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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

The upper tropospheric-lower stratospheric ozone drives summer precipitation and wildfire changes in West Siberia

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Science Bulletin 2025年第2期70卷 255-262页

作者： Fei Xie Yan Xia Wenshou Tian Martyn p.Chipperfield Wuhu Feng Ke Gui Yingli Niu na Liu Yuanyuan han School of Systems Science Beijing Normal UniversityBeijing 100875China Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China School of Earth and Environment University of LeedsLeedsLS29JTUK national Centre for Earth Observation University of LeedsLeedsLS29JTUK national Centre for Atmospheric Science University of LeedsLeedsLS29PHUK State Key Laboratory of Severe Weather&Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological SciencesBeijing 100081China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China Key Laboratory of Textile Chemical Engineering Auxiliaries School of Environmental and Chemical EngineeringXi’an Polytechnic UniversityXi’an 710048China

Siberian wildfires are pivotal in determining the carbon cycle and climate dynamics,exerting a profound impact on the ecosystems of the entire Arctic *** the past few decades,variations in summer precipitation in West Siberia have significantly influenced wildfire *** study analyzed precipitation trends in West Siberia from 1982 to 2021 using observations and transient simulations,uncovering a strong correlation between precipitation variability and ozone concentrations in the upper troposphere-lower stratosphere(UTLS).Heightened UTLS ozone levels warm the upper atmosphere over West Siberia during *** warming modifies the regional polar jet stream,intensifying its southern branch and weakening the northern one,leading to a southward shift in the jet ***,cyclonic circulation anomalies emerge in the upper troposphere,characterized by a barotropic structure with unusual upward movements around 60°*** upward motion triggers corresponding anomalies in zonal winds in the lower troposphere,fostering a low-pressure system at the *** atmospheric shift results in an influx of warm,moist air from the south and cold,dry air from the north into Siberia,enhancing cloud formation and ***,our analysis suggests that the rise in summer precipitation in West Siberia between 1993 and 2010 is linked to increased UTLS ozone concentrations during this ***,the decline in UTLS ozone since 2010 may increase the risk of wildfires by suppressing *** findings underscore the pivotal role of stratospheric chemistry in shaping the regional climate and wildfire behavior.?2024 Science China *** by Elsevier *** Science China *** rights are reserved,including those for text and data mining,AI training,and similar technologies.

关键词： Upper troposphere-lower stratosphere Ozone Radiative effect precipitation Siberia

A comparison of the proto-dolomite induced by cyanobacteria and halophilic bacteria:implications for dolomite-inducing microbe identification

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Journal of palaeogeography 2025年第01期14卷 277-290页

作者：赵延洋 Xiang-Yu Wei Xiao Gao na Guo Jie Li Kai-Ming Hu Chao han Qi-Yu Wang 韩作振 Shandong provincial Key Laboratory of Depositional Mineralization and Sedimentary Minerals College of Earth Science and Engineering Shandong University of Science and Technology Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and Technology Key Laboratory of Sedimentary Basin and Oil and Gas Resources Ministry of Natural Resources Key Laboratory of Deep Oil and Gas China University of Petroleum

This study investigates the morphological and mineralogical characteristics of proto-dolomite induced by two specific microorganisms with varying lifestyles:the extremely halophilic bacterium Vibrio harveyi QpL2 and the cyanobacterium Leptolyngbya boryana. Halophilic bacterially-induced proto-dolomite(HBD) and cyanobacterially-induced proto-dolomite (CBD) were subjected to comprehensive characterization techniques, including X-ray diffraction, scanning electron microscopy, Focused Ion Beam, thermogravimetric analysis, and X-ray photoelectron spectroscopy. The results indicate that both HBD and CBD exhibit a low degree of crystallinity and possess comparable molar ratios of MgCO3to CaCO3. Moreover, neither of them exhibits the ordered structure of ideal dolomite. HBD and CBD exhibit notable distinctions in external morphology and internal structure. HBD forms a subunit aggregate with a less dense surface and numerous pinhole structures resulting from bacterial survival. In contrast, CBD adopts a bispherical shape with a relatively dense surface and minimal indications of cyanobacterial survival. Both HBD and CBD have an internal hollow structure. However, HBD is characterized by sparse population and loosely arranged subunits, while CBD features only a central cavity. Additionally, HBD particles are smaller compared to CBD particles. These morphological differences suggest that HBD primarily grows through bacterial surface-dependent processes,whereas the growth of CBD is not directly reliant on the surface of cyanobacteria. Compositionally, the weightpercentage of crystalline water in CBD exceeded that of HBD with a value of 29.42%compared to 5.9%. This increase in internal crystalline water enables a faster conversion of CBD to the ordered ideal dolomite in a specific diagenetic environment. This study implies that the morphology and composition of microbial protodolomite may aid in identifying the type of dolomite-inducing microbes.

