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Acta Pharmaceutica Sinica B 2016年第4期6卷 259-260页

作者： Zhonggao Gao Han-Chang Kang the Chinese Academy of Medical Sciences the Department of Pharmaceutics Institute of Materia Medica The Catholic University of Korea The University of Utah

Interest in functional materials,nanocarriers,and formulations for targeted therapy,which can selectively deliver therapeutic or diagnostic payloads to target sites such as organs,tissues,cells,and subcellular organel... 详细信息

关键词： targeted deliver facilitate organs targeting diagnostic Editor Profile continuously pharmaceutical sustained

Traditional Chinese Medicine and Traditional Indonesian Medicine:A Comparative Review of Herbal Medicines Restricted in Pregnancy

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Chinese Journal of Integrative Medicine 2021年第10期27卷 794-800页

作者： Purumea Jun Endang Rahmat chang-Hyun han changsop Yang Youngmin kang University of Science&Technology Campus of Korea Institute of Oriental MedicineKorean Convergence Medicine MajorDaejeonRepublic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineDaejeonRepublic of Korea Herbal Medicine Resources Research Center Korea Institute of Oriental MedicineJeollanam-doRepublic of Korea

The decline in birth rates has become a very serious problem in various parts of the world.Many countries have implemented national programs for increasing birth rates,one of which involves the use of traditional medicine as an alternative solution.Among the fast-growing traditional medicines,traditional Chinese medicine(TCM)and traditional Indonesian medicine(TIM)have attracted a lot of demand globally.Here,we analyzed and compared the herbal medicines from TCM and TIM that must be avoided by pregnant women for preventing miscarriage and maintaining safety during pregnancy and the postpartum period.This review uses data from official reports from the respective government and national and international electronic databases for analysis.Although TCM and TIM have their own characteristics of treatment,they also have some similarities in concept and treatment,especially those related to herbal medicines.This review can be used as a reference base to help pregnant women consume herbal medicines at appropriate conditions and doses.

关键词： traditional Chinese medicine Chinese herbal medicine traditional indonesian medicine jamu restricted herbal medicines herbal contraindications for pregnancy

Inhibitory role of peroxiredoxin 2 in LRRK2 kinase activity induced cellular pathogenesis

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The Journal of Biomedical Research 2020年第2期34卷 103-113页

作者： kang Yan Wenfeng Zhang Xu han Fei chang Yongjian Liu Jiangsu Key Laboratory of Xenotransplantation School of Basic Medical ScienceNanjing Medical UniversityNanjingJiangsu 211166China Department of Pharmacology&Chemical Biology University of Pittsburgh School of MedicinePittsburghPA 15216USA

Parkinson’s disease(PD) is a major neurodegenerative disease. One of the known genetic contributors to PD pathogenesis is leucine-rich repeat kinase 2(LRRK2) whose mutations with elevated kinase activity could lead to both familial and sporadic PD. However, how the pathogenic kinase activity of LRRK2 is regulated remains largely unclear. Here we report that peroxiredoxin 2(Prx2) was identified as a novel interacting protein to LRRK2 with preferential expression in dopaminergic neurons over other Prx proteins. We also confirmed that Prx2 interacted with LRRK2 through its COR domain and its overexpression significantly decreased the kinase activity of mutant LRRK2. Functionally, overexpressed Prx2 rescued the transfected cells from LRRK2 mutant induced apoptotic processes. Importantly, overexpressed Prx2 reversed the altered subcellular distribution of cationindependent mannose 6-phosphate receptor(CI-M6 PR) induced by PD-mutant LRRK2. Our results suggest that,by interacting with LRRK2, Prx2 may play an inhibitory role in the LRRK2 mediated cellular toxicity in PD by inhibiting its kinase activity.

