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Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury

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Neural Regeneration Research 2018年第8期13卷 1417-1424页

作者： Lin Zhu Tao Tang Rong Fan Jie-Kun Luo han-jin cui Chun-Hu Zhang Wei-Jun Peng Peng Sun Xin-Gui Xiong Yang Wang Laboratory of Ethnopharmacology Institute of Integrated Traditional Chinese and Western Medicine Xiangya Hospital Central South University Changsha Hunan Province China Department of-Integrated Traditional Chinese and Western Medicine Second Xiangya Hospital Central South University Changsha Hunan Province China College of Pharmacy Shandong University of Traditional Chinese Medicine Jinan Shandong Province China

Xuefu Zhuyu decoction has been used for treating traumatic brain injury and improving post-traumatic dysfunction, but its mechanism of action needs further investigation. This study established rat models of traumatic brain injury by controlled cortical impact. Rat models were intragastrically administered 9 and 18 g/kg Xuefu Zhuyu decoction once a day for 14 or 21 days. Changes in neurological function were assessed by modified neurological severity scores and the Morris water maze. Immunohistochemistry, western blot assay, and re- verse-transcription polymerase chain reaction were used to analyze synapsin protein and mRNA expression at the injury site of rats. Our results showed that Xuefu Zhuyu decoction visibly improved neurological function of rats with traumatic brain injury. These changes were accompanied by increased expression of synaptophysin, synapsin I, and postsynaptic density protein-95 protein and mRNA in a dose-de- pendent manner. These findings indicate that Xuefu Zhuyu decoction increases synapsin expression and improves neurological deficits alder traumatic brain injury.

关键词： nerve regeneration traumatic brain injury Xuefu Zhuyu decoction neurological dysfunction synapsin synaptophysin synapsin I posts vnaptic density protein-95 neuroprotection neural regeneration

Buyang Huanwu Decoction promotes Vascular Endothelial Growth Factor Receptor-2 activation in mice brains of Intracerebral Hemorrhage(Abstract)

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Buyang Huanwu Decoction promotes Vascular Endothelial Growth...

Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

第九次全国中西医结合基础理论研究学术研讨会

作者： han-jin cui A-Li Yang Cong Wang 唐涛 Institute of Integrative Chinese Medicine Xiangya HospitalCentral South University

Object Angiogenesis following Intracerebral Hemorrhage(ICH) is of importance for the reparative processes and neurological deficits *** activation of Vascular endothelial growth factor receptor 2(VEGFR2) contributes to *** present study aimed to investigate the effect of Buyang Huanwu Decoction(BYHWD),a traditional Chinese medicine formula,on VEGFR2 activation,through which angiogenesis may be promoted. Methods ICH model was induced in Kunming mice by injection of Collagenase typeⅦinto the right globus pallidus.4.4g/kg BYHWD was administrated by introgastric *** test the involvement of VEGFR2 activation in BYHWD-promoted angiogenesis,SU5416,an inhibitor to VEGFR2,was *** deficits recovery was evaluated by body weights,modified Neurological Severity Scores(mNSS),corner turn test and foot-fault *** and western blot to determine the pVEGFR2 expression and angiogenesis. Results the Neurological outcomes,the pVEGFR2 expression and the number of BrdU-/ vWF-positive nuclei were all significantly better in BYHWD-treated group and ICH group,as compared with their inhibitor-treated counterparts,*** similar results could also be detected in the comparison between BYHWD-treated group and ICH group. Conclusion Administration of BYHWD can promote neurological outcomes and angiogenesis after ICHin part,by activation ofVEGFR2.

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang Yang Jianfeng Zheng Guoyu Wang Yifei Gao Yatao Yang Jia Li Xiaojin han Yan cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Photoelectrocatalysis Z-scheme C–C coupling Ethanol

Efficacy of deferoxamine in animal models of intracerebral hemorrhage:a systematic review and stratified meta-analysis

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Efficacy of deferoxamine in animal models of intracerebral h...

