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Exploration for the Priority of HIV Intervention:Modelling Health Impact and Cost-Effectiveness—Six Cities,Eastern China,2019-2028

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China CDC weekly 2024年第20期6卷 463-468,I0008-I0014页

作者： Youran Zhang Lili Wang Zhen jiang Hongjing Yan Xiaoxia Liu Jing Gu Guoyong Wang Xiaosong Cheng Qiyan Leng Qisui Long Zimian liang Jing Wang liang liang Yanchao Qiu Lin Chen hang Hong School of Health Service Management Anhui Medical UniversityHefei CityAnhui ProvinceChina Division of Prevention and intervention National Center for AIDS and STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina Zhenjiang Center for Disease Control and Prevention Zhenjiang CityJiangsu ProvinceChina Wuxi Center for Disease Control and Prevention Wuxi CityJiangsu ProvinceChina Shandong Provincial Center for Disease Control and Prevention Jinan CityShandong ProvinceChina Yantai Center for Disease Control and Prevention Yantai CityShandong ProvinceChina Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Foshan Center for Disease Control and Prevention Foshan CityGuangdong ProvinceChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Shijiazhuang Center for Disease Control and Prevention Shijiazhuang CityChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Ningbo Center for Disease Control and Prevention Ningbo CityZhejiang ProvinceChina

Introduction:In order to enhance the effectiveness of resource allocation,regions must tailor their responses to their specific epidemiological and economic ***:Utilizing Spectrum software,we projected the cost-effectiveness of 10 chosen HIV interventions in six cities in eastern China from 2019 to *** assessed three scenarios—Base,Achievable,and Idealized—for each *** analysis included the projected number of HIV infections and deaths averted,as well as the incremental costeffectiveness ratios for each intervention in the six ***:In Shijiazhuang,Wuxi,Yantai,and Zhenjiang,cities with initially low antiretroviral therapy(ART)coverage,ART showed significant effectiveness,especially for ***,in Foshan and Ningbo,where ART coverage was notably high,oral pre-exposure prophylaxis(PrEP)for men who have sex with men(MSM)proved effective in the Idealized *** outreach,ART for males,and ART for females demonstrated cost-effectiveness across all six cities in both Achievable and Idealized scenarios at the predefined thresholds for each ***:Maintaining an appropriate coverage rate for outreach to MSM can lead to *** cities with low ART coverage,scaling up ART remains a crucial *** regions with high ART coverage,consideration may be given to the utilization of oral PrEP for MSM individuals,requiring budget allocation.

关键词： Eastern Ningbo Impact

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ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway

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Current Medical Science 2024年第2期44卷 406-418页

作者： Cheng-cheng ZHU Heng-liang SUN Teng-fei LONG Yuan-yuan LYU jiang-li LIU Guan-tai NI Anhui Medical University Hefei 230032China Department of Obstetrics and Gynecology The First Affiliated Hospital of Wannan Medical CollegeWuhu 241001China

Objective:Uterine corpus endometrial carcinoma(UCEC),a kind of gynecologic malignancy,poses a significant risk to women’s *** precise mechanism underlying the development of UCEC remains *** finger protein 554(ZNF554),a member of the Krüppel-associated box domain zinc finger protein superfamily,was reported to be dysregulated in various illnesses,including malignant *** study aimed to examine the involvement of ZNF554 in the development of ***:The expression of ZNF554 in UCEC tissues and cell lines were examined by qRT-PCR and Western blot *** with stably overexpressed or knocked-down ZNF554 were established through lentivirus ***-8,wound healing,and Transwell invasion assays were employed to assess cell proliferation,migration,and *** iodide(PI)staining combined with fluorescence-activated cell sorting(FACS)flow cytometer was utilized to detect cell cycle ***-PCR and Western blotting were conducted to examine relative mRNA and protein *** immunoprecipitation assay and luciferase reporter assay were used to explore the regulatory role of ZNF554 in RNA binding motif 5(RBM5).Results:The expression of ZNF554 was found to be reduced in both UCEC samples and cell *** expression of ZNF554 was associated with higher tumor stage,decreased overall survival,and reduced disease-free survival in ***554 overexpression suppressed cell proliferation,migration,and invasion,while also inducing cell cycle *** contrast,a decrease in ZNF554 expression resulted in the opposite ***,ZNF554 transcriptionally regulated RBM5,leading to the deactivation of the Wingless(WNT)/β-catenin signaling ***,the findings from rescue studies demonstrated that the inhibition of RBM5 negated the impact of ZNF554 overexpression onβ-catenin and p-glycogen synthase kinase-3β(p-GSK-3β).Similarly,the deliberate activation of RBM5 reduced the increase inβ-catenin and

关键词： zinc finger protein 554 endometrial carcinoma RNA binding motif 5 Wingless/β-catenin signaling pathway

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Countermeasure against blinding attack for single-photon detectors in quantum key distribution

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Journal of Semiconductors 2024年第4期45卷 76-81页

作者： Lianjun jiang Dongdong Li Yuqiang Fang Meisheng Zhao Ming Liu Zhilin Xie Yukang Zhao Yanlin Tang Wei jiang Houlin Fang Rui Ma Lei Cheng Weifeng Yang Songtao han Shibiao Tang QuantumCTek Co. Ltd.Hefei 230088China Shandong Institute of Quantum Science and Technology Co. Ltd.Jinan 250101China QuantumCTek(Beijing)Co. Ltd.Beijing 100193China School of Cyber Science and Technology University of Science and Technology of ChinaHefei 230027China Anhui Armed Police Force Hefei 230026China School of Electrical Engineering and Automation Anhui UniversityHefei 230601China

Quantum key distribution(QKD),rooted in quantum mechanics,offers information-theoretic ***,practi-cal systems open security threats due to imperfections,notably bright-light blinding attacks targeting single-photon ***,we propose a concise,robust defense strategy for protecting single-photon detectors in QKD systems against blinding *** strategy uses a dual approach:detecting the bias current of the avalanche photodiode(APD)to defend against con-tinuous-wave blinding attacks,and monitoring the avalanche amplitude to protect against pulsed blinding *** integrat-ing these two branches,the proposed solution effectively identifies and mitigates a wide range of bright light injection attempts,significantly enhancing the resilience of QKD systems against various bright-light blinding *** method forti-fies the safeguards of quantum communications and offers a crucial contribution to the field of quantum information security.

关键词： quantum key distribution single photon detector blinding attack pulsed blinding attack countermeasure quan-tum communication

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Energy release characteristics of PTFE/Al/TiH2 reactive jet with different TiH2 content

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Defence Technology 2024年第09期 168-176页

作者： Chunlan jiang Jingbo Zhang Rong Hu liang Mao Ming Li State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

Titanium hydride（TiH2）, a promising high-energy additive, is doped into PTFE/Al to optimize the energy output structure of the reactive jet and strive for better aftereffect damage ability to the target. Six types of PTFE/Al/TiH2reactive liners with different TiH2content are prepared by the molding and sintering method. The energy release characteristics of PTFE/Al/TiH2reactive jet are tested by the transient explosion energy test, and are characterized from pressure and temperature. The reaction delay time,pressure history, and temperature history of the energy release process are obtained, then the actual value of released energy and reaction efficiency of the reactive jet are calculated. The results show that the peak pressure and temperature of the PTFE/Al/TiH2jet initially increase and then decrease with increasing TiH2content. When the TiH2content is 10%, the actual value of released energy and reaction efficiency increased by 24% and 6.4%, respectively, compared to the PTFE/Al jet. The reaction duration of the reactive material is significantly prolonged as the TiH2content increased from 0% to 30%. Finally,combined with the energy release behaviors of PAT material and the dynamic deformation process of liner, the enhancement mechanism of TiH2on energy release of the reactive jet is expounded.

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In SAR-derived surface deformation characteristics and mining subsidence parameters in mountain coal mines

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Journal of Mountain Science 2024年第09期 3139-3156页

作者： jiang Xiaowei SHI Wenbing liang Feng GUI Jingjing LI Jiawei Key Laboratory of Karst Georesources and Environment Ministry of Education Guizhou University Mountain Geohazard Prevention R&D Center of Guizhou Province College of Resources and Environmental Engineering Guizhou University

Mining-induced surface deformation disrupts ecological balance and impedes economic progress. This study employs SBAS-In SAR with 107-view of ascending and descending SAR data from Sentinel-1, spanning February 2017 to September 2020, to monitor surface deformation in the Fa'er Coal Mine, Guizhou Province. Analysis on the surface deformation time series reveals the relationship between underground mining and surface shifts. Considering geological conditions, mining activities, duration, and ranges, the study determines surface movement parameters for the coal mine. It asserts that mining depth significantly influences surface movement parameters in mountainous mining areas. Increasing mining depth elevates the strike movement angle on the deeper side of the burial depth by 22.84°, while decreasing by 7.74° on the shallower side. Uphill movement angles decrease by 4.06°, while downhill movement angles increase by 15.71°. This emphasizes the technology's suitability for local mining design, which lays the groundwork for resource development, disaster prevention, and ecological protection in analogous contexts.

