检索结果-南通市图书馆

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： xiu-Ying Chen Fa Shen Chang Cheng Yu-han Wang wen-Chao Cheng De-Zhi Yuan wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao yao-wen Chang Hong-Yu Tang Chun-Mao Yuan jun-Bo Yang Zhi-Li Zuo han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词：

同方期刊数据库

Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan Yang han Jia Tuo Liu Yuzhen Yang jun Yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

Single-cell omics: experimental workflow, data analyses and applications

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao jing-Dong J.han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Hamiltonian Tri-Integrable Couplings of the AKNS Hierarchy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2013年第4期59卷 385-392页

作者： MENG jing-han MA wen-xiu Department of Mathematics and Statistics University of South Florida 4202 E. Fowler Avenue Tampa FL 33620 USA

We propose a systematic approach for generating Hamiltonian tri-integrable couplings of soliton hierarchies. The resulting approach is based on semi-direct sums of matrix Lie algebras consisting of 4× 4 block matrix Lie algebras. We apply the approach to the AKNS soIRon hierarchy, and Hamiltonian structures of the obtained tri-integrable couplings are constructed by the variational identity.

关键词： tri-integrable coupling non-semisimple matrix loop algebra AKNS hierarchy bi-Hamiltonianstructure symmetry conservation law

维普期刊数据库

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen Yu han jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

Enantioselective Total Synthesis of(+)-Propolisbenzofuran B

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第22期42卷 2833-2839页

作者： wen-xiu Xu Li-han Zhao yao Zhu Hai-Hua Lu Department of Chemistry Zhejiang University866 Yuhangtang RoadHangzhouZhejiang 310058China Key Laboratory of Precise Synthesis of Functional Molecules of zhejiang Province Department of Chemistry and Research Center for Industries oftheFutureWestlake University600 Dunyu RoadHangzhouZhejiang 310030China Institute of Natural Sciences Westlake Institute for Advanced Study18 Shilongshan RoadHangzhouZhejiang 310024China

Comprehensive Summary The first catalytic asymmetric total synthesis of(+)-propolisbenzofuran B,enabled by a highly enantioselective rhodium-catalyzed hydrogenation of a tetrasubstituted olefin,was *** noteworthy aspects include the construction of the central hydrodibenzo[b,d]furan core through a sequence of Zn(II)-mediated regioselective benzofuran formation and Dieckmann condensation,as well as C-H oxidations,involving a visible light-induced Fe(III)-catalyzed benzylic C(sp3)-H ***,the absolute configuration was confirmed by X-ray analysis of a carbonate intermediate.

关键词： Propolisbenzofuran B Total synthesis Enantioselective hydrogenation Photocatalysis C-H functionalization Natural products Alkenes Chirality

基于UPLC-Q-TOF/MS的当归化学成分鉴定及活血作用机制

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理学通报 2025年第1期41卷 147-156页

作者：焦文星魏江霞郭晶晶杨志军杨锡仓杨秀娟甘肃中医药大学附属医院药学部甘肃兰州730000 甘肃中医药大学药学院甘肃兰州730000 杨锡仓全国名老中医药专家传承工作室甘肃兰州730000 西北中藏药省部共建协同创新中心甘肃兰州730000 陇药产业创新研究院甘肃兰州730000

目的研究当归的化学成分及其活血作用机制。方法UPLC-Q-TOF-MS鉴定化学成分;观察大鼠证侯学和心脏病理切片变化;检测血液动力学指标和蛋白质组学。结果当归共鉴定出270个化合物;给药后,大鼠弓背、耸毛,蜷缩少动,爪尾部紫暗,耳缘及鼻唇发... 详细信息

目的研究当归的化学成分及其活血作用机制。方法UPLC-Q-TOF-MS鉴定化学成分;观察大鼠证侯学和心脏病理切片变化;检测血液动力学指标和蛋白质组学。结果当归共鉴定出270个化合物;给药后,大鼠弓背、耸毛,蜷缩少动,爪尾部紫暗,耳缘及鼻唇发白,饮水、进食量减少,对外界刺激反应迟钝等证候有很大改善;心肌纤维排列轻度紊乱,较模型组紧密,心肌纤维较窄,接近正常,周围可见轻度水肿、渗出,炎性细胞浸润;颈总动脉收缩压明显降低、左心室收缩压明显升高(P<0.05)。共筛选出62个差异蛋白,GO功能集中在细胞外基质、细胞骨架蛋白结合和蛋白水解的负调节等,KEGG通路富集在补体和凝血级联反应、白细胞经内皮细胞迁移及趋化因子信号通路等。结论当归可能是通过蛋白的表达,调控补体和凝血级联反应及血管平滑肌收缩等信号通路达到补血的效果。

关键词：当归化学成分蛋白质组学急性血瘀证活血作用作用机制

Dynamical properties of the Haldane chain with bond disorder

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of physics 2022年第3期17卷 43-51页

作者： jing-Kai Fang jun-han Huang han-Qing Wu Dao-Xin yao Center for Neutron Science and Technology School of PhysicsSun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China

By using Lanczos exact diagonalization and quantum Monte Carlo combined with stochastic analytic continuation,we study the dynamical properties of the S=1 antiferromagnetic Heisenberg chain with different strengths of bond *** the weak disorder region,we find weakly coupled bonds which can induce additional low-energy excitation below the one-magnon *** the disorder increases,the average Haldane gap closes at δ_(∆)~0.5 with more and more low-energy excitations coming *** the critical disorder strength δ_(C)~1,the system reaches a random-singlet phase with prominent sharp peak atω=0 and broad continuum atω>0 of the dynamic spin structure *** addition,we analyze the distribution of random spin domains and numerically find three kinds of domains hosting effective spin-1/2 quanta or spin-1 sites in ***“spins”can form the weakly coupled longrange singlets due to quantum fluctuation which contribute to the sharp peak atω=0.

关键词： Haldane chain Heisenberg model magnetic excitation quantum phase transition random singlet disorder exact diagonalization quantum Monte Carlo

维普期刊数据库