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The regulatory role of AT 1 receptor on activated HSCs in hepat,c fibrogenesis,effects of RAS inhibitors on hepatic fibrosis induced by CCl_4

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World Journal of Gastroenterology 2000年第6期6卷 824-828页

作者： Hong Shan Wei han Ming lu ding Guo Li Yu Tao Zhan Zhi Rong Wang Xin Huang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China

AIM To assess the effect of ACE inhibitor andAng Ⅱ type Ⅰ（AT1）receptor antagonist inpreventing hepatic fibrosis caused by CCl4administration in rats;to investigate whether ornot there are expression of AT 1 receptors onhepatic stellate cells;and to observe the effectof Ang Ⅱ on proliferation and ECM synthesis ofcultured *** Studies were conducted in maleSprague-Dawley *** for thehepatofibrotic model group and the controlgroup,in three treated groups,either enalapril（5 mg/kg）,or Iosartan（10 mg/kg）,or enalapril+Iosartan were given to the fibrotic rats bydaily gavage,and saline vehicle was given tomodel and normal control *** 6 weeks,liver fibrosis was assessed directly by hepaticmorphometric analysis,which has beenconsidered the gold standard for thequantification of *** expressions of AT1 receptors and（α-mooth muscle actin,α-SMA）in liver tissue or isolated hepatic stellate cells（HSCs）were detected by *** effect of Ang Ⅱ on HSCproliferation was determined by MTT *** of Ang Ⅱ on collagen synthesis of HSCswas determined by 3H-proline *** Contrasted to the fibrosis in rats ofthe model group,groups of rats treated with either enalapril or Iosartan,or a combination oftwo drugs showed a limited expansion of theinterstitium（4.23±3.70 vs 11.22±4.79,P0.05）.Expression of AT 1receptors was found in fibrotic interstitium offibrotic rats,whereas in normal control rats theywere limited to vasculature only to a very *** 1 receptors were also expressed onactivated HSCs in the *** concentrationsfrom 10-9to 10-5mol/L,Ang Ⅱ stimulated HSCproliferation in culture in a *** Ang Ⅱ concentrationsproduced corresponding increases in 3*** among groups were ***

关键词： renin-angiotensin system liver cirrhosis enalapril extracellular matrix immunohistochemistry losartan liver/injuries

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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin lu Bing-Chun Yan han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

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三维Stokes绕流问题的格林函数解法

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水动力学研究与进展 1987年第3期 62-72页

作者：韩庆书鲁守智丁忠满北京大学

本文采用Green函数方法,对双球的无界空间三维绕流问题进行了数值计算,并通过对单球小雷诺数绕流的计算结果与准确解的比较,考察了计算的精度,得到了令人满意的结果。本文的计算适合任意形状多体的三维Stokes绕流问题的数值求解。

关键词：多体 Stokes 任意形状绕流

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肝X受体激动剂上调人肾小球内皮细胞血栓调节蛋白表达的机制和作用

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中国现代医学杂志 2016年第5期26卷 1-6页

作者：丁涵露李怡冯韵霖陈瑾钟翔王楠汪伟张萍王莉四川省医学科学院(四川省人民医院)肾内科四川成都610072 四川省成都市第二人民医院肾内科四川成都610017

目的探讨肝X受体(LXR)激动剂T0901317上调人肾小球内皮细胞(HRGEC)血栓调节蛋白(TM)表达的机制和作用。方法 Western blot检测25 mmol高糖和2μmol T0901317刺激后的HRGEC上IκBα、磷酸化IκBα、核转录因子-κB(NF-κB)p65、磷酸化NF-... 详细信息

目的探讨肝X受体(LXR)激动剂T0901317上调人肾小球内皮细胞(HRGEC)血栓调节蛋白(TM)表达的机制和作用。方法 Western blot检测25 mmol高糖和2μmol T0901317刺激后的HRGEC上IκBα、磷酸化IκBα、核转录因子-κB(NF-κB)p65、磷酸化NF-κB p65表达;免疫共沉淀法检测LXR与P300之间有无结合;重组腺病毒Ad TMsh RNA转染HRGEC,观察其对高糖下HRGEC分泌炎症介质的影响。结果T0901317能显著降低高糖刺激后的IκBα和NF-κB p65磷酸化(P0.05)。结论LXR可能通过与P300发生相互作用阻断了NF-κB与P300之间的竞争性结合而提高TM的表达并抑制炎症介质的分泌。