关键词： proto-dolomite Cyanobacteria Halophile Crystal morphology Water of crystallization

Tauroursodeoxycholic acid targets HSp90 to promote protein homeostasis and extends healthy lifespan

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Science China(Life Sciences) 2025年第2期68卷 416-430页

作者： Jia-Yu Liu Yao Wang Yue Guo Run-Qi Zheng Yun-Ying Wang Yan-Yan Shen Yan-Hong Liu Ai-ping Cao Rui-Bo Wang Bo-Yang Xie Shuai Jiang Qiu-Ying han Jing Chen Fang-Ting Dong Kun He na Wang Xin pan Tao Li Tao Zhou Ai-Ling Li Qing Xia Wei-na Zhang nanhu Laboratory National Center of Biomedical AnalysisBeijing 100850China

As the elderly population expands,the pursuit of therapeutics to reduce morbidity and extend lifespan has become increasingly *** an FDA-approved drug for chronic cholestatic liver diseases,tauroursodeoxycholic acid(TUDCA),a natural bile acid,offers additional health benefits beyond liver ***,we show that TUDCA extends the lifespan and healthspan of ***,oral supplementation of TUDCA improves fitness in old mice,including clinically relevant phenotypes,exercise capacity and cognitive ***,TUDCA treatment drives broad transcriptional changes correlated with anti-aging ***,we discover that TUDCA targets the chaperone HSp90 to promote its protein refolding *** collaboration further alleviates aging-induced endoplasmic reticulum(ER)stress and facilitates protein homeostasis,thus offering resistance to *** summary,our findings uncover new molecular links between an endogenous metabolite and protein homeostasis,and propose a novel anti-aging strategy that could improve both lifespan and healthspan.

关键词： tauroursodeoxycholic acid lifespan healthspan protein homeostasis

A robust statistical prediction model for late-summer heavy precipitation days in North China

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Science China Earth Sciences 2025年第1期68卷 158-171页

作者： Shunli JIANG Tingting han Xin ZHOU Huijun WANG Zhicong YIN Xiaolei SONG Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of EducationNanjing University for Information Science and TechnologyNanjing210044China nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519080China

Recently,heavy precipitation(Hp)events have occurred frequently in North China(NC),causing devastating economic losses and human ***,the short-term climate prediction of Hp is quite *** year-to-year increment(DY)method and sliding correlations,we developed a robust seasonal prediction model for late-summer Hp days(HpDs)in NC during 1982–2022,utilizing three independent predictors—February sea surface temperature(SST)in the Indian Ocean(SST_IO),February snow depth over North Asia(SDE_na),and May melted snow depth in NC(MSDE_NC).The SST_IO anomalies affect NC's precipitation through the pacific-Japan *** SDE_na anomalies are associated with East Asian anomalous anticyclone by southeastern propagation of Rossby wave at *** MSDE_NC anomalies are followed by vertical motion and moisture anomalies in situ and thereby cause precipitation *** prediction model can well simulate the variations of the HpDs,with a correlation coefficient(CC)of 0.81(0.65)between the observed and predicted HpDs_DY(HpDs_anomaly).The percentage with the same sign for 15 extreme HpDs_anomaly years(pSSE)is 100%.Moreover,in the cross-validation test during 1982–2022,the pSSE for HpDs_anomaly is as high as 100%,along with a low rootmean-square error of *** independent hindcasts during 2013–2022,the CC between the observed and predicted HpDs_DY(HpDs_anomaly)is 0.93(0.83),together with high nash-Sutcliffe efficiency(0.82)and agreement index(0.89).Specifically,the predictions are broadly consistent with the observations for 2015,2016,2017,2021,and 2022,reflecting excellent performance of this prediction model of HpDs in NC.

