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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie mao Zhimin Zhang han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-mao Yuan Jun-Bo Yang Zhi-Li Zuo han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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卫生规划和卫生资源配置评价研究进展

中国卫生资源 2017年第2期20卷 118-122页

作者：邱五七严晓玲胡广宇董佩丁晗玥毛阿燕中国医学科学院医学信息研究所公共卫生信息研究室北京100020

卫生规划是以一种有效的方式去满足健康需要的过程,其核心是卫生资源的优化配置。为判断卫生资源配置是否合理,卫生规划是否达到预期效果,需要对规划实施和资源配置具体情况进行评估。文章梳理了卫生规划和卫生资源配置及评估相关基本... 详细信息

卫生规划是以一种有效的方式去满足健康需要的过程,其核心是卫生资源的优化配置。为判断卫生资源配置是否合理,卫生规划是否达到预期效果,需要对规划实施和资源配置具体情况进行评估。文章梳理了卫生规划和卫生资源配置及评估相关基本概念、研究进展及评估工作情况,为我国卫生规划与卫生资源配置研究和决策提供参考。

关键词：卫生规划卫生资源卫生资源配置评价

A data-driven rolling optimization method for trajectory tracking error prediction of CNC machine tools

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Science China Technological Sciences 2025年第1期 274-289页

作者： Yinxin GUAN Jixiang YANG Shizhong TAN han ding School of Mechanical Science and Engineering State Key Laboratory of Intelligent Manufacturing Equipment and TechnologyHuazhong University of Science and Technology

The dynamic performance of the feed-drive system in CNC machine tools directly influences the accuracy of machined parts. To enhance the motion control performance of CNC machine tools, a high-precision model of the feed-drive system is critical. However, current modeling methods for feed-drive systems seldom consider time-varying factors such as loads, wear, and lubrication. As a result, the model accuracy degrades when the system characteristics are affected by these time-varying factors. In this paper, a rolling optimization method with partial weights frozen is developed to realize quick iterative learning of a data-driven model for a feed drive system with time-varying characteristics using a small amount of ***, the long short-term memory fully connected(LSTM-FC) network is built and divided into feature extraction and output fitting parts based on their functions. Then, a weight freezing-based rolling optimization method is applied. The weights in the feature extraction part are frozen, which preserves the learned common knowledge and patterns by solidifying the way that high-dimensional features are extracted from the input. By adjusting the weights in the output fitting part, the extracted highdimensional features are remapped to the new data distribution changed by time-varying factors. Finally, the performance of the developed rolling optimization method is confirmed by experiments. The results show that the proposed rolling optimization method reduces the maximum prediction errors by 49.5% and the total training time by 96.3% compared with existing methods,which demonstrates that the proposed method can restore model accuracy when the system characteristics change due to timevarying factors, and significantly accelerate the optimization process by rolling optimization.

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi han Ying ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-Chun Yan han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Carbon nanotube network film-based ring oscillators with sub l O-ns propagation time and their applications in radio-frequency signal transmission

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Nano Research 2018年第1期11卷 300-310页

作者： Yingjun Yang Li ding Hengjia Chen Jie han Zhiyong Zhang Lian-mao Peng Key Laboratory for the Physics and Chemistry of Nanodevices and Department of Electronics Peking University Beijing 100871 China

We have fabricated top-gated ambipolar field-effect transistors （FETs） based on solution-derived carbon nanotube （CNT） network films, and then constructed inverters and ring oscillators （ROs） that can work under supply voltages as low as 0.2 V owing to the high uniformity of the devices. Significant improvements were achieved in the performance of these CNT-based ambipolar FETs and CMOS-like circuits by scaling down the gate length of the CNT FETs and optimizing the device structure and RO layout. In particular, the optimized five-stage RO is shown to present a record high oscillation frequency of up to 17.4 MHz with a propagation time of 5.6 ns at a 12-V working voltage. The CNT film-based ROs were used as carrier-wave generators in radio-frequency systems to demonstrate a complete signal transmission process. These results suggest that CNT thin film-based FETs and integrated circuits may soon find their way to radio-frequency applications with a frequency band of 13.56 MHz.

