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Progress in approved drugs from natural product resources

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Chinese Journal of Natural Medicines 2024年第3期22卷 195-211页

作者： LUO Zhongwen yin Fucheng wang Xiaobing KONG Lingyi State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Natural products (NPs) have consistently played a pivotal role in pharmaceutical research, exerting profound impactson the treatment of human diseases. A significant proportion of approved molecular entity drugs are either directly derived from NPs orindirectly through modifications of NPs. This review presents an overview of NP drugs recently approved in China, the United States,and other countries, spanning various disease categories, including cancers, cardiovascular and cerebrovascular diseases, centralnervous system disorders, and infectious diseases. The article provides a succinct introduction to the origin, activity, development process, approval details, and mechanism of action of these NP drugs.

关键词： New drugs Natural products Structural modification

Multistate transition and coupled solid-liquid modeling of motion process of long-runout landslide

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2694-2714页

作者： Yang Gao Yueping yin Bin Li han Zhang Weile Wu Haoyuan Gao Institute of Geomechanics Chinese Academy of Geological SciencesChina Geological SurveyBeijing100081China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesBeijing100081China China Institute of Geological Environment Monitoring China Geological SurveyBeijing100081China School of Geological Engineering and Geomatics Chang’an UniversityXi’an710054China

The recognition,repetition and prediction of the post-failure motion process of long-runout landslides are key scientific problems in the prevention and mitigation of geological *** this study,a new numerical method involving LPF3D based on a multialgorithm and multiconstitutive model was proposed to simulate long-runout landslides with high precision and *** following results were obtained:(a)The motion process of landslides showed a steric effect with mobility,including gradual disintegration and *** sliding mass can be divided into three states(dense,dilute and ultradilute)in the motion process,which can be solved by three dynamic regimes(friction,collision,and inertial);(b)Coupling simulation between the solid grain and liquid phases was achieved,focusing on drag force influences;(c)Different algorithms and constitutive models were employed in phase-state *** volume fraction is an important indicator to distinguish different state types and solid‒liquid *** flume experimental results were favorably validated against long-runout landslide case data;and(d)In this method,matched dynamic numerical modeling was developed to better capture the realistic motion process of long-runout landslides,and the advantages of continuum media and discrete media were combined to improve the computational accuracy and *** new method can reflect the realistic physical and mechanical processes in long-runout landslide motion and provide a suitable method for risk assessment and pre-failure prediction.

关键词： Long-runout landslide Multistate transition Mixed solid‒liquid flow Post-failure process Numerical simulation

Slip distribution inversion of seismic sub-fault dip iteration using gradient based optimizer algorithm

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Geodesy and Geodynamics 2024年第2期15卷 114-121页

作者： Leyang wang han Li Ming Pang Key Laboratory of Mine Environmental Monitoring and Improving Around Poyang Lake of Ministry of Natural Resources East China University of TechnologyNanchang 330013China School of Surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China College of Resources and Environment Shandong Agricultural UniversityTaian 271018China

This paper considers setting different dips for different sub-faults to fit the actual rupture situation based on the fault rupture of the 2013 Lushan M_(S)7.0 ***,combined with the coseismic GNSS data of the Lushan earthquake,the source parameters and sliding distribution of the Lushan earthquake fault are ***,we use the gradient based optimizer(GBO)in nonlinear inversion to obtain the source parameters of this seismic *** inversion results indicate that the strike of the fault is 206.52°,the dip is 44.10°,the length is 21.92 km,and the depth is 12.79 *** refine the sliding distribution of the seismic fault,the seismic fault is divided into 3×3 ***,we fix the central sub-fault dip of 44.10°;the dip of other sub-faults is obtained by *** that,the model is further divided into a fault layer model composed of 23×19 sub fault slices,and using the Matlab fitting function is used to fit the dip of the 23×19 sub ***,the Lushan seismic fault plane is established as a shovel structure with steep upper and gentle lower,steep south and gentle *** slip distribution inversion results indicate that the depth of the slip peak is 13 km,the corresponding maximum slip momentum is 0.67 m,the seismic moment is 1.10×10^(19)N·m and the corresponding moment magnitude is *** results above are consistent with the research results of seismology.

