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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 57-58页

作者： Fung s.K Andreone P han s.h. A.s.F. Lok 孟欣颖 Division of Gastroenterology University of Michigan 3912 Taubman Center Ann Arbor MI 48109-0362 United States

Background/Aims: The susceptibility of adefovir-resistant hepatitis B virus ( hBV) mutants is only reduced by 3-10-fold in in vitro studies, suggesting that virologic breakthrough and clinical deterioration are unlikely. The aim of this study was to describe the clinical course of patients with adefovir-resistant hBV infection. Methods: Testing for adefovir-resistant mutations was performed on patients who had a suboptimal response or virologic breakthrough on adefovir. Adefovir-resistant mutations were detected using a line probe assay and direct sequencing of the hBV P-gene. Results: Eight male patients with pre-existing lamivudine resistance or breakthrough (mean age 47±13 years) were found to have adefovir-resistant mutations rtA181V/T or rtN236T. Baseline median ALT was 66 IU/L (range, 27-1161) and median hBV DNA 7.9 log10 copies/ml (range, 6-8.3). A t the time of adefovir resistance (mean of 20±9 months), hBV DNA increased to ≥5 log10 copies/ml in 7 patients. After detection of adefovir resistance, hepat ic decompensation occurred in 2 patients, 1 of whom died. salvage therapy with l amivudine, entecavir or tenofovir was given to 7 patients and a reduction in hBV DNA by ≥3 log10 was seen in 3 patients. Conclusions: In conclusion, adefovir r esistance can be associated with significant viral rebound and hepatic decompens ation which may be fatal.

关键词：乙型肝炎耐药突变恩替卡韦替诺福韦 DNA 临床病情临床过程补救治疗直接测序法中位值

ON ThE GLOBAL sTABILITY CONJECTURE OF ThE GENOTYPE sELECTION MODEL

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Acta Mathematica scientia 2011年第2期31卷 512-528页

作者： s.h. saker Department of Mathematics King Saud University Department of Mathematics Faculty of Science Mansoura University

In 1994, Grove, Kocic, Ladas, and Levin conjectured that the local stability and global stability conditions of the fixed point -y= 1/2 in the genotype selection model should be equivalent. In this article, we give an affirmative answer to this conjecture and prove that local stability implies global stability. some illustrative examples are included to demonstrate the validity and applicability of the results.

关键词： Local stability global stability discrete genotype selection model

self-propagating high temperature synthesis of Mosi_2 matrix composites

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Rare Metals 2006年第3期25卷 225-230页

作者： Akhtar Farid s.h. Islam Materials science and Engineering s.h.ol State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China

Mosi2 is presently regarded as the most important material for electrical heating and as one with huge potential for high temperature structural uses. Mosi2 and Mosi2 matrix composites were prepared by self-propagating high temperature synthesis （shs）. Pure Mosi2 was obtained and a compound of Mosi2 and Wsi2was synthesized in the form of predominant solid solution （Mo,W）si2. By adding aluminum of 5.5 at.% to Mo-si, the crystal structure of Mosi2 changed into a mixture of tetragonal Cllb Mosi2and hexagonal C40 Mo（si,Al）2. The （Mo,W）si2-Mo（si,Al）2-W（si,Al）2 composite materials were synthesized by adding aluminum of 5.5 at.% to Mo-W-si. however, if the amount of the added aluminum was not larger than 2.5 at.%, it did not have any significant effect. shs is an effective technology for synthesis of Mosi2 and Mosi2 matrix composites.

