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Chinese Medical Journal 2024年第4期137卷 473-475页

作者： han-lei jiang Yu Du Qiang Tong Sheng-Ming Dai Department of Rheumatology and Immunology Shanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200233China

To the Editor:Psoriatic arthritis(PsA)is a highly heterogeneous inflammatory *** occurs in up to 30%of patients with psoriasis and can have severe impacts on peripheral joints,spine,tendon insertions,and fingers. ^([1])Radiographic progression is currently the preferred method for assessing structural damage of PsA. ^([2])Biologic treatment options for PsA include tumor necrosis factor-αinhibitors(TNFi),interleukin-12/23 inhibitors,and interleukin-17(IL-17)*** therapeutic effects of IL-17 inhibitors on structural damage were not consistent over multiple ***,a systematic review and meta-analysis of the available randomized controlled trials(RCTs)was conducted to quantify the overall effect of IL-17 inhibitors on structural damage in *** study was registered with PROSPERO(***42022301774).

关键词： damage analysis inhibitors

Seismic safety assessment with non-Gaussian random processes for train-bridge coupled systems

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 241-260页

作者： Zhao han Gao lei Wei Biao Tan Jincheng Guo Peidong jiang Lizhong Xiang Ping Key Laboratory of Geomechanics and Embankment Engineering of Ministry of Education Hohai UniversityNanjing 210024China School of Civil Engineering Central South UniversityChangsha 410075China

Extensive high-speed railway(HSR)network resembled the intricate vascular system of the human body,crisscrossing *** events,known for their unpredictability,pose a significant threat to both trains and bridges,given the HSR’s extended operational ***,ensuring the running safety of train-bridge coupled(TBC)system,primarily composed of simply supported beam bridges,is *** methods like the Monte Carlo method fall short in analyzing this intricate system ***,efficient algorithm like the new point estimate method combined with moment expansion approximation(NPEM-MEA)is applied to study random responses of numerical simulation TBC *** of the NPEM-MEA’s feasibility is conducted using the Monte Carlo *** analysis confirms the accuracy and efficiency of the method,with a recommended truncation order of four to six for the ***,the influences of seismic magnitude and epicentral distance are discussed based on the random dynamic responses in the TBC *** methodology not only facilitates seismic safety assessments for TBC systems but also contributes to standard-setting for these systems under earthquake conditions.

关键词： train-bridge coupled(TBC)system random vibration new point estimate method(NPEM) seismic safety assessment moment expansion approximation(MEA) non-Gaussian distributions

General formalism for dirty extreme-mass-ratio inspirals

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 22-29页

作者： Ye jiang Wen-Biao han Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Shanghai Frontiers Science Center for Gravitational Wave Detection Shanghai 200240China

Detecting the environment around the supermassive black holes and tests of general relativity are important applications of extreme-mass-ratio inspirals(EMRIs).There is still a challenge to efficiently describe various“dirty”impacts on the inspirals,such as dark matter,gas,dipole radiation,and electromagnetic *** this study,we find the inherent linearity of the asymptotic solution of the inhomogeneous Teukolsky *** the basis of this property,we completely decouple the factors of the perturber and the background spacetime in the energy fluxes and *** the new decoupling form,the waveforms of EMRIs with non-geodesic motion in Kerr spacetime can be conveniently *** will help to resolve the environment(including gas,field,dark matter,electromagnetic interaction)around supermassive black holes and test general relativity.

关键词： gravitational wave Teukolsky equation extreme-mass-ratio inspirals

A Multiscale Model of Mass-Functionally Graded Beam-Fluid System Under Bending and Vibration Responses

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Acta Mechanica Solida Sinica 2024年第2期37卷 327-340页

作者： lei Zhang Jianping Lin Jiaqing jiang Guannan Wang Department of Civil Engineering Zhejiang University866 Yuhangtang RoadHangzhou310058China Center for Balance Architecture Zhejiang UniversityHangzhou310007China College of Civil Engineering Huaqiao UniversityXiamen361021China Key Laboratory for Intelligent Infrastructure and Monitoring of Fujian Province Huaqiao UniversityXiamen361021China Department of Engineering Mechanics Zhejiang UniversityHangzhou310027China

In this paper,a multiscale model is developed for the mass functionally graded(FG)beam-fluid system to investigate its static and dynamic responses based on 3D printed porous beam free vibration tests,which are determined by two *** the microstructural level,the gradient variation is realized by arbitrary distribution of matrix pores,and the effective moduli under specific distribution are obtained using the micromechanics homogenization *** the meantime,at the structural level,the mechanical responses of FG porous beams subjected to mass loading are considered in a static fluid ***,the explicit expressions of local finite-element(FE)expressions corresponding to the static and dynamic responses are given in the *** present results are validated against numerical and experimental results from the literature and mechanical tests of 3D printed structures,with good agreement generally obtained,giving credence to the present *** this basis,a comprehensive parametric study is carried out,with a particular focus on the effects of boundary conditions,fluid density,and slenderness ratio on the bending and vibration of FG beams with several different gradations.

