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Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding yuan-yuan Fang Wen-Jie Fan Chen-yu zhang Shao-Fei Wang Jing Hu Wei han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui yu Yan Xie Jian yu Kun-Ning zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi zhang yu-Ying Tan Li zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 169-175页

作者： Xiao-Jing Shi yu Song Xue-Xue Liang Ting Chen Huang-yu Hao Xue han Ya-Nan Chen Department of Oncology Zhangjiagang First People's HospitalSuzhou 215600Jiangsu ProvinceChina

BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced *** a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table *** control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous *** observation group received the same treatment as the control group,supplemented by oral administration of Senqi Shiyiwei *** groups underwent treatment cycles of 3 weeks,with a minimum of two *** therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the *** objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(P0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.

关键词： Sindilizumab FOLFOX4 chemotherapy Advanced gastric cancer Ginseng Qi Xiangyi granule Clinic treatment

Fos expression in tyrosine hydroxylase-containing neurons in rat brainstem after visceral noxious stimulation:an immunohistochemical study

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World Journal of Gastroenterology 2003年第5期9卷 1045-1050页

作者： Feng han yu-Fei zhang yun-Qing Li Department of Anatomy and K.K.Leung Brain Research Centre,the Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Department of Anatomy and K. K. Leung Brain Research Centre the Fourth Military Medical University Xi''an 710032 Shanxi Province China

AIM: To prove that neurons in the different structures of the brainstem that express tyrosine hydroxylase (TH) are involved in the transmission and modulation of visceral or somatic nociceptive information in ***: Immunohistochemical double-staining method was used to co-localize TH and Fos expression in neurons of the rat brainstem in visceral or subcutaneous noxious stimulation ***: Neurons co-expressing TH/Fos were observed in lateral reticular nucleus (LRT), rostroventrolateral reticular nucleus (RVL), solitary tract nucleus (SOL), locus coeruleus (LC), A5, A7 neuronal groups and ventrolateral subdivision of the periaqueductal gray (vlPAG) in both models. But the proportion and number of the double-labeled neurons responding to the two noxious stimuli were significantly different in the LRT, RVL and LC nuclei. The proportion and number of the TH/Fos double-labeled neurons in the visceral pain model were smaller than that in the subcutaneous pain model. However, in the case of SOL, they were similar in the two ***: Differences of Fos expression in TH immunoreactive neurons in animals after visceral and somatic noxious stimulation indicate that the mechanisms of the transmission and modulation of visceral nociceptive information in the brainstem may be different from that of somatic nociceptive information.

关键词：酪氨酸羟化酶链神经元脑干动物实验内脏损害免疫组织化学 Fos

Preparation and X-ray Crystal Structure of Di-chlorobis (p-t-butylphenylbutyl Sulfide)Palladium(Ⅱ)

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Chinese Journal of Structural Chemistry 1999年第1期18卷 3-5页

作者： ZHAO Bei a GUO Song Shan a WANG han zhang a\ yu Kai Bei b a (Chemistry and Chemical Engineering College, Suzhou University, Suzhou, 215006) b (Chengdu Institute of Organic Chemistry, the Chinese Academy of Sciences, Chengdu, 6

PdCl 2 (CH 3) 3CC 6H 4SC 4H 9- S 2, C 28 H 44 Cl 2S 2Pd, M r =622.0756, triclinic, space group P1, a=10.403(2), b=12.346(2), c=13.475(2) , α=89 11(1)°, β=75.44(1)°, γ=69.52(1)°, ... 详细信息

PdCl 2 (CH 3) 3CC 6H 4SC 4H 9- S 2, C 28 H 44 Cl 2S 2Pd, M r =622.0756, triclinic, space group P1, a=10.403(2), b=12.346(2), c=13.475(2) , α=89 11(1)°, β=75.44(1)°, γ=69.52(1)°, V=1564.2(5)  3, Z=2, D c =1.32 g/cm 3, Mo Kα radiation, μ =9.00 cm -1 , F(000)=647.95, R =0.0316 for 4561 observed reflections with I≥3σ(I) . Pd(Ⅱ) is coordinated by two chloride atoms and two sulfur atoms of organic ligands, forming a rhombic quadrilateral plane with Pd-S of 2.325(1)  and Pd-Cl of 2.295(1) .