关键词： powder metallurgy Mosi2 matrix composites self-propagating high temperature synthesis molybdenumtungsten disilicide molybdenum aluminosilicide

心包积液分析和活检未能诊断的恶性心包积液:CT扫描的重要性

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世界核心医学期刊文摘(心脏病学分册) 2007年第9期 49-49页

作者： han s.h. Koh K.K. Lee s.J. 郭俊 Division of Cardiology Department of Internal Medicine Gachon Medical s.h.ol Incheon southKorea

1例47岁女性因呼吸困难1个月入急诊室就诊。初始胸部X线示心脏影增大,急诊超声心动图检查显示大量心包积液。行心包造口术和心包活检。通过积极的心包积液分析和心包活检未能查出大量血性心包积

关键词：心包积液心包活检 CT

Ideals Whose First Two Betti Numbers Are Close

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Algebra Colloquium 2015年第4期22卷 671-676页

作者： Keivan Borna s.h. hassanzadeh Faculty of Mathematical sciences and Computer Kharazmi University Tehran Iran School of Mathematics Institute for Research in Fundamental Sciences (IPM) Tehran Iran Faculty of Mathematical sciences and Computer Kharazmi University Tehran Iran Institute of Mathematics Universidade Federal de Rio de Janeiro Brasil

For an ideal I of a Noetherian local ring （R, m, k） one hasβR1（I） -β0R（I） ≥-1. It is demonstrated that some residual intersections of an ideal I for whichβ1R（I） -β0R（I） = -1 or 0 are perfect.

关键词： Betti numbers linlkage theory perfect Gorenstein ideals residual intersection

Investigation of Micro Formability of Bulk Amorphous Alloy in the supercooled Liquid state Based on Fluid Flow and Finite Element Analysis

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Journal of Materials science & Technology 2009年第2期25卷 277-280页

作者： M. Cheng s.h. Zhang Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Research results on the viscous flow deformation behavior of bulk amorphous alloy in different systems are reviewed. The material exhibits an ideal Newtonian fluid at a high temperature. Analytical solution of lamellar fluid flow behavior is used to discuss the viscous flow behavior of the bulk amorphous alloy in the supercooled liquid state. A material model, which describes such deformation behavior of Mg6oCusoYlo amorphous alloy, is introduced into the finite element method of microformin8 process. surface feature size was investigated and found not sensitive to the micro formability. Bulk amorphous alloy may possibly be applied to microelectro-mechanical-systems （MEMs） fabrication.

关键词： Bulk amorphous alloy supercooled liquid state Micro formability Lamellar fluid flow

CFD-DEM simulation of a pseudo-two-dimensional spouted bed comprising coarse particles

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Particuology 2019年第2期17卷 171-180页

作者： B. Mahmoodi s.h. hosseini G. Ahmadi llam Gas Treating Company llam Iran Department of Chemical Engineering llam University llam 69315-516 Iran Department of Mechanical and Aeronautical Engineering Clarkson University Potsdam NY 13699-5725 USA

In the present study, computational fluid dynamics (CFD) and the discrete element method (DEM) are used in conjunction with the Eulerian-Lagrangian method to simulate a pseudo-two-dimensional spouted bed comprising coarse 6-mm particles. The open-source OpenFOAM code is used to solve the governing equations. The predicted vertical particle velocity along the bed axis, particle velocity profiles in the radial directi on, power spectral den sity, time-averaged particle velocity vectors, bed pressure drop, and solid flow pattern are evaluated and compared with existing experimental data. Good agreement is found between the CFD-DEM results and the measured data. It is also shown that the present CFD-DEM model accurately predicts the particle flow pattern throughout the bed. It is found that the drag force, solid stresses, and gravity play important roles in the CFD-DEM simulation of a spouted bed comprising coarse particles.

关键词： CFD-DEM Pseudo-2D spouted bed hydrodynamics Coarse particles

Crystallization Modulation and holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)se_(2)Tandem solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung hsien Wu Jiwen Jiang Fei Long Liyuan han Qifeng han Yi‑Bing Cheng Yong Peng state Key Laboratory of Advanced Technology for Materials synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China state Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)se_(2)(CIGs)tandem solar cells(TsCs.h.ve been considered as an ideal tandem cell because of their best bandgap matching regarding to shockley–Queisser(s–Q)***,the nature of the irregular rough morphology of commercial CIGs prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGs surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGs tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGs TsCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGs tandem solar cells.

关键词： PVK/CIGs TsCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han Tang Jianian hu siying Kang song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina state Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. however, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. studies employing lineage-tracing techniques.h.ve revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus.h.s a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes.h.avily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this.h.pothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis.h.lds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte