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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang han-zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Hybrid Continuous-Time MILP Model for Crude Oil Scheduling under the Influence of High Tides

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China Petroleum Processing & Petrochemical Technology 2021年第3期23卷 76-89页

作者： zhou Zhiju zhou Xiang zhou han SINOPEC Research Institute of Petroleum Processing Beijing 100083

Vessels,especially very large or ultra large crude carriers(VLCCs or ULCCs),often can only dock and leave the berth during high tide periods to prevent being ***,the current crude scheduling models do not take into account tidal conditions,which will seriously affect the feasibility of crude *** we first focus on the docking and leaving operations under the tidal actions,and establish a new hybrid continuous-time mixed integer linear programming(MILP)model which incorporates global event based formulation and unit-specific event based *** considering that the multiple blending of crude oil can easily cause the production fluctuating,there are some reasonable assumptions that storage tanks can only store pure crude,and charging tanks just can be refilled after being emptied,which helps us obtain a simple MILP model without composition discrepancy caused by crude *** cases are used to demonstrate the efficacy of proposed scheduling *** results show that the optimization schedule can minimize the demurrage of the vessels and the number of feeding changeovers of crude oil distillation units(CDUs).

关键词： crude scheduling tide continuous-time representation mixed integer linear programming

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A review of topology optimization for additive manufacturing:Status and challenges

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Chinese Journal of Aeronautics 2021年第1期34卷 91-110页

作者： Jihong ZHU han zhou Chuang WANG Lu zhou Shangqin YUAN Weihong ZhanG State IJR Center of Aerospace Design and Additive Manufacturing Northwestern Poly technical UniversityXi'an 710072China MIIT Lab of Metal Additive Manufacturing and Innovative Design Northwestern Polytechnical UniversityXi'an 710072China Institute of Intelligence Material and Structure Unmanned System TechnologiesNorthwestern Polytechnical UniversityXi'an 710072China

Topology optimization was developed as an advanced structural design methodology to generate innovative lightweight and high-performance configurations that are difficult to obtain with conventional *** manufacturing is an advanced manufacturing technique building asdesigned structures via layer-by-layer joining material,providing an alternative pattern for complex *** integration of topology optimization and additive manufacturing can make the most of their advantages and potentials,and has wide application prospects in modern *** article reviews the main content and applications of the research on the integration of topology optimization and additive manufacturing in recent years,including multi-scale or hierarchical structural optimization design and topology optimization considering additive manufacturing ***,some challenges of structural design approaches for additive manufacturing are discussed,such as the performance characterization and scale effects of additively manufactured lattice structures,the anisotropy and fatigue performance of additively manufactured material,and additively manufactured functionally graded material issues,*** is shown that in the research of topology optimization for additive manufacturing,the integration of material,structure,process and performance is important to pursue high-performance,multi-functional and lightweight *** article provides a reference for further related research and aerospace applications.

关键词： Additive manufacturing Aerospace applications Hierarchical structure Manufacturing constraints Material feature Topology optimization

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Multilevel coverage location model of earthquake relief material storage repository considering distribution time sequence characteristics

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第2期8卷 209-224页

作者： Xianjun Guan han zhou Mengxin Li Ligang zhou Huayou Chen School of Economics and Management Tongji UniversityShanghai 200092China School of Mathematical Sciences Anhui UniversityHefei 230601China

The scientific location of earthquake emergency supply warehouses is conducive to the effective distribution of emergency relief resources and improved rescue efficiency in earthquake hazard. Comprehensively considering the regional population as well as coverage quality at the demand points, this paper aims to divide the coverage thresholds of earthquake emergency rescue and logistic supplies according to their time-series features,and to build a location model for supply warehouses according to the variety and amount of stored supplies considering their time-series features, in hope of optimizing the set covering issue of earthquake relief supply warehouses. The solution is approached with two methods: the target deviation rate minimization model and NSGA-Ⅱ algorithm. The results obtained by solving the target deviation rate minimization model can balance every target. The branch and bound algorithm can find the global optimal solution at a certain calculation scale with high calculation efficiency, but its efficiency decreases significantly when the operation scale increases. The NSGA-Ⅱ algorithm is more suitable for large-scale solution calculations with high calculation efficiency, and it can output a set of non-inferior solutions for decision makers to select from according to different preference. Taking Aba Prefecture in Sichuan Province as illustration, the feasibility of the model is validated;meanwhile, the effectiveness and benefits of the two approaches in solving the problem of multi-objective set covering of the warehouses are compared and analyzed.