关键词：人肾小球内皮细胞肝X受体血栓调节蛋白核转录因子-κB

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi han Ying ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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A general, fast and robust B-spline fitting scheme for micro-line tool path under chord error constraint

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Science China(Technological Sciences) 2019年第2期62卷 321-332页

作者： BI QingZhen HUANG Jie lu YaoAn ZHU LiMin ding han State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University School of Electromechanical Engineering Guangdong University of Technology

The discontinuity of linear tool path(or G01 blocks) brings about unnecessary feedrate deceleration and fluctuation during machining. To improve the continuity, the linear tool path is usually smoothed by the local transition method or the global fitting method. For micro-line tool path, the transition method will significantly decrease the machining efficiency and introduce feedrate fluctuation. The global fitting method cannot be directly used in the NC interpolation because the indispensable chord error checking and iterative fitting processes are computation-intensive. This paper presents a general, fast and robust B-spline fitting scheme under chord error constraint for high speed interpolation of micro-line tool path. The proposed fitting method guarantees the chord error by utilizing the strong convex hull property of B-spline curves. The knot vector and control points are initially generated by a progressive iterative approximation method and locally refined to conform to the chord error constraint by using an analytical method. The analytical approximation and refining methods avoid solving a linear system of equations that is necessary in the standard B-spline fitting method. The feasibility and efficiency of the proposed scheme has been verified via simulations and experiments. Compared with the traditional fitting method, the proposed scheme can strictly constrain the chord error and can significantly decrease the computational load. Compared with the transition scheme, the proposed scheme can significantly increase the machining efficiency for the same micro-line tool path under the same chord error tolerance.

关键词： NC interpolation high speed machining micro-line segments path smoothing B-spline fitting

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水蛭素治疗以血尿为主要表现的免疫球蛋白A型肾病的随机对照临床研究

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中西医结合学报 2008年第3期6卷 253-257页

作者：李开龙何娅妮左洪炜王惠民丁涵露杨聚荣第三军医大学大坪医院野战外科研究所肾内科重庆400042

目的:观察以血尿为主要表现的免疫球蛋白A型肾病(immunoglobulin A nephropathy,IgAN)患者使用水蛭素治疗的近期疗效和副作用。方法:选择1998～2007年我科经肾组织活检病理证实的以血尿为主要表现的IgAN患者262例,按口服水蛭素(肠溶脉... 详细信息

目的:观察以血尿为主要表现的免疫球蛋白A型肾病(immunoglobulin A nephropathy,IgAN)患者使用水蛭素治疗的近期疗效和副作用。方法:选择1998～2007年我科经肾组织活检病理证实的以血尿为主要表现的IgAN患者262例,按口服水蛭素(肠溶脉血康胶囊)和潘生丁不同,随机分成水蛭素组和潘生丁组。以尿红细胞形态及计数、24 h尿蛋白定量、血肌酐(serum creatinine,Scr)、内生肌酐清除率(creatinine clearance rate,Ccr)、血脂4项、凝血5项和副作用等为疗效评价指标。结果:两组患者治疗半年后,水蛭素组尿红细胞畸形率与计数和24 h尿蛋白定量均较治疗前显著下降(P<0.01),且显著低于潘生丁组(P<0.05):水蛭素组Ccr较治疗前明显升高,并显著高于潘生丁组(P<0.01);水蛭素组患者的血脂也有改善,但差异无统计学意义;水蛭素抗凝作用明显强于潘生丁(P<0.01)。综合判定,水蛭素组的总有效率、完全缓解率和显著缓解率均显著高于潘生丁组(P<0.01)。两组发生副作用的病例数均较少,水蛭素组胃肠道不良反应的发生率也显著低于潘生丁组(P<0.05)。结论:水蛭素在降低IgAN血尿、蛋白尿和肾脏保护方面比潘生丁更具有优势。

