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Site-selective oral delivery of therapeutic antibodies to the inflamed colon via a folic acid-grafted organic/inorganic hy brid nanocomposite system

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Acta Pharmaceutica Sinica B 2022年第11期12卷 4249-4261页

作者： Sang hoon Lee Jae Geun Song Hyo-Kyung han College of Pharmacy Dongguk University-SeoulGoyang 10326South Korea

This study aimed to develop a pH-responsive folic acid-grafted organic/inorganic hybrid nanocomposite system for site-selective oral delivery of therapeutic antibodies. A folic acid-grafted aminoclay(FA-AC) was prepared via an in situ sol-gel method. Then, a drug-loaded nanocomplex was prepared via the electrostatic interaction of FA-AC with infliximab(IFX), a model antibody, and coated with Eudragit? S100(EFA-AC-IFX). FA-AC exhibited favorable profiles as a drug carrier including low cytotoxicity, good target selectivity, and capability to form a nanocomplex with negatively charged macromolecules. A pH-responsive FA-AC-based nanocomplex containing IFX(EFA-AC-IFX) was also obtained in a narrow size distribution with high entrapment efficiency(>87%). The conformational stability of IFX entrapped in EFA-AC-IFX was well maintained in the presence of proteolytic enzymes. EFA-ACIFX exhibited pH-dependent drug release, minimizing premature drug release in gastric conditions and the upper intestine. Accordingly, oral administration of EFA-AC-IFX to colitis-induced mice was effective in alleviating the progression of ulcerative colitis, while oral IFX solution had no efficacy. These results suggest that a pH-responsive FA-AC-based nanocomposite system can be a new platform for the site-selective oral delivery of therapeutic antibodies.

关键词： Infliximab Aminoclay Colonic delivery:TNF-x Infammation Folate rceptor Anibody Nanocomposite

Does antiviral therapy reduce complications of cirrhosis?

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World Journal of Gastroenterology 2014年第23期20卷 7306-7311页

作者： Goh Eun Chung jeong-hoon Lee Yoon Jun Kim Department of Internal Medicine Healthcare Research InstituteGangnam Healthcare CenterSeoul National University HospitalSeoul 135-984South Korea Department of Internal Medicine and Liver Research Institute Seoul National College of MedicineSeoul 110-744South Korea

Chronic hepatitis B infection is associated with the development of cirrhosis, hepatocellular carcinoma, and finally liver-related mortality. Each year, approximately, 2%-5% of patients with hepatitis B virus (HBV)-related compensated cirrhosis develop decompensation, with additional clinical manifestations, such as ascites, jaundice, hepatic encephalopathy, and gastrointestinal bleeding. The outcome of decompensated HBV-related cirrhosis is poor, with a 5-year survival of 14%-35% compared to 84% in patients with compensated cirrhosis. Because the risk of disease progression is closely linked to a patient’s serum HBV DNA level, antiviral therapy may suppress viral replication, stabilize liver function and improve survival. This article briefly reviews the role that antiviral therapy plays in cirrhosis complications, particularly, in decompensation and acute-on-chronic liver failure.

关键词： Antiviral therapy Cirrhosis Complication Hepatitis B Decompensation

Predictive factors for early clinical response in community-onset Escherichia coli urinary tract infection and effects of initial antibiotic treatment on early clinical response

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World Journal of Clinical Cases 2020年第19期8卷 4342-4348页

作者： Young Jun Kim jeong-Mi Lee Jae-hoon Lee Department of Internal Medicine Wonkwang University College of MedicineIksan 54538South Korea Department of Public Health Wonkwang University College of MedicineIksan 54538South Korea Department of Internal Medicine and Institute of Wonkwang Medical Science Wonkwang University College of MedicineIksan 54538South Korea

BACKGROUND Urinary tract infection(UTI)is a common *** often requires hospitalization,and severe presentations,including sepsis and other complications,have a mortality rate of 6.7%-8.7%.AIM To evaluate the predictive factors for early clinical response and effects of initial antibiotic therapy on early clinical response in community-onset Escherichia coli(***)urinary tract infections(UTIs).METHODS This retrospective study was conducted at Wonkwang University Hospital in South Korea between January 2011 and December *** patients(aged>18 years)who were diagnosed with community-onset *** UTI were enrolled in this *** A total of 511 hospitalized patients were included.66.1%of the patients had an early clinical *** mean length of hospital stay in patients with an early clinical response were each 4.3 d shorter than in patients without an early clinical *** the multiple regression analysis,initial appropriate antibiotic therapy(OR=2.449,P=0.006),extended-spectrum(3-lactamase(ESBL)-producing ***(OR=2.112,P=0.044),improper use of broad-spectrum antimicrobials(OR=0.411,P=0.006),and a stay in a healthcare facility before admission(OR=0.562,P=0.033)were the factors associated with an early clinical *** broadspectrum antibiotic therapy was not associated with an early clinical *** ESBL producing ***,and the type of residence before hospital admission were the factors associated with an early clinical *** of initial antibiotic therapy was a predictive factor for an early clinical response,but broadspectrum of initial antibiotic therapy did not impact early clinical response.