骨表面受累病变的平片、二维CT及三维CT重建对比研究

第十二次全国中西医结合实验医学专业委员会暨第七次湖南省中西医结合神经科专业委员会学术年会

作者： han-jin cui Hao-yu He A-Li Yang Hua-Jun Zhou Cong Wang Jie-Kun Luo Yuan Lin Tao Tang Institute of Integrative Medicine Xiangya Hospital Central South University Institute of Neurology Xiangya HospitalCentral South University Institute of Mental Health The Second Xiangya HospitalCentral South University Key Lab of Chinese Gan of SATCM Institute of Neurology The First College of Clinical Medical SciencesChina Three Gorges University

Intracerebral hemorrhage(ICH) is a subtype of stroke associated with high morbidity and mortality *** proven treatments are available for this ***-mediated free radical injury is assoc

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实用放射学杂志 2003年第7期19卷 618-620页

作者：陈海松韩金花崔新建青岛医学院第二附属医院放射科青岛医学院第二附属医院放射科山东青岛266042

目的　研究螺旋CT三维重建对骨表面受累病变的定位与定性诊断价值 ,并与平片及二维CT做对比研究。方法　对平片显示的骨表面受累病变进行术前螺旋CT二维横断扫描 ,对其中 2 0例有手术病理结果者进行多平面重组及表面遮盖法三维立体重建 ... 详细信息

目的　研究螺旋CT三维重建对骨表面受累病变的定位与定性诊断价值 ,并与平片及二维CT做对比研究。方法　对平片显示的骨表面受累病变进行术前螺旋CT二维横断扫描 ,对其中 2 0例有手术病理结果者进行多平面重组及表面遮盖法三维立体重建 ,并比较各种影像学方法的定位与定性正确率。结果　平片、CT横断、多平面重组、表面遮盖法立体重建对骨表面受累病变的定性正确率分别为 75 %、80 %、65 %、60 % ;定位正确率分别为 90 %、75 %、85 %、95 %。二维CT横断扫描的定性正确率最高 ,CT三维立体重建的定位正确率最高。结论　螺旋CT三维重建对骨表面受累病变的定位诊断有重大价值

关键词：骨螺旋CT 三维重建

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生物学实验课程体系的改革创新

科教文汇 2017年第8期 46-47页

作者：韩晓菲金晔崔红利王欢侯义龙大连大学生命科学与技术学院生命科学工作室辽宁大连116622

课程体系不仅是培养人才的基础,而且是贯彻人才培养方案及实现人才培养目标的重要环节。依据生命科学人才培养目标,在原有生物学实验课程体系基础上,提升实验教学理念,并以此为引领,通过师资队伍建设,教材建设,课程内容、方法和手段的完... 详细信息

课程体系不仅是培养人才的基础,而且是贯彻人才培养方案及实现人才培养目标的重要环节。依据生命科学人才培养目标,在原有生物学实验课程体系基础上,提升实验教学理念,并以此为引领,通过师资队伍建设,教材建设,课程内容、方法和手段的完善,建立有效的实验教学考核体系,以及优化实验室管理模式和加强实验教学环境建设等措施,保证了生物学实验教学体系的可持续发展,对于培养适应未来生物学技术发展的应用型、创新性人才具有十分重要的意义。

关键词：生物学实验课程体系教学理念师资队伍建设

Geometric structure design of passive label-free microfluidic systems for biological micro-object separation

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Microsystems & Nanoengineering 2022年第3期8卷 1-28页

作者： Hao Tang Jiaqi Niu han jin Shuing Lin Daxiang cui Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong University800 Dongchuan RDShanghai 200240China National Engineering Research Center for Nanotechnology Shanghai Jiao Tong University28 Jiangchuan EasternroadShanghai 200241China

Passive and label-free microfluidic devices have no complex external accessories or detection-interfering label *** devices are now widely used in medical and bioresearch applications,including cell focusing and cell *** structure plays the most essential role when designing a passive and label-free microfluidic *** exquisitely designed geometric structure can change particle trajectories and improve chip ***,the geometric design principles of passive and label-free microfluidics have not been comprehensively ***,we review the geometric innovations of several microfluidic schemes,including deterministic lateral displacement(DLD)inertial microfluidics(IMF),and viscoelastic microfluidics(VEM),and summarize the most creative innovations and design principles of passive and label-free *** aim to provide a guideline for researchers who have an interest in geometric innovations of passive label-free microfluidics.