关键词： peroxiredoxin 2 LRRK2 Parkinson's disease

Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes:current strategies and future perspectives

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Acta Pharmaceutica Sinica B 2018年第6期8卷 862-880页

作者： Gantumur Battogtokh Yeon Su Choi Dong Seop kang Sang Jun Park Min Suk Shim kang Moo Huh Yong-Yeon Cho Joo Young Lee Hye Suk Lee han chang kang Department of Pharmacy Integrated Research Institute of Pharmaceutical Sciences and BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy College of Pharmacy The Catholic University of Korea Division of Bioengineering Incheon National University Department of Polymer Science and Engineering Chungnam National University

mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Other moieties, including short peptides,dequalinium, guanidine, rhodamine, and F16, are also known to be promising mitochondrial targeting agents. Direct conjugation of mitochondrial targeting moieties to anticancer drugs, antioxidants and sensors results in increased cytotoxicity, anti-oxidizing activity and sensing activity, respectively,compared with their non-targeting counterparts, especially in drug-resistant cells. Although many mitochondria-targeted anticancer drug conjugates have been investigated in vitro and in vivo, further clinical studies are still needed. On the other hand, several mitochondria-targeting antioxidants have been analyzed in clinical phases I, II and III trials, and one conjugate has been approved for treating eye disease in Russia. There are numerous ongoing studies of mitochondria-targeted sensors.

关键词： Anticancer agents Antioxidants Direct conjugation Mitochondria-targeting Sensing agents

Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood-brain barrier

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药学学报:英文版 2023年第9期13卷 3834-3848页

作者： Thuy Giang Nguyen Cao Ji Hee kang Su Jin kang Quan Truong Hoang han chang kang Won Jong Rhee Yu Shrike Zhang Young Tag Ko Min Suk Shim Division of Bioengineering Incheon National UniversityIncheon 22012Republic of Korea College of Pharmacy Gachon UniversityIncheon 21936Republic of Korea Department of Pharmacy Integrated Research Institute of Pharmaceutical Sciencesand BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future PharmacyCollege of Pharmacythe Catholic University of KoreaGyeonggi-do 14662Republic of Korea Research Center for Bio Materials&Process Development Incheon National UniversityIncheon 22012Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA

Glioblastoma(GBM)is the most aggressive malignant brain tumor and has a high mortality rate.Photodynamic therapy(PDT)has emerged as a promising approach for the treatment of malignant brain tumors.However,the use of PDT for the treatment of GBM has been limited by its low blood-brain barrier(BBB)permeability and lack of cancer-targeting ability.Herein,brain endothelial cell-derived extracellular vesicles(bEVs)were used as a biocompatible nanoplatform to transport photosensitizers into brain tumors across the BBB.To enhance PDT efficacy,the photosensitizer chlorin e6(Ce6)was linked to mitochondria-targeting triphenylphosphonium(TPP)and entrapped into bEVs.TPPconjugated Ce6(TPP-Ce6)selectively accumulated in the mitochondria,which rendered brain tumor cells more susceptible to reactive oxygen species-induced apoptosis under light irradiation.Moreover,the encapsulation of TPP-Ce6 into b EVs markedly improved the aqueous stability and cellular internalization of TPP-Ce6,leading to significantly enhanced PDT efficacy in U87MG GBM cells.An in vivo biodistribution study using orthotopic GBM-xenografted mice showed that b EVs containing TPP-Ce6[b EV(TPP-Ce6)]substantially accumulated in brain tumors after BBB penetration via transferrin receptor-mediated transcytosis.As such,b EV(TPP-Ce6)-mediated PDT considerably inhibited the growth of GBM without causing adverse systemic toxicity,suggesting that mitochondria are an effective target for photodynamic GBM therapy.

