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THE GLOBAL EXISTENCE OF STRONG SOLUTIONS FOR A NON-ISOTHERMAL IDEAL GAS SYSTEM

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Acta Mathematica Scientia 2024年第3期44卷 865-886页

作者：韩斌赖宁安 Andrei TARFULEA Department of Mathematics Hangzhou Dianzi UniversityHangzhou310018China School of Mathematical Sciences Zhejiang Normal UniversityJinhua321004China Department of Mathematics Louisiana State UniversityBaton Rouge70803USA

We investigate the global existence of strong solutions to a non-isothermal ideal gas model derived from an energy variational *** first show the global wellposedness in the Sobolev space H^(2)(R^(3)) for solutions near equilibrium through iterated energy-type bounds and a continuity *** then prove the global well-posedness in the critical Besov space B^(3/2)_(2,1) by showing that the linearized operator is a contraction mapping under the right circumstances.

关键词： thermal fluid equations energy-variational method well-posedness theory for PDE paraproduct calculus

Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice

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Acta Pharmaceutica Sinica B 2023年第8期13卷 1164-1179页

作者： Xiaoqing Fan Chutian Mai Ling Zuo Jumin Huang Chun Xie Zebo Jiang Runze Li Xiaojun Yao Xingxing Fan Qibiao Wu Peiyu Yan Liang Liu Jianxin Chen Ying Xie Elaine lai-han Leung Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyTaipaMacao 999078China Beijing University of Chinese Medicine Beijing 100029China Cancer Center Faculty of Health Science、MOE Frontiers Science Center for Precision OncologyUniversity of MacaoMacao 999078China Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510120China

Sepsis-induced liver injury(SILI)is an important cause of septicemia ***(BWBDS)was extracted from a formula of Panax ginseng ***,Lilium brownie *** ex Miellez *** Baker,Polygonatum sibiricum *** Redoute,Lonicera japonica Thunb.,Hippophae rhamnoides Linn.,Amygdalus Communis Vas,Platycodon grandiflorus(Jacq.)***.,and Cortex ***,we investigated whether the BWBDS treatment could reverse SILI by the mechanism of modulating gut *** protected mice against SILI,which was associated with promoting macrophage anti-inflammatory activity and enhancing intestinal *** selectively promoted the growth of Lactobacillus johnsonii(***)in cecal ligation and puncture treated *** microbiota transplantation treatment indicated that gut bacteria correlated with sepsis and was required for BWBDS anti-sepsis ***,*** significantly reduced SILI by promoting macrophage anti-inflammatory activity,increasing interleukin-10+M2 macrophage production and enhancing intestinal ***,heat inactivation ***(***)treatment promoted macrophage anti-inflammatory activity and alleviated *** findings revealed BWBDS and gut microbiota *** as novel prebiotic and probiotic that may be used to treat *** potential underlying mechanism was at least in part,via ***-dependent immune regulation and interleukin-10+M2 macrophage production.

关键词： BaWeiBaiDuSan Sepsis-induced liver injury Network pharmacology 16S PacBio SMRT sequencing Lactobacillus johnsonii Macrophages Interleukin-10

IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα

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Acta Pharmaceutica Sinica B 2022年第2期12卷 651-664,F0004页

作者： Juan Liu Yuxin Zhuang Jianlin Wu Qiang Wu Meixian Liu Yue Zhao Zhongqiu Liu Caiyan Wang Linlin Lu Yingjiao Meng Kawai Lei Xiaojuan Li Qibiao Wu Elaine lai-han Leung Zhengyang Guo Liang Liu Ting Li State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao SAR 999078China International Institute for Translational Chinese Medicine Guangzhou University of Chinese MedicineGuangzhou 510006China Guangdong Provincial Key Laboratory of New Drug Screening/Laboratory of Anti-inflammatory and Immunomodulatory Pharmacology School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease Macao University of Science and TechnologyMacao SAR 999078China Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China Macao University of Science and TechnologyMacao SAR 999078China