关键词：免疫球蛋白A型肾病血屎水蛭素临床研究随机对照试验

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Efficacy and Safety of Niaoduqing Particles for Delaying Moderate-to-severe Renal Dysfunction： A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study

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Chinese Medical Journal 2017年第20期130卷 2402-2409页

作者： Ying Zheng Guang-Yan Cai Li-Qun He Hong-Li Lin Xiao-Hong Cheng Nian-Song Wang Gui-Hua Jian Xu-Sheng Liu Yu-Ning Liu Zhao-Hui Ni Jing-Ai Fang han-lu ding Wang Guo Ya-Ni He Li-Hua Wang Ya-Ping Wang Hong-Tao Yang Zhi-Ming Ye Ren-Huan YU Li-Juan Zhao Wen-Hua Zhou Wen-Ge Li Hui-Juan Mao Yong-Li Zhan Zhao Hu Chen Yao Ri-Bao Wei Xiang-Mei Chen Department of Nephrology Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Institute of Nephrology State Key Laboratory of Kidney Diseases (2011DAVO0088) National Clinical Research Center for Kidney Diseases Beijing 100853 China Department of Nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200021 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology Shaanxi Traditional Chinese Medicine Hospital Xi'an Shaanxi 710003 China Department of Nephrology and Rheumatology Affiliated Sixth People's Hospital Shanghai Jiao Tong University Shanghai 200233 China Department of Nephrology Guangdong Provincial Hospital of Chinese Medicine Guangzhou Guangdong 510120 China Department of Nephrology Dongzhimen Hospital The First Affiliated Hospital of Beijing University of Chinese Medicine Beijing 100700 China Department of Nephrology Renji Hospital Shanghai Jiao Tong University Shanghai 200127 China Department of Nephrology First Affiliated Hospital of Shanxi Medical University Taiyuan Shanxi 030001 China Department of Nephrology University of Electronic Science and Technology Sichuan Academy of Sciences and Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Nephrology Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Nephrology Daping Hospital Third Military Medical University Chongqing 400042 China Department of Nephrology Second Affiliated Hospital of Shanxi Medical University Taiyuan Shanxi 030001 China Department of Nephrology Army General Hospital Beijing 100700 China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tiaojin 300192 China Department of Nephrology Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510030 China Department o

Background： Chronic kidney disease （CKD） with moderate-to-severe renal dysfunction usually exhibits an irreversible course, and available treatments for delaying the progression to end-stage renal disease are limited. This study aimed to assess the efficacy and safety of the traditional Chinese medicine, Niaoduqing particles, for delaying renal dysfunction in patients with stage 3b-4 ***： The present study was a prospective, randomized, double-blind, placebo-controlled, naulticentcr clinical trial. Frorn May 2013 to December 2013,300 CKD patients with an estimated glomerular filtration rate （eGFR） between 20 and 45 ml ＂rain ~＂ 1.73 m 2, aged 18-70 years were recruited from 22 hospitals in 11 Chinese provinces. Patients were randomized in a 1：1 ratio to either a test group, which was administered Niaoduqing particles 5 g thrice daily and 10 g before bedtime for 24 weeks, or a control group, which was administered a placebo using the same methods. The primary endpoints were changes in baseline serum creatinine （Scr） and eGFR after completion of treatment. The primary endpoints were analyzed using Student＇s t-test or Wilcoxon＇s rank-sum test. The present study reported results based on an intention-to-treat （ITT） analysis. Results： A total of 292 participants underwent the ITT analysis. At 24 weeks, the median （interquartile range） change in Scr was 1.1 （-13.0-24.1） and 11.7 （-2.6-42.9） p, mol/L for the test and control groups, respectively （Z = 2.642, P = 0.008）, and the median change in eGFR was -0.2 （-4.3-2.7） and -2.2 （-5.7-0.8） ***-1·1.73 m-2, respectively （Z = -2.408, P = 0.016）. There were no significant differences in adverse events between the groups. Conclusions： Niaoduqing particles safely and effectively delayed CKD progression in patients with stage 3b-4 CKD. This traditional Chinese medicine may be a promising alternative medication for patients with moderate-to-severe renal dysfunction.

