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Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis:A case-control study

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World Journal of Gastroenterology 2018年第23期24卷 2482-2490页

作者： Ben-Gang Wang Qian Xu Zhi Lv Xin-Xin Fang han-Xi ding Jing Wen Yuan Yuan Tumor Etiology and Screening Department of Cancer Institute and General Surgery the First Hospital of China Medical Universityand Key Laboratory of Cancer Etiology and Prevention (China Medical University)Liaoning Provincial Education Department Hepatobiliary Surgery Department of General Surgery Institute the First Hospital of China Medical University

AIM To evaluate the association of 12 tag single nucleotide polymorphisms(tag SNPs) in three onco-long non-coding RNA(lnc RNA) genes(HOTTIP,CCAT2,MALAT1) with the risk and prognosis of hepatocellular cancer(HCC). METHODS Twelve tag SNPs covering the three onco-lnc RNAs were genotyped by the KASP method in a total of 1338 samples,including 521 HCC patients and frequencymatched 817 controls. The samples were obtained from an unrelated Chinese population at the First Hospital ofChina Medical University from 2012-2015. The expression quantitative trait loci(e QTL) analyses were conducted to explore further the potential function of the promising SNPs. RESULTS Three SNPs in HOTTIP,one promoter SNP in MALAT1,and one haplotype of HOTTIP were associated with HCC risk. The HOTTIP rs17501292,rs2067087,and rs17427960 SNPs were increased to 1.55-,1.20-,and 1.18-fold HCC risk under allelic models(P = 0.012,0.017 and 0.049,respectively). MALAT1 rs4102217 SNP was increased to a 1.32-fold HCC risk under dominant models(P = 0.028). In addition,the two-way interaction of HOTTIP rs17501292-MALAT1 rs619586 polymorphisms showed a decreased effect on HCC risk(P interaction = 0.028,OR = 0.30) and epistasis with each other. HOTTIP rs3807598 variant genotype showed significantly longer survival time in HBV negative subgroup(P = 0.049,HR = 0.12),and MALAT1 rs591291 showed significantly better prognosis in female and HBV negative subgroups(P = 0.022,HR = 0.37; P = 0.042,HR = 0.25,respectively). In the study,no significant effect was observed in e QTL analysis. CONCLUSION Specific lnc RNA(HOTTIP and MALAT1) SNPs have potential to be biomarkers for HCC risk and prognosis.

关键词： Hepatocellular cancer Single nucleotide polymorphism Long non-coding RNA Risk Prognosis

Directed and Elliptic Flows in ^(112)Sn+^(112)Sn Collisions

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Chinese Physics Letters 2001年第6期18卷 756-758页

作者： ZhanG Hu-Yong MA Yu-Gang YU Li-Ping SHEN Wen-Qing CAI Xiang-Zhou FANG De-Qing ZHONG Chen han ding-ding Shanghai Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800 Department of Physics Ningbo UniversityNingbo 315211 Department of Electronic Engineering East China Normal UniversityShanghai 200062

The directed and elliptic flow in collisions of ^(112)Sn+^(112)Sn at energies from 35 to 90 MeV/nucleon are studied in an isospin-dependent quantum molecule dynamics *** increasing incident energy,the directed flow rises from negative to *** magnitude depends on the nuclear equation of state(EOS).However,the elliptic flow decreases with increasing incident energy and its magnitude is not very sensible to *** studies of the impact parameter dependence and the cluster mass dependence are also *** study of directed flow at intermediate energies thus provides a means of extracting the information on the nuclear equation of state.

关键词： state directed flow

Human-Robot Collaboration Framework Based on Impedance Control in Robotic Assembly

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Engineering 2023年第11期30卷 83-92页

作者： Xingwei Zhao Yiming Chen Lu Qian Bo Tao han ding State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Human–robot(HR)collaboration(HRC)is an emerging research field because of the complementary advantages of humans and *** HRC framework for robotic assembly based on impedance control is proposed in this *** the HRC framework,the human is the decision maker,the robot acts as the executor,while the assembly environment provides *** robot is the main executor to perform the assembly action,which has the position control,drag and drop,positive impedance control,and negative impedance control *** reveal the characteristics of the HRC framework,the switch condition map of different control modes and the stability analysis of the HR coupled system are *** the end,HRC assembly experiments are conducted,where the HRC assembly task can be accomplished when the assembling tolerance is 0.08 mm or with the interference *** show that the HRC assembly has the complementary advantages of humans and robots and is efficient in finishing complex assembly tasks.

