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Remote ischemic conditioning prevents ischemic cerebrovascular events in children with moyamoya disease:a randomized controlled trial

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World Journal of Pediatrics 2024年第9期20卷 925-934页

作者： Shuang-Feng Huang Jia-Li Xu Chang-Hong Ren nathan Sim Cong han Yi-Qin han Wen-Bo Zhao Yu-Chuan Ding Xun-Ming Ji Si-Jie Li Department of Neurology Xuanwu HospitalCapital Medical UniversityNo 45Changchun StreetXicheng DistrictBeijing100053China Department of Rehabilitation Medicine Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Capital Medical UniversityNo.10XitoutiaoYou’anmenwaiFengtai DistrictBeijing100053China Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Wayne State UniversityDetroitMIUSA Department of Neurosurgery The Fifth Medical CentreChinese PLA General HospitalBeijingChina Department of Emergency Xuanwu HospitalCapital Medical UniversityBeijingChina

Background Moyamoya disease(MMD)is a significant cause of childhood stroke and transient ischemic attacks(TIAs).This study aimed to assess the safety and efficacy of remote ischemic conditioning(RIC)in children with *** In a single-center pilot study,46 MMD patients aged 4 to 14 years,with no history of reconstructive surgery,were randomly assigned to receive either RIC or sham RIC treatment twice daily for a *** primary outcome measured was the cumulative incidence of major adverse cerebrovascular events(MACEs).Secondary outcomes included ischemic stroke,recurrent TIA,hemorrhagic stroke,revascularization rates,and clinical improvement assessed using the patient global impression of change(PGIC)scale during ***-related adverse events were also recorded,and cerebral hemodynamics were evaluated using transcranial *** All 46 patients completed the final follow-up(23 each in the RIC and sham RIC groups).No severe adverse events associated with RIC were ***-Meier analysis indicated a significant reduction in MACEs frequency after RIC treatment[log-rank test(Mantel-Cox),P=0.021].At 3-year follow-up,two(4.35%)patients had an ischemic stroke,four(8.70%)experienced TIAs,and two(4.35%)underwent revascularization as the qualifying *** clinical improvement rate in the RIC group was higher than the sham RIC group on the PGIC scale(65.2%vs.26.1%,P<0.01).No statistical difference in cerebral hemodynamics post-treatment was *** RIC is a safe and effective adjunct therapy for asymptomatic children with *** was largely due to the reduced incidence of ischemic cerebrovascular events.

关键词： Asymptomatic moyamoya disease Children Remote ischemic conditioning Stroke

Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑Woong Shin Dong‑Je Kim Tae‑Min Jang Won Bae han Joong Hoon Lee Gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun han Heeseok Kang Jun Hyeon lim Chan‑Hwi Eom Amay J.Bandodkar hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

Long-term outcomes of very low birth weight infants with intraventricular hemorrhage:a nationwide population study from 2011 to 2019

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World Journal of Pediatrics 2024年第7期20卷 692-700页

作者： Joonsik Park Sook-Hyun Park Yu-ra Kwon So Jin Yoon Joo Hee lim Jung Ho han Jeong Eun Shin Ho Seon Eun Min Soo Park Soon Min Lee Department of Pediatrics Yonsei University College of Medicine211 Eonjuro GangnamguSeoul 06273Republic of Korea

Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)*** study explores IVH prevalence and long-term outcomes of very low birth weight(VLBW)infants in Korea over a *** Using Korean National Health Insurance data(NHIS,2010-2019),we identified 3372 VLBW infants with IVH among 4,129,808 live ***-related claims data,encompassing diagnostic codes,diagnostic test costs,and administered procedures were sourced from the NHIS *** results of the developmental assessments are categorized into four groups based on standard deviation(SD)*** characteristics and complications were compared among the *** regression models were employed to identify significant changes in the incidence of complications and to calculate odds ratios with corresponding 95%confidence intervals for each risk factor associated with mortality and morbidity in ***-term growth and development were compared between the two groups(years 2010-2013 and 2014-2017).Results IVH prevalence was 12%in VLBW and 16%in extremely low birth weight(ELBW)*** the past decade,IVH rates increased significantly in ELBW infants(P=0.0113),while mortality decreased(P=0.0225).Major improvements in certain neurodevelopmental outcomes and reductions in early morbidities have been observed among VLBW infants with *** percent of the population received surgical treatments such as external ventricular drainage(EVD)or a ventriculoperitoneal(VP)shunt,with the choice of treatment methods remaining consistent over *** IVH with surgical intervention group exhibited higher incidences of delayed development,cerebral palsy,seizure disorder,and growth failure(height,weight,and head circumference)up to 72 months of age(P<0.0001).Surgical treatments were also significantly associated with abnormal developmental screening test *** The neurodevelopmental outcomes of infa

关键词： Cerebral intraventricular hemorrhage Developmental Hydrocephalus Mortality Posthemorrhagic ventricular dilatation Surgery

V_(2)O_(3)/VN electrocatalysts with coherent heterogeneous interfaces for selecting low-energy nitrogen reduction pathways

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SusMat 2024年第4期4卷 90-103页

作者： Tae-Yong An Chengkai Xia Minyeong Je Hyunjung Lee Seulgi Ji Min-Cheol Kim Subramani Surendran Mi-Kyung han Jaehyoung lim Dong-Kyu Lee Joon Young Kim Tae-Hoon Kim Heechae Choi Jung Kyu Kim Uk Sim Hydrogen Energy Technology Laboratory Korea Institute of Energy Technology(KENTECH)NajuRepublic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea Materials&Chemistry Group Institute of Inorganic ChemistryUniversity of CologneCologneGermany Department of Polymer Engineering Graduate SchoolAlan G.MacDiarmid Energy Research Institute&School of Polymer Science and EngineeringChonnam National UniversityGwangjuRepublic of Korea Research Institute NEEL SciencesJeollanamdoRepublic of Korea Department of Materials Science and Engineering Chonnam National UniversityGwangjuRepublic of Korea Department of Chemistry Xi’an Jiaotong-Liverpool UniversitySuzhouChina

Electrochemical nitrogen reduction reaction(NRR)is a sustainable alterna-tive to the Haber-Bosch process for ammonia(NH3)***,the significant uphill energy in the multistep NRR pathway is a bottleneck for favorable serial *** overcome this challenge,we designed a vanadium oxide/nitride(V_(2)O_(3)/VN)hybrid electrocatalyst in which V_(2)O_(3)and VN coex-ist coherently at the heterogeneous *** single-phase V_(2)O_(3)and VN exhibit different surface catalytic kinetics for NRR,the V_(2)O_(3)/VN hybrid elec-trocatalyst can provide alternating reaction pathways,selecting a lower energy pathway for each material in the serial NRR *** a result,the ammo-nia yield of the V_(2)O_(3)/VN hybrid electrocatalyst was 219.6µg h^(-1)cm^(-2),and the Faradaic efficiency was 18.9%,which is much higher than that of single-phase VN,V_(2)O_(3),and VNxOy solid solution catalysts without *** functional theory calculations confirmed that the composition of these hybrid electrocatalysts allows NRR to proceed from a multistep reduction reaction to a low-energy reaction pathway through the migration and adsorption of interme-diate ***,the design of metal oxide/nitride hybrids with coherent heterointerfaces provides a novel strategy for synthesizing highly efficient elec-trochemical catalysts that induce steps favorable for the efficient low-energy progression of NRR.

