to the radiance Jacobian to atmospheric state variables,cloud water emission dominates its *** rain water,the emission of channels 1–4 dominates *** with the GMI 2A precipitation product,the 1DVAR precipitation rate has a higher correlation coefficient(0.713)with the IMERG product and can better reflect the location of TC *** the TC eyewall,the highest radar echo top indicates strong *** the melting layer where Ka-band attenuation is strong,the double frequency difference of DPR data reflects the location of the *** DPR drop size distribution(DSD)product shows that there is a significant increase in particle size below the melting layer in the spiral rain ***,the particle size may be one of the main reasons for the smaller rain water below the melting layer retrieved from 1DVAR.

关键词： cloud-dependent 1DVAR hydrometeor precipitation GMI DPR

SAT-Based Automatic Searching for Differential and Linear Trails: Applying to CRAX

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第1期33卷 72-79页

作者： Yiyi han Caibing WANG Zhongfeng NIU Lei hu State Key Laboratory of Information Security Institute of Information Engineering Chinese Academy of Sciences School of Cyber Security University of Chinese Academy of Sciences

Boolean satisfiability problem(SAT) is now widely applied in differential cryptanalysis and linear cryptanalysis for various cipher *** generated many excellent results for some ciphers,for example,*** this research,we study the differential and linear propagations through the operations of addition,rotation and XOR(ARX),and construct the SAT *** apply the models to CRAX to search differential trails and linear trails *** this sense,our contnbution can be broadly divided into two *** give the bounds for differential and linear cryptanalysis of Alzette both up to 12 steps,by which we present a 3-round differential attack and a 3-round linear attack for *** construct a 4-round key-recovery attack for CRAX with time complexity289times of 4-round encryption and data complexity 225.

关键词： Ciphers Encryption Complexity theory Time complexity

Identifying and localizing of seismogenic electromagnetic anomalies from data observed by permanent MT stations

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第5期67卷 1698-1713页

作者： Bing han Wenbao hu Guoze ZHAO Ji TANG State Key Laboratory of Earthquake Dynamics Institute of GeologyBeijing 100029China Key Laboratory of Exploration Technologies for Oil and Gas Resources of Ministry of Education Yangtze UniversityWuhan 430100China

In this research, an arbitrarily oriented electric dipole at subsurface is used to simulate Seismogenic Electromagnetic(SEM) radiation emanating from a seismic zone during its gestation phase. Analytical synthesis of responses at the Lijiang magnetotelluric(MT) station has revealed that SEM radiation could induce identifiable anomalies in the electromagnetic(EM)spectrum, apparent resistivity and phase within specific frequency bands. Background variations were extracted from long-term observation data of Dali and Lijiang MT stations, enabling the identification of SEM anomalies related to the Yunlong and Yangbi earthquakes. Multiple parameters of dipole sources at subsurface were obtained by applying the Differential Ant Colony Optimization(DACO) algorithm to anomalous data of two stations with multi-frequencies and various response functions. The spatial distribution of these predicted dipoles is predominantly clustered in or around the seismogenic area, with their azimuthal orientation aligning towards the seismogenic fault in general. This study has demonstrated the potential of using subsurface electric dipole simulations for SEM radiation analysis, offering a feasible approach for the prediction and understanding of seismogenic zones.

关键词： MT responses Identifying SEM anomaly Vector electric dipole responses Localizing SEM sources by inversion

Variability of the Pacific subtropical cells under global warming in CMIP6 models

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2024年第1期42卷 24-40页

作者： Xue han Junqiao FENG Yunlong LU Dunxin hu Key Laboratory of Ocean Circulation and Waves Chinese Academy of SciencesQingdao 266071China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Laboratory for Ocean Dynamics and Climate Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The Pacific subtropical cells(STCs)are shallow meridional overturning circulations connecting the tropics and subtropics,and are assumed to be an important driver of the tropical Pacific decadal *** variability of STCs under global warming is investigated using multimodal outputs from the latest phase of the Coupled Model Inter-comparison Project(CMIP6)and ocean reanalysis ***,the volume transport diagnostic analysis is employed to evaluate how coupled models and ocean reanalysis products reproduce interior STC *** variation of heat transport by the interior STC under the high-emissions warming scenarios is also *** results show that the multimodal-mean linear trends of the interior STC transport along 9°S and 9°N are-0.02 Sv/a and 0.04 Sv/a under global warming,respectively,which is mainly due to the combined effect of the strengthened upper oceanic stratification and the weakening of wind *** is a compensation relationship between the interior STC and the western boundary transport in the future climate,and the compensation relationship of 9°S is more significant than that of 9°*** addition,compared with ocean reanalysis products,the coupled models tend to underestimate the variability of the interior STC transport convergence,and thus may lose some sea surface temperature(SST)driving force,which may be the reason for the low STC-SST correlation simulated by the *** future scenario simulation shows that the heat transport of interior STC is weakened under global warming,with a general agreement across models.

关键词： interior subtropical cell(STC) global warming Coupled Model Inter-comparison Project(CMIP6) western boundary transport