关键词： carbon nanotube nanoelectronics field-effect transistors radio-frequency ring oscillator

Selective capture of silver ions from aqueous solution by series of azole derivatives-functionalized silica nanosheets

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Chinese Journal of Chemical Engineering 2023年第5期57卷 319-328页

作者： Shanshan mao Tao Shen Qing Zhao Tong han Fan ding Xin Jin Manglai Gao State Key Laboratory of Heavy Oil Processing College of ScienceChina University of PetroleumBeijing 102249China Unconventional Natural Gas Institute China University of PetroleumBeijing 102249China

The introduction of bifunctional groups into low-cost adsorbents for selective adsorption of Ag(I) through synergistic effect will have a profound impact on the recovery of precious metals. Organo silica nanosheets(organo-Si NSs) functionalized by series of azole derivatives(2-mercaptoimidazole(MI), 2-mercaptobenzimidazole(MBT) and 1H-1,2,4-triazole-3-thiol(MTT)), are fabricated and employed for selective removal of Ag(I). The structures of the organo-Si NSs are investigated using several characterization methods. The results of batch adsorption experiments display that the maximum adsorption amounts are 70.3, 103.2 and 139.5 mg·g^(-1) on MI-Si NSs, MBI-Si NSs and MTT-Si NSs for Ag(I) ions, and reach rapid equilibrium within 10–30 min. The adsorption processes are chemisorption and fit pseudo-second-order kinetic model and Langmuir adsorption isotherm model. Notably, MTT-Si NSs is greatly selective for Ag(I) in multicomponent system, and the distribution coefficient value of Ag(I) ions reaches 2331.26 ml·g^(-1). The reusability of organo-Si NSs is verified by four cycles of regeneration tests with 0.1 mol·L^(-1) HNO_(3) as the eluent. A combination of experimental, structural along with theoretical analysis is conducted to proclaim the structure-adsorptivity relationship:(i) The adsorption mechanisms are attributed to complexation.(ii) The amino group and sulfhydryl group of MTT-Si NSs as well as MBISi NSs may have synergistic impacts on Ag(I) capture.(iii) The differences in adsorption behavior and selectivity of the three organo-Si NSs are mainly related to the form of function groups, charge density and steric hindrance of adsorbent. This work not only sheds light on the promise of functionalized organo-Si NSs for the rapid and selective removal/enrichment of Ag(I) ions in complex water systems,but also provides new insights for designing cost-effective Si NSs-based adsorbents.

关键词： Organo silica nanosheets Adsorption Silver ions Selectivity Mechanism Waste treatment

Bending vibration control of pipes conveying fluids by nonlinear torsional absorbers at the boundary

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Science China(Technological Sciences) 2021年第8期64卷 1690-1704页

作者： mao XiaoYe ding Hu CHEN LiQun Shanghai Institute of Applied Mathematics and Mechanics Shanghai UniversityShanghai200072China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai UniversityShanghai200072China School of Mechanics and Engineering Science Shanghai UniversityShanghai200444China

A nonlinear torsional absorber,which can overcome the influence of the fluid velocity on the natural frequency,is employed at the boundary to restrain the bending vibration of a pipe for the first *** using the rotating angle at the end of the pipe,the bending vibration energy is pumped to the boundary *** nonlinearly coupled pipe-absorber governing equations are obtained by the generalized Hamilton’s ***-state responses subjected to a basement excitation are discussed by the *** to this method,the boundaries of the pipe are treated as the generalized governing *** this way,those nonlinearities and time-dependent terms in the boundary are involved in the response completely.A direct simulation method,called the differential quadrature element method(DQEM),is used to verify these analytical *** investigation indicates that the nonlinear boundary absorber owns two outstanding *** first one is that the natural characters remain the same and the absorber can capture the resonance of the pipe *** second one is that the absorber works at all natural ***,by using the nonlinear damping,the absorber will not worsen the weak vibration in the non-resonance *** parameters of the absorber are investigated to optimize the efficiency in *** result finds that good efficiency can be achieved with a tiny ***,the efficiency becomes better as the damping *** the help of these investigations,the work provides a new strategy to protect pipes conveying fluids from being destroyed by the vibration.

关键词： pipes conveying fluid boundary control nonlinear torsional absorber boundary nonlinear energy sink nonlinear damping

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