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The synergistic regulatory effect of PTP1B and PTK inhibitors on the development of Oedaleus decorus asiaticus Bei-Bienko

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Journal of Integrative Agriculture 2024年第8期23卷 2752-2763页

作者： Shuang Li Sibo liu Chaomin Xu Shiqian Feng Xiongbing Tu Zehua Zhang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Chongqing Academy of Agricultural Sciences Chongqing 401329China Institute of Grassland Research Chinese Academy of Agricultural SciencesHohhot 010010China Inner Mongolia University Hohhot 010019China Scientific Observation and Experimental Station of Pests in Xilin Gol Rangeland Institute of Plant ProtectionChinese Academy of Agricultural SciencesXilinhot 026000China

Tyrosine phosphorylation is crucial for controlling normal cell growth,survival,intercellular communication,gene transcription,immune responses,and other *** tyrosine phosphatase(PTP)and protein tyrosine kinases(PTK)can achieve this goal by regulating multiple signaling *** decorus asiaticus is an important pest that infests the Mongolian Plateau *** aimed to evaluate the survival rate,growth rate,overall performance,and ovarian developmental morphology of the 4th instar nymphs of *** asiaticus while inhibiting the activity of protein tyrosine phosphatase-1B(PTP1B)and *** addition,the expression and protein phosphorylation levels of key genes in the MAPK signaling pathway and antioxidant enzyme activity were *** results showed no significant differences in survival rate,growth rate,or overall performance between PTP1B inhibitor treatment and ***,after PTK inhibitor treatment,these indexes were significantly lower than those in the *** ovarian size of female larvae after 15 days of treatment with PTK inhibitors showed significantly slower development,while female larvae treated with PTP1B exhibited faster ovarian growth than the control *** comparison to controls and nymphs treated with PTK inhibitors,the expression and phosphorylation levels of key genes in the MAPK signaling pathway under PTP1B inhibitor treatments were significantly higher in 4th instar ***,reactiveoxygen(ROS)species levels and the activities of NADPH oxidase and other antioxidant enzymes were considerably reduced,although they were significantly greater in the PTK inhibitor *** results suggest that PTP1B and PTK feedback inhibition in the mitogen-activated-protein kinases(MAPK)signal transfer can regulate the physiological metabolism of the insect as well as its developmental *** findings can facilitate future uses of PTP1B and PTK inhibitors in controlling insect development to help contro

关键词： PTP1B PTK inhibitor MAPK pathway Oedaleus decorus asiaticus development

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Utilization of Pyrrolic Compounds as Indicators of Secondary Migration for Woodford Oils in the Anadarko Basin,Oklahoma,USA

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Journal of Earth Science 2024年第5期35卷 1499-1512页

作者： Mu liu R.Paul Philp Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Geosciences University of OklahomaNorman 73109United States

Migration pathways and distances of the oils in reservoir are thought to affect the distribution of pyrrolic compounds such as carbazole,its alkyl derivatives(alkylated carbazoles)and benzocarbazoles,although other factors,including maturity and depositional environments may also affect the distribution of these organic nitrogen *** this study,14 oil samples produced from conventional reservoirs in Pauls Valley,south Oklahoma were investigated using organic geochemical *** sterane and hopane fingerprints suggest that most of the oils were sourced from the Devonian Woodford *** parameters consistently indicate that the maturity level of the studied samples are all of similar maturity(Rc=~0.7%),suggesting the distribution of the organic nitrogen organic compounds is possibly reflecting variations in relative migration *** distribution of alkylcarbazoles revealed a preferential enrichment during migration,with the nitrogen-shielded alkylcarbazole tending to be enriched relative to the nitrogen-semi-shielded alkylcarbozoles particularly in oils produced close to the Arbuckle uplift to the ***,another family of pyrrolic compounds,benzocarbazoles,whose distributions also indicated that the Pauls Valley Woodford oils came from deeper part of the Anadarko Basin as the benzo-[a]/([a]+[c])-carbazole ratios decrease *** more specific migration systems,although the pyrrolic compound indicators are potentially disturbed by the structural complexes,the general migration directions suggest that the studied oils in Pauls Valley Hunton uplift were sourced from the deep basin area,and migrate upwards in porous sediments due to the *** study investigates the feasibility of using pyrrolic compounds to estimate relative migration distances and will aid in the interpretation of migration history by using the distribution of carbazole,alkylated carbazoles,benzocarbazoles isomers in the Anadarko and Ardmore Basin

