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M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： Ha Eun Shin Jun-Hyeok han Seungyong Shin Ga-Hyun Bae Boram son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

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Ultra-thin light-weight laser-induced-graphene (LIG) diffractive optics

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Light(Science & Applications) 2023年第7期12卷 1268-1300页

作者： Younggeun Lee Mun Ji Low Dongwook Yang han Ku Nam Truong-son Dinh Le Seung Eon Lee Hyogeun han Seunghwan Kim Quang Huy Vu Hongki Yoo Hyosang Yoon Joohyung Lee Suchand Sandeep Keunwoo Lee Seung-Woo Kim Young-Jin Kim Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daehak-roYuseong-guDaejeon 34141Republic of Korea School of Mechanical and Aerospace Engineering Nanyang Technological University(NTU)50 Nanyang Avenue639798 SingaporeSingapore Panasonic Factory Solutions Asia Pacific(PFSAP) 285 Jalan Ahmad Ibrahim639931 SingaporeSingapore Department of Aerospace Engineering Korea Advanced Institute of Science and Technology(KAlST)Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Mechanical System Design Engineering Seoul National University of Science and Technology(Seuoltech)232 Gongneung-roNowon-guSeoul 01811Republic of Korea LASER N GRAPN INC 193 Munj-roYuseong-guDaejeon 34051Republicof Korea

The realization of hybrid optics could be one of the best ways to fulfll the technological requirements of compact,light-weight,and multi-functional optical systems for modern *** diffractive lens(PDL)such as diffractive lenses,photonsieves,and metasurfaces can be patterned on ultra-thin flexible and stretchable substrates and be conformally attached on top of arbitrarily shaped *** this review,we introduce recent research works addressed to the design and manufacturing of ultra-thin graphene optics,which will open new markets in compact and light-weight optics for next-generation endoscopic brain imaging,space internet,real-time surface proflometry,and multi-functional mobile *** provide higher design flexibility,lower process complexity,and chemical-free process with reasonable investment cost,direct laser writing(DLW)of laser-induced-graphene(LIG)is actively being applied to the patterning of *** realizing the best optical performances in DLW,photon-material interactions have been studied in detail with respect to different laser parameters;the resulting optical characteristics have been evaluated in terms of amplitude and phase.A series of exemplary laser-written 1D and 2D PDL structures have been actively demonstrated with different base materials,and then,the cases are being expanded to plasmonic and holographic *** combination of these ultra-thin and light-weight PDL with conventional bulk refractive or reflective optical elements could bring together the advantages of each optical *** integrating these suggestions,we suggest a way to realize the hybrid PDL to be used in the future micro-electronics surface inspection,biomedical,outer space,and extended reality(XR)industries.

关键词： optics weight holographic

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Formation and Morphology of Anodic Oxide Films of Ti

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Journal of Materials Science & Technology 2001年第1期17卷 33-34页

作者： Kyo-han Kim X.L.Zhu and Won-Woo son Department of Dental Biomaterials, Kyungpook National University, Taegu 700-422, Korea Yong-Soo Jeong Department of Surface Engineering, Korea institute of Machinery and Materials, Changwon, Korea Dep. of Dental Biomater. Kyungpook Natl. Univ. Taegu 700-422 South Korea

The morphology and structure of the oxide films of Ti in H3PO4 were investigated by galvanos tatic anodization, SEM and XRD. The oxide film grew from some pores in the grooves to layered microdomains as increasing anodizing voltage. The crystallinity of the oxide films decreased with the increase of the concentration of the electrolyte. The model has been proposed for the growth of the oxide films by two steps, i.e. by uniform thickening and by local deposition.

关键词： Res Formation and Morphology of Anodic Oxide Films of Ti

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Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites

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World Journal of Gastroenterology 2008年第24期14卷 3884-3890页

作者： Soong Lee Seung-Cheol son Moon-Jong han Woo-Jin Kim Soo-Hyun Kim Hye-Ran Kim Woo-Kyu Jeon Ki-Hong Park Myung-Geun Shin Department of Internal Medicine College of MedicineSeonam University and Seonam University Hospital Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National University Hwasun Hospital Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Medical School Department of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Korea Polymer Testing & Research Institute Ltd.