关键词： 3D printed test Mass functionally graded beam-fluid system Multiscale model Local finite-element expressions Static bending Free vibration

Drug-Target Interactions Prediction Based on Signed Heterogeneous Graph Neural Networks

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Chinese Journal of Electronics 2024年第1期33卷 231-244页

作者： Ming CHEN Yajian jiang Xiujuan lei Yi PAN Chunyan JI Wei jiang College of Information Science and Engineering Hunan Normal University School of Computer Science Shaanxi Normal University Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Computer Science Department BNU-HKBU United International College

Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.

关键词： Drugs Training Proteins Measurement Message passing Prediction methods Graph neural networks

Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 65-82页

作者： Xiaojian jiang Lihong lei Weilian SUN Yingming WEI Jiayin han Shuaiqi ZHONG Xianyan YANG Zhongru GOU Lili CHEN Department of Oral Medicine the Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China Bio-nanomaterials and Regenerative Medicine Research Division Zhejiang–California International Nanosystem InstituteZhejiang UniversityHangzhou310058China

Magnesium-doped calcium silicate(CS)bioceramic scaffolds have unique advantages in mandibular defect repair;however,they lack antibacterial properties to cope with the complex oral ***,for the first time,the CS scaffold was functionally modified with a novel copper-containing polydopamine(PDA(Cu^(2+)))rapid deposition method,to construct internally modified(*P),externally modified(@PDA),and dually modified(*P@PDA)*** morphology,degradation behavior,and mechanical properties of the obtained scaffolds were evaluated in *** results showed that the CS*P@PDA had a unique micro-/nano-structural surface and appreciable mechanical *** the prolonged immersion stage,the release of copper ions from the CS*P@PDA scaffolds was rapid in the early stage and exhibited long-term sustained *** in vitro evaluation revealed that the release behavior of copper ions ascribed an excellent antibacterial effect to the CS*P@PDA,while the scaffolds retained good cytocompatibility with improved osteogenesis and angiogenesis ***,the PDA(Cu^(2+))-modified scaffolds showed effective early bone regeneration in a critical-size rabbit mandibular defect ***,it was indicated that considerable antibacterial property along with the enhancement of alveolar bone regeneration can be imparted to the scaffold by the two-step PDA(Cu^(2+))modification,and the convenience and wide applicability of this technique make it a promising strategy to avoid bacterial infections on implants.

关键词： Copper-containing polydopamine Modification Antibacterial property Bone regeneration Angiogenesis Bioceramic scaffold

Multi-physics multi-scale simulation of unique equiaxed-to-columnar-to-equiaxed transition during the whole solidification process of Al-Li alloy laser welding

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Journal of Materials Science & Technology 2024年第4期171卷 235-251页

作者： Chu han Ping jiang Shaoning Geng Liangyuan Ren School of Mechanical Science and Engineering Huazhong University of Science&Technology(HUST)Wuhan430074China

In this study,a novel multi-physics multi-scale model with the dilute multicomponent phase-field method in three-dimensional(3D)space was developed to investigate the complex microstructure evolu-tion in the molten pool during laser welding of Al-Li *** accurately compute mass data within both two and three-dimensional computational domains,three efficient computing methods,including central processing unit parallel computing,adaptive mesh refinement,and moving-frame algorithm,were *** was placed on the distinctive equiaxed-to-columnar-to-equiaxed transition phenomenon that occurs during the entire solidification process of Al-Li alloy laser *** results indi-cated that the growth distance of columnar grains that epitaxially grew from the base metal(BM)de-creased as the nucleation rate *** the nucleation rate increased,the morphology of the newly formed grains near the fusion boundary(FB)changed from columnar to equiaxed,and newly formed equiaxed grains changed from having high-order dendrites to no obvious dendrite *** the nucleation rate was sufficiently high,non-dendritic equiaxed grains could directly form near the FB,and there was nearly no epitaxial growth from the ***,simulation results illustrated the com-petition among multiple grains with varying orientations that grow in 3D space near the ***,how equiaxed grain bands develop was *** equiaxed band not only hindered the growth of early columnar grains but also some of its grains could grow epitaxially to form new columnar *** predicted results were in good agreement with experimental measurements and observations.

