检索结果-南通市图书馆

Ocular surface changes in moderate-to-severe acne vulgaris

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1049-1057页

作者： Ci-Yi Pan Dong-Jie Sun han-ling li li Ma Min Zhang Song-Yuan Tang Hui Zhang Department of Ophthalmology First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Dermatology First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Stomatology the First People’s Hospital of Yunnan ProvinceKunming 650100Yunnan ProvinceChina Institute of Health Studies School of Public HealthKunming Medical UniversityKunming 650500Yunnan ProvinceChina

AIM:To investigate ocular surface disorders and tear function changes in patients with acne vulgaris and explore the potential relationship between acne vulgaris and dry ***:This cross-sectional study included right eyes of 53 patients with acne vulgaris and 54 healthy *** participants completed the Ocular Surface Disease Index(OSDI)*** following ocular surface-related parameters were measured:tear meniscus height(TMH),noninvasive tear breakup time(NIBUT),Schirmer I test(SIT),lipid layer thickness(LLT)score of the tear film,meibum score,meibomian gland orifice obstruction score,the ratio of meibomian gland loss,conjunctival hyperemia score,and corneal fluorescein staining(CFS)***:The stability of the tear film decreased in acne vulgaris *** the acne group,the TMH and NIBUT were lower,whereas the OSDI,meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss,and conjunctival hyperemia score were higher compared with controls(P0.05).In two dry eye groups,the TMH,NIBUT,and LLT score were lower in the acne with dry eye(acne-DE)group,and the meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss and conjunctival hyperemia score in the acne-DE group were higher(P0.05).CONCLUSION:Patients with moderate-to-severe acne vulgaris are more likely to experience dry eye than those without acne *** tear film stability and meibomian gland structure dysfunction are more pronounced in patients with moderate-to-severe acne and dry eye.

关键词： acne vulgaris meibomian gland dysfunction dry eye tear film

Flow Boiling Heat Transfer Characteristics and Delayed Dry-Out Ability of Non-Azeotropic Mixtures R245fa/R134a in Microchannels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第3期33卷 1174-1188页

作者： LU Yongjie ling Yongjun ZHUANG Yuan li Chenyang OUYANG Hongsheng han Xiaohong Key Laboratory of Refrigeration and Cryogenic Technology of Zhejiang Province Institute of Refrigeration and CryogenicsZhejiang UniversityHangzhou310007China Zhejiang Zhongguang Electrical Co. Ltd.Lishui323000China State Key Lab for Fluorine Greenhouse Gases Replacement and Control Treatment Zhejiang Research Institute of Chemical IndustryHangzhou310014China

Microchannel flow boiling heat transfer has the advantages of strong heat dissipation capacity,good temperature uniformity,and compact *** is an excellent way to thermally manage electronic devices,but when the heat flux exceeds CHF(Critical Heat Flux),the heat transfer performance deteriorates as the working fluid dries ***-azeotropic mixtures have the potential to effectively delay or avoid dry-out during the boiling process due to their temperature slide characteristics which causes the mass transfer *** understand the influence of non-azeotropic mixtures on microchannel flow boiling,using the phase-change microchannel heat sink as the research object,the experiments on the flow boiling heat transfer performance of R245fa/R134a mixtures under different working conditions were carried out,and the characteristics of flow boiling heat transfer were obtained under the different working conditions,and comparison was developed with those of pure substance *** results demonstrated that a small amount of low-boiling-point components in the high-boiling-point working fluid inhibited boiling heat transfer to some extent,and lowered the average heat transfer coefficient under the non-dryout condition slightly lower than that of the pure substance;however,it also effectively delayed the onset of local dry-out and prevented significant deterioration in thermal transfer performance under the lower mass flow rate and higher heat flux,which could enhance the heat sink's stability.

关键词： microchannel flow boiling non-azeotropic mixture heat transfer characteristics dry-out

Vitamin D binding protein in psychiatric and neurological disorders:Implications for diagnosis and treatment

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 324-334页

作者： ling li Bing han Yan Kong Gaojia Zhang Zhijun Zhang Research Institution of Neuropsychiatry School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalNanjingJiangsu 210009China Department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care MedicineSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biochemistry and Molecular Biology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Brain Cognition and Brain Disease Institute Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China

Vitamin D binding protein(VDBP)serves as a key transporter protein responsible for binding and delivering vitamin D and its metabolites to target *** plays a crucial part in the inflammatory reaction following tissue damage and is engaged in actin *** research has shed light on its potential role in various diseases,leading to a growing interest in understanding the implications of VDBP in psychiatric and neurological *** purpose of this review was to provide a summary of the existing understanding regarding the involvement of VDBP in neurological and psychiatric *** examining the intricate interplay between VDBP and these disorders,this review contributes to a deeper understanding of underlying mechanisms and potential therapeutic *** gained from the study of VDBP could pave the way for novel strategies in the diagnosis,prognosis,and treatment of psychiatric and neurological disorders.