关键词： passive structure fluid

Hot Deformation Behavior and Workability of(SiC_p + Mg_2B_2O_(5w))/6061 Al Hybrid and SiC_p/6061 Al Composites

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Acta Metallurgica Sinica(English Letters) 2014年第1期27卷 63-74页

作者： Mingliang Wang Peipeng jin jinhui Wang Li han Chuang cui Qinghai Provincial Key Laboratory of New Light Alloys Qinghai University

The hot deformation behavior of （3 vol% SiCp -4- 3 vol% Mg2B2Osw）/6061 A1 （W3P3） hybrid composite and 6 vol% SiCp/6061 A1 （P6） composite have been characterized in the temperature range of 300--450 ℃ and strain rate range of 0.0001-0.1 s-1 using isothermal constant true strain rate tests. The flow behavior and processing maps have been investigated using the corrected data to eliminate the effect of friction. Under the same deformation conditions, the compressive resistance of the singular composite remains superior to that of the hybrid composites. The processing map of W3P3 hybrid composite exhibits a single hot working domain at the temperature between 350 and 450 ℃ with strain rate between 0.0001 and 0.003 s-1 （domain A）. Two hot working domains exist for P6 composite：（i） 300-400 ℃/ 0.0001-0.003 s-1 （domain B1）; （ii） 380-450 ℃/0.01-0.1 s-1 （domain B2）. The processing maps also reveal the flow instability of the two composites, which is associated with whiskers breakage, whisker/matrix interfacial debonding, SiCp/ matrix interfacial decohesion, adiabatic shear bands or flow localization, and wedge cracking in the corresponding regions. The estimated apparent activation energies are about 224 kJ mo1-1 in domain A for W3P3 hybrid composite, 177 kJ mo1-1 in domain B1 and 263 kJ mo1-1 in domain B2 for P6 composite, respectively. These values are higher than that for self-diffusion in A1 （142 kJ mol-1）, suggesting that there is a significant contribution from the back stress caused by the presence of particles and/or whiskers in the matrix. The deformation mechanisms corresponding to domain B 1 and domain B2 are dislocation climb controlled creep and cross-slip for P6 composite, respectively. For W3P3 hybrid composite, the deformation mechanisms contain dislocation climb controlled creep and grain boundary sliding caused by DRX in domain A.

关键词： Hybrid composite Hot deformation Processing map Hot working Kinetic analysis

Tunable multistability and nonuniform phases in a dimerized two-dimensional Rydberg lattice

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Chinese Physics B 2020年第1期29卷 235-240页

作者： han-Xiao Zhang Chu-Hui Fan cui-Li cui jin-Hui Wu Center for Quantum Sciences Northeast Normal UniversityChangchun 130117China College of Physics Jilin UniversityChangchun 130012China

We study the multistability of fixed points for a dimerized system of Rydberg atoms driven by two laser fields and trapped in a two-dimensional(2D)square *** identical driving fields,the fixed points of this system exhibit stable uniform,unstable uniform,stable nonuniform,or oscillating nonuniform phases in the presence of a bistable *** different driving fields,however,all(stable,unstable,or oscillating)phases become nonuniform instead,which then results in two islets isolated from the mainland of Rydberg *** also show that a tristable region may stretch out from the(nonuniform)bistable region near the islets,indicating that a richer phase diagram can be attained by tuning the Rabi frequencies and/or detunings of the driving *** but not least,the fixed points can adiabatically evolve from the islets to the mainland but can not inversely evolve from the mainland to the islets.

关键词： Rydberg atoms dimerized system fixed point nonuniform phase