关键词： coherent heterogeneous interfaces green ammonia synthesis hybrid electrocatalyst low-energy progression nitrogen reduction reaction(NRR) vanadium oxide/nitride(V_(2)O_(3)/VN)

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钒钛铁尾矿制备绿色建筑材料的研究进展

材料导报 2024年第19期38卷 115-124页

作者：田小平王长龙 Hidayati Asrah lim Chung han 平浩岩齐洋马锦涛荆牮霖刘治兵郑永超翟玉新刘枫河北工程大学土木工程学院河北邯郸056038 马来西亚沙巴大学工程学院沙巴哥打京那巴鲁88400 北京建筑材料科学研究总院有限公司固废资源化利用与节能建材国家重点实验室北京100041 中铁建设集团有限公司北京100040 中铁建设集团建筑发展有限公司北京100070

钒钛磁铁矿是以铁、钒、钛为主的多金属元素共生的复合矿,在世界分布不均衡。中国是该矿石的主要产出国之一,该矿石分布在五个主要矿带。钒钛铁尾矿是钒钛磁铁矿选矿过程中产生的固体工业废弃物,是一种多金属伴生的铁尾矿。该尾矿在中... 详细信息

钒钛磁铁矿是以铁、钒、钛为主的多金属元素共生的复合矿,在世界分布不均衡。中国是该矿石的主要产出国之一,该矿石分布在五个主要矿带。钒钛铁尾矿是钒钛磁铁矿选矿过程中产生的固体工业废弃物,是一种多金属伴生的铁尾矿。该尾矿在中国的堆存量巨大,富含很多有用化学组分,也被称为人工矿床。该尾矿以硅酸盐为主,主要化学成分是二氧化硅、三氧化二铝、氧化钙和氧化铁等,主要矿物是脉石矿物。国内外学者对其在绿色建筑材料综合利用方面做了很多有益探索,但总体来看,这些研究更多停留在实验室里。主要原因是(1)不同尾矿库甚至同一尾矿库的钒钛铁尾矿理化性能可能有较大差异,尾矿原料的稳定性不足;(2)受尾矿原料不稳定的理化性能影响,中试结果经常出现较大差异,难以实现规模化利用;(3)钒钛铁尾矿库大多地处偏僻,运输成本高,且缺乏高附加值的尾矿产品,规模以上企业因投入大产出小望而生畏。本文综述了钒钛铁尾矿在中国的地域分布和堆存量,重点研究了其化学组成、矿物组成、粒度分布和重金属浸出,分析了其作为主要原料在绿色建筑材料方面的研究进展,指出了存在问题并展望了发展前景。

关键词：钒钛磁铁矿钒钛铁尾矿绿色建筑材料混凝土矿物掺合料

LEUNIG_HOMOLOG and LEUNIG Regulate Seed Mucilage Extrusion in Arabidopsis

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Journal of Integrative Plant Biology 2011年第5期53卷 399-408页

作者： Minh Bui nathan lim Paja Sijacic Department of Cell Biology and Molecular Genetics University of MarylandCollege ParkMaryland 20742USA

LEUNIG （LUG） and LEUNIG_HOMOLOG （LUH） encode two closely related Arabidopsis proteins, belonging to the Gro/TLE family of transcriptional co-repressors. These two genes were previously shown to exhibit partially overlapping functions in embryo and flower development. In this report, the role of both LUH and LUG on seed mucilage extrusion was examined. Seed mucilage extrusion occurs after the seeds are imbibed, serving as functional aid in seed hydration, germination, and dispersal. While luh-1 mutants exhibited strong defects in seed mucilage extrusion, lug-3 mutants exhibited a minor phenotype in mucilage extrusion. Further characterization indicates that luh-1 does not exhibit any obvious defect in seed epidermal cell differentiation, mucilage synthesis, or mucilage deposition, suggesting a specific role of LUH in mucilage extrusion. This seed mucilage phenotype of luh-1 is identical to that of mucilage modified 2 （mum2） mutants. MUM2 encodes a β-galactosidase required for the modification of the mucilage. Quantitative reverse transcription polymerase chain reaction of RNA extracted from siliques detected a slight decrease of MUM2 mRNA in the luh-1 mutant compared to the wild type. Together, LUH and possibly LUG may specifically regulate mucilage extrusion by promoting the expression of genes required for mucilage maturation.