关键词： Laser welding Al-Li alloy Equiaxed-to-columnar-to-equiaxed transition Multi-physics multi-scale model Multicomponent alloys 3D phase-field model

Research on Optimal Preload Method of Controllable Rolling Bearing Based on Multisensor Fusion

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3329-3352页

作者： Kuosheng jiang Chengrui han Yasheng Chang School of Mechanical and Electrical Engineering Anhui University of Science and TechnologyHuainan232001China School of Optical and Electronic Information Suzhou City University&Suzhou Key Laboratory of BiophotonicsSuzhou215104China State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an710054China

Angular contact ball bearings have been widely used in machine tool spindles,and the bearing preload plays an important role in the performance of the *** order to solve the problems of the traditional optimal preload prediction method limited by actual conditions and uncertainties,a roller bearing preload test method based on the improved D-S evidence theorymulti-sensor fusion method was ***,a novel controllable preload system is proposed and ***,multiple sensors are employed to collect data on the bearing parameters during preload ***,a multisensor fusion algorithm is used to make predictions,and a neural network is used to optimize the fitting of the preload *** limitations of conventional preload testing methods are identified,and the integration of complementary information frommultiple sensors is used to achieve accurate predictions,offering valuable insights into the optimal preload *** results demonstrate that the multi-sensor fusion approach outperforms traditional methods in accurately measuring the optimal preload for rolling bearings.

关键词： Multi-sensor information fusion neural network preload force

Association between serum resistin level and cardiovascular events in postmenopausal women with acute coronary syndrome undergoing percutaneous coronary intervention

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Chinese Medical Journal 2013年第6期126卷 1058-1062页

作者： LI lei han jiang-li MAO Jie-ming GUO Li-jun GAO Wei Department of Cardiology Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing 100191 China

Background As an adipocytokine, resistin has been proposed as a link between inflammation, metabolic disorder and atherosclerosis. The aim of the study is to evaluate whether serum resistin is associated with acute coronary syndrome （ACS） and major adverse cardiovascular events （MACEs） among postmenopausal women with ACS undergoing percutaneous coronary intervention （PCI）. Methods A total of 106 consecutive postmenopausal women who underwent coronary angiography for evaluation of suspected myocardial ischemia were enrolled. Pre-procedure serum resistin, inflammatory and metabolic biomarkers were measured. All participants were followed for seven years for MACEs, including cardiovascular death, recurrent nonfatal myocardial infarction, and re-PCl. Results Patients with ACS （n=69） had significantly higher resistin levels than those without coronary artery disease （CAD）（n=37）（4.61 （1.79-10.80） ng/ml vs. 2.36 （0.85-4.15） ng/ml, P=0.002）. Correlation analysis revealed positive correlations between resistin levels and inflammatory and metabolic factors （P 〈0.05）. A follow-up of a mean of 83.4 months showed that patients with ACS suffered more MACEs than those without （13.0% vs. 2.7%, P=0.05）. Adjusted for cardiovascular risks, inflammatory and metabolic factors, multiple Logistic regression analysis indicated that an elevated resistin level was an independent predictor of ACS onset （OR=1.139, 95% CI 1.024-1.268, P=0.017） and of MACEs after PCI （OR=1.099, 95% CI 1.015-1.189, P=-0.019）. To clarify the association between resistin levels and MACEs, ACS patients were divided into two subgroups on the basis of resistin levels. Compared with the low resistin subgroup （≤4.35 ng/ml, n=32）, patients in the high resistin subgroup （〉4.35 ng/ml, n=37） were more prone to suffer MACEs （21.6% vs. 3.1%, P=0.015）. Kaplan-Meier analysis showed a significantly lower event-free survival rate in ACS patients with high resistin levels than in the low resistin subgroup （78.4% vs. 96.9%, Log r

关键词： postmenopausal women resistin acute coronary syndrome major adverse cardiovascular events

Numerical simulations of earthquake rupture induced by pressure perturbation

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Geodesy and Geodynamics 2024年第5期15卷 477-487页

作者： Bingquan Ren Caijun Xu Guoyan jiang lei Yang School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China Key Laboratory of Geospace Environment and Geodesy Ministry of EducationWuhan UniversityWuhan 430079China Key Laboratory of Geophysical Geodesy Ministry of Natural ResourcesWuhan 430079China

The subsurface fluid injection can cause pressure increase within faults,leading to earthquake ***,the factors controlling earthquake rupture due to pressure perturbation remain poorly *** resolve this problem,we simulate the physical processes of earthquake nucleation and rupture on strike-slip faults perturbated by pressure migration based on the slip-weakening *** kinds of factors,including background stress,fluid injection rates,the area of the pressurized region,fault geometry,and fault friction coefficients,are considered in our *** simulation results reveal that the ratio of shear stress to normal stress rather than their absolute values controls the rupture *** the large stress ratios,high injection rates,and large pressurized areas,earthquakes are prone to propagate as runaway ***,faults with large aspect ratios of length to width are also favorable for causing runaway *** contrast,the factors of fault strike,dip angles and friction coefficients have minor influence on rupture behavior.

关键词： Induced seismicity Finite element simulation Rupture mode