关键词： Neurological disorder Polymorphism Psychiatric disorder Structure Vitamin D binding protein

A Compact Filtering Antenna System with Wide-Angle Scanning Capability for V2I Communication

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第2期33卷 516-526页

作者： Chuang han Tong li Zhaolin ZhanG ling WANG Guangwei YANG School of Electronics and Information Northwestern Polytechnical University School of Electronic Engineering and Computer Science Queen Mary University of London

A compact filtering antenna system with wide-angle scanning is proposed for vehicle to infrastructure(V2I) communication which would handle complex communication scenarios. In this work, a wide beam filtering antenna is realized by using some inductive resistance structures such as metal pins and pillars, and capacitive structures such as slots, parasitical patches to produce the radiation nulls at two sides of the operating frequency band and improve the impedance matching in the passband. Meanwhile, the wide beam capability is also realized by the above structure. Furthermore, two H-and E-plane linear arrays are designed for the beam scanning capability with filtering characteristics based on the proposed antenna. To verify the proposed design concept, a prototype is fabricated and measured. The measurement and simulation agree well, demonstrating an excellent filtering characteristic with the operating frequency band from 3.18 to 3.45 GHz(about 8.1%), the high total efficiency of about 88%, and 3-d B-beamwidth of more than 100° and 120° in the above two arrays, respectively. Additionally, the proposed arrays can realize the beam scanning up to the coverage of 112° and 120° with a lower gain reduction and a good filtering characteristic, respectively.

关键词： Antenna measurements Radio frequency Resistance Slot antennas Filtering Communication systems Vehicle-to-infrastructure

同方期刊数据库

New insights into the pre-lithiation kinetics of single-crystalline Ni-rich cathodes for long-life li-ion batteries

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第3期9卷 556-564页

作者： Qiang han Lele Cai Zhaofeng Yang Yanjie Hu Hao Jiang Chunzhong li Shanghai Engineering Research Center of Hierarchical Nanomaterials School of Chemical EngineeringEast China University of Science and TechnologyShanghai200237China Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China

Developing single-crystalline Ni-rich cathodes is an effective strategy to improve the safety and cycle life of li-ion batteries(liBs).However,the easy-to-loss of li and O in high-temperature lithiation results in unsatisfactory ordered layered structure and ***,we demonstrate the synthesis of highly-ordered and fully-stoichiometric single-crystalline liNi_(0.83)Co_(0.12)Mn_(0.05)O_(2)(SC-NCM83)cathodes by the regulation of pre-lithiation *** well-balanced pre-lithiation kinetics have been proved to greatly improve the proportion of layered phase in the intermediate by inhibiting the formation of metastable spinel phase,which promoted the rapid transformation of the intermediate into highly-ordered layered SC-NCM83 in the subsequent lithiation *** coating a layer of li_(2)O–B_(2)O_(3),the resultant cathodes deliver superior cycling stability with 90.9%capacity retention at 1C after 300 cycles in pouch-type full *** enhancement mechanism has also been *** findings exhibit fundamental insights into the pre-lithiation kinetics process for guiding the synthesis of high-quality singlecrystalline Ni-rich cathodes.

关键词： Single-crystalline cathode Ni-rich oxides Pre-lithiation li-ion batteries Surface modification

Development and validation of a prediction model for early screening of people at high risk for colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第5期30卷 450-461页

作者： ling-li Xu Yi lin li-Yuan han Yue Wang Jian-Jiong li Xiao-Yu Dai Department of General Surgery Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina Center for Health Economics Faculty of Humanities and Social SciencesUniversity of NottinghamNingbo 315100Zhejiang ProvinceChina Department of Global Health Ningbo Institute of Life and Health IndustryUniversity of Chinese Academy of SciencesNingbo 315000Zhejiang ProvinceChina School of Public Health Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a serious threat *** early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still not *** China,the incidence of CRC in the Yangtze River Delta region is increasing dramatically,but few studies have been ***,it is necessary to develop a simple and efficient early screening model for *** To develop and validate an early-screening nomogram model to identify individuals at high risk of *** Data of 64448 participants obtained from Ningbo Hospital,China between 2014 and 2017 were retrospectively *** cohort comprised 64448 individuals,of which,530 were excluded due to missing or incorrect *** 63918,7607(11.9%)individuals were considered to be high risk for CRC,and 56311(88.1%)were *** participants were randomly allocated to a training set(44743)or validation set(19175).The discriminatory ability,predictive accuracy,and clinical utility of the model were evaluated by constructing and analyzing receiver operating characteristic(ROC)curves and calibration curves and by decision curve ***,the model was validated internally using a bootstrap resampling *** Seven variables,including demographic,lifestyle,and family history information,were *** logistic regression analysis revealed that age[odds ratio(OR):1.03,95%confidence interval(CI):1.02-1.03,Plifestyle(OR:0.45,95%CI:0.42-0.48,Plifestyle was a protective factor,whereas family history was the most significant risk *** area under the curve was 0.734(95%CI:0.723-0.745)for the final validation set ROC curve and 0.735(95%CI:0.728-0.742)for the training s

