检索结果-南通市图书馆

Cellular & Molecular Immunology 2013年第6期10卷 490-496页

作者： Shengli Song Miaomiao han han zhang Yuanxia wang Hong Jiang Shanghai Institute of Immunology Shanghai Jiao Tong University School of Medicine Shanghai China

HLA-A＊02 is the most prevalent and polymorphic major histocompatibility complex （MHC） allele family in humans. Functional differences have been revealed among subtypes, demanding further subtyping of HLA-A＊02 in basic and clinical settings. However, the fast growing polymorphisms render traditional primeror probe-based typing methods impractical and result in increasing ambiguities in direct sequence-based typing. In this study, we combined group-specific amplification and mono-allelic sequencing to design and validate a simple scheme for the complete screening and accurate subtyping of all 540 reported HLA-A＊02 alleles. This scheme could be performed in routine labs to facilitate studies with an interest in HLA-A＊02.

关键词： genotyping techniques group-specific amplification HLA-A*02 antigen mono-allelic sequencing seq uence-based typi ng

Image interpretation: mining the visible and syntactic correlation of annotated words

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第12期10卷 1759-1768页

作者： Ding-yin XIA Fei WU Wen-hao LIU han-wang zhang Scool of Computer Science and Technology Zhejiang University Hangzhou 310027 China

Automatic web image annotation is a practical and effective way for both web image retrieval and image understanding. However, current annotation techniques make no further investigation of the statement-level syntactic correlation among the annotated words, therefore making it very difficult to render natural language interpretation for images such as "pandas eat bamboo". In this paper, we propose an approach to interpret image semantics through mining the visible and textual information hidden in images. This approach mainly consists of two parts: first the annotated words of target images are ranked according to two factors, namely the visual correlation and the pairwise co-occurrence; then the statement-level syntactic correlation among annotated words is explored and natural language interpretation for the target image is obtained. Experiments conducted on real-world web images show the effectiveness of the proposed approach.

关键词： Web image annotation Visibility Pairwise co-occurrence Natural language interpretation

Silodosin is effective for treatment of LUTS in men wii BPH： a systematic review

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2013年第1期15卷 121-128页

作者： Hui Ding Wan Du Zi-Zhen Hou han-zhang wang Zhi-Ping wang Institute of Urology Key Laboratory of Diseases of Urological System Gansu Province Gansu Nephro-Urological Clinical Center The Second Hospital of Lanzhou University Lanzhou China 0tolaryngological Department The Second Hospital of Lanzhou University Lanzhou China The Medical College of Shandong University Jinan China

The aim of this study was to systematically review the evidence on the efficacy and safety of silodosin treatments on lower urinary tract symptoms （LUTS） in men with benign prostatic hyperplasia （BPH） from randomized controlled trials. We searched PubMed （1966- December 2011）, Embase （1974-December 2011） and the Cochrane Library Database （2011, Issue 12）. The assessed outcome measures were the change from baseline for the International Prostate Symptom Score （IPSS）, quality of life （QoL） score, peak urine maximum flow rate （Qmax）, QoL related to urinary symptoms and adverse effects. Two authors independently assessed the study quality and extracted data. All data were analysed using RevMan 5.1. The meta-analysis included four randomized controlled trials with a total of 2504 patients. The study durations were each 12 weeks. At the follow-up end points, the pooled results showed that the change from baseline for the silodosin group was significantly higher than the placebo group for the IPSS, QoL score and Qmax（mean difference （MD）=-2.78, P〈O.O0001; MD=-O.42, P--O.O04; MD= 1.17, P〈***,respectively） and patients felt more satisfied with QoL related to urinary symptoms in the silodosin group than the placebo group. Ejaculation disorder was the most commonly reported adverse effect. The pooled results also showed that the silodosin group was superior to the 0.2 mg tamsulosin group with respect to the IPSS and QoL score （IPSS： MD=- 1.14, P=O.02; QoL score： MD=-0.26, P=O.02） and inferior to the 0.2 mg tamsulosin group with respect to Qmax （MD=-0.85, P=O.01）. In contrast, there was no significant difference in the incidence of ejaculation disorder and dizziness between the silodosin and 0.2 mg tamsulosin groups. The current meta-analysis suggested that silodosin is an effective therapy for LUTS in men with BPH and is not inferior to 0.2 mg tamsulosin.