关键词： Heavy precipitation at North China Year-to-year increment approach Robust seasonal prediction Sea surface temperature Snow depth

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基于暂态能量的直驱风电机组阻尼研究

太阳能学报 2025年第1期46卷 42-52页

作者：曹娜韩清宇张子洁于群山东科技大学电气与自动化工程学院青岛266590 国网山东省电力公司东平县供电公司泰安271000

风电机组控制参数设置不当会引起风电机组阻尼变弱而发生自由振荡。为采取合理措施抑制风电机组的振荡,需要研究风电机组控制参数对机组阻尼的影响机理。以直驱风电机组为例,首先计及锁相环控制的比例系数K_(ppll)和积分系数K_(ipll)、... 详细信息

风电机组控制参数设置不当会引起风电机组阻尼变弱而发生自由振荡。为采取合理措施抑制风电机组的振荡,需要研究风电机组控制参数对机组阻尼的影响机理。以直驱风电机组为例,首先计及锁相环控制的比例系数K_(ppll)和积分系数K_(ipll)、网侧变流器内环控制的比例系数K_(p1)和积分参数K_(i1),推导直驱风电机组暂态能量函数,分析不同控制参数对机组暂态能量及阻尼的影响机理;定义机组耗能功率及阻尼影响因子,定量分析不同控制参数对机组阻尼的影响;最后,在pSCAD/EMTDC平台上建模分析,通过耗能功率的变化深入分析控制参数对机组阻尼的影响。仿真结果表明,一定范围内变流器控制参数减小,直驱机组耗能功率增大,阻尼变弱;锁相环控制参数增大,机组耗能功率增大,阻尼变弱;控制参数K_(p1)、K_(i1)、K_(ppll)、K_(ipll)单位变化率相同时,对机组阻尼的影响按照从大到小的顺序为K_(i1)、K_(p1)、K_(ppll)、K_(ipll)。

关键词：风电场稳定性控制暂态能量函数阻尼特性

Unraveling the reaction mechanism of high reversible capacity Cup_(2)/C anode with native oxidation pO_(x) component for sodium-ion batteries

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Chinese Chemical Letters 2025年第1期36卷 574-578页

作者： Huixin Chen Chen Zhao Hongjun Yue Guiming Zhong Xiang han Liang Yin Ding Chen State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China CAS key Laboratory of Design and Assembly of Functional nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesNanjing Forestry UniversityNanjing 210037China Laboratory of Advanced Spectro-electrochemistry and Li-ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of physics Chinese Academy of SciencesBeijing 100190China Xiamen Key Laboratory of Rare Earth photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi institutesChinese Academy of SciencesXiamen 361021China

phosphorus-based anode is a promising anode for sodium-ion batteries(SIBs)due to its high specific capacity,however,suffers from poor electronic conductivity and unfavorable electrochemical *** metals such as copper(Cu)into phosphorus has been demonstrated to not only improve the electronic conductivity but also accommodate the volume change during cycling,yet the underline sodiation mechanism is not ***,take a copper phosphide and reduced graphene oxide(Cup_(2)/C)composite as an example,which delivers a high reversible capacity of>900 mAh/***,it is revealed that the native oxidation pO_(x)components of the Cup_(2)/C composite show higher electrochemical reversibility than the bulk Cu p_(2),based on a quantitative analysis of high-resolution solid-state^(31)p NMR,ex-situ XpS and synchrotron X-ray diffraction characterization *** sodiation products na_(3)pO_(4) and na_(4)p_(2)O_(7) derived from pO_(x) could react with na-p alloys and regenerate to pO_(x) during charge process,which probably accounts for the high reversible capacity of the Cu p_(2)/C *** findings also illustrate that the phosphorus transforms into nanocrystalline na_(3)p and na_(x)p alloys,which laterally shows crystallization-amorphization evolution process during cycling.