关键词： carbazole migration oil Oklahoma biomarker organic geochemistry

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Asymptotic Behavior of Singular Solution to the k-Hessian Equation with a Matukuma-Type Source

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Wuhan University Journal of Natural Sciences 2024年第3期29卷 242-256页

作者： liu Jinyu WANG Biao ChanG Caihong College of Science Xi'an University of Science and TechnologyXi'an 710054ShaanxiChina

This paper is concerned with radially positive solutions of the k-Hessian equation involving a Matukuma-type source S_(k)(D^(2)(-φ))=|x|^(λ-2)/(1+|x|^(2))^(λ2)φ^(q),x∈Ω,where S_(k)(D^(2)(-φ))is the k-Hessian operator,q>k>1,λ>0,n>2k,k∈N,andΩis a suitable bounded do-main in R~*** turns out that there are two different types of radially positive solutions for k>1,i.e.,M-solution(singular at r=0)and Esolution(regular at r=0),which is distinct from the case when k=*** 1

关键词： k-Hessian equation singular solutions asymptotic expansion

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Surveillance-image-based outdoor air quality monitoring

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Environmental Science and Ecotechnology 2024年第2期18卷 60-69页

作者： Xiaochu Wang Meizhen Wang Xuejun liu Ying Mao Yang Chen Songsong Dai School of Geography Nanjing Normal UniversityNanjing210023China Key Laboratory of Virtual Geographic Environment Nanjing Normal UniversityMinistry of EducationNanjing210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing Normal UniversityNanjing210023China

Air pollution threatens human health,necessitating effective and convenient air quality ***,there has been a growing interest in using camera images for air quality ***,a major challenge has been nighttime detection due to the limited visibility of nighttime *** we present a hybrid deep learning model,capitalizing on the temporal continuity of air quality changes for estimating outdoor air quality from surveillance *** model,which integrates a convolutional neural network(CNN)and long short-term memory(LSTM),adeptly captures spatial-temporal image features,enabling air quality estimation at any time of day,including PM_(2.5) and PM10 concentrations,as well as the air quality index(AQI).Compared to independent CNN networks that solely extract spatial features,our model demonstrates superior accuracy on self-constructed datasets with R^(2)?0.94 and RMSE=5.11 mg m^(-3) for PM_(2.5),R^(2)=0.92 and RMSE=7.30 mg m^(-3) for PM10,and R^(2)=0.94 and RMSE?5.38 for ***,our model excels in daytime air quality estimation and enhances nighttime predictions,elevating overall *** across diverse image datasets and comparative analyses underscore the applicability and superiority of our model,reaffirming its applicability and superiority for air quality monitoring.

关键词： Outdoor air quality estimation Hybrid deep learning model Convolutional neural network Long short-term memory Image sequences

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蛋白质精准修饰客体分子的方法

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高等学校化学学报 2024年第6期45卷 69-84页

作者：戴震刘育刘涛南开大学化学学院元素有机化学国家重点实验室天津300071 北京大学药学院天然药物及仿生药物国家重点实验室北京100191 北京大学药学院化学生物学交叉中心北京100191 北京大学药学院药学院分子与细胞药理学系北京100191

客体分子在蛋白质上的精准修饰为超分子调控蛋白质活性提供了重要技术基础,尤其是带正电荷的芳香官能团客体,可以与葫芦脲高效地结合.然而,该类分子很难通过非天然氨基酸定点修饰技术精准修饰到蛋白质上,而生物正交反应的连接子通常又... 详细信息

客体分子在蛋白质上的精准修饰为超分子调控蛋白质活性提供了重要技术基础,尤其是带正电荷的芳香官能团客体,可以与葫芦脲高效地结合.然而,该类分子很难通过非天然氨基酸定点修饰技术精准修饰到蛋白质上,而生物正交反应的连接子通常又较大从而影响主客体分子识别.为此,本文通过非天然氨基酸定点修饰技术先将带碘或炔烃官能团的非天然氨基酸定点修饰到目的蛋白质上,再通过钯催化的Suzuki和Sonogashira偶联反应进一步修饰上带有正电荷的吡啶分子,以期与葫芦脲分子高效识别结合,通过对反应条件的筛选插入了带有炔烃官能团的非天然氨基酸,并通过Sonogashira偶联反应在蛋白质表面定点偶联带正电荷的吡啶分子,为主客体化学调控蛋白质奠定了重要的技术基础.