关键词： benign prostatic hyperplasia (BPH) KMD-3213 lower urinary tract symptoms (LUTS) silodosin tamsulosin systematic review meta-analysis

Photoselective green-light laser vaporisation vs. TURP for BPH. meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第5期14卷 720-725页

作者： Hui Ding Wan Du Ze-Ping Lu Zhen-Xing Zhai han-zhang wang Zhi-Ping wang Institute of Urology Key Laboratory of Urological Diseases in Gansu ProvinceGansu Nephro-Urological Clinical CenterThe Second Hospital of Lanzhou UniversityLanzhou 730000China Otolaryngological Department The Second Hospital of Lanzhou UniversityLanzhou 730000China The Medical College of Shandong University Jinan 250000China

This study sought to evaluate the efficacy and safety of photoselective vaporisation （PVP） vs. transurethral resection of the prostate （TURP） for patients with benign prostatic hyperplasia （BPH）. Eligible studies were identified from electronic databases （Cochrane Library, PubMed and EMBASE）. The database search, quality assessment and data extraction were performed independently by two reviewers. Efficacy （primary outcomes： maximum urinary flow rate （Qmax）, international prostate symptom score （IPSS）, postvoid residual urine （PVR） and quality of life （QoL）; secondary outcomes： operative time, hospital time and catheter removal time） and safety （complications, such as transfusion and capsular perforation） were explored by using Review Manager 5.0. Six randomized controlled trials （RCTs） and five case-controlled studies of 1398 patients met the inclusion criteria. A meta-analysis of the extractable data showed that there were no differences in I PSS, Qmax, QoL or PVR between PVP and TU RP （mean difference （MD）： prostate sizes 〈 70 ml, Qmax at 24 months, MD=0.01, P=0.97; IPSS at 12 months, MD=0.18, P=0.64; QoL at 12 months, MD=-0.00, P=0.96; PVR at 12 months, MD=0.52, P=0.43; prostate sizes 〉70 ml, Qmax at 6 months, MD=-3.46, P=0.33; IPSS at 6 months, MD=3.11, P=0o36; PVR at 6 months, MD=25.50,P=-0.39）. PVP was associated with a shorter hospital time and catheter removal time than TURP, whereas PVP resulted in a longer operative time than TURP. For prostate sizes 〈70 ml, there were fewer transfusions, capsular perforations, incidences of TUR syndrome and clot retentions following PVP compared with TURP. These results indicate that PVP is as effective and safe as TURP for BPH at the mid-term patient follow-up, in particular for prostate sizes 〈70 ml. Due to the different energy settings available for green-light laser sources and the higher efficiency and performance of higher-quality lasers, large-sample, long-term RCTs are required to verify whether different energy

关键词： benign prostatic hyperplasia (BPH) meta-analysis photoselective vaporisation transurethral resection of the prostate(TURP)

Should few retrieved oocytes be as an indication for intracytoplasmic sperm injection?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第9期13卷 717-722页

作者： Qing-song XI Li-xia ZHU Juan HU Li WU han-wang zhang Reproductive Medicine Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective:To reevaluate whether relatively few oocytes obtained in one cycle are an indication for intracytoplasmic sperm injection(ICSI).Methods:A total of 406 cycles with three or fewer retrieved oocytes performed in 396 non-male infertile couples were retrospectively *** were classified into three groups by different fertilization techniques:the in vitro fertilization(IVF) group,insemination with conventional IVF;the ICSI group,insemination with ICSI though semen parameters were normal;and the rescue ICSI group,re-insemination with ICSI after conventional IVF ***:The ICSI group resulted in higher normal fertilization compared with the conventional IVF ***,the cycle cancellation rate was decreased in the ICSI group,though it was not statistically *** clinical pregnancy rate and implantation rate were lower in the ICSI group compared with the conventional IVF *** ICSI was a method to avert total fertilization failure in conventional IVF,increasing fertilization and ensuring embryo availability for transfer,but the normal fertilization was the lowest due to delayed insemination and the chance of pregnancy was very ***:Obtaining only few oocytes in one cycle is not considered as an indication for ICSI when the sperm sample is apparently *** ICSI is either not recommended if conventional insemination *** patients should not be subjected to the unnecessary costs and potential risks of ICSI.