关键词： Cup_(2)/C composite pOx component Reaction mechanism Solid-state NMR Sodium-ion batteries

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min han Institute of pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China national Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering Rna(siRna)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-Tpp(HSTD)for loading siRna to overcome the problem of siRna release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRna,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering Rna(siRna) doxorubicin

长江流域再分析与卫星反演降水数据的适用性分析

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河海大学学报(自然科学版) 2025年第1期53卷 50-61页

作者：沈哲辉韩静妍桂敬聪那嘉明南京林业大学土木工程学院江苏南京210037 河海大学水灾害防御全国重点实验室江苏南京210098 南京师范大学虚拟地理环境教育部重点实验室江苏南京210095

为评估再分析和卫星反演降水数据在长江流域的适用性,以气象站点观测数据为地面参考,采用相关系数、均方根误差、相对偏差、命中率、误报率、关键成功率等评价指标,在日尺度上比较了再分析降水数据ERA5-Land和卫星反演降水数据IMERG-Fi... 详细信息

为评估再分析和卫星反演降水数据在长江流域的适用性,以气象站点观测数据为地面参考,采用相关系数、均方根误差、相对偏差、命中率、误报率、关键成功率等评价指标,在日尺度上比较了再分析降水数据ERA5-Land和卫星反演降水数据IMERG-Final在长江流域的适用性。结果表明:相比IMERG-Final,ERA5-Land在长江上游高原地形区的适用性较差,主要表现为对降水强度的严重高估及较高的误报率;在长江中下游地区,ERA5-Land和IMERG-Final具有各自的优势和缺点,虽然ERA5-Land对降水事件的综合捕捉能力总体上强于IMERG-Final,但其对降水强度的模拟能力弱于IMERG-Final;在冬季ERA5-Land对降水事件的探测能力显著强于IMERG-Final,且与地面气象站点观测值的相关程度也高于IMERG-Final;IMERG-Final在夏季的精度则远高于ERA5-Land,表明在降水强度高的季节,卫星反演方法对降水的估算比气象模式再分析方法更加可靠。

关键词：降水数据 ERA5-Land IMERG-Final 误差分析探测能力地形影响长江流域

phonon-mediated superconductivity in orthorhombic XS (X = Nb, Ta or W)

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CHINESE pHYSICS B 2025年第2期34卷 419-423页

作者： Liu, Guo-Hua Jiang, Kai-Yue Wan, Yi Qiao, Shu-Xiang Tan, Jin-han Jiao, na Zhang, ping Lu, Hong-Yan Qufu Normal Univ Sch Phys & Phys Engn Qufu 273165 Peoples R China Inst Appl phys & Computat Math Beijing 100088 Peoples R China

The unique three-dimensional orthorhombic NbS (o-NbS) compound synthesized in 1969 has recently been experimentally confirmed to be a superconductor [phys. Rev. B 108 174517 (2023)]. However, there is currently no theoretical research on its superconducting mechanism. In this work, we investigate the superconducting properties of o-NbS from first-principles calculations. Based on the Eliashberg equation, it is found that the superconductivity mainly originates from the coupling between the electrons of Nb-4d orbitals and the vibrations of Nb atoms in the low-frequency region and those of S atoms in the high-frequency region. A superconducting transition temperature (Tc) of 10.7 K is obtained, which is close to the experimental value and higher than most transition metal chalcogenides (TMCs). The calculated thermodynamic properties in the superconducting state, such as specific heat, energy gap, isotope coefficient, etc., also indicate that o-NbS is a conventional phonon-mediated superconductor. These results are consistent with recent experimental reports and provide a good understanding of the superconducting mechanism of o-NbS. Furthermore, the TMCs of o-TaS and o-WS are also investigated;these belong to the same and neighboring groups of Nb, and we find that o-TaS and o-WS are also phonon-mediated superconductors with Tc of 8.9 K and 7.2 K, respectively.

关键词： first-principles calculations phonon-mediated superconductivity orthorhombic transition metal chalcogenides 74.25.-q 63.20.dk 74.25.Jb 74.20.Fg