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Xiao Tan San Jie Fang Hampers the Growth of Colon Cancer Stem Cells through the Wnt/β-catenin Signaling Pathway

World Journal of Traditional Chinese Medicine 2024年第2期10卷 171-179页

作者： Yu-Qi Zhou Jun-fei Yuan Hong-shi Shen Ya-Ping Wang han-fei shi De-Jian Pan Min Ye Department of Hematology and Oncology The 904^(th) Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Clinical Laboratory The 904^(th)Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical UniversityShanghaiChina

Objective: The purpose of this research was to examine the potential anticancer properties of Xiao Tan San Jie Fang(XTSJF) and its potential mechanism of action against colorectal cancer. Materials and Methods: HCT116 cells were induced into HCT116 spheres in DMEM/F12 medium by treatment with epidermal growth factor + fibroblast growth factor + leukemia inhibitory factor + B27. The proliferation ability and stemness of HCT116 spheres was examined. Various concentrations of XTSJF were used to treat HCT116 spheres to observe the impact on proliferation, apoptosis, and expression of stem cell markers. Next, Wnt/β-catenin pathway-related factor proteins were detected. Results: The findings revealed that XTSJF suppressed cell growth and induced cell death in HCT116 cells in a dosage-dependent manner. Similarly, XTSJF promotes apoptosis, inhibits cell proliferation, prolongs survival, and maintains the expression of stem cells through the Wnt/-catenin/TCF4 axis. XTSJF also inhibits AKT activity and subsequently activates glycogen synthesis kinase-3β expression, inhibiting Wnt/beta-catenin pathway activity and downstream target gene transcript expression. The Wnt/β-catenin signaling pathway is inhibited by the XTSJF, leading to the suppression of colon cancer stem cell proliferation. Conclusion: Xiaotan Sanjie Prescription inhibited colon cancer stem cell growth through Wnt/β-catenin signaling pathway.

关键词： Apoptosis colorectal cancer proliferation traditional Chinese medicine Wnt/β-catenin signaling

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Overview of enhancing biological treatment of coal chemical wastewater:New strategies and future directions

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Journal of Environmental Sciences 2024年第1期135卷 506-520页

作者： Weiwei Ma Xiaoqi Zhang Hongjun han Xueqing shi Qiaoping Kong Tong Yu fei Zhao School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266520China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China

Coal chemical wastewater(CCW)is a type of refractory industrial wastewater,and its treatment has become the main bottleneck restricting the sustainable development of novel coal chemical *** treatment is considered as an economical,effective and environmentally friendly technology for CCW ***,conventional biological process is difficult to achieve the efficient removal of refractory organics because of CCW with the characteristics of composition complexity and high ***,seeking the novel enhancement strategy appears to be a favorable solution for enhancing biological treatment efficiency of *** review focuses on presenting a comprehensive picture about the exogenous enhancement strategies for CCW biological *** performance and potential application of exogenous enhancement strategies,including co-metabolic substrate enhancement,biofilm filler enhancement,adsorption material enhancement and conductive mediator enhancement,were ***,the enhancing mechanisms of different strategies were comprehensively discussed from a biological ***,the prospects of enhancement strategies based on the engineering performance,economic cost and environmental impact(3E)evaluation were *** novel enhancement strategy based on“low carbon emissions”,“resource recycling”and“water environment security”in the context of carbon neutrality was *** together,this review provides technical reference and new direction to facilitate the regulation and optimization of typical industrial wastewater biological treatment.

