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补肾断续汤结合髓内钉固定治疗预防胫骨中下段骨折不愈合临床研究

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新中医 2020年第3期52卷 55-58页

作者：韩田浦王爱国黄河水利委员会黄河中心医院河南郑州450000 郑州市骨科医院河南郑州450052

目的:观察胫骨中下段骨折应用补肾断续汤联合髓内钉固定治疗的临床疗效。方法:将择期行手术治疗的98例胫骨中下段骨折患者随机分为观察组与对照组,每组49例;对照组行髓内钉固定术治疗,术后予以常规处理;观察组在对照组的基础上于术后第... 详细信息

目的:观察胫骨中下段骨折应用补肾断续汤联合髓内钉固定治疗的临床疗效。方法:将择期行手术治疗的98例胫骨中下段骨折患者随机分为观察组与对照组,每组49例;对照组行髓内钉固定术治疗,术后予以常规处理;观察组在对照组的基础上于术后第2天开始口服补肾断续汤治疗,所有患者均治疗3个月;观察比较2组临床疗效及骨折愈合时间、骨折不愈合发生率,治疗前后疼痛视觉模拟评分法(VAS)评分、血液流变学指标[全血高切黏度(WBHV)、低切黏度(WBLV)、红细胞聚集指数(EAI)、血浆黏度(PV)]、骨代谢指标[碱性磷酸酶(ALP)、骨钙素(BGP)、钙(Ca)、磷(P)]水平变化。结果:骨折愈合总有效率观察组为95.9%,对照组为81.6%,差异有统计学意义(P <0.05)。治疗后,观察组骨折愈合时间短于对照组、骨折不愈合率低于对照组,差异均有统计学意义(P <0.05)。治疗后,2组疼痛VAS评分均较治疗前显著下降(P <0.05),且观察组VAS评分明显低于对照组(P <0.05)。治疗后,2组各项血流变学指标WBHV、WBLV、EAI、PV值均较治疗前显著降低(P <0.05);且观察组各项指标值均低于对照组(P <0.05)。治疗后,2组患者血清ALP、BGP、P水平均较治疗前显著升高(P <0.05),血清Ca水平显著降低(P <0.05);且观察组上述各项指标改善较对照组更显著(P <0.05)。结论:补肾断续汤联合髓内钉固定治疗胫骨中下段骨折,能明显缩短患者骨折愈合时间,减轻疼痛,有效预防骨折不愈合的发生,其机制可能与改善体内血流变学状态、调控骨代谢有关。

关键词：胫骨骨折中下段骨折骨折不愈合补肾断续汤髓内钉固定

防旋型股骨近端髓内钉治疗高龄不稳定型股骨粗隆间骨折患者的效果及其对髋关节功能恢复的影响

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国际医药卫生导报 2022年第5期28卷 633-636页

作者：张晓马胜利李磊韩田浦黄河中心医院骨科郑州450000 郑州大学第一附属医院急诊骨科郑州450000

目的探索防旋型股骨近端髓内钉(PFNA)治疗高龄不稳定型股骨粗隆间骨折(IFF)患者的效果及其对髋关节功能恢复的影响。方法选取黄河中心医院骨科2018年10月至2020年10月收治的94例高龄不稳定型IFF患者作为研究对象,随机数字表法分为常规组... 详细信息