关键词： Escherichia coli Urinary tract infections Adult Community acquired infections

Bioinspired magnetic cilia:from materials to applications

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Microsystems & Nanoengineering 2023年第6期9卷 107-128页

作者： Seongjin Park Geonjun Choi Minsu Kang Woochan Kim Jangho Kim hoon Eui jeong Department of Mechanical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan44919Republic of Korea Department of Convergence Biosystems Engineering Chonnam National UniversityGwangju61186Republic of Korea Interdisciplinary Program in IT-Bio Convergence System Chonnam National UniversityGwangju61186Republic of Korea

Microscale and nanoscale cilia are ubiquitous in natural systems where they serve diverse biological *** artificial magnetic cilia have emerged as a highly promising technology with vast potential applications,ranging from soft robotics to highly precise *** this review,we comprehensively discuss the roles of cilia in nature and the various types of magnetic particles utilized in magnetic cilia;additionally,we explore the top-down and bottom-up fabrication techniques employed for their ***,we examine the various applications of magnetic cilia,including their use in soft robotics,droplet and particle control systems,fluidics,optical devices,and ***,we present our conclusions and the future outlook for magnetic cilia research and development,including the challenges that need to be overcome and the potential for further integration with emerging technologies.

关键词： magnetic overcome precise

Gravitational waves from the vacuum decay with LISA

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Chinese Physics C 2022年第7期46卷 189-200页

作者： Bum-hoon Lee Wonwoo Lee Dong-han Yeom Lu Yin Center for Quantum Spacetime Sogang University Seoul 04107 Kora Department of Physics Sogang UniversitySeoul 04107Korea Asia Pacific Center for Theoretical Physics PostechPohang 37673Korea Department of Physics Education Pusan National UniversityBusan 46241Korea Research Center for Dielectric and Advanced Matter Physics Pusan National UniversityBusan 46241Korea

We investigate the gravitational wave spectrum originating from the cosmological first-order phase *** compare two models:one is a scalar field model without gravitation,while the other is a scalar field model with *** on the sensitivity curves of the LISA space-based interferometer on the stochastic gravitational-wave background,we compare the difference between the gravitational wave spectra of the former and the latter cases obtained from the bubble collision *** particular,we numerically calculate the speed of the bubble wall before collision for the two *** demonstrate that the difference between the amplitudes of these spectra can clearly distinguish between the two *** expect that the LISA with Signal to Noise Ratio=10 could observe the spectrum as the fast first-order phase transition.

关键词： gravitational wave first order phasetransition bubble collision

Endoscopic papillary balloon dilation:Revival of the old technique

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World Journal of Gastroenterology 2013年第45期19卷 8258-8268页

作者： Seung Uk jeong Sung-hoon Moon Myung-Hwan Kim Department of Internal Medicine Jeju National University School of Medicine Jeju 690-767 South Korea Department of Internal Medicine Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang 431-070 South Korea Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea

Radiologists first described the removal of bile duct stones using balloon dilation in the early ***,there has been renewed interest in endoscopic balloon dilation with a small balloon to avoid the complications of endoscopic sphincterotomy(EST)in young patients undergoing laparoscopic ***,there is a disparity in using endoscopic balloon papillary dilation(EPBD)between the East and the West,depending on the origin of the *** the early 2000s,EST followed by endoscopic balloon dilation with a large balloon was introduced to treat large or difficult biliary *** balloon dilation with a large balloon has generally been recognized as an effective and safe method,unlike ***,fatal complications have occurred in patients with endoscopic papillary large balloon dilation(EPLBD).The safety of endoscopic balloon dilation is still a debatable ***,guidelines of indications and techniques have not been established in performing endoscopic balloon dilation with a small balloon or a large *** this article,we discuss the issue of conventional and large balloon endoscopic *** also suggest the indications and optimal techniques of EPBD and EPLBD.

