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Laparoscopic liver resection for hepatocellular carcinoma complicated with significant portal hypertension:A propensity score-matched survival analysis

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 358-365页

作者： Zhang-You Guo yuan Hong Bing Tu Yao cheng Xiao-Mei Wang Department of Minimally Invasive Interventional Therapy Yunnan Cancer HospitalThe Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer CenterKunming 650118China Medical Laboratory The First Affiliated Hospital of Kunming Medical UniversityInstitute of Experimental Diagnostics of Yunnan ProvinceKey Laboratory of Laboratory Medicine of Yunnan ProvinceKunming 650032China Department of Hepatobiliary Surgery The Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China

Background: Significant portal hypertension(SPH) is a relative contraindication for patients with resectable hepatocellular carcinoma(HCC). However, increasing evidence indicates that liver resection is feasible for HCC patients with SPH. Methods: HCC patients with cirrhosis who underwent laparoscopic liver resection(LLR) in two centers from January 2013 to April 2018 were included. Surgical and survival outcomes were analyzed to explore potential prognostic factors. Propensity score matching(PSM) analysis was performed to minimize bias. Results: A total of 165 patients were divided into two groups based on the presence(SPH, n = 76) or absence(non-SPH, n = 89) of SPH. Patients in the SPH group had longer operative time, more blood loss, and more advanced TNM stage than patients in the non-SPH group( P 0.05). After PSM, alpha-fetoprotein(AFP) ≥ 400 μg/L [hazard ratio(HR) = 4.71, 95% confidence interval(CI): 2.69-8.25], ascites(HR = 2.18, 95% CI: 1.30-3.66), American Society of Anesthesiologists(ASA) classification(Ⅲ vs. Ⅱ)(HR = 2.13, 95% CI: 1.11-4.07) and tumor diameter > 5 cm(HR = 3.91, 95% CI: 2.02-7.56) independently predicted worse OS. Conclusions: LLR for patients with HCC complicated with SPH appears feasible at the price of increasing operative time and blood loss. AFP, ascites, ASA classification and tumor diameter may predict the prognosis of HCC complicat

关键词： Hepatocellular carcinoma Significant portal hypertension Laparoscopic liver resection Propensity score matching analysis

A Detailed Study of Mode Changing and Modulation of PSR B1237+25 with FAST

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Research in Astronomy and Astrophysics 2022年第7期22卷 73-83页

作者： Zheng-Wu Wang Mao yuan Lin Wang cheng-Min Zhang Bo Peng CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

PSR B1237+25,whose mean pulse profile has five components,is a well-known star to study pulsar emission *** conducted mode changing and modulation analysis on this pulsar using FAST data at 1.25 GHz with a bandwidth of 400 *** observed and identified three emission modes of this pulsar:a quiet normal mode that has little or no core activity with distinctive 2.8-period subpulse modulation on its outer cone,a flare normal mode in which the core is highly active and an abnormal mode in which the core is active and the last component is *** found that the core activity cuts off the position angle traverse in flare normal mode and leads to a position angle jumping in abnormal *** also found that there exists a quasi-periodical modulation on the outer conal *** modulation shows an irregular wave-like pattern,and has a weak correlation with the core *** discuss the likely origin of such a modulation,and argue that this modulation can be interpreted as precession of the emission cones around the magnetic axis.

关键词： (stars:)pulsars:individual(PSR B1237+25) radiation mechanisms:non-thermal magnetic fields polarization

三百棒通过调控PI3K/Akt信号通路改善胶原诱导性类风湿性关节炎大鼠的血管翳

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南方医科大学学报 2024年第8期44卷 1582-1588页

作者：向珊张宗星江露刘道忠李玮怡包卓玛田瑞陈丹袁林湖北恩施学院湖北恩施445000 湖北民族大学风湿性疾病发生与干预湖北省重点实验室湖北恩施445000 湖北民族大学医学部湖北恩施445000 湖北民族大学湖北省肾脏病临床医学研究中心湖北恩施445000

目的探讨三百棒醇提物(TAAE)通过PI3K/Akt信号通路改善胶原诱导性(CIA)大鼠血管翳的治疗作用及其机制。方法将60只雄性SD大鼠随机分为正常组、模型组、雷公藤多苷片组(TGT)、三百棒醇提物低剂量组(TAAE-L)、三百棒醇提物中剂量组(TAAE-M... 详细信息

目的探讨三百棒醇提物(TAAE)通过PI3K/Akt信号通路改善胶原诱导性(CIA)大鼠血管翳的治疗作用及其机制。方法将60只雄性SD大鼠随机分为正常组、模型组、雷公藤多苷片组(TGT)、三百棒醇提物低剂量组(TAAE-L)、三百棒醇提物中剂量组(TAAE-M)、三百棒醇提物高剂量组(TAAE-H),10只/组。除正常组外,对其余大鼠采用二次免疫法建立CIA大鼠模型。二次免疫结束后,三百棒醇提物组和雷公藤多苷组按相应剂量灌胃给药,1次/d,连续35 d。采用关节炎指数(AI)评分评估大鼠关节炎症程度;HE染色法观察膝关节滑膜病理变化;ELISA检测细胞因子(TNF-α、IL-6、IL-1β)的水平;Western blotting法检测各组大鼠滑膜组织中PI3K、Akt、p-PI3K、p-Akt、血管内皮生长因子(VEGF)、血管内皮抑制因子内皮抑素(ES)、缺氧诱导因子1-α(HIF-1α)、基质金属蛋白酶(MMP1、MMP3、MMP9)蛋白含量的变化;RT-PCR检测各组大鼠滑膜组织中TNF-α、IL-6、IL-1β、VEGF、HIF-1α、PI3K、Akt mRNA水平。结果与模型组相比较,TAAE和TGT组大鼠的足肿胀度和AI评分降低(P0.05)。结论TAAE可通过PI3K/Akt信号通路调控HIF-1α、VEGF、ES、MMP1、MMP3、MMP9等蛋白的表达,改善CIA大鼠关节症状,抑制RA血管翳形成。

关键词：三百棒类风湿性关节炎血管翳炎症 PI3K/Akt信号通路

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揭示氨对正己酸生产影响的机制——影响途径、关键酶和微生物

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Engineering 2024年第4期35卷 180-190页

作者： Qing-Lian Wu Ke-Xin yuan Wei-Tong Ren Lin Deng Hua-Zhe Wang Xiao-Chi Feng He-Shan Zheng Nan-Qi Ren Wan-Qian Guo State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China College of Architecture and Environment Sichuan UniversityChengdu 610065China State Key Laboratory of Urban Water Resource and Environment School of Civil and Environmental EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China College of Chemistry and Chemical Engineering Qiqihar UniversityQiqihar 161006China

n-Caproate,which is produced via chain elongation(CE)using waste biomass,can supply various fossilderived products,thus advancing the realization of carbon *** released from the degradation of nitrogen-rich waste biomass can act as a nutrient or an inhibitor in anaerobic bioprocesses,including CE,with the distinction being primarily dependent on its ***,the optimal concentration of ammonia and the threshold of toxicity for open-culture n-caproate production using ethanol as an electron donor,along with the underlying mechanisms,remain *** study revealed that the optimal concentration of ammonia for n-caproate production was 2.0 g∙L^(-1),whereas concentrations exceeding this threshold markedly suppressed the CE *** of the mechanism revealed the involvement of two forms of ammonia(i.e.,ammonium ions and free ammonia)in this inhibitory *** ammonia levels(5.0 g∙L^(-1))induced excessive ethanol oxidation and suppressed the reverse β-oxidation(RBO)process,directly leading to the enhanced activities of enzymes(phosphotransacetylase and acetate kinase)responsible for acetate formation and diminished activities of butyryl-coenzyme A(CoA):acetyl-CoA transferase,caproyl-CoA:butyryl-CoA transferase,and caproyl-CoA:acetyl-CoA transferase that are involved in the syntheses of n-butyrate and ***,the composition of the microbial community shifted from Paraclostridium dominance(at 0.1 g∙L^(-1)ammonia)to a co-dominance of Fermentimonas,Clostridium sensu stricto 12,and Clostridium sensu stricto 15 at 2.0 g∙L^(-1)***,these CE-functional bacteria were mostly absent in the presence of excessive ammonia(5.0 g∙L^(-1)ammonia).Metagenomic analysis revealed the upregulation of functions such as RBO,fatty acid synthesis,K^(+)efflux,adenosine triphosphatase(ATPase)metabolism,and metal cation export in the presence of 2.0 g∙L^(-1)ammonia,collectively contributing to enhanced n-caproate produc

关键词： Ammonia inhibition Medium chain fatty acids n-Caproate Enzyme Metagenomics

HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones from indoles and isatins

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Chinese Chemical Letters 2020年第9期31卷 2465-2468页

作者： Xiaohan yuan Shuai Wang Jialing cheng Bin Yu Hong-Min Liu School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Gordon Center for Medical Imaging Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02129United States State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

The first HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones(27 examples,up to 98% yield) from readily available indoles and isatin derivatives are *** protocol shows well tolerance of different functional groups and features mild reaction conditions such as short reaction time(~1 h),no usage of catalyst,easy operation and product *** particular intere st is the formation of two C-C bonds and one all-carbon quaternary *** protocol could serve as an alternative strategy to synthesize biologically important 3,3-di(indolyl)indolin-2-ones for biological testing.