关键词：精准修饰非天然氨基酸主客体蛋白质

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Should Low-Frequency-High-Consumption Enterprises Add Online-to-Offline Platforms?An Empirical Study Using the VAR Model

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Journal of Systems Science and Information 2024年第1期12卷 81-95页

作者： Wei LI Ying liu Haizhen YANG Sha ZhanG Binhong XU School of Economics and Management Univeristy of Chinese Academy of SciencesBeijing 100190China School of Business University of Chinese Academy of Social SciencesBeijing 102488China

This study investigates the impact of online-to-offline(O2O)platforms,such as *** and Meituan,on offline sales in low-frequency-high-consumption industries,specifically a mid-to-highend liquor distribution *** data from 77 offline stores in Beijing collected during 2019-2022,the study employs a VAR model to analyze the relationship between offline sales and the use of O2O *** results reveal a long-term equilibrium between the two,with most indicators showing a positive impact of O2O platforms on offline *** research provides valuable insights for lowfrequency-high-consumption enterprises in making multi-channel decisions and quantifies the impact of O2O platforms on offline sales.

关键词： O2O platform low-frequency-high-consumption liquor distribution chain enterprise store sales VAR model

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不同剂量环泊酚在老年患者全身麻醉诱导中的应用

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中国新药与临床杂志 2024年第9期43卷 676-680页

作者：徐勇郭建联刘杰侯雪琦厦门大学附属中山医院麻醉科福建厦门361001

目的分析不同剂量环泊酚用于老年患者的全身麻醉诱导效果,以及对患者血流动力学的影响。方法将择期手术的120例老年患者随机纳入环泊酚0.2 mg·kg^(-1)组(C_(0.2)组)、环泊酚0.3 mg·kg^(-1)组(C_(0.3)组)和环泊酚0.4 mg·kg^(-1)组(C_(... 详细信息

目的分析不同剂量环泊酚用于老年患者的全身麻醉诱导效果,以及对患者血流动力学的影响。方法将择期手术的120例老年患者随机纳入环泊酚0.2 mg·kg^(-1)组(C_(0.2)组)、环泊酚0.3 mg·kg^(-1)组(C_(0.3)组)和环泊酚0.4 mg·kg^(-1)组(C_(0.4)组),每组40例。依照分组情况静脉注射环泊酚对应剂量,注射时间30 s,并静脉注射罗库溴铵0.6 mg·kg^(-1)、舒芬太尼0.5μg·kg^(-1)诱导,后给予环泊酚0.8~2.4 mg·kg^(-1)·h^(-1)、瑞芬太尼8~15μg·kg^(-1)·h-1静脉泵注,1%七氟烷吸入麻醉维持,术中维持脑电双频指数(BIS)在40~60。监测患者平均动脉压(MAP)、心率(HR)和BIS,记录麻醉诱导成功率、补救镇静例数和意识消失时间,观察不良反应发生情况。结果3组麻醉诱导后即刻(T_(1))、气管插管后10 s(T_(2))、气管插管后3 min(T_(3))的MAP、HR、BIS均显著低于同组入室时水平(P0.05)。3组麻醉诱导成功率比较无显著差异(P>0.05),C_(0.2)组补救镇静率显著高于C_(0.3)组和C_(0.4)组(P0.05)。C_(0.4)组低血压、心动过缓发生率显著高于C_(0.2)组和C_(0.3)组(P0.05)。结论环泊酚0.3 mg·kg^(-1)用于老年患者全身麻醉诱导具有良好的安全性和有效性。

关键词：环泊酚麻醉,全身血流动力学老年人

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Equitable Cluster Partition of Planar Graphs with Girth at Least 12

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Journal of Mathematical Research with Applications 2024年第2期44卷 152-160页

作者： Xiaoling liu Lei SUN Wei ZHENG Department of Mathematics and Statistics Shandong Normal University

An equitable(Ok1, Ok2,..., Okm)-partition of a graph G, which is also called a k cluster m-partition, is the partition of V(G) into m non-empty subsets V1, V2,..., Vm such that for every integer i in {1, 2,..., m}, G[Vi] is a graph with components of order at most k, and for each distinct pair i, j in {1,..., m}, there is-1 ≤ |Vi|-|Vj| ≤ 1. In this paper, we proved that every planar graph G with minimum degree δ(G) ≥ 2 and girth g(G) ≥ 12 admits an equitable(O71, O72,..., O7m)-partition, for any integer m ≥ 2.

关键词： equitable cluster partition planar graph girth discharging

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Damage degradation mechanism and macro-meso structural response of mudstone after water wetting

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Journal of Mountain Science 2024年第8期21卷 2825-2843页

作者： SHAO Zhixin SONG Yanqi ZHENG Junjie SHEN Fuxin liu Chuanpeng YANG Juntao School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining&Technology(Beijing)Beijing 100083China

The predominant presence of weak interlayers primarily composed of mudstone renders them highly susceptible to a reduction in bearing capacity due to the water-rock weakening effect,significantly impacting the safety of open-pit mining *** study focuses on the weak mudstone layers within open-pit mine *** mineral composition of mudstone and the microstructure evolution characteristics before and after water wetting were analyzed by X-ray diffraction(XRD)and scanning electron microscope(SEM).The meso-structure and parameter variation characteristics of mudstone interior space after water-rock interaction were quantified by computed tomography scanning test,and the damage variable characterization method was ***,according to the uniaxial compression test,the degradation characteristics of the macroscopic mechanical behavior of mudstone under different water wetting time were explored,and the elastic modulus and strength attenuation model of mudstone based on mesoscopic damage were ***,building upon the macro-meso structural response characteristics of mudstone,an exploration of the failure characteristics and deterioration mechanism under the influence of water-rock interactions was *** results show that the water-rock interaction makes the internal defects of mudstone gradually develop and form a fracture network structure,which eventually leads to the deterioration of its macroscopic mechanical *** porosity,fractal dimension and damage characteristics of mudstone show an exponential trend with the increase of water wetting ***,the deterioration mechanism of mudstone after water wetting are postulated to encompass factors such as the hydrophilicity of mineral molecular structures,hydration stress and expansion effects on clay particles,as well as the spatial distribution of microcracks and the phenomenon of fracture *** outcomes of this research endeavor aim to provide cer

关键词： Moisture absorption of mudstone Computed tomography scanning test Fracture structure evolution Macro-meso structural response Deterioration mechanism

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Attribution analysis of groundwater level fluctuation in the Xinxiang section of the Lower Yellow River's suspended river after the construction of the Xiaolangdi Reservoir

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Journal of Geographical Sciences 2024年第7期34卷 1348-1370页

作者： LI He PING Jianhua LENG Wei MEI Xuemei ZhanG Min liu Jiaqi School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou450001China College of Ecology and Environment Zhengzhou UniversityZhengzhou450001China Geothermal and Ecological Geology Research Center Zhengzhou UniversityZhengzhou450001China Institute of Geology and Geophysics CASBeijing100101China

The clear identification and quantification of the factors affecting groundwater systems is crucial for protecting groundwater resources and ensuring safety in agricultural *** Lower Yellow River(LYR)is a suspended river that replenishes groundwater continuously due to clear differences in the water head,especially in the Xinxiang *** its construction,the Xiaolangdi Reservoir has reversed the LYR’s *** accurately determine the factors influencing the groundwater level(GWL),the study area was divided into five subzones based on hydrogeology.A dynamic factor model(DFM),variational mode decomposition(VMD),and a multiple linear regression model were used to identify and quantify the factors influencing the *** impact of the suspended river on the groundwater before and after the construction of the Xiaolangdi Reservoir was *** results show that:(1)The rate of decrease in the GWL was 8.53×10^(–4)m/month,and the rate of decrease in the Yellow River water level(RWL)was 4.63×10^(–4)m/month.(2)Mountain front recharge(MFR)(scale=3 months)and precipitation(scale=9 months)were the dominant factors in subzones I and II,accounting for more than 40%of the fluctuation in the *** III was dominated by exploitation(scale=7 months)and precipitation(scale=12months),accounting for 28.43%,and 23.44%of changes in the GWL,*** subzone IV,agricultural irrigation(scale=12 months)was the major factor,accounting for32.47%of GWL changes,while in subzone V,the RWL(scale=12 months)accounted for52.52%of these changes.(3)The Xiaolangdi Reservoir has increased the lateral seepage of the suspended river and altered the inter-annual *** results of this study can provide a valuable reference for controlling groundwater overexploitation and ensuring water supply security.

关键词： groundwater level influencing factor dynamic factor analysis Xiaolangdi Reservoir Lower Yellow River lateral seepage of the Yellow River

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