关键词： p t butylphenylbutyl sulfide Pd(Ⅱ) complex chloro t butylphenylbutyl sulfide palladium

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普通高校残障学生参与体育课的策略

武汉体育学院学报 2007年第9期41卷 73-76页

作者：韩玉璋郭淑范秦曼上海杉达学院体育教学部上海201209 上海金融学院体育教学部上海201209

通过文献资料法、问卷调查法、数理统计法与逻辑分析法对我国9个城市26所普通高校残障学生参与体育课现状进行调查研究,提出了普通高校残障学生参与体育课的对策,即制定适合残障学生体育锻炼的体育课程,注重特殊体育教师师资培训工作,... 详细信息

通过文献资料法、问卷调查法、数理统计法与逻辑分析法对我国9个城市26所普通高校残障学生参与体育课现状进行调查研究,提出了普通高校残障学生参与体育课的对策,即制定适合残障学生体育锻炼的体育课程,注重特殊体育教师师资培训工作,加强场地、器材与经费管理,加强康复体育的研究和推广工作。

关键词：康复体育残障学生体育课程教学方式

健康教育干预对肝硬化失代偿期患者生活质量的影响

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世界华人消化杂志 2008年第33期16卷 3814-3817页

作者：张汉语瞿金娥刘平郧阳医学院附属太和医院营养科湖北省十堰市442000

目的:探讨健康教育干预对肝硬化失代偿期患者生活质量的影响.方法:选择我院2005-08/2007-07住院的肝硬化失代偿期患者58例,随机分为两组,干预组(n=30)除常规临床治疗外,给予健康教育干预;对照组(n=28)常规临床治疗.治疗前后两组均用SCL... 详细信息

目的:探讨健康教育干预对肝硬化失代偿期患者生活质量的影响.方法:选择我院2005-08/2007-07住院的肝硬化失代偿期患者58例,随机分为两组,干预组(n=30)除常规临床治疗外,给予健康教育干预;对照组(n=28)常规临床治疗.治疗前后两组均用SCL-90量表、健康信念调查表和肝硬化失代偿期患者生活质量表进行评估.结果:健康教育干预后两组心理障碍(焦虑、恐惧、抑郁、敌对、躯体化),健康信念(遵医行为、健康生活方式、治疗满意度、疾病重视程度)和生活质量(躯体、心理、社会及物质状态功能和总分)比较,差异均具有统计学意义(t=4.23,5.31,4.82,5.01,6.44;χ2=33.6,13.72,20.15,24.92;t=10.58,6.61,5.47,4.85,6.72,均P<0.05).结论:对肝硬化失代偿期患者实施健康教育干预可以提高其生活质量.

关键词：健康教育肝硬化失代偿期生活质量

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-yu Chen Pei-Yao Wang Bang Liu Yang-Pu Jia Zhao-Xiong zhang Xin Liu Dao-han Wang Yong-Jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

施用污泥堆肥品对土壤和植物总汞及甲基汞的影响

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环境科学 2017年第1期38卷 405-411页

作者：余亚伟杨雨浛张成易建婷安思危王定勇西南大学资源环境学院重庆400715 重庆市农业资源与环境研究重点实验室重庆400715

采用田间试验,分别施加两种不同的污泥堆肥品(含生物质炭和不含生物质炭),研究污泥堆肥土地利用过程土壤及植物总汞和甲基汞变化情况、迁移转化特征和植物富集能力.结果表明,施加污泥堆肥品会引起土壤总汞和甲基汞含量升高,但总汞含量... 详细信息

采用田间试验,分别施加两种不同的污泥堆肥品(含生物质炭和不含生物质炭),研究污泥堆肥土地利用过程土壤及植物总汞和甲基汞变化情况、迁移转化特征和植物富集能力.结果表明,施加污泥堆肥品会引起土壤总汞和甲基汞含量升高,但总汞含量低于国家土壤环境质量二级标准.生物质炭堆肥品可能促进土壤汞的甲基化,但不同处理土壤甲基汞/总汞(Me Hg/THg)比值较低.植物成熟后不同处理植物总汞含量明显低于幼苗期,而甲基汞含量均高于幼苗期.施加两种堆肥品对植物富集总汞没有明显差异,但对甲基汞富集影响显著.施加生物质炭堆肥品的土壤甲基汞含量明显高于施加无生物质炭堆肥品的土壤,而植物甲基汞含量则相反.生物质炭的加入可能有利于土壤甲基汞形成,但不利于甲基汞的迁移,抑制植物对土壤甲基汞的富集.植物对甲基汞的富集能力较强(富集系数为1.24~14.63),需关注长期施肥带来的土壤环境汞生态风险.

关键词：污泥堆肥品土地利用植物总汞甲基汞富集生物质炭