关键词： Coal chemical wastewater Biological treatment Exogenous enhancement Refractory organics 3E evaluation

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Biotoxicity dynamic change and key toxic organics identification of coal chemical wastewater along a novel full-scale treatment process

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Journal of Environmental Sciences 2024年第4期138卷 277-287页

It is particularly important to comprehensively assess the biotoxicity variation of industrial wastewater along the treatment process for ensuring the water environment ***,intensive studies on the biotoxicity reduction of industrial wastewater are still *** this study,the toxic organics removal and biotoxicity reduction of coal chemical wastewater(CCW)along a novel full-scale treatment process based on the pretreatment process-anaerobic process-biological enhanced(BE)process-anoxic/oxic(A/O)process-advanced treatment process was *** process performed great removal efficiency of COD,total phenol,NH_(4)^(+)-N and total *** the biotoxicity variation along the treatment units was analyzed from the perspective of acute biotoxicity,genotixicity and oxidative *** results indicated that the effluent of pretreatment process presented relatively high acute biotoxicity to Tetrahymena *** the acute biotoxicity was significantly reduced in BE-A/O *** the genotoxicity and oxidative damage to Tetrahymena thermophila were significantly decreased after advanced *** polar organics in CCW were identified as the main biotoxicity *** were positively correlated with acute biotoxicity,while the nitrogenous heterocyclic compounds and polycyclic aromatic hydrocarbons were positively correlated with *** the biotoxicity was effectively reduced in the novel full-scale treatment process,the effluent still performed potential biotoxicity,which need to be further explored in order to reduce environmental risk.

关键词： Acute biotoxicity Genotoxicity Oxidative damage Toxic organics Coal chemical wastewater Novel full-scale treatment process

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Early Growth Response Gene-1 Deficiency Interrupts TGFβ1 Signaling Activation and Aggravates Neurodegeneration in Experimental Autoimmune Encephalomyelitis Mice

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Neuroscience Bulletin 2024年第3期40卷 283-292页

作者： Yunyi Lan Xinyan han fei Huang Hailian shi Hui Wu Liu Yang Zhibi Hu Xiaojun Wu Shanghai Key Laboratory of Compound Chinese Medicines The Ministry of Education Key Laboratory for Standardization of Chinese MedicinesThe State Administration of TCM Key Laboratory for New Resources and Quality Evaluation of Chinese MedicineInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai201203China Central Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200021China

Early growth response protein 1(Egr-1)triggers the transcription of many genes involved in cell growth,differentiation,synaptic plasticity,and ***,its mechanism in neuronal survival and degeneration is still poorly *** study demonstrated that Egr-1 was down-regulated at mRNA and protein levels in the central nervous system(CNS)of experimental autoimmune encephalomyelitis(EAE)***-1 knockout exacerbated EAE progression in mice,as shown by increased disease severity and incidence;it also aggravated neuronal apoptosis,which was associated with weakened activation of the BDNF/TGFβ1/MAPK/Akt signaling pathways in the CNS of EAE ***,Egr-1 siRNA promoted apoptosis but mitigated the activation of BDNF/TGFβ1/MAPK/Akt signaling in SH-SY5Y *** results revealed that Egr-1 is a crucial regulator of neuronal survival in EAE by regulating TGFβ1-mediated signaling activation,implicating the important role of Egr-1 in the pathogenesis of multiple sclerosis as a potential novel therapy target.

关键词： Early growth response protein 1 Transforming growth factor-beta 1 Multiple sclerosis Experimental autoimmune encephalomyelitis Neurodegeneration

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Regulation of Tumor Microenvironment Under Malignant Conditions:Application of nMOFs in Sonodynamic Therapy

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Chemical Research in Chinese Universities 2024年第4期40卷 611-626页

作者： YANG Yilin YAN fei shi Zhan State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun130012P.R.China

In this review,we delve into the intricate regulation of the tumor microenvironment(TME)under malignant conditions and explore the transformative potential of nanoscale metal-organic frameworks(nMOFs)in the realm of sonodynamic therapy(SDT).The TME serves as a dynamic milieu influencing tumor progression and therapeutic response,presenting formidable challenges,such as hypoxia,acidity,excess hydrogen peroxide,high expression of glutathione,and *** the exceptional attributes of nMOFs,including their tunable structures and biocompatibility,holds immense promise for enhancing SDT efficacy and reshaping the TME *** integrating nMOFs with SDT,researchers aim to assemble multiple functionalities in a single platform that enhance tumor cell eradication while counteracting unfavorable TME conditions and immune *** potential of nMOFs to revolutionize tumor therapies by precisely targeting TME and overcoming therapeutic barriers is underscored by an in-depth analysis of recent breakthroughs in the use of nMOFs-based sonosensitizers to remodulate TME to amplify the efficacy of SDT.