关键词： Gradient basedoptimizer(GBO) Lushan earthquake Non-planefault model Slid distribution

A CRISPR/Cas12a-based platform for rapid on-site bovine viral diarrhea virus diagnostics

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Journal of Integrative Agriculture 2024年第8期23卷 2872-2876页

作者： Meixi wang Jitao Chang Yuxin han Chaonan wang Songkang Qin Jun wang Lulu Zhang Yuanmao Zhu Fei Xue Fang wang Hongliang Chai Yulong wang Xinjie wang Xin yin State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 150040China Institute of Western Agriculture Chinese Academy of Agricultural SciencesChangji 831100China

Bovine viral diarrhea virus(BVDV)is a positive-sense single-stranded RNA virus,belonging to the genus Pestivirus in the Flaviviridae family(Riitho et al.2020).Currently,BVDV is divided into 3 main genotypes,BVDV-1,BVD... 详细信息

关键词： BVDV CRISPR/Cas diarrhea

Stability analysis of tunnel face reinforced with face bolts

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Journal of Mountain Science 2024年第7期21卷 2445-2461页

作者： TIAN Chongming JIANG yin YE Fei OUYANG Aohui han Xingbo SONG Guifeng School of Highway Chang’an UniversityXi’an 710064China Civil Structural&Environmental EngineeringUniversity College CorkCork T12 YF78Ireland Yunnan Laman Expressway Co.Ltd. Xishuangbanna 666300China

Face bolting has been widely utilized to enhance the stability of tunnel face,particularly in soft soil ***,the influence of bolt reinforcement and its layout on tunnel face stability has not been systematically *** on the theory of linear elastic mechanics,this study delved into the specific mechanisms of bolt reinforcement on the tunnel face in both horizontal and vertical *** also identified the primary failure types of ***,a design approach for tunnel face bolts that incorporates spatial layout was established using the limit equilibrium method to enhance the conventional wedge-prism *** proposed model was subsequently validated through various means,and the specific influence of relevant bolt design parameters on tunnel face stability was ***,design principles for tunnel face bolts under different geological conditions were *** findings indicate that bolt failure can be categorized into three stages:tensile failure,pullout failure,and comprehensive *** cohesion,internal friction angle,bolt density,and overlap length can effectively enhance tunnel face *** to significant variations in stratum conditions,tailored design approaches based on specific failure stages are necessary for bolt design.

关键词： Highway tunnels Tunnel face Face bolts Limit equilibrium method Slice method

Small-signal Stability Constrained Optimal Power Flow Considering Eigenvalue Distribution

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1052-1062页

作者： Zheng Huang Kewen wang Yi wang Jing han Jun Liang the School of Electrical and Information Engineering Zhengzhou UniversityZhengzhou 450001China Cardiff University Cardiff CF243AAU.K.

In the existing small-signal stability constrained op-timal power flow(SSSC-OPF)algorithms,only the rightmost ei-genvalue or eigenvalues that do not satisfy a given threshold,e.g.,damping ratio threshold and real-part threshold of eigen-value,are considered in the small-signal stability *** effect of steady-state,i.e.,operating point,changes on eigen-values is not fully taken into *** this paper,the small-signal stability constraint that can fully reflect the eigenvalue change and system dynamic performance requirement is formed by analyzing the eigenvalue distribution on the complex *** small-signal stability constraint is embedded into the standard optimal power flow model for generation *** simultaneous solution formula of the SSSC-OPF is es-tablished and solved by the quasi-Newton approach,while pen-alty factors corresponding to the eigenvalue constraints are de-termined by the stabilization degree of constrained *** improve the computation speed,a hybrid algorithm for ei-genvalue computation in the optimization process is proposed,which includes variable selection for eigenvalue estimation and strategy selection for eigenvalue *** effectiveness of the proposed algorithm is tested and validated on the New England 10-machine 39-bus system and a modified practical 68-machine 2395-bus system.

关键词： Damping ratio eigenvalue optimal power flow quasi-Newton approach sensitivity small-signal stability

A robust viscoelastic surfactant tolerating 20% HCl up to 150℃ for oil well stimulation

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Petroleum Science 2024年第3期21卷 1865-1874页

作者： Ji wang Ning Qi Hong-Yao yin Yu-Jun Feng Polymer Research Institute State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065SichuanPR.China Tianfu Yongxing Laboratory New Theory and Technology of CO_(2) Capture Research CenterChengdu610065SichuanPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