关键词： Colorectal cancer Early screening model High-risk population Nomogram model Questionnaire survey Dietary habit living habit

Fracture sealing performance of granular lost circulation materials at elevated temperature:A theoretical and coupled CFD-DEM simulation study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第1期21卷 567-581页

作者： Chong lin Qi-Cong Xu lie-Xiang han Gao li Hai He Hong-ling Zhou Ji-Ping She CCDC Drilling&Production Technology Research Institute Guanghan618300SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina College of Materials Science and Engineering Chongqing UniversityChongqing400044China State Key Lab of Oil and Gas Reservoir Geology and Exploitation(Chengdu University of Technology) Chengdu610059SichuanChina College of Energy Chengdu University of TechnologyChengdu610059SichuanChina

Lost circulation is a common downhole problem of drilling in geothermal and high-temperature,high-pressure(HTHP)*** circulation material(LCM)is a regular preventive and remedial measure for lost ***,conventional LCMs seem ineffective in high-temperature *** may be due to the changes in the mechanical properties of LCMs and their sealing performance under high-temperature *** understand how high temperature affects the fracture sealing performance of LCMs,we developed a coupled computational fluid dynamics-discrete element method(CFD-DEM)model to simulate the behavior of granular LCMs in *** summarized the literature on the effects of high temperature on the mechanical properties of LCMs and the rheological properties of drilling *** conducted sensitivity analyses to investigate how changing LCM slurry properties affected the fracture sealing efficiency at increasing *** results show that high temperature reduces the size,strength,and friction coefficient of LCMs as well as the drilling fluid ***,softer,and less frictional LCM particles have lower bridging probability and slower bridging *** particles tend to form dual-particle bridges rather than single-particle *** result in a deeper,tighter,but unstable sealing *** drilling fluid viscosity leads to faster and shallower sealing zones.

关键词： Geothermal well drilling HTHP formationLost circulation material CFD-DEM Fracture sealing

Poly(3-hexylthio) thiophene Field-effect Transistor Device Performance: Impact of the Content of Hexylthio Side Chain on Backbone

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第1期42卷 14-23,I0005页

作者： Hao-Yu liu lian-He han ling-Wei Kong li-Ping Zhu Xiao-Lan Qiao Mei-Fang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Regioregular poly(3-hexylthio)thiopene(P3HTT) has emerged tremendous potential in organic electronic applications due to the strong noncovalent interactions from the sulfur atom linked to thiophene. However, P3HTT generally exhibits low charge mobility mostly due to poor solution processability attributed to dense arrangement of hexylthio side chain in polymer, which led to strong noncovalent interactions among sulfur atoms. To balance the nonvalent interaction and aggregation for P3HTT, herein, we systematically study the effect of hexylthio side chain content in polymer backbone on the structure and properties. A series of regioregular P3HTT-based homopolymers(P3HTT, P3HTT-50,P3HTT-33 and P3HTT-25) were prepared via Kumada catalyst transfer polycondensation method from a set of mono-, bi-, ter-and quarterthiophenes containing different contents of hexylthio side chain. The DFT calculation shows the planarity of polymers backbone could be improved through reducing the density of hexylthio side chain in polymer mainchain. And significant changes in their crystallinity, aggregation and optical properties were observed with the content of hexylthio side chain reducing. The P3HTT-33 displayed the highest field-effect transistor hole mobility of 2.83×10^(-2) cm^(2)·V^(-1)·s^(-1) resulting from a balance between the crystallinity and planarity. This study demonstrates modulating the content of hexylthio side chain in P3HTT is an effective strategy to optimize the opto-electronic properties of polymer obtaining excellent semiconductor device performance.

关键词： Conjugated polymer Polythiophene Noncovalent interaction Molecular aggregation Organic field-effect transistor

Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第2期16卷 306-321页

作者： Jiayi Wu Feifei li Peng Yu Changhao Yu Chuyi han Yitian Wang Fanyuan Yu ling Ye State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal *** extensive studies on mineralized parenchymal tissue rebuilding,regenerating and maintaining undifferentiated mesenchyme within calvarial bone remain very challenging with limited advances *** knowledge has evidenced the indispensability of rebuilding suture mesenchymal stem cell niches to avoid severe brain or even systematic *** to date,the absence of promising therapeutic biomaterials/scaffolds *** reason lies in the shortage of fundamental knowledge and methodological evidence to understand the cellular fate regulations of *** address these issues,in this study,we systematically investigated the cellular fate determinations and transcriptomic mechanisms by distinct types of commonly used calvarial *** data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.A feasible scaffold,polylactic acid electrospinning membrane(PLA),was next identified to precisely control mesenchymal ingrowth and self-renewal to rebuild non-osteogenic suture-like tissue at the defect center,meanwhile supporting proper osteointegration with defect bony ***,transcriptome analysis and cellular mechanisms underlying the well-orchestrated cell fate determination of PLA were *** study for the first time cellularly decoded the fate regulations of scaffolds in suture-bony composite defect healing,offering clinicians potential choices for regenerating such complicated injuries.

关键词： injuries healing suture