检索结果-南通市图书馆

China Ocean Engineering 2024年第2期38卷 233-246页

作者： DING Xin-dong WANG Shu-qing LIU Wen-cheng YE Xiao-han College of Engineering Ocean University of ChinaQingdao 266100China Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China Department of Marine Technology Norwegian University of Science and Technology(NTNU)Trondheim NO-7491Norway

The collapse pressure is a key parameter when RTPs are applied in harsh deep-water *** investigate the collapse of RTPs,numerical simulations and hydrostatic pressure tests are *** the numerical simulations,the eigenvalue analysis and Riks analysis are combined,in which the Hashin failure criterion and fracture energy stiffness degradation model are used to simulate the progressive failure of composites,and the“infinite”boundary conditions are applied to eliminate the boundary *** for the hydrostatic pressure tests,RTP specimens were placed in a hydrostatic chamber after filled with *** has been observed that the cross-section of the middle part collapses when it reaches the maximum *** collapse pressure obtained from the numerical simulations agrees well with that in the ***,the applicability of NASA SP-8007 formula on the collapse pressure prediction was also *** has a relatively greater difference because of the ignorance of the progressive failure of *** the parametric study,it is found that RTPs have much higher first-ply-failure pressure when the winding angles are between 50°and 70°.Besides,the effect of debonding and initial ovality,and the contribution of the liner and coating are also discussed.

关键词： reinforced thermoplastic pipes post-buckling behavior progressive failure of composites debonding initial ovality

维普期刊数据库

Real-world insights for the evolving intervention strategy for non-mild acute pancreatitis: 35-year experience in a Chinese Tertiary Center

在线全文

学校读者我要写书评

暂无评论

胰腺病学杂志(英文) 2024年第2期7卷 111-118页

作者： Yan Xiaxiao Zhou Jingya Cao Jian Xu Qiang han Xianlin Wang Duan Zhang Shengyu wu dong Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Medical Records Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China WHO Family of International Classifications Collaborating Center of China Beijing China Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Background: With the accumulation of experience and evidence, guidelines for invasive intervention for acute pancreatitis (AP) have continuously evolved, followed in Peking Union Medical College Hospital (PUMCH). We aimed to review AP case series to help understand the impact of guideline evolution on the management and prognosis of AP in real-world ***: This was a single-center study of AP patients who had received invasive interventions from 1988 to 2022. Patient demographics, baseline severity, imaging findings, and the indication, timing, and specific modalities of invasive interventions were collected. The composite primary endpoint was death during hospitalization or major complications after intervention. Other endpoints included pancreatic fistula, incision infection, number of interventions, length of intensive care stay, length of hospitalization, and total medical ***: A total of 195 patients were included. The most common indication for invasive intervention was suspected infection, followed by persistent symptoms. The step-up and delayed strategies reduced the incidence of major complications or death. Over 35 years, the number of patients requiring surgery has gradually declined, and more patients need only minimally invasive procedures for remission. The incidence of the primary outcome decreased as well as the duration of ***: The management of AP patients at PUMCH in the last 35 years has undergone therapeutic guideline changes that support the efficacy and safety of the deferred step-up strategy in real-world practice.

关键词： Acute pancreatitis Drainage Invasive intervention Necrosectomy Step-up

Key genes and regulatory networks for diabetic retinopathy based on hypoxia-related genes:a bioinformatics analysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1411-1417页

作者： Cai-han Yu Cai-Xia wu Dai Li Lan-Lan Gong Xu-dong Lyu Jie Yang Department of Ophthalmology Xianning Central HospitalThe First Affiliated Hospital of Hubei University of Science and TechnologyXianning 437100Hubei ProvinceChina School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100Hubei ProvinceChina School of Optometry Hubei University of Science and TechnologyXianning 430071Hubei ProvinceChina

AIM:To prevent neovascularization in diabetic retinopathy(DR)patients and partially control disease ***:Hypoxia-related differentially expressed genes(DEGs)were identified from the GSE60436 and GSE102485 datasets,followed by gene ontology(GO)functional annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** candidate drugs were screened using the CMap ***,a protein-protein interaction(PPI)network was constructed to identify hypoxia-related hub genes.A nomogram was generated using the rms R package,and the correlation of hub genes was analyzed using the Hmisc R *** clinical significance of hub genes was validated by comparing their expression levels between disease and normal groups and constructing receiver operating characteristic curve(ROC)***,a hypoxia-related miRNA-transcription factor(TF)-Hub gene network was constructed using the NetworkAnalyst online ***:Totally 48 hypoxia-related DEGs and screened 10 potential candidate drugs with interaction relationships to upregulated hypoxia-related genes were identified,such as ruxolitinib,meprylcaine,and *** addition,8 hub genes were also identified:glycogen phosphorylase muscle associated(PYGM),glyceraldehyde-3-phosphate dehydrogenase spermatogenic(GAPDHS),enolase 3(ENO3),aldolase fructose-bisphosphate C(ALDOC),phosphoglucomutase 2(PGM2),enolase 2(ENO2),phosphoglycerate mutase 2(PGAM2),and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3).Based on hub gene predictions,the miRNA-TF-Hub gene network revealed complex interactions between 163 miRNAs,77 TFs,and hub *** results of ROC showed that the except for GAPDHS,the area under curve(AUC)values of the other 7 hub genes were greater than 0.758,indicating their favorable diagnostic ***:PYGM,GAPDHS,ENO3,ALDOC,PGM2,ENO2,PGAM2,and PFKFB3 are hub genes in DR,and hypoxia-related hub genes exhibited favorable diagnostic perform

关键词： diabetic retinopathy hypoxia-related genes hub genes miRNA-TF-Hub gene drug prediction

Effect of chemical regulators on the recovery of leaf physiology,dry matter accumulation and translocation,and yield-related characteristics in winter wheat following dry-hot wind

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第1期23卷 108-121页

作者： Yanan Xu Yue wu Yan han Jiqing Song Wenying Zhang Wei han Binhui Liu Wenbo Bai Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Dryland Farming Research Hebei Academy of Agriculture and Forestry SciencesHengshui 053000China Shandong General Station of Agricultural Technology Extension Jinan 250100China

Dry-hot wind stress causes losses in wheat productivity in major growing regions worldwide,especially winter wheat in the Huang-Huai-Hai Plain of China,and both the occurrence and severity of such events are likely to increase with global climate *** investigate the recovery of physiological functions and yield formation using a new noncommercial chemical regulator(NCR)following dry-hot wind stress,we conducted a three-year field experiment(2018-2021)with sprayed treatments of tap water(control),monopotassium phosphate(CKP),NCR at both the jointing and flowering stages(CFS),and NCR only at the jointing stage(FSJ)or flowering stage(FSF).The leaf physiology,biomass accumulation and translocation,grain-filling process,and yield components in winter wheat were *** the single spraying treatments,the FSJ treatment was beneficial for the accumulation of dry matter before anthesis,as well as larger increases in the maximum grain-filling rate and mean grain-filling *** FSF treatment performed better in maintaining a high relative chlorophyll content as indicated by the SPAD value,and a low rate of excised leaf water loss in flag leaves,promoting dry matter accumulation and the contribution to grain after anthesis,prolonging the duration of grain filling,and causing the period until the maximum grain-filling rate reached *** CFS treatment was better than any other treatments in relieving the effects of dry-hot *** exogenous NCR treatments significantly increased grain yields by 12.45-18.20% in 2018-2019,8.89-13.82% in 2019-2020,and 8.10-9.00% in *** conventional measure of the CKP treatment only increased grain yield by 6.69% in *** CFS treatment had the greatest mitigating effect on yield loss under dry-hot wind stress,followed by the FSF and FSJ treatments,and the CKP treatment only had a minimal *** summary,the CFS treatment could be used as the main chemical control measure for wheat stress resistance and yield

关键词： preparation stress foliar spraying grain-filling remobilization

维普期刊数据库

LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation in Paralichthys olivaceus

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第1期45卷 25-35页

作者： Xian-Hui Ning Bing han Ye Peng Shao-wu Yin College of Marine Science and Engineering Nanjing Normal UniversityNanjingJiangsu 210023China CAS Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdaoShandong 266071China Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province LianyungangJiangsu 222005China