关键词： Sonodynamic therapy Metal-organic framework Tumor microenvironment Modification of sonosensitizer

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An efficient parallel algorithm of variational nodal method for heterogeneous neutron transport problems

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Nuclear Science and Techniques 2024年第4期35卷 29-45页

作者： han Yin Xiao-Jing Liu Teng-fei Zhang School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 2002040China

The heterogeneous variational nodal method(HVNM)has emerged as a potential approach for solving high-fidelity neutron transport ***,achieving accurate results with HVNM in large-scale problems using high-fidelity models has been challenging due to the prohibitive computational *** paper presents an efficient parallel algorithm tailored for HVNM based on the Message Passing Interface *** algorithm evenly distributes the response matrix sets among processors during the matrix formation process,thus enabling independent construction without *** the formation tasks are completed,a collective operation merges and shares the matrix sets among the *** the solution process,the problem domain is decomposed into subdomains assigned to specific processors,and the red-black Gauss-Seidel iteration is employed within each subdomain to solve the response matrix ***-to-point communication is conducted between adjacent subdomains to exchange data along the *** accuracy and efficiency of the parallel algorithm are verified using the KAIST and JRR-3 test *** results obtained with multiple processors agree well with those obtained from Monte Carlo *** parallelization of HVNM results in eigenvalue errors of 31 pcm/-90 pcm and fission rate RMS errors of 1.22%/0.66%,respectively,for the 3D KAIST problem and the 3D JRR-3 *** addition,the parallel algorithm significantly reduces computation time,with an efficiency of 68.51% using 36 processors in the KAIST problem and 77.14% using 144 processors in the JRR-3 problem.

关键词： Neutron transport Variational nodal method Parallelization KAIST JRR-3

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Optical sensor array for the discrimination of liquors

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未来食品学报(英文) 2024年第1期4卷 48-60页

作者： Yang Yu Fangfang shi Yi Zhang fei Li Jinsong han State Key Laboratory of Natural Medicines National R&D Center for Chinese Herbal Medicine ProcessingDepartment of Food Quality and SafetyCollege of EngineeringChina Pharmaceutical UniversityNanjing 210009China

The discrimination of liquors plays a vital role in our daily life as a large amount of cheap alcoholic beverages and low-quality counterfeits greatly damage the health of ***-based optical sensors have been developed as a fast and effective tool to discriminate multi-analytes or complex mixtures with similar structures,such as acids,esters,aldehydes and *** the past decades,optical sensor arrays have demonstrated remarkable capabilities in fast and accurate detection of diverse types,qualities,and authentic *** identification strategy mainly focuses on the specific/non-specific interactions of flavor compounds in liquors with sensor *** cross-reactive optical signal readouts from the combination of sensor elements with liquors and multiple machine learning algorithms are essential to ensure the discriminatory capability of sensing *** this review,we discuss the advantages and recent advances in pattern recognition of liquors in terms of the design of various types of sensing materials and the construction strategies of sensor arrays.