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Nitrogen accumulation in a big lake affected by groundwater discharge in Central Yangtze River Basin

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Journal of Earth Science 2024年

作者： Liansong Tang Rui Ma Lin Jingjing Ying liang Xue jiang Hubei Key Laboratory of Yangtze River Basin Environmental Aquatic Science， School of Environmental Studies and State Key Laboratory of Biogeology and Environmental Geology， China University of Geosciences Changjiang Basin Ecology and Environment Monitoring and Scientific Research Center，Changjiang Basin Ecology and Environment Administration， Ministry of Ecology and Environment

Nitrogen pollution is a major cause of lake eutrophication， garnering global concern for its detrimental impact on lake-water quality. However， the intricate interplay between lakes and groundwater in the accumulation and release of nitrogen remains largely overlooked. Using Honghu Lake as a case study， a large lake in the Yangtze River basin long plagued by nitrogen pollution， this study analyzed the temporal shifts in its water area from 1990 to 2021 using remote-sensing image classification algorithms. From 1990 to 2005， the natural water area of Hong Lake decreased by 72%. The transformation of much of this area into aquaculture zones and agricultural lands has led to a substantial influx of pollutants， culminating in the degradation of the water quality. Despite efforts to restore the natura water area post ban on aquaculture activities， the water quality of the lake remains compromised， indicating other pollution sources menacing the ecosystem of the lake. Field investigations conducted in 2011 and 2019 unveiled substantially higher concentrations of NH4-N and NO3-N in groundwater compared to lake water， with a discernible upward trajectory in pollutant levels over time. The18O mass-balance model was employed to assess groundwater flow dynamics， revealing an estimated lacustrine groundwater discharge of 0.71×106m3/d， underscoring the substantial annual influx of pollutants into the lake via groundwater pathways. Through a comprehensive analysis of surface water and groundwater quality trends within the study area， this research provides novel evidence implicating groundwater as a formidable contributor to the persistent nitrogen pollution afflicting Honghu Lake.

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Activation of biomass-derived porous carbon for supercapacitors:A review

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Chinese Chemical Letters 2024年第7期35卷 121-138页

作者： Zixuan Guo Xiaoshuai han Chunmei Zhang Shuijian He Kunming Liu Jiapeng Hu Weisen Yang Shaoju Jian Shaohua jiang Gaigai Duan jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China Institute of Materials Science and Devices Suzhou University of Science and TechnologySuzhou 215009China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China Fujian Provincial Key Laboratory of Eco-Industrial Green Technology Key Laboratory of Green Chemical Technology of Fujian Province UniversityCollege of Ecological and Resources EngineeringWuyi UniversityWuyishan 354300China

Due to the advantages of renewable,low pollution and wide distribution of biomass resources,it is selected as the electrode material for *** carbon-based electrode materials,specific surface area and pore structure have a great *** and summarizing the influence of activation on pore structure will greatly broaden this *** on the activation mechanism of activator,this paper summarizes the latest progress of biomass activation applied to supercapacitors,including traditional physical and chemical activation methods and non-traditional methods such as biological activation method,self-activation method,template assisted activation method and green activator ***,the challenges,strategies and prospects for the future development of biomass-derived carbon material activation are pointed *** summary,this review will help researchers choose appropriate strategies to design biomass-derived carbon electrode materials for supercapacitors,thereby promoting the application of biomass materials.

关键词： Biomass-derived Activation Pore structure Electrochemistry Supercapacitor

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A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy

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Chinese Chemical Letters 2024年第10期35卷 379-385页

作者： han han Bi-Te Chen Jia-Rong Ding Jin-Ming Si Tian-Jiao Zhou Yi Wang Lei Xing Hu-Lin jiang State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University Department of Nephrology Changhai Hospital Naval Medical University College of Pharmacy Yanbian University

Activated pancreatic stellate cells(PSCs) are the main source of collagen layer deposition and the key target in pancreatic fibrosis. However, no effective treatment specific to pancreatic fibrosis clinically, owing to the drug accumulation blocked by the collagen barrier and thus it is difficult to inhibit activated PSCs precisely. Herein, a PSCs-targeting nano-system based on “nanodrill” strategy(LA-PC) was designed to enhance the accumulation of all-trans retinoic acid(ATRA) in PSCs, relying on the platelet-derived growth factor receptor beta(PDGFRβ)-targeting peptide(p PB: C*SRNLIDC*) and collagenase(Col). After being injected into fibrotic mice via tail vein, the Col modified on LA-PC can remove the excess collagen layer,and the drug delivery efficiency through pPB targeting peptide was more than 5 times higher than that of free ATRA, as well as the degree of fibrosis significantly reduced. Notably, this nano-system effectively inhibited platelet-derived growth factor subunit B(PDGF-BB)/PDGFRβ axis on PSCs via a down-regulated extracellular signal-regulated protein kinase(ERK) pathway, and accordingly reduced the level of PDGFBB. Thus, the smart platform provided a promising strategy for the treatment of pancreatic fibrosis to achieve the precise regulation of PSCs.