Viscoelastic surfactants(VES)are often used as viscous diverters in acidizing stimulation to prolong the acid consumption time and maximize zonal coverage of the acid for improving well ***,the ceiling temperature of commercial VES cannot exceed 120℃in practical use because of the poor thermal stability and fragile molecular structure,hindering their implementation in hightemperature oil reservoirs,i.e.,≥150℃.Here we synthesized a novel C22-tailed diamine,N-erucaminopropyl-N,N-dimethylamine(EDPA),and examined comparatively its rheological behavior,assemblies morphology and molecular stability in 20 wt%HCl with a commercial VES,erucyl dimethyl amidopropyl betaine(EDAB).The feasibility of EDPA for acidizing stimulation was assessed by acid etching of carbonate rock with its HCl solution at 150℃.Rheological results showed that the 2.5 wt%EDPA—20 wt%HCl solution maintains stable viscosity of 90 m Pa s at 150℃for 60 min,while that of 2.0 wt%EDAB HCl solution is just 1 m Pa s under identical conditions.1H NMR spectra and cryo-TEM observations revealed that the chemical structure and self-assembled architectures of EDPA remained intact in such context,but the EDAB suffered from degradation due to the hydrolysis of the amide group,accounting for the poor heat-resistance and *** reaction rate of 2.5 wt%EDPA HCl solution with carbonate rock was one order of magnitude lower than that of 20 wt%HCl solution at 150℃,underpinning the potential of EDPA to be used in the high-temperature reservoirs *** work improved the thermal tolerance of VES in highly concentrated HCl solution,paving a feasible way for the acidization of high-temperature reservoir environments(~150℃).

关键词： Viscoelastic surfactants Thermal stability Self-diverting acid Wormlike micelles Acidizing stimulation

Enhancing heavy gas capture in confined spaces through ventilation control technology

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Building Simulation 2024年第7期17卷 1161-1182页

作者： Tianqi wang Angui Li Yuanqing Ma ying Zhang Haiguo yin School of Building Services Science and Engineering Xi’an University of Architecture and TechnologyNo.13 Yanta RDXi’anShaanxi710055China

Gas leakage accidents occur frequently in confined spaces,and heavy gases with a relative density greater than 1.15 among hazardous gases and greenhouse gases are commonly stored in confined ***,atmospheric pollutant emission standards are becoming more stringent,and it is essential to remove heavy gas after accidents while reducing emissions to the *** study proposes using a heavy gas collection tank(HGCT)to safeguard the internal environment and minimize emissions to the *** capture efficiencies applicable to heavy-gas environments under different ventilation strategies are *** research analyzes the impact of the exhaust rate,leakage rate,density of heavy gas,and air supply modes on the indoor concentration *** results demonstrate that the mass flow rate of heavy gas into the exhaust is positively correlated with the exhaust rate,but the gas from the exhaust system contains more *** exhaust rate should be greater than four times the space volume per hour;otherwise,heavy gas above 1000 ppm accumulates to a height of 0.67 m at ground ***,attachment ventilation as make-up air helps to reduce upstream heavy gas accumulation and reduces the extension of heavy gas along the room *** an HGCT with floor slope and attachment ventilation achieves an efficiency of 96.28%.This study provides valuable insights and references for preventing hazardous heavy gas leakage.

关键词： confined gases otherwise

A general descriptor for guiding the electrolysis of CO_(2)in molten carbonate

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Green Energy & Environment 2024年第4期9卷 748-757页

作者： Zhengshan Yang Bowen Deng Kaifa Du Huayi yin Dihua wang School of Resource and Environmental Sciences Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and EnergyWuhan UniversityWuhan430072China

Molten carbonate is an excellent electrolyte for the electrochemical reduction of CO_(2)to carbonaceous ***,the electrolyte–electrode-reaction relationship has not been well ***,we propose a general descriptor,the CO_(2)activity,to reveal the electrolyte–electrode-reaction relationship by thermodynamic calculations and experimental *** studies agree well with theoretical predictions that both cations(Li^(+),Ca^(2+),Sr^(2+)and Ba^(2+))and anions(BO_(2)^(-),Ti_(5)O_(14)^(8-),SiO_(3)^(2-))can modulate the CO_(2)activity to control both cathode and anode reactions in a typical molten carbonate electrolyzer in terms of tuning reaction products and *** this regard,the reduction of CO_(3)^(2-)can be interpreted as the direct reduction of CO_(2)generated from the dissociated CO_(3)^(2-),and the CO_(2)activity can be used as a general descriptor to predict the electrode reaction in molten ***,the CO_(2)activity descriptor unlocks the electrolyte–electrode-reaction relationship,thereby providing fundamental insights into guiding molten carbonate CO_(2)electrolysis.

关键词： Molten carbonate CO_(2)activity CO_(2)RR Electrolyte engineering Carbon