关键词： Sensor array Chemical tongue Chemical nose Liquors Fluorescent Colorimetric Pattern recognition Machine learning algorithm

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A discussion of fatigue properties of notched specimens subjected to prestressing treatment machined from FGH4097

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Chinese Journal of Aeronautics 2024年第4期37卷 508-523页

作者： Rongxi shi Dasheng WEI Le han Shun YANG School of Energy and Power Engineering Beihang UniversityBeijing 100191China Jiangxi Research Institute Beihang UniversityNanchang 330096China Research Institute of Aero-Engine Beihang UniversityBeijing 100191China

Experimental and numerical investigations were performed to reveal the effect of prestress on the fatigue properties of FGH4097 so as to quantitatively evaluate the overspeed benefit of the disc of aeroengine. A corresponding experiment was performed to examine the effect of prestress on the fatigue life of FGH97. A complete model describing the fatigue properties of the prestressed notch specimen was proposed. After the modification of mean stress, stress gradient and prestressing treatment, the model is finally verified by fatigue test of presstressed notch specimens machined from FGH4097 with satisfactory accuracy and good engineering applicability. The new model highlights that for the variable fatigue loads, the introduction of appropriate prestress is expected to benefit to the notch specimens and certainly to the disc of aeroengine regards of their fatigue properties. Both the calculation method of fatigue life parameters and the prestress correction model are proved to have good prediction accuracy.

关键词： Turbine blisk Overspeed test Prestress Fatigue life prediction FGH4097

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The relationship between interannual dry/wet changes and nomadic wars in the Hexi Corridor region of China during the period 241–1912 A.D.

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Science China Earth Sciences 2024年第6期67卷 1922-1931页

作者： fei TANG Zhilin shi Qinhua TIAN Xiaogang DU Yong ZhanG Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Institute of Dunhuang Studies Lanzhou UniversityLanzhou 730020China National Climate Center China Meteorological AdministrationBeijing 100081China Longchanghe Station Gansu Qilian Mountain National Nature ReserveZhangye 734400China University of Chinese Academy of Sciences Beijing 100049China

The link between climate and war has long been a topic of great scientific and social *** this study,we investigate the influence of climate on warfare in China’s Hexi Corridor region since 241 *** the superposed epoch analysis of tree-ring data and historical war data,we observe a notable correlation between interannual dry-wet variations and wars instigated by nomadic groups in the Hexi ***,this relationship is dynamic and influenced by the region’s relative *** periods in which the Hexi Corridor was ruled by multiple regimes,wars tended to follow dry climatic conditions,which may be due to the fact that unusual drought during these periods likely heightened competition for resources and ***,during times of regional unity,wars were more likely to occur when climatic conditions were wet because the expansion of rangelands and the accumulation of resources helped fuel the nomads’outward *** findings underscore the complexity of the relationship between war and climate *** gain a more comprehensive understanding of this relationship,continuous,high-resolution historical temperature and humidity datasets with broader and more uniform coverage are needed across multiple *** addition,collecting and examining disaggregated historical war data for regions with distinct characteristics is essential.

关键词： Drought Interannual dry and wet variations War The Hexi Corridor Tree ring Nomadic groups

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Learning topological defects formation with neural networks in a quantum phase transition

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Communications in Theoretical Physics 2024年第5期76卷 68-76页

作者： han-Qing shi Hai-Qing Zhang Center for Gravitational Physics Department of Space ScienceBeihang UniversityBeijing 100191China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China

Neural networks possess formidable representational power,rendering them invaluable in solving complex quantum many-body *** they excel at analyzing static solutions,nonequilibrium processes,including critical dynamics during a quantum phase transition,pose a greater challenge for neural *** address this,we utilize neural networks and machine learning algorithms to investigate time evolutions,universal statistics,and correlations of topological defects in a one-dimensional transverse-field quantum Ising ***,our analysis involves computing the energy of the system during a quantum phase transition following a linear quench of the transverse magnetic field *** excitation energies satisfy a power-law relation to the quench rate,indicating a proportional relationship between the excitation energy and the kink ***,we establish a universal power-law relationship between the first three cumulants of the kink numbers and the quench rate,indicating a binomial distribution of the ***,the normalized kink-kink correlations are also investigated and it is found that the numerical values are consistent with the analytic formula.

关键词： neural networks machine learning transverse-field quantum Ising model kibble-zurek mechanism

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