关键词： Earthquake Emergency supplies repository Location Coverage problem Multi-objective optimization NSGA-Ⅱ

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A Deep Learning Drug-Target Binding Affinity Prediction Based on Compound Microstructure and Its Application in COVID-19 Drug Screening

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Journal of Beijing Institute of Technology 2023年第4期32卷 396-405页

作者： Yijie Guo Xiumin Shi han zhou School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

Drug target relationship(DTR)prediction is a rapidly evolving area of research in com-putational drug *** recent advances in computational solutions that have overcome the challenges of in vitro and in vivo experiments,most computational methods still focus on binary *** ignore the importance of binding affinity,which correctly distinguishes between on-targets and *** this study,we propose a deep learning model based on the microstruc-ture of compounds and proteins to predict drug-target binding affinity(DTA),which utilizes topo-logical structure information of drug molecules and sequence semantic information of *** this model,graph attention network(GAT)is used to capture the deep features of the compound molecular graph,and bidirectional long short-term memory(BiLSTM)network is used to extract the protein sequence features,and the pharmacological context of DTA is obtained by combining the *** results show that the proposed model has achieved superior performance in both cor-rectly predicting the value of interaction strength and correctly discriminating the ranking of bind-ing strength compared to the state-of-the-art baselines.A case study experiment on COVID-19 con-firms that the proposed DTA model can be used as an effective pre-screening tool in drug discovery.

关键词： compound microstructure drug-target interaction binding affinity deep learning COVID-19

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Analysis and Research on Mechanical Stress and Multiobjective Optimization of Synchronous Reluctance Motor

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CES Transactions on Electrical Machines and Systems 2024年第3期8卷 274-283页

作者： han zhou Xiuhe Wang Lixin Xiong Xin Zhang School of Electrical Engineering Shandong UniversityJinan 250061China School of Electrical and Electronic Engineering Shandong University of TechnologyZibo 255000China Shandong Kehui Power Automation Co. Zibo 255000China

The mechanical strength of the synchronous reluctance motor(SynRM)has always been a great *** paper presents an analysis method for assessing stress equivalence and magnetic bridge stress interaction,along with a multiobjective optimization *** the complex flux barrier structure and inevitable stress concentration at the bridge,the finite element model suitable for SynRM is ***,a neural network structure with two inputs,one output,and three layers is *** functions are constructed to enhance ***,the equivalent stress can be converted into a contour distribution of a three-dimensional stress *** contour line distribution illustrates the matching scheme for magnetic bridge lengths under equivalent ***,the paper explores the analysis of magnetic bridge interaction *** optimization levels corresponding to the length of each magnetic bridge are defined,and each level is analyzed by the finite element *** Taguchi method is used to determine the specific gravity of the stress source on each magnetic *** on this,a multiobjective optimization employing the Multiobjective Particle Swarm Optimization(MOPSO)technique is *** taking the rotor magnetic bridge as the design parameter,ten optimization objectives including air-gap flux density,sinusoidal property,average torque,torque ripple,and mechanical stress are *** relationship between the optimization objectives and the design parameters can be obtained based on the response surface method(RSM)to avoid too many experimental *** optimized model is compared with the initial model,and the optimized effect is ***,the temperature distribution of under rated working conditions is analyzed,providing support for addressing thermal stress as mentioned earlier.

关键词： Multiobjective optimization Neural network Stress equivalence Synchronous reluctance motor Taguchi method

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Optimization Design and Performance Analysis of Vehicle Powertrain Mounting System

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Chinese Journal of Mechanical Engineering 2018年第2期31卷 76-88页

作者： han zhou Hui Liu Pu Gao Chang-Le Xiang School of Mechanical Engineering Beijing Institute of Technology National Key Lab of Vehicular Transmission Beijing Institute of Technology

The design strategies for powertrain mounting systems play an important role in the reduction of vehicular vibration and noise. As stiffness and damping elements connecting the transmission system and vehicle body, the rubber mount exhibits better vibration isolation performance than the rigid connection. This paper presents a complete design process of the mounting system, including the vibration decoupling, vibration simulation analysis, topology optimization, and experimental verification. Based on the 6?degrees?of?freedom vibration coupling model of the powertrain mounting system, an optimization algorithm is used to extract the best design parameters of each mount, thus rendering the mounting system fully decoupled and the natural frequency well configured, and the optimal parameters are used to design the mounting system. Subsequently, vibration simulation analysis is applied to the mounting system, considering both transmission and road excitations. According to the results of finite element analysis, the topological structure of the metal frame of the front mount is optimized to improve the strength and dynamic characteristics of the mounting system. Finally, the vibration bench test is used to verify the availability of the optimization design with the analysis of acceleration response and vibration transmissibility of the mounting system. The results show that the vibration isolation performance of the mounting system can be improved effectively using the vibration optimal decoupling method, and the structural modification of the metal frame can well promote the dynamic characteristics of the mounting system.