关键词： Fertilization rate Intracytoplasmic sperm injection (ICSI) Indication Oocyte number Patient age

Effect of V on high-temperature mechanical properties of Al-5Cu-1.5Ni alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第7期31卷 1792-1810页

作者： Jun-ge Cui Yong-bin Chen Xiang-zhou Fu Hai-long Yang han-zhang wang An-min Li Li-wen Pan School of Resources Environment and MaterialsGuangxi UniversityNanning 530004GuangxiChina State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning 530004GuangxiChina Guangxi Higher Education Key Laboratory of Advanced Materials Nanning 530004GuangxiChina

The effects of V on microstructure,room temperature,and high-temperature(350℃)mechanical properties of Al-5Cu-1.5Ni alloy were *** results show that Al-5Cu-1.5Ni-xV alloys mainly compriseα-Al,Al_(2)Cu,Al_(3)(Ni,Cu)_(2),Al_(3)Ni,Al7Cu4Ni,and Al_(10)V *** addition of V can signally refineα-Al dendritic structure,which improves the mechanical properties of the as-cast alloys at room and high *** T6 heat treatment(540℃/12 h/WC+170℃/8 h/AC),α-Al,network skeleton structure Al_(3)(Ni,Cu)_(2),and Al_(10)V phases all show coarsening,while the fine nano-θ'-Al_(2)Cu precipitated from the matrix and dispersed *** introduction of V promotes the quantity of precipitatedθ'-Al_(2)Cu *** ultimate tensile strength of the heat-treated alloys at room and high temperatures is greatly improved compared to that of the as-cast *** highest high-temperature ultimate tensile strength of the alloys with V is 111.8 MPa,21.5%higher than that of the base *** analysis shows that the improvement of high-temperature mechanical properties after heat treatment is mainly due to the introduction of V,increasing the precipitated quantity of nano-θ'-Al_(2)Cu particles and improving its thermal *** dispersion strengthening effect ofθ'-Al_(2)Cu particles exceeds the weakening effect of other adverse microstructures on the mechanical properties.

关键词： Al-Cu-Ni-V alloy θ'-Al_(2)Cu phase Heat treatment Microstructure Mechanical property

Transrectal microwave thermotherapy causing a short-time influence on sperm quality in Chinese chronic nonbacterial prostatitis patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2017年第5期19卷 548-553页

作者： Jia-Xin Jin han-zhang wang Zheng-Xing Zhai Bao-Liang Ma Qin-Fang Li Nan Xiao Zhi-Ping wang Ronald Rodriguez Institute of Urology Department of Urology Key Laboratory of Diseases of Urological System Gansu Province Gansu Nephro-Urological Clinical Center LanzhouUniversity Second Hospital The Second Clinical Medical College of Lanzhou University Lanzhou 730000 China Department of Urology University of Texas HealthScience Center 7703 Floyd Curl Drive San Antonio Texas 78229-3900 USA

Chronic prostatitis can affect the sperm＇s quality. Previous studies have shown that transrectal microwave thermotherapy （TRMT） results in symptomatic relief in patients with chronic prostatitis, but the effects on sperm have not been carefully investigated. This study evaluates the impact of TRMT on the relief or decrease of symptoms and quality of sperm when used to treat patients with chronic nonbacterial prostatitis. Sixty patients were enrolled in the study. TRMT treatment was administered over 5 days, 1 h per day. Semen examination was carried out pretreatment and immediately at the conclusion of the 5-day treatment. Also, it was repeated 1 month, 3 months, and 6 months later. The treatment＇s symptom relief efficacy was evaluated using the National Institutes of Health Chronic Prostatitis Symptom Index （NIH-CPSI）. After the treatment, the overall NIH-CPSI scores were lower compared to those of pretreatment. In addition, the white blood cells and lecithin in expressed prostatic secretion were normal after the treatment. The sperm count was decreased by 23.8% 3 months after the treatment, sperm motility was reduced by 10.3% immediately after treatment, and sperm deformity was increased by 17.2%. The sperm volume and PH were not affected. However, the sperm quality recovered after treatment and the malformation rate was also lower at 6 months after treatment. TRMT is a favorable and safe treatment option for patients with nonbacterial chronic prostatitis. It could relieve the patient＇s symptoms and impact on sperm quality in the short-term.