关键词： Human-robot collaboration Impedance control Robotic assembly

Enhancement of physicochemical properties and baking quality of broken rice flour through superheated steam

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Grain & Oil Science and Technology 2024年第4期7卷 229-236页

作者： Zixiu Zhang Jingxin Li Xishuang Wang Xinzhu Wu Jialin Wang Xiaolin Zhang han ding Ju Qiu Ruge Cao State Key Laboratory of Food Nutrition and Safety College of Food Science and EngineeringTianjin University of Science and TechnologyTianjin 300457China School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological University21 Nanyang LinkSingapore 637371Singapore Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100083China

This study investigated the effects of superheated steam(SS)treatment at different temperatures(120℃,150℃,180℃)on the physicochemical properties of broken rice flour and the quality of broken rice *** treatment at 120℃ significantly enhanced the moisture content of broken rice flour(Phance the quality of broken rice cakes,especially at 150℃ and 180℃.This study presents a method for improving the quality of broken rice flour and rice cakes using superheated steam treatment,addressing challenges related to poor flour characteristics and suboptimal cake *** findings offer technical and theoretical support for enhancing rice cake production,contributing to the comprehensive utilization of rice resources.

关键词： Broken rice Rice flour Physicochemical properties Broken rice cake Baking quality Textural properties

基于TLESO/HLESO/RLESO的PMSM调速系统研究

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工程设计学报 2018年第1期25卷 94-102页

作者：韩丁丁俊西南石油大学机电工程学院四川成都610500 西南石油大学石油天然气装备教育部重点实验室四川成都610500

为了提高永磁同步电机(permanent magnet synchronous motor,PMSM)调速系统的抗扰动和噪声抑制能力,针对PMSM转速环设计了3种线性自抗扰控制器(linear active disturbance rejection control,LADRC),即传统线性自抗扰控制器(traditional LADRC,TLADRC)、高阶线性自抗扰控制器(high-order LADRC,HLADRC)和降维线性自抗扰控制器(reduced-order LADRC,RLADRC)。各LADRC的区别在于线性扩张状态观测器(linear extended state observer,LESO)的不同,即传统线性扩张状态观测器(traditional LESO,TLESO)、高阶线性扩张状态观测器(high-order LESO,HLESO)和降维线性扩张状态观测器(reduced-order LESO,RLESO)。采用叠加原理对各LADRC控制转速环的稳定性进行了证明,同时对各LESO的收敛条件进行了分析。通过对各LESO的频域分析可得出:TLESO的相位滞后最大,其扰动估计能力最弱;HLESO在中高频段的幅值增益最大,其鲁棒性最差;RLESO相位滞后最小,扰动估计能力最强。最后,在MATLAB/Simulink环境下,对各LADRC控制的转速环进行仿真,仿真结果验证了频域分析的结论,即TLADRC在抗扰动时转速曲线有最大的转速降,HLADRC在抗扰动时转速曲线有振荡,而RLADRC同时具有优良的抗扰能力和抑制噪声能力。所得出的结论可为LADRC应用中LESO的选取提供有力的支持,为PMSM调速系统的优化设计提供理论依据。

关键词：线性扩张状态观测器线性自抗扰控制器永磁同步电机调速

TFT-LCD Mura缺陷机器视觉检测方法

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机械工程学报 2010年第12期46卷 13-19页

作者：毕昕丁汉上海交通大学机械与动力工程学院上海200240

针对液晶显示器(Liquid crystal display,LCD)制程中Mura缺陷检测的重要性和人工检测的弊端,研究TFT-LCD Mura缺陷的机器视觉自动检测方法。基于国际半导体设备与材料组织(Semiconductor Equipment and Materials International,SEMI)标准中Mura缺陷的测量规范和LCD视觉检测试验平台,针对Mura缺陷边缘模糊、对比度低、图像中存在重复纹理背景和整体的亮度不均匀等特点,分别研究基于实值Gabor小波滤波的纹理背景抑制方法、基于同态变换和独立分量分析的亮度不均匀校正方法、基于主动轮廓模型和水平集方法的缺陷分割以及基于SEMI标准的缺陷量化方法,综合几个方面的研究,建立Mura缺陷自动检测流程。检测试验证明,所提出方法能较好地抑制纹理背景、校正背景亮度不均匀和莫尔条纹,准确的分割缺陷并进行量化评定。该方法适用于Mura缺陷的自动检测,检测方法与人的视觉特性相似,具有较好的鲁棒性。对于50个带有Mura缺陷的LCD样本,有48个样本被成功检测。