关键词： Liposome Pancreatic fibrosis Pancreatic stellate cells PDGFRβ pPB peptide

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On-chip integrated GeSe_(2)/Si vdW heterojunction for ultravioletenhanced broadband photodetection,imaging,and secure optical communication

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Nano Research 2024年第7期17卷 6544-6549页

作者： Zhiman Zhou Kunxuan Liu Di Wu Yunrui jiang Ranran Zhuo Pei Lin Zhifeng Shi Yongtao Tian Wei han Longhui Zeng Xinjian Li School of Physics and Microelectronics Key Laboratory of Material Physics Ministry of EducationZhengzhou UniversityZhengzhou 450052China Department of Electrical and Computer Engineering University of California San DiegoLa JollaCalifornia 92093USA Institute of Microelectronics and Integrated Circuits School of MicroelectronicsHubei UniversityWuhan 430062China

Broadband photodetection,spanning from ultraviolet(UV)to infrared(IR),is pivotal in diverse technological domains including astronomy,remote sensing,environmental monitoring,and medical ***,current commercially available broadband photodetectors,predominately based on conventional narrow-bandgap semiconductors,exhibit limited sensitivity in the UV *** limitation,stemming from the significant energy disparity between the semiconductor bandgap and UV photon,narrows their application ***,we report an innovative approach involving the in-situ van der Waals(vdW)integration of two-dimensional(2D)GeSe_(2)layers onto a Si *** process yields a high-quality GeSe_(2)/Si vdW heterojunction device,which features a broad response range covering from UV to near-IR(NIR)with a greatly-enhanced sensitivity in the UV *** device possesses high responsivities of 325 and 533.4 mA/W,large detectivities of 1.24×10^(13)and 2.57×10^(13)Jones,and fast response speeds of 20.6/82.1 and 17.7/81.0μs under 360 and 980 nm,***,the broadband image sensing and secure invisible optical communication capabilities of the GeSe_(2)/Si heterojunction device are *** work provides a viable approach for UV-enhanced broadband photodetection technology,opening up new possibilities and applications across various scientific and technological domains.

关键词： germanium diselenide van der Waals(vdW)integration ultraviolet enhanced broadband photodetection imaging

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Association between physical activity and risk of gastroesophageal reflux disease:A systematic review and meta-analysis

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Journal of Sport and Health Science 2024年第5期13卷 687-698页

作者： Chuting Yu Tinglu Wang Ye Gao Yunfei Jiao Huishan jiang Yan Bian Wei Wang han Lin Lei Xin Luowei Wang Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China National Clinical Research Center for Digestive Diseases(Shanghai) Shanghai 200433China

Background:Lifestyle plays an important role in preventing and managing gastroesophageal reflux disease(GERD).In response to the conflicting results in previous studies,we performed a systematic review and meta-analysis to investigate this ***:Relevant studies published until January 2023 were retrieved from 6 databases,and the prevalence of symptomatic gastroesophageal reflux(GER)or GERD was determined from the original studies.A random effects model was employed to meta-analyze the association by computing the pooled relative risk(RR)with 95%confidence intervals(95%CIs).Furthermore,subgroup and dose-response analyses were performed to explore subgroup differences and the association between cumulative physical activity(PA)time and ***:This meta-analysis included 33 studies comprising 242,850 participants.A significant negative association was observed between PA and the prevalence of symptomatic GER(RR=0.74,95%CI:0.66-0.83;p<0.01)or GERD(RR=0.80,95%CI:0.76-0.84;p<0.01),suggesting that engaging in PA might confer a protective benefit against *** analyses consistently indicated the presence of this association across nearly all subgroups,particularly among the older individuals(RR_(<40 years):RR_(≥40 years)=0.85:0.69,p<0.01)and smokers(RR_(smoker):RR_(non-smoker)=0.67:0.82,p=0.03).Furthermore,a dose-response analysis revealed that individuals who engaged in 150 min of PA per week had a 72.09%lower risk of developing ***:Maintaining high levels of PA decreased the risk of GERD,particularly among older adults and *** the recommended PA level of 150 min per week may significantly decrease the prevalence of GERD.

关键词： Physical activity Gastroesophageal reflux disease Prevalence Systematic review

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