Inhibitor of nuclear factor kappa-B kinase subunit beta(IKKβ)is one of important kinases in inflammation to phosphorylate inhibitor of nuclear factor kappa-B(IκBα)and then activate nuclear factor kappa-B(NF-κB).Inhibition of IKKβhas been a therapeutic strategy for inflammatory and autoimmune *** we report that IKKβis constitutively activated in healthy donors and healthy Ikkβ^(C46A)(cysteine 46 mutated to alanine)knock-in mice although they possess intensive IKKβ-IκBα-NF-κB signaling *** indicate that IKKβactivation probably plays homeostatic role instead of causing *** to IkkβWTlittermates,lipopolysaccharides(LPS)could induce high mortality rate in Ikkβ^(C46A) mice which is correlated to breaking the homeostasis by intensively activating p-IκBα-NF-κB signaling and inhibiting phosphorylation of 5’adenosine monophosphate-activated protein kinase(p-AMPK)*** then demonstrated that IKKβkinase domain(KD)phosphorylates AMPKa1 via interacting with residues Thr183,Ser184,and Thr388,while IKKβhelix-loop-helix motifs is essential to phosphorylate IκBαaccording to the previous *** assay further demonstrated that IKKβsimultaneously catalyzes phosphorylation of AMPK and IκBαto mediate ***,activation of AMPK rather than inhibition of IKKβcould substantially rescue LPS-induced mortality in Ikkβ^(C46A) mice by rebuilding the *** conclude that IKKβactivates AMPK to restrict inflammation and IKKβmediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα.

关键词： IKKβ Homeostasis Kinase domain AMPK Inflammation IκBα Anti-inflammatory drug Phosphorylation

Control of GaN inverted pyramids growth on c-plane patterned sapphire substrates

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Journal of Semiconductors 2024年第6期45卷 92-96页

作者： Luming Yu Xun Wang Zhibiao Hao Yi Luo Changzheng Sun Bing Xiong Yanjun han Jian Wang Hongtao Li Lin Gan lai Wang Beijing National Research Center for Information Science and Technology Department of Electronic EngineeringTsinghua UniversityBei-jing 100084China Center for Flexible Electronics Technology Tsinghua UniversityBeijing 100084China

Growth of gallium nitride(GaN)inverted pyramids on c-plane sapphire substrates is benefit for fabricating novel devices as it forms the semipolar *** this work,GaN inverted pyramids are directly grown on c-plane patterned sapphire substrates(PSS)by metal organic vapor phase epitaxy(MOVPE).The influences of growth conditions on the surface morphol-ogy are experimentally studied and explained by Wulff *** competition of growth rate among{0001},{1011},and{1122}facets results in the various surface morphologies of GaN.A higher growth temperature of 985 ℃ and a lowerⅤ/Ⅲratio of 25 can expand the area of{}facets in GaN inverted *** the other hand,GaN inverted pyramids with almost pure{}facets are obtained by using a lower growth temperature of 930℃,a higherⅤ/Ⅲratio of 100,and PSS with pattern arrangement perpendicular to the substrate primary flat.

关键词： inverted pyramids GaN MOVPE crystal growth competition model

ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria

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Nano-Micro Letters 2020年第6期12卷 138-151页

作者： Xing-xing Fan Meng-ze Xu Elaine lai-han Leung Cai Jun Zhen Yuan Liang Liu State Key Laboratory of Quality Research in Chinese Medicine Macao Institute For Applied Research in Medicine and HealthMacao University of Science and TechnologyAvenida Wai LongTaipaMacao SARChina Faculty of Health Sciences University of MacaoTaipaMacao SARChina

Rheumatoid arthritis(RA)is an autoimmune disease,which attacks human joint system and causes lifelong inflammatory *** date,no cure is available for RA and even the ratio of achieving remission is very ***,to enhance the efficacy of RA treatment,it is essential to develop novel approaches specifically targeting pathological *** this study,we discovered that RA synovial fibroblasts exhibited higher reactive oxygen species(ROS)and mitochondrial superoxide level,which were adopted to develop ROS-responsive nano-medicines in inflammatory microenvironment for enhanced RA treatment.A selenocystamine-based polymer was synthesized as a ROS-responsive carrier nanoplatform,and berberine serves as a tool *** assembling,ROS-responsive berberine polymeric micelles were fabricated,which remarkably increased the uptake of berberine in RA fibroblast and improved in vitro and in vivo efficacy ten times ***,the anti-RA effect of micelles was blocked by the co-treatment of AMPK inhibitor or palmitic acid,indicating that the mechanism of micelles was carried out through targeting mitochondrial,suppressing lipogenesis and finally inhibiting cellular *** together,our ROS-responsive nano-medicines represent an effective way of preferentially releasing prodrug at the inflammatory microenvironment and improving RA therapeutic efficacy.