关键词： Extracellular vesicle Chlorin e6 Triphenylphosphonium Mitochondria-targeting photosensitizer Photodynamic therapy Blood-brain barrier Glioblastoma Transferrin receptor

Effects of Ethylene Tar-Based Pitch Coatings on the Electrochemical Properties of Graphite Anode Materials

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China Petroleum Processing & Petrochemical Technology 2023年第2期25卷 41-50页

作者： Xing Yicheng Dai chang Wu Qiang Wang Taoxiang Li Zhi Lei Jie han Haibo Li kang Wang Youhe Luoyang R&D Center of Technology of Sinopec Engineering(Group)Co.Ltd. Luoyang 471003China State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdao 266580China Sinopec Maoming Petrochemical Co.Ltd. Maoming 525000China

To improve the electrochemical performance of graphite anode materials,pitches with various softening points(150℃,180℃,200℃,and 250℃)were prepared from ethylene tar and used to coat graphite through a liquid coating process.The effects of the softening point of the pitch and the coating amount on the microstructure and electrochemical properties of graphite were studied by methods including thermogravimetric analysis,X-ray diffraction,Raman spectroscopy,surface area analysis,scanning electron microscopy,transmission electron microscopy,and electrochemical testing.The graphite particles were coated uniformly by the pyrolytic carbon in the pitch.The coating changed the degree of graphitization,decreased the average specific surface area,and improved the electrochemical performance significantly.The best battery anode performance was obtained when the mass ratio of pitch to graphite was 10%,the heat treatment temperature was 1100℃,and the softening point of the pitch was 250℃.Under the optimum conditions,the irreversible capacity loss in the first cycle at 0.1 C was only 23 mAh/g,and the first Coulombic efficiency reached 94.2%.The capacity retention rate was 98.3%after 100 charge-discharge cycles at 0.1 C.

关键词： ethylene tar pitch graphite anode Li-ion batteries

NUCLEAR PORE ANCHOR and EARLY IN SHORT DAYS 4 negatively regulate abscisic acid signaling by inhibiting Snf1-related protein kinase2 activity and stability in Arabidopsis

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Journal of Integrative Plant Biology 2022年第11期64卷 2060-2074页

作者： Ya-Nan chang Zhijuan Wang Ziyin Ren Chun-han Wang Pengcheng Wang Jian-kang Zhu Xia Li Cheng-Guo Duan Shanghai Center for Plant Stress Biology and Center of Excellence in Molecular Plant Sciences the Chinese Academy of ScienceShanghai 201602China University of Chinese Academy of Sciences Beijing 100049China National Key Laboratory of Crop Genetic and Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Department of Horticulture and Architecture Landscape Purdue UniversityWest LafayetteIN 47907USA

Abscisic acid(ABA)is a key regulator of plant responses to abiotic stresses,such as drought.Abscisic acid receptors and coreceptors perceive ABA to activate Snf1-related protein kinase2 s(SnRK2s)that phosphorylate downstream effectors,thereby activating ABA signaling and the stress response.As stress responses come with fitness penalties for plants,it is crucial to tightly control SnRK2 kinase activity to restrict ABA signaling.However,how SnRK2 kinases are inactivated remains elusive.Here,we show that NUCLEAR PORE ANCHOR(NUA),a nuclear pore complex(NPC)component,negatively regulates ABA-mediated inhibition of seed germination and post-germination growth,and drought tolerance in Arabidopsis thaliana.The role of NUA in response to ABA depends on SnRK2.2 and SnRK2.3 for seed germination and on SnRK2.6 for drought.NUA does not directly inhibit the phosphorylation of these SnRK2s or affects their abundance.However,the NUA-interacting protein EARLY IN SHORT DAYS 4(ESD4),a SUMO protease,negatively regulates ABA signaling by directly interacting with and inhibiting SnRK2 phosphorylation and protein levels.More importantly,we demonstrated that SnRK2.6 can be SUMOylated in vitro,and ESD4 inhibits its SUMOylation.Taken together,we identified NUA and ESD4 as SnRK2 kinase inhibitors that block SnRK2 activity,and reveal a mechanism whereby NUA and ESD4 negatively regulate plant responses to ABA and drought stress possibly through SUMOylation-dependent regulation of SnRK2s.