关键词： Chronic Kidney Disease Moderate-to-severe Renal Dysfunction Niaoduqing Particles Randomized Controlled Trial Traditional Chinese Medicine

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An Experimental and Analytical Study on Cross-Laminated Bamboo Rocking Walls with Friction Dampers

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Journal of Renewable Materials 2021年第10期9卷 1757-1779页

作者： Qingfang Lv Tongchen han Ye Liu Yi ding Yujie lu Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of Education Southeast UniversityNanjing210096China Key Laboratory of Deep Underground Science and Engineering(Ministry of Education) College of Architecture and EnvironmentSichuan UniversityChengdu610065China

Cross-laminated bamboo(CLB)have a high strength to weight ratio and stable bidirectional mechanical *** by the investigation on cross-laminated timber(CLT)rocking walls,CLB rocking walls with conventional friction dampers(CFDs)are studied in this *** investigate the mechanical properties of the CLB rocking wall,seven tests are conducted under a cyclic loading scheme,and different test parameters,including the existence of the CFDs,the moment ratio,and the loading times,are *** test results show a bilinear behavior of the CLB rocking *** small residual displacements of the CLB rocking wall demonstrate an idealized self-centering *** cumulative energy dissipation curves indicate that the energy dissipation capacity of the CLB rocking wall can be greatly improved with *** limit states of the CLB rocking wall under a lateral force are proposed based on the strains,stress,and damage level of the CLB material and posttensioned *** addition,an analytical model of the CLB rocking wall is developed based on the proposed limit states of the CLB rocking wall to evaluate the hysteretic response of the CLB rocking wall,and the model is validated by the experimental *** comparison results show the potential value of the analytical model for engineering design.

关键词： Cross-laminated bamboo(CLB) rocking wall friction dampers self-centering posttensioned rebar

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Edge-functionalized graphene quantum dots as a thickness-insensitive cathode interlayer for polymer solar cells

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Nano Research 2018年第8期11卷 4293-4301页

作者： han Xu lu Zhang Zicheng ding Junli Hu Jun Liu Yichun Liu Key Laboratory of UV-Emitting Materials and Technology (Northeast Normal University) Ministry of Education Changchun 130024China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022 China han Xu and lu Zhang contributed equally to this work.

A thickness-insensitive cathode interlayer （CIL） is necessary for large-area polymer solar cells （PSCs）, in which thickness variation is unavoidable. These C1L materials are typically based on n-type conjugated polymer/molecule backbones, which show strong light absorption in the visible/near-infrared （NIR） region. This interferes with the sunlight absorption by the active layer and deteriorates device efficiency. In this study, we developed graphene quantum dots functionalized with ammonium iodide （GQD-NI） at the edge as a thickness-insensitive CIL with high optical transparency. The peripheral ammonium iodide groups of GQD-NI formed the desired interfacial dipole with the cathode to decrease the work function. The graphene basal planes of GQD-NI with a lateral size of ca. 3 nm demonstrated a good conductivity of 3.56 ×10-6 ***-1 and high transparency in the visible/NIR region （λmax abs = 228 nm）. Moreover, GQD-NI was readily soluble in polar organic solvents, e.g., methanol, which enabled multilayer device fabrication with orthogonal solvent processing. As a result, the PSC device with GQD-NI as the CIL exhibited a power conversion efficiency （PCE） of 7.49%, which was much higher than that of the device without the CIL （PCE = 5.38%） or with calcium as the CIL （PCE = 6.72%）. Moreover, the PSC device performance of GQD-NI was insensitive to the GQD-NI layer thickness in the range of 2-22 nm. These results indicate that GQD-NI is a very promising material for application as a CIL in large-area printed PSCs.

关键词： graphene quantum dots ammonium edge-functionalization cathode interlayer polymer solar cells

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