Long non-coding RNAs(lncRNAs)function as key modulators in mammalian immunity,particularly due to their involvement in lncRNA-mediated competitive endogenous RNA(ceRNA)*** their recognized significance in mammals,research on lncRNAs in lower vertebrates remains *** the present study,we characterized the first immune-related lncRNA(pol-lnc78)in the teleost Japanese flounder(Paralichthys olivaceus).Results indicated that pol-lnc78 acted as a ceRNA for pol-miR-n199-3p to target the sterile alpha and armadillo motif-containing protein(SARM),the fifth discovered member of the Toll/interleukin 1(IL-1)receptor(TIR)adaptor *** ceRNA network regulated the antibacterial responses of flounder via the Toll-like receptor(TLR)signaling ***,SARM acted as a negative regulator and exacerbated bacterial infection by inhibiting the expression of inflammatory cytokines IL-1βand tumor necrosis factor-α(TNF-α).Pol-miR-n199-3p reduced SARM expression by specifically interacting with the 3’untranslated region(UTR),thereby promoting SARM-dependent inflammatory cytokine expression and protecting the host against bacterial ***,pol-lnc78 sponged pol-miR-n199-3p to ameliorate the inhibition of SARM *** infection,the negative regulators pol-lnc78 and SARM were significantly down-regulated,while pol-miR-n199-3p was significantly up-regulated,thus favoring host antibacterial *** findings provide novel insights into the mechanisms underlying fish immunity and open new horizons to better understand ceRNA crosstalk in lower vertebrates.

关键词： LncRNA SARM miRNA ceRNA Antibacterial response

维普期刊数据库

An ultra-sensitive biosensor for circulating microRNA detection with Fe single-atom enhanced cathodic luminol-O2 electrochemiluminescence

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第9期17卷 7926-7934页

作者： Yudie Sun Yunxiang han Mingyue Wang Mingfu Ye Konglin wu Kui Zhang School of Chemistry and Chemical Engineering Anhui University of TechnologyMa'anshan 243032China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOEQingdao University of Science and TechnologyQingdao 266042China Engineering Research Center of Biofilm Water Purification and Utilization Technology of Ministry of Education Anhui University of TechnologyMa'anshan 243032China

Circulating microRNAs(miRNAs)play a pivotal role in the occurrence and development of acute myocardial infarction(AMI),and precise detection of them holds significant clinical *** development of luminol-based luminophores in the field of electrochemiluminescence(ECL)for miRNA detection has been significant,while their effectiveness is hindered by the instability of co-reactant hydrogen peroxide(H_(2)O_(2)).In this work,an iron single-atom catalyst(Fe-PNC)was employed for catalyzing the luminol-O2 ECL system to achieve ultra-sensitive detection of myocardial *** miRNA triggers a hybridization chain reaction(HCR),resulting in the generation of a DNA product featuring multiple sticky ends that facilitate the attachment of Fe-PNC probes to the electrode *** Fe-PNC catalyst exhibits high promise and efficiency for the oxygen reduction reaction(ORR)in electrochemical energy conversion *** resulting ECL biosensor allowed ultrasensitive detection of myocardial miRNA with a low detection limit of 0.42 fM and a wide linear range from 1 fM to 1.0 ***,it demonstrates exceptional performance when evaluated using serum samples collected from patients with *** work expands the application of single-atom catalysis in ECL sensing and introduces novel perspectives for utilizing ECL in disease diagnosis.

关键词： circulating miRNAs single-atom catalyst luminol-O2 electrochemiluminescence hybridization chain reaction

Large-scale manufacturing of functional single-atom ink for convenient glucose sensing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 7256-7263页

作者： Muyu Yan Xiaofei Zhu Can Xiong Xiao han Zhenggang Xue Yuen wu Department of Endocrinology Institute of Endocrine and Metabolic DiseasesThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Deep Space Exploration Laboratory University of Science and Technology of ChinaHefei 230026China NEST Laboratory Department of PhysicsDepartment of ChemistryCollege of ScienceShanghai UniversityShanghai 200444China Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China

Printing techniques hold great potential in the manufacture of electronics such as sensors,micro-supercapacitors,and flexible ***,developing large-scale functional conductive inks with appropriate rheological properties and active components still remains a ***,through optimizing the formulations of ink,iron single sites supported N-doped carbon black(Fe_(1)-NC)inks can serve as both conductive electrodes and high-reactive catalysts to realize convenient glucose detection,which pronouncedly reduces the dosage of enzyme and simplifies the sensors *** detail,utilizing in-situ pyrolysis method,Fe_(1)-NC single-atom catalysts(SACs)are prepared in bulk(dekagram-level).The batched Fe_(1)-NC SACs materials can be uniformly mixed with modulated ink to realize the screen printing with high resolution and ***,the whole scalable preparation and ink-functional process can be extended to various metals(including Co,Ni,Cu,and Mn).The introduction of highly active Fe_(1)-NC sites reduces the amount of enzyme used in glucose detection by at least 50%,contributing to the cost reduction of *** strategy in harnessing the SACs onto the carbon inks thus provides a broad prospect for the low-cost and large-scale printing of sensitive sensing devices.

关键词： large-scale manufacturing single-atom inks screen printing glucose sensing low enzyme dosage

Optimized Design of Bio-Inspired Wind Turbine Blades

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2024年第7期20卷 1647-1664页

作者： Yuanjun Dai dong Wang Xiongfei Liu Weimin wu School of Mechanical Engineering Shanghai DianJi UniversityShanghai201306China School of Information Engineering Yinchuan University of Science and TechnologyYinchuan750000China School of Mechanical and Power Engineering Chongqing University of Science and TechnologyChongqing401331China School of Aeronautical Mechanical and Electrical Engineering Chongqing Aerospace PolytechnicChongqing400021China

To enhance the aerodynamic performance of wind turbine blades,this study proposes the adoption of a bionic airfoil inspired by the aerodynamic shape of an *** on the blade element theory,a non-uniform extraction method of blade elements is employed for the optimization design of the considered wind turbine ***,Computational Fluid Dynamics(CFD)is used to determine the aerodynamic performances of the eagle airfoil and a NACA2412 airfoil,thereby demonstrating the superior aerodynamic performance of the ***,a mathematical model for optimizing the design of wind turbine blades is introduced and a comparative analysis is conducted with respect to the aerodynamic performances of blades designed using a uniform extraction *** is found that the blades designed using non-uniform extraction exhibit better aerodynamic performance.

关键词： Airfoil wind turbines blade design CFD

Radiation build-up and dissipation in Raman random fiber laser

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第1期67卷 254-260页

作者： Shengtao LIN Zinan WANG Jiaojiao ZhanG Pan WANG han wu Yifei QI Key Laboratory of Optical Fiber Sensing and Communications University of Electronic Science and Technology of China College of Electronics and Information Engineering Sichuan University

Raman random fiber laser(RRFL) is a complex physical system that arises from the distributed Raman amplification and the intrinsic stochasticity of fiber *** analysis of the underlying lightwave kinetics at steady state has been the focus of considerable ***,the transient state,such as the RRFL build-up and dissipation,is particularly important for revealing the lightwave interaction ***,we investigate for the first time the RRFL dynamics at the transient state and track the RRFL temporal and spectral evolution theoretically and ***,with the contribution of random distributed feedback,RRFL build-up exhibits continuous Verhulst logistic growth curves without cavity-related features,which is significantly different from the step-like growth curve of conventional fiber ***,the radiation build-up duration is inversely related to the pump power,and the spectral evolution of the RRFL undergoes two phases,i.e.,from spectral density increase to spectral *** the steady state to the pump switch-off state,the RRFL output power dissipates immediately,and the remaining Stokes lightwave from the Rayleigh scattering will gradually disappear after one round *** work provides new insights into the transient dynamic features of the RRFL.

关键词： random fiber laser stimulated Raman scattering transient phenomenon nonlinear optics łinebreak biological growth dynamics

Generating empathetic responses through emotion tracking and constraint guidance

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第2期18卷 243-245页

作者： Jing LI donghong han Zhishuai GUO Baiyou QIAO Gang wu School of Computer Science and Engineering Northeastern UniversityShenyang 110000China Key Laboratory of Intelligent Computing in Medical Image(Ministry of Education) Northeastern UniversityShenyang 110000China Neusoft Corporation Shenyang 110000China

1 Introduction Empathy is an essential human trait,which reflects the ability of understanding and reflecting on the thoughts and feelings of *** empathetic dialogue system can improve user's experience and establishlong-termhuman-machine *** speaker's emotions and predict response's emotions are necessary steps in empathetic dialogue generation.

关键词： interaction. constraint steps