关键词： chronic pelvic pain symptom chronic prostatitis sperm quality transrectal microwave thermotherapy

Association of Genetic Polymorphisms of Anti-Müllerian Hormone (AMH) and Its Type II Receptor with Ovarian Hyperstimulation Syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Reproduction and Contraception 2013年第1期24卷 30-37页

作者： Yi-qing ZHAO han-wang zhang Medical Reproductive Center Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Objective To explore the association of genetic polymorphisms in the genes encoding the anti-Miillerian hormone （AMH） and its type H receptor （AMHRII） with ovarian hyperstimulation syndrome （OHSS）. Methods Using polymerase chain reaction （PCR） and DNA sequencing techniques, the exons of AMH and AMHRII were analyzed in 27 OHSS patients （OHSS group） and 22 non-OHSS patients （control group） who were applied controlled ovarian hyper- stimulation （COH）. Single nucleotide polymorphisms （SNPs） were also analyzed. Results SNPs G〉 T at position 146 of AMH exon 1 and G〉 A at position 134 of AMH exon 2 showed significant differences between the OHSS group and control group （P〈0.05）. SNP G〉 T at position 303 of AMH exon 1 showed no significant difference between the OHSS group and control group （P〉0.05）. No SNP was detected from the AMHR H exons 1 to 11 in either groups. Conclusion Genetic polymorphisms in the AMH gene may be a cause of ovarian hypersensitivity to exogenous hormone stimulation and the development of OHSS.

关键词： ovarian hyperstimulation syndrome (OHSS) anti-Mtillerian hormone (AMH) anti-M/illerian hormone type II receptor (AMHRII) single nucleotidepolymorphisms (SNPs)

Downregulation of the circadian clock gene period 2 aggravates prognosis in breast cancer patients with obesity

在线全文

学校读者我要写书评

暂无评论

Oncology and Translational Medicine 2024年第2期10卷 73-78页

作者： Ru-Xing Wu Dan Hu han-wang zhang Xiao-Yuan Huang Liang Zhuang Reproductive Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Cancer Biology Research Centre Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Cancer Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Background:Obese individuals diagnosed with breast cancer often experience a less favorable prognosis;however,the underlying mechanisms linking obesity to breast cancer outcomes remain *** study aimed to identify and validate novel prognostic markers associated with breast cancer in patients with ***:We conducted a reanalysis of gene expression profiles from normal-weight,overweight,and obese breast cancer patients to identify candidate ***,we validated the protein levels of these candidates using ***,we investigated the association between candidate genes and breast cancer prognosis at Tongji Hospital,utilizing data from an 8-year follow-up through the Kaplan-Meier method and univariate and multivariate Cox regression ***:The fold change of the circadian clock gene period 2(PER2),which exhibited a declining trend with increasing body mass index,was 0.76 in obese patients compared with normal-weight *** expression rates of PER2 protein were 44.7%,51.5%,and 61.3%in normal-weight,overweight,and obese patients,*** 8-year recurrence-free survival rates were 75.9%,69.6%,and 64.1%,whereas the 8-year overall survival rates were 86.8%,83.0%,and 76.1%in normal-weight,overweight,and obese patients,respectively(P<0.05).Furthermore,the 8-year recurrence-free survival rates were 66.2%and 76.4%,and the 8-year overall survival rates were 79.9%and 86.3%in the low and high PER2 expression groups,respectively(P<0.05).The unadjusted hazard ratio for PER2 was 1.550(95%confidence interval,1.029–2.335),and the adjusted hazard ratio was 3.003(95%confidence interval,1.838–4.907).Conclusions:Our findings indicate that low PER2 expression serves as an independent risk factor for breast cancer prognosis and may contribute to the unfavorable outcomes observed in obese patients.

关键词： Breast cancer Obesity PER2 Prognosis

Superplastic Forming and Diffusion Bonding for Sandwich Structure of Ti-6Al-4V Alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2005年第1期21卷 60-62页

作者： Wenbo han, Kaifeng zhang, Guofeng wang and Xiaojun zhangSchool of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, ChinaProf., Ph.D., Sch. of Mat. Sci. and Eng. Harbin Inst. of Technol. Harbin 150001 China

Superplastic forming and diffusion bonding (SPF/DB) is a well-established process for the manufacture of components almost exclusively from Ti-6AI-4V sheet material. The sandwich structure of Ti-6AI-4V alloy is investigated. The effects of the microstructure on the SPF/DB process were discussed. The microstructure at the interfaces and the distribution of thickness were researched.

关键词： Superplastic forming Diffusion bonding Sandwich structure TI-6A1-4V alloy