关键词： Genes Extrusion Mucilages Adhesives Transcription Exhibitions Lymphocytes Defects Phenotypes Dispersants

Advanced metal–organic frameworks for aqueous sodium-ion rechargeable batteries

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Journal of Energy Chemistry 2021年第2期30卷 396-406,I0014页

作者： Dongkyu Choi Seonguk lim Dongwook han School of Nano Convergence Technology Hallym UniversityChuncheon 24252Gangwon-doRepublic of Korea Nano Convergence Technology Center Hallym UniversityChuncheon 24252Gangwon-doRepublic of Korea

Inexpensive and abundant sodium resources make energy storage systems using sodium chemistry promising replacements for typical lithium-ion rechargeable batteries(LIBs).Fortuitously,aqueous sodium-ion rechargeable batteries(ASIBs),which operate in aqueous electrolytes,are cheaper,safer,and more ionically conductive than batteries that operate in conventional organic electrolytes;furthermore,they are suitable for grid-scale energy storage *** electrode materials for storing Na~+ ions in ASIBs,a variety of multifunctional metal-organic frameworks(MOFs) have demonstrated great potential in terms of having porous 3 D crystal structures,compatibility with aqueous solutions,long cycle lives(≥1000 cycles),and ease of *** present review describes MOF-derived technologies for the successful application of MOFs to ASIBs and suggests future challenges in this area of research based on the current understanding.

关键词： Metal–Organic Framework(MOF) Prussian blue Metal hexacyanoferrate Aqueous electrolyte Sodium-ion Rechargeable battery

Complete Solution of Sun Tracking for Heliostat

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Communications in Theoretical Physics 2006年第1期45卷 165-166页

作者： CHEN Ying-Tian lim Boon-han lim Chern-Sing Department of Astronomy and Applied Physics University of Science and Technology of China Hefei 230026 China

A general solution of sun tracking for an arbitrarily oriented heliostat towards an arbitrarily located target on the earth is published. With the most general form of solar tracking formulae, it is seen that the used azimuthelevation, spinning-elevation tracking formulae etc. are the special cases of it. The possibilities of utilizing the general solution and its significance in solar energy engineering are discussed.

关键词： solar tracking azimuth-elevation spinning-elevation optical aberration heliostat

Automation 5.0: The Key to Systems Intelligence and Industry 5.0

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1723-1727页

作者： Ljubo Vlacic Hailong Huang Mariagrazia Dotoli Yutong Wang Petros A.Ioannou Lili Fan Xingxia Wang Raffaele Carli Chen Lv Lingxi Li Xiaoxiang Na Qing-Long han Fei-Yue Wang Institute of Intelligent and Integrated Systems and the School of Engineering and Built Environment Griffith UniversityNathanQLD 4111Australia Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Electrical and Information Engineering Polytechnic of Bari70126 BariItaly State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190and also with the Qingdao Academy of Intelligent IndustriesQingdao 266114China Department of Electrical Engineering-Systems University of Southern CaliforniaLos AngelesCA 90007 USA School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049 Beijing Huairou Academy of Parallel Sensing Beijing 101499China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Computer Engineering Purdue School of Engineering and TechnologyIndiana University-Purdue University IndianapolisIndianapolisIN 46202 USA Department of Engineering University of CambridgeCB21TN CambridgeU.K. School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Dazhou Artificial Intelligence Institute Dazhouand the Faculty of Innovation EngineeringMacao University of Science and TechnologyMacao 999078China

AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with *** rise of steam engines and water wheels represented the first generation of industry,which is now called Industry Citation:***,***,***,***,***,***,***,***,***,***,***,Q.-***,and F.-***,“Automation 5.0:The key to systems intelligence and Industry 5.0,”IEEE/CAA ***,vol.11,no.8,pp.1723-1727,Aug.2024.

关键词： Automation machinery intelligence