关键词： Mura缺陷 Gabor滤波独立分量分析主动轮廓模型水平集

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基于预期流优化的空间网络引力模型

物理学报 2009年第5期58卷 3028-3033页

作者：钱江海韩定定华东师范大学信息科学技术学院通信工程系上海200241

从优化预期流的角度提出了一个空间网络模型,其构建目标是使得整个网络的预期流总和最大化.通过改变表征网络对节点适应度和对地理因素依赖程度的两个参数α和γ的取值,网络的拓扑可从异质的星形类网络逐渐演变成同质的类似道路网的网络... 详细信息

从优化预期流的角度提出了一个空间网络模型,其构建目标是使得整个网络的预期流总和最大化.通过改变表征网络对节点适应度和对地理因素依赖程度的两个参数α和γ的取值,网络的拓扑可从异质的星形类网络逐渐演变成同质的类似道路网的网络.利用所提出的引力模型仿真了中国城市航空网,并将其统计特征与实际网络进行了比较.最后,讨论了预期流和实际流(网络中实际的边权)之间的关系.

关键词：空间网络预期流引力中国城市航空网

A Comprehensive Evaluation of Policy Effectiveness for Energy Efficiency in Existing Buildings

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Frontiers of Engineering Management 2014年第4期1卷 341-347页

作者： Xing Wei han-ding Guo School of Economics and Management Tianjin Chengjian University

The healthy and stable development of energy ef ficiencies in existing buildings cannot be separated from effective policy operation, and evaluating policy effectiveness contributes to scienti fically-sound government decision-making. This paper creates an evaluation index system and a grey comprehensive evaluation model for policy effectiveness for energy ef ficiency in existing buildings using three dimensions: 1) the effect of the policy itself; 2)the administrative effect of the policy; and 3) policy implementation effects. It chooses the government's subsidy policy and preferential tax policy at market cultivation stage for its empirical comparative *** evaluation indicates that the former is more ***, it puts forward policy development suggestions from the perspective of: 1) clarifying incentive object;2) broadening incentive scope; 3) increasing incentive intensity; and 4) innovating incentive mode.

关键词： grey comprehensive evaluation existing buildings energy efficiency policies effectiveness

Low-dose metformin treatment in the subacute phase improves the locomotor function of a mouse model of spinal cord injury

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Neural Regeneration Research 2021年第11期16卷 2234-2242页

作者： Wen-Ye Song han ding Tiffany Dunn Jun-Ling Gao Javier Allende Labastida Caitlin Schlagal Guang-Zhi Ning Shi-Qing Feng Ping Wu Department of Neuroscience Cell Biology&AnatomyUniversity of Texas Medical Branch at GalvestonGalvestonTXUSA Department of Orthopedics Tianjin Medical University General HospitalTianjinChina

Metformin,a first-line drug for type-2 diabetes,has been shown to improve locomotor recovery after spinal cord ***,there are studies reporting no beneficial ***,we found that high dose of metformin(200 mg/kg,intraperitoneal)and acute phase administration(immediately after injury)led to increased mortality and limited locomotor function ***,we used a lower dose(100 mg/kg,i.p.)metformin in mice,and compared the effect of immediate administration after spinal cord injury(acute phase)with that of administration at 3 days post-injury(subacute phase).Our data showed that metformin treatment starting at the subacute phase significantly improved mouse locomotor function evaluated by Basso Mouse Scale(BMS)*** studies also revealed significant inhibitions of microglia/macrophage activation and astrogliosis at the lesion ***,metformin treatment at the subacute phase reduced neutrophil *** changes were in parallel with the increased survival rate of spinal neurons in animals treated with *** findings suggest that low-dose metformin treatment for subacute spinal cord injury can effectively improve the functional recovery possibly through anti-inflammation and *** study was approved by the Institute Animal Care and Use Committee at the University of Texas Medical Branch(approval No.1008041C)in 2010.

关键词： inflammation locomotor function metformin microglia mortality neuroprotection spinal cord injury subacute administration