关键词： Rheumatoid arthritis Reactive oxygen species Nanoparticles Berberine Oxygen consumption rate

High-rate metal-free MXene microsupercapacitors on paper substrates

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Carbon Energy 2024年第5期6卷 94-104页

作者： han Xue Po‐han Huang Lee‐Lun lai Yingchun Su Axel Strömberg Gaolong Cao Yuzhu Fan Sergiy Khartsev Mats Göthelid Yan‐Ting Sun Jonas Weissenrieder Kristinn BGylfason Frank Niklaus Jiantong Li School of Electrical Engineering and Computer Science KTH Royal Institute of TechnologyStockholmSweden School of Engineering Sciences KTH Royal Institute of TechnologyStockholmSweden

MXene is a promising energy storage material for miniaturized microbatteries and microsupercapacitors(MSCs).Despite its superior electrochemical performance,only a few studies have reported MXene-based ultrahigh-rate(>1000 mV s^(−1))on-paper MSCs,mainly due to the reduced electrical conductance of MXene films deposited on ***,ultrahigh-rate metal-free on-paper MSCs based on heterogeneous MXene/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)(PEDOT:PSS)-stack electrodes are fabricated through the combination of direct ink writing and femtosecond laser *** a footprint area of only 20 mm^(2),the on-paper MSCs exhibit excellent high-rate capacitive behavior with an areal capacitance of 5.7 mF cm^(−2)and long cycle life(>95%capacitance retention after 10,000 cycles)at a high scan rate of 1000 mV s^(−1),outperforming most of the present on-paper ***,the heterogeneous MXene/PEDOT:PSS electrodes can interconnect individual MSCs into metal-free on-paper MSC arrays,which can also be simultaneously charged/discharged at 1000 mV s^(−1),showing scalable capacitive *** heterogeneous MXene/PEDOT:PSS stacks are a promising electrode structure for on-paper MSCs to serve as ultrafast miniaturized energy storage components for emerging paper electronics.

关键词： direct ink writing femtosecond laser scribing MXene on-paper microsupercapacitors PEDOT:PSS ultrahigh rate capability

马克思主义科技与人文相融合的理与路——科技伦理共识问题研究

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科学技术哲学研究 2022年第3期39卷 97-103页

作者：韩来平陈璇河北师范大学马克思主义学院石家庄050024 河北师范大学科学与社会发展研究所石家庄050024

马克思从现实的人的实践生存论出发得出科技与人文、社会科学相统一的论断,揭示了科学技术的本体论基础,明确了人的自由解放与全面发展的科技价值目标。马克思科技与人文相融合的思想,奠定了科技异化与调控的认识论和方法论基础;当代科... 详细信息

马克思从现实的人的实践生存论出发得出科技与人文、社会科学相统一的论断,揭示了科学技术的本体论基础,明确了人的自由解放与全面发展的科技价值目标。马克思科技与人文相融合的思想,奠定了科技异化与调控的认识论和方法论基础;当代科技与人文的实质性融合寓于科技利益攸关方多元参与的科技评估与审查中;实质性融合的表征,在于利益攸关方多元参与形成的科技伦理共识。实现实质性融合的实践进路,一是构建科技与人文之间有机互动的实践空间;二是确立以基本道德共识为核心的科技伦理语境;最后是以基本道德共识为逻辑起点,通过共识影响要素的调节,形成促进伦理共识形成的引导原则,以此促使科技与人文实质性融合并为科技异化的调控提供依据。

关键词：马克思主义科技人文融合科技伦理共识

miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis

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Acta Pharmaceutica Sinica B 2022年第2期12卷 821-837页

作者： Tao Su Suchao Huang Yanmin Zhang Yajuan Guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine lai-han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Molecular and Cellular Oncology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao(SAR)999078China Department of Pharmacological and Pharmaceutical Sciences University of HoustonHoustonTX 77204USA

Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and *** overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical ***,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,***-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer *** data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 ***-β2 is a direct target of miR-7-5 *** reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung ***,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer ***,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’*** are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer *** study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)*** study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment.

关键词： Acidic tumor microenvironment miR-7-5p TGF-β2 Metastasis Lung cancer pH Invasion

Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis

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Bioactive Materials 2022年第7期7卷 23-36页

作者： Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine lai-han Leung Tian Xie Qibiao Wu Xinbing Sui State Key Laboratory of Quality Research in Chinese Medicines Faculty of Chinese MedicineMacao University of Science and TechnologyMacao School of Pharmacy and Department of Medical Oncology The Affiliated Hospital of Hangzhou Normal UniversitySchool of MedicineHangzhou Normal UniversityHangzhou311121ZhejiangChina Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines China Engineering Laboratory of Development and Application of Traditional Chinese Medicines China Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal UniversityHangzhou311121ZhejiangChina Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health Guangzhou510006China

Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer ***,the effect and molecular mechanism of curcumenol in lung cancer are largely ***,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer ***,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first ***,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated *** of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol ***,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of *** conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell ***,our findings will hopefully provide a valuable drug for treating lung cancer patients.

关键词： Curcumenol Ferroptosis Lung cancer lncRNA H19 miRNA-19b-3p FTH1