关键词： Indoles Isatins HFIP Catalyst-free synthesis 3,3-Di(indoly)indolin-2-ones

Theory-driven designed TiO_(2)@MoO_(2)heterojunction:Balanced crystallinity and nanostructure toward desirable kinetics and highrate sodium-ion storage

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Nano Research 2023年第4期16卷 4941-4949页

作者： Junyi Yin Pengqi Hai yuan Gao Zihan Gan Chao Wu Yonghong cheng Xin Xu State Key Laboratory of Electrical Insulation and Power Equipment Center of Nanomaterials for Renewable EnergySchool of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049China Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an 710049China

Sodium-ion batteries(SIBs)are promising candidates for large-scale energy storage due to their cost effectiveness and the unlimited availability of ***,there remains a need for the rational design of better anodic materials than are currently available,as these materials are critical for the sodium-ion storage *** this work,theoretical calculations were performed to design a conceptually novel TiO_(2)@MoO_(2)heterojunction(TMH)anode that was expected to exhibit better electrochemical performance than current *** TMH anode was fabricated via a facile and cost-effective method,and the results of in-depth sodium-ion-storage performance and reaction kinetics analyses indicate that it exhibited an excellent rate capability and enhanced pseudocapacitive response,due to its high *** electrochemical performance was superior to that of previously reported anodic materials,confirming the accuracy of the theoretical *** of TMH’s nanostructure at high temperatures resulted in a decrease in its electrochemical performance,indicating the key role played by the nanostructure in TMH’s ability to store sodium *** study demonstrates that integration of theoretical predictions with experimental investigations offers insights into how materials’crystallinity and nanostructure affect their pseudocapacitive sodiumion storage capabilities,which will help to guide the rational design of effective anodic materials for SIBs.

关键词： theory-driven electrode development heterojunction crystallinity nanostructure enhanced pseudocapacitive response

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高中语文大单元教学的三种方法论实践可能

教学与管理 2024年第22期 34-38页

作者：袁海锋广东省中山市中山纪念中学广东中山528454

大单元教学呈现出一种纯然民间而野生的状态,却并不意味着其教学效果的虚浮与空洞。作为一种教学方法论,其至少存在面向展扩、线性展进、点式展发三种维度迥异的实践可能。以三种可能为基点,拓清各自的整合逻辑、组文风貌及设计路向,无... 详细信息

大单元教学呈现出一种纯然民间而野生的状态,却并不意味着其教学效果的虚浮与空洞。作为一种教学方法论,其至少存在面向展扩、线性展进、点式展发三种维度迥异的实践可能。以三种可能为基点,拓清各自的整合逻辑、组文风貌及设计路向,无疑可使大单元教学由野生而登堂室。

关键词：大单元教学面向展扩线性展进点式展发

Effects of Mo addition on microstructure of a 4th generation Ni-based single crystal superalloy

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Progress in Natural Science:Materials International 2022年第6期32卷 745-751页

作者： yuan cheng Xinbao Zhao Wanshun Xia Qinghai Pan Quanzhao Yue Yuefeng Gu Ze Zhang Institute of Superalloys Science and Technology School of Materials Science and Engineering Zhejiang University

The effects of Mo addition on the microstructure of a 4th generation Ni-based single crystal superalloy were *** addition significantly promoted elements Mo,W and Re partition into γ phase and enhanced absolute lattice misfit at 1100℃.The increase of Mo concentration from 2 wt% to 4 wt% also decreased the content of eutectic islands and the segregation ratios of other alloying elements in the as-cast state,especially Re and *** heat treatments,the size of γ' phase and width of γ channels decreased slightly with higher Mo *** Mo additions slightly enhanced the segregation behavior of Re while reducing the segregation behavior of ***,it revealed that the primary and secondary dendrite arm spacings were barely affected by Mo addition.

关键词： Ni-based single crystal superalloys Mo Segregation ratio Lattice misfit

贵州织金寒武系戈仲伍组赫尔克壳类(Halkieria)的研究

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微体古生物学报 2024年第2期41卷 105-117页

作者：袁媛王德智杨兴莲朱万林贵州大学资源与环境工程学院贵州省古生物研究中心贵阳550025 喀斯特地质资源与环境教育部重点实验室贵阳550025

Halkieria是一类体表具贝壳状壳体和多种类型钙质骨片的两侧对称动物,多以离散骨片形式保存于全球寒武纪地层中,但其系统发育位置仍存在较大争议。本文系统研究了贵州织金戈仲伍剖面戈仲伍组磷块岩中的Halkieria,根据骨片形态鉴定出1属2... 详细信息

Halkieria是一类体表具贝壳状壳体和多种类型钙质骨片的两侧对称动物,多以离散骨片形式保存于全球寒武纪地层中,但其系统发育位置仍存在较大争议。本文系统研究了贵州织金戈仲伍剖面戈仲伍组磷块岩中的Halkieria,根据骨片形态鉴定出1属2种(Halkieria uncostatus,***),描述了其基本形态特征及纤维束等显微结构,观察到骨片表面具叠瓦状纹饰及平行纵脊排列的瘤状突起、孔洞。此外,运用多元统计分析方法探讨了Halkieria与其他冠轮动物类群之间的亲缘关系。聚类分析及主坐标分析结果表明,Halkieria与托莫特壳类的骨片形态特征相似性较高,推测Halkieria与托莫特壳类的亲缘关系更近,而与威瓦西亚虫间的亲缘关系相对较远。

关键词： Halkieria 显微结构定量分析戈仲伍组寒武纪