关键词： Mounting system Optimization algorithm Vibration simulation analysis Topological structure Acceleration response Vibration transmissibility

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Electrolyte-gated SrCoO_(x) FET sensor for highly sensitive detecting pH in extreme alkalinity solution

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Nano Research 2024年第4期17卷 3079-3086页

作者： han zhou Gaocan Qi Wenbin Li Yuhang Wang Zhihao Yuan School of Materials Science and Engineering Tianjin Key Lab of Photoelectric Materials&Devicesand Key Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)Tianjin University of TechnologyTianjin 300384China

The pH monitoring is significantly important in chemical industry,biological process,and pollution ***,it remains a great challenge to measure pH in extreme alkalinity ***,we employ an electrolyte-gated field-effect-transistor(FET)strategy using non-stoichiometric SrCoO_(x) with rich oxygen-vacancy defects as channel materials for detecting extreme *** corresponding channel can provide effective oxygen-ion-migration sites for reversible transformation of OH-↔O_(2)-+H^(+)driven by electric *** resultant electrolyte-gated FET sensor exhibits a sensitive linear response to high concentrations of alkaline solution,1–20 ***,the sensor has the ability to directly indicate the pH values ranging from 14.0 to 17.0 in consideration of ion-activity coefficient *** work offers a great possibility for directly detecting base concentration as well as pH values in extreme alkaline solutions.

关键词： field-effect-transistor(FET) pH sensor extreme alkaline solution SrCoO_(x) oxygen-ion migration

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Fusion expression of pedA gene to obtain biologically active pediocin PA-1 in Escherichia coli

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 65-71页

作者： Shan-na LIU Ye han Zhi-jiang zhou School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Two heterologous expression systems using thioredoxin (trxA) as a gene fusion part in Escherichia coli were developed to produce recombinant pediocin *** PA-1 structural gene pedA was isolated from Pediococcus acidilactici PA003 by the method of polymerase chain reaction (PCR),then cloned into vector pET32a(+),and expressed as thioredoxin-PedA fusion protein in the host strain *** BL21 (DE3).The fusion protein was in the form of inclusion body and was refolded before purification by nickel-iminodiacetic acid (Ni-IDA) agarose resin *** activity of recombinant pediocin PA-1 was analyzed after cleavage of the fusion protein by *** diffusion test revealed that 512-arbitrary unit (AU) recombinant pediocin PA-1 was obtained from 1 ml culture medium of *** (pPA003PED1) using Listeria monocytogenes as the indicator ***-PedA fusion gene was further cloned into pET20b(+).Thioredoxin-PedA fusion protein was detected in both the periplasmic and cytoplasmic *** recombinant pediocin PA-1 from the soluble fraction attained 384 AU from 1 ml culture medium of *** (pPA003PED2).Therefore,biologically active pediocin PA-1 could be obtained by these two hybrid gene expression methods.

关键词： Bacteriocin Fusion expression Inclusion body Pediocin PA-1 Thioredoxin

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Nonlinear empirical failure criterion for rocks under triaxial compression

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International Journal of Mining Science and Technology 2024年第3期34卷 351-369页

作者： Hongtao Liu zhou han Zijun han Zihan Chen Qinyu Liu Hongkai Zhang Rongguang Zhang Linfeng Guo School of Energy&Mining Engineering China University of Mining and Technology-BeijingBeijing 100083China China National Coal Association Beijing 100010China

Based on existing triaxial compression experimental data,a new empirical failure criterion with wide applicability was proposed considering hydrostatic pressure,second stress invariance,and maximum shear *** fitting evaluation indicators were used to verify the consistency of the new failure criterion,and the differences with the other 6 failure criteria were *** characteristics of the new failure criteria in the principal stress space were finally *** results indicate that(1)the new failure criterion exhibits strong predictive ability for triaxial experiments and has good applicability for both intact and jointed rocks;(2)the influence of hydrostatic pressure on the failure surface exhibits a non-linear trend,and different hydrostatic pressure also exhibits different distribution patterns on the deviatoric stress plane,with a distribution characteristic pattern of hexagonal snowflake-regular *** maximum shear stress has a torsional effect on the new criterion,in the three-dimensional failure *** parameters a and b of the rock have an impact on the failure surface morphology of the new criterion function on the offset surface.

关键词： surface. criterion hydrostatic

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