关键词： Endoscopic papillary balloon dilation Endoscopic papillary large balloon dilation Common bile duct stone Endoscopic sphincterotomy Mechanical lithotripsy

Femtosecond laser-mediated anchoring of polymer layers on the surface of a biodegradable metal

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Journal of Magnesium and Alloys 2021年第4期9卷 1380-1388页

作者： Jaeho Park Bo-In Park Young Ju Son Sun Hee Lee Seung-hoon Um Yu-Chan Kim Myoung-Ryul Ok jeong-Yun Sun Hyung-Seop han Hojeong Jeon Center for Biomaterials Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Materials science and Engineering Seoul National University(SNU)Seoul 08826Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

Mg has received much attention as a next-generation implantable material owing to its biocompatibility,bone-like mechanical properties,and biodegradability in physiological *** application of various polymer coatings has been conducted in the past to reduce the rapid formation of hydrogen gas and the local change in pH during the initial phase of the chemical reaction with the body ***,we propose femtosecond(fs)laser-mediated Mg surface patterning for significant enhancement of the binding strength of the coating material,which eventually reduces the corrosion *** of the structural,physical,crystallographic,and chemical properties of the Mg surface have been conducted in order to understand the mechanism by which the surface adhesion increases between Mg and the polymer coating *** on the fs laser conditions,the surface structure becomes rough owing to the presence of several microscaled pits and grooves of nanoporous MgO,resulting in a tightly bonded poly(lactic-co-glycolic acid)(PLGA)*** corrosion rate of the PLGA-coated,fs laser-treated Mg is considerably slow compared with the non-treated Mg;the treated Mg is also more biocompatible compared with the non-treated *** fs laser-based surface modification technique offers a simple and quick method for introducing a rough coating on Mg;further,it does not require any chemical treatment,thereby overcoming a potential obstacle for its clinical use.

关键词： Femtosecond laser Biodegradable metal Polymer coating Surface modification Surface adhesion

Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy

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Nano-Micro Letters 2020年第7期12卷 156-174页

作者： Wenquan Ou Kang Sik Nam Dae hoon Park Jungho Hwang Sae Kwang Ku Chul Soon Yong Jong Oh Kim jeong hoon Byeon College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea College of Korean Medicine Daegu Haany UniversityGyeongsan 38610Republic of Korea School of Mechanical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea

Because of enhanced e cacy and lower side e ects,cancer immunotherapies have recently been extensively investigated in clinical trials to overcome the limitations of conventional cancer *** engineering attempts have been made to build nanosystems even including stimulus nanomaterials for the e cient delivery of antigens,adjuvants,or anticancer drugs to improve immunogenic cancer cell death,this requires huge R&D e orts and investment for clinically relevant findings to be approved for translation of the *** this end,in this study,an air–liquid two-phase electrospray was developed for stable bubble pressing under a balance between mechanical and electrical parameters of the spray to continuously produce biomimetic nanosystems consisting of only clinically relevant compounds[paclitaxel-loaded fake blood cell Eudragit particle(Eu-FBCP/PTX)]to provide a conceptual leap for the timely development of translatable chemo-immunotherapeutic *** was pursued as the e cacy of systems for delivering anticancer agents that has been mainly influenced by nanosystem shape because of its relevance to transporting behavior to organs,blood circulation,and cell–membrane *** resulting Eu-FBCP/PTX nanosystems exhibiting phagocytic and micropinocytic uptake behaviors can confer better e cacy in chemo-immunotherapeutics in the absence and presence of anti-PD-L1 antibodies than similar sized PTX-loaded spherical Eu particles(Eu-s/PTX).

关键词： Cancer immunotherapies Air–liquid two-phase electrospray Paclitaxel-loaded fake blood cell Eudragit particle Translatable chemo-immunotherapeutic nanosystems Anti-PD-L1 antibodies

Flow characteristics of aluminum coated boron steel in hot press forming

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中国有色金属学会会刊：英文版 2009年第4期19卷 913-916页

作者： jeong-Hwan JANG Jae-Ho LEE Bye ong-Don JOO Young-hoon MOON School of Mechanical Engineering Pusan National University

The flow characteristics of aluminum coated boron steel in hot press forming were ***,the effects of aluminum coated layer on press forming were analyzed during deep *** results show that aluminum coated boron steel exhibits a high sensitivity on temperature and strain *** coating layer appears in surface flaking in a temperature range of 700-800 ℃,but smooth surface is formed above 900 ℃.

关键词：热压成型流动特性铝涂层硼钢表面剥落温度范围冲压成形高灵敏度