关键词： ABA drought tolerance ESD4 NUA SnRK2

Experiments and computer simulation analysis of impact behaviors of micro-sized abrasive in waterjet cutting of thin multiple layered materials

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中国有色金属学会会刊：英文版 2012年第S3期22卷 864-869页

作者： Jung-han LEE kang-Su PARK Myung chang kang Bo Sik kang Bo Sung SHIN Engineering Research Center Pusan National University National Core Research Center Pusan National University Mechanical System Safety Research Division Korea Institute of Machinery and Materials

The abrasive waterjet (AWJ) is now widely used in the advanced cutting processes of polymers,metals,glass,ceramics and composite materials like thin multiple-layered material (TMM).Various research and development efforts have recently been made to understand the science of AWJ.However,the interaction mechanism between a workpiece and high-velocity abrasive particles still remains a complicated problem.In this work,the material removal mechanisms of AWJ such as micro penetration and micro dent were experimentally investigated.In addition,a new computer simulation model considering high strain rate effect was proposed to understand the micro impact behavior of high-velocity micro-sized abrasives in AWJ cutting.

关键词： abrasive waterjet thin multiple layered materials micro-sized abrasive micro penetration micro dent

Sensitive and Label-Free Detection of Protein Secondary Structure by Amide Ⅲ Spectral Signals using Surface-Enhanced Raman Spectroscopy

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Chinese Journal of Chemical Physics 2019年第5期32卷 603-610页

作者： kang-zhen Tian chang-chun Cao Xin-ming Nie Wen Wang Cai-qin han Jiangsu Key Laboratory of Advanced Laser Materials and Devices School of Physics and Electronic Engineering Jiangsu Normal University Xuzhou 221116 China The 95979 Army of Chinese People's Liberation Army Taian 271200 China

Proteins and peptides perform a vital role in living systems, however it remains a challenge for accurate description of proteins at the molecular level. Despite that surface-enhanced Raman spectroscopy (SERS) can provide the intrinsic fingerprint information of samples with ultrahigh sensitivity, it suffers from the poor reproducibility and reliability. Herein, we demonstrate that the silver nanorod array fabricated by an oblique angle deposition method is a powerful substrate for SERS to probe the protein secondary structures without exogenous labels. With this method, the SERS signals of two typical proteins (lysozyme and cytochrome c) are successfully obtained. Additionally, by analyzing the spectral signals of the amide Ⅲ of protein backbone, the influence of concentration on the folding status of proteins has been elucidated. With the concentration increasing, the components of α-helix and β-sheet structures of lysozyme increase while the secondary structures of cytochrome c almost keep constant. The SERS method in this work offers an effective optical marker to characterize the structures of proteins.

关键词： Surface-enhanced Raman spectroscopy Silver nanorod Protein secondary structures

Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance

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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 146-158页

作者： chang-Soo han Ji-Hyun kang Eun hye Park Hyo-Jung Lee So-Jeong Jeong Dong-Wook Kim Chun-Woong Park College of Pharmacy Chungbuk National UniversityCheongju 28160Republic of Korea School of Pharmacy Jeonbuk National UniversityJeonju 54896Republic of Korea College of Pharmacy Wonkwang UniversityIksan 54538Republic of Korea

Corrugated surface microparticles comprising levofloxacin(LEV),chitosan and organic acid were prepared using the 3-combo spray drying method.The amount and the boiling point of the organic acid affected the degree of roughness.In this study,we tried to improve the aerodynamic performance and increase aerosolization by corrugated surface microparticle for lung drug delivery efficiency as dry powder inhaler.HMP175 L20 prepared with 175 mmol propionic acid solution was corrugated more than HMF175 L20 prepared with 175 mmol formic acid solution.The ACI and PIV results showed a significant increase in aerodynamic performance of corrugated microparticles.The FPF value of HMP175 L20 was 41.3%±3.9%compared with 25.6%±7.7%of HMF175 L20.Corrugated microparticles also showed better aerosolization,decreased x-axial velocity,and variable angle.Rapid dissolution of drug formulationswas observed in vivo.Lowdoses administered to the lungs achieved higher LEV concentrations in the lung fluid than high doses administered orally.Surface modification in the polymer-based formulation was achieved by controlling the evaporation rate and improving the inhalation efficiency of DPIs.

关键词： Chitosan Organic acid Levofloxacin Corrugated surface Aerodynamic performance