目的探索防旋型股骨近端髓内钉(PFNA)治疗高龄不稳定型股骨粗隆间骨折(IFF)患者的效果及其对髋关节功能恢复的影响。方法选取黄河中心医院骨科2018年10月至2020年10月收治的94例高龄不稳定型IFF患者作为研究对象,随机数字表法分为常规组和PFNA组。常规组47例,男27例,女20例,年龄(79.00±3.27)岁;PFNA组47例,男28例,女19例,年龄(78.00±3.35)岁。常规组给予半髋关节置换术治疗,PFNA组给予PFNA治疗。对比两组手术相关指标、髋关节功能、并发症,应用独立样本t检验和卡方检验对相关统计学数据进行分析。结果PFNA组骨折愈合时间(14.00±2.71)周,常规组(13.00±2.62)周,差异无统计学意义(t=1.8188,P=0.0722);PFNA组术中出血量、卧床时间、手术时间、切口长度均低于常规组[(122.03±16.23)ml比(132.05±18.76)ml、(2.00±1.34)d比(5.00±1.51)d、(51.00±5.38)min比(62.00±6.05)min、(7.21±1.62)cm比(11.49±2.27)cm],术后开始负重站立时间长于常规组[(23.00±3.18)d比(15.00±2.61)d],差异均有统计学意义(均P<0.05)。PFNA组髋关节功能优良率91.49%(43/47),高于常规组的80.85%(38/47),但差异无统计学意义(χ^(2)=2.2317,P=0.1352)。PFNA组并发症发生率8.51%(4/47),低于常规组的14.89%(7/47),但差异无统计学意义(χ^(2)=0.9266,P=0.3357)。结论对于骨质疏松状态较为严重、不存在严重内科疾病、自身机体素质相对良好的患者,选用半髋关节置换术,但可能引起深静脉血栓、伤口感染等;对于骨质疏松状态较轻、存在较多内科疾病、自身机体素质低下的患者,选用PFNA,但可能引起髋内翻、股骨头切割等,应避免过早负重活动,及时进行抗骨质疏松治疗。

关键词：防旋型股骨近端髓内钉股骨粗隆间骨折髋关节功能

不同入路人工髋关节置换术治疗老年股骨颈骨折效果观察及其对血清骨特异性碱性磷酸酶抗酒石酸酸性磷酸酶5b水平的影响

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山西医药杂志 2022年第3期51卷 247-250页

作者：张晓马胜利李磊韩田浦郑州市黄河中心医院骨科 450000 郑州大学第一附属医院急诊骨科

目的探究不同入路人工髋关节置换术应用于老年股骨颈骨折患者的效果。方法选取我科123例行人工髋关节置换治疗老年股骨颈骨折患者,根据随机数字表法分组。对照组61例给予传统后外侧入路人工髋关节置换术,观察组62例给予前外侧入路人工... 详细信息

目的探究不同入路人工髋关节置换术应用于老年股骨颈骨折患者的效果。方法选取我科123例行人工髋关节置换治疗老年股骨颈骨折患者,根据随机数字表法分组。对照组61例给予传统后外侧入路人工髋关节置换术,观察组62例给予前外侧入路人工髋关节置换术,对比2组患者手术指标、髋关节功能、血液学指标及术后并发症。结果观察组切口长度、手术时间、术中出血量、术后引流量、抗酒石酸酸性磷酸酶5b(TRACP5b)、脱氧吡啶酚(DPD)水平、并发症发生率均低于对照组,髋关节功能(Harris)各项评分、骨特异性碱性磷酸酶(BALP)水平高于对照组(P<0.05)。结论前外侧入路人工髋关节置换术对老年股骨颈骨折患者治疗,可有效改善骨吸收状态、髋关节功能,降低术中出血量、手术时间、术后引流量及术后并发症,安全性高。

关键词：股骨颈骨折关节成形术,置换,髋老年人

Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

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Science China Chemistry 2025年第1期 35-45页

作者： Xinyu Peng Qian Ma Da han School of Life Science Shanghai University Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine State Key Laboratory of Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Department of Research and Development Intellinosis Biotechnologies Co.Ltd.

Gastric cancer(GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of distinctive symptoms often leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal for improving the survival rates and outcomes of GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of GC. Conventional protein biomarkers, such as carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and carbohydrate antigen 72-4(CA72-4), exhibit insufficient sensitivity and specificity for GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells(CTCs), circulating tumor cell DNA(ct DNA), and circulating free RNA(cf RNA), have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and specificity. This review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

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Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang Fei Long Liyuan han Qifeng han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han Tang Jianian Hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli han Bowen Duan Lei Liu Shilong Fang Weiwei Wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan Yang han Jia Tuo Liu Yuzhen Yang Jun Yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang Yang Jianfeng Zheng Guoyu Wang Yifei Gao Yatao Yang Jia Li Xiaojin han Yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Photoelectrocatalysis Z-scheme C–C coupling Ethanol