AIM： To determine intestinal permeability, the serum tumor necrosis factor （TNF）-α level and urine nitric oxide （NO） metabolites are altered in liver cirrhosis （LC） with or without ascites. METHODS： Fifty-three patients with LC and 26 healthy control subjects were enrolled in the study. The intestinal permeability value is expressed as the percentage of polyethylene glycol （PEG） 400 and 3350 retrieval in 8-h urine samples as determined by high performance liquid chromatography. Serum TNF-α concentrations and urine NO metabolites were determined using an enzyme-linked immunosorbent assay （ELISA） and Greiss reaction method, respectively. RESULTS： The intestinal permeability index wassignificantly higher in patients with LC with ascites than in healthy control subjects or patients with LC without ascites （0.88 ± 0.12 vs 0.52 ± 0.05 or 0.53 ± 0.03, P 〈 0.05） and correlated with urine nitrite excretion （r = 0.98）. Interestingly, the serum TNF-α concentration was significantly higher in LC without ascites than in control subjects or in LC with ascites （198.9 ± 55.8 pg/mL vs 40.9 ± 12.3 pg/mL or 32.1 ± 13.3 pg/mL, P 〈 0.05）. Urine nitrite excretion was significantly higher in LC with ascites than in the control subjects or in LC without ascites（ 1170.9± 28.7 μmol/L vs 903.1 ± 55.1 μmol/L or 956.7 ± 47.7 μmol/L, P 〈 0.05）. COMCLUSIOM： Increased intestinal macromolecular permeability and NO is probably of importance in the pathophysiology and progression of LC with ascites, but the serum TNF-α concentration was not related to LC with ascites.

关键词： Intestinal permeability Tumor necrosisfactor-R Nitric oxide Liver cirrhosis Ascites

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Relationship between physicochemical characteristics of Korean wheat flour and quality attributes of steamed bread

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Journal of Integrative Agriculture 2019年第11期18卷 2652-2663页

作者： Ji-Eun Kim Byung-Kee Baik Chul Soo Park Jae-han son Chang-Hyun Choi Youngjun Mo Tae-Il Park Chon-Sik Kang Seong-Woo Cho Department of Crop Science&Biotechnology Chonbuk National UniversityJeonju 54896Korea USDA-ARS CSWQRU Soft Wheat Quality LaboratoryWoosterOH 44691USA National Institute of Crop Science Rural Development AdministrationWanju 55365Korea

The purpose of this study is to identify major factors affecting the manufacture and quality of steamed bread,consumed in Southeast Asia including China,Japan,and ***,flours of 11 Korean wheat cultivars were used to evaluate quality attributes of two different styles of steamed bread,Korean style steamed bread(KSSB)and northern-style Chinese steamed bread(NSCSB).KSSB prepared more ingredients and higher optimum water absorption of dough than NSCSB because Korean consumers prefer white and glossy surface and soft *** showed lower height,larger diameter and volume of steamed bread,higher stress relaxation,and softer texture of crumb than *** correlation between flour characteristics and quality of steamed bread was different in KSSB and *** 90%of variability in the height and volume of KSSB could be predicted from protein content,mixing tolerance of Mixograph,average particle size of flour,final viscosity and solvent retention *** content and quality parameters also could explain the variation of steamed bread height in *** wheat carrying Glu-A3c allele produced higher volume of steamed bread(704.7 mL)than Glu-A3d allele(645.8 mL)in KSSB,although there was no significant difference in volume of NSCSB by glutenin ***-D1d and Glu-A3c alleles had softer texture of crumb than Glu-D1f and Glu-A3d alleles in KSSB,Glu-B3i allele also showed lower hardness of crumb than their counterpart allele in *** wheat showed higher height and volume of steamed bread,and lower stress relaxation and hardness of crumb than soft wheat in KSSB.

关键词： steamed bread quality wheat flour evaluation

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Effect of open-field experimental warming on the leaf phenology of oriental oak (Quercus variabilis) seedlings

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Journal of Plant Ecology 2014年第6期7卷 559-566页

作者： Saerom han Haegeun Chung Nam Jin Noh Sun Jeoung Lee Wooyong Jo Tae Kyung Yoon Koong Yi Chan-woo Park Suin Ko Yowhan son Department of Environmental Science and Ecological Engineering Graduate SchoolKorea UniversitySeoul 136-713Korea Department of Environmental Engineering Konkuk UniversitySeoul 143-701Korea River Basin Research Center Gifu UniversityGifu 501-1193Japan Forest and Climate Change Center Korea Forest Research InstituteSeoul 130-712Korea hanlim Patent and Law Office Seoul 152-050Korea Forest Soil and Water Conservation Division Korea Forest Research InstituteSeoul 130-712Korea Environmental Policy Research Group Korea Environment InstituteSeoul 122-706Korea

Aims An open-field warming experiment enables us to test the effects of projected temperature increase on change in plant phenology with fewer confounding factors and to study phenological response to temperature ranges beyond natural *** study aims to(i)examine the effect of temperature increase on leaf unfold-ing and senescence of oriental oak(Quercus variabilis Blume)under experimental warming and(ii)measure temperature-related parameters used in estimating phenological response to tempera-ture *** Using an open-field warming system with infrared heaters,we increased the air temperature by~3℃ in the warmed plots compared with that of the control plots consistently for 2 *** unfolding and senescence dates of *** seedlings were recorded and temperature-related phenological parameters were *** Findings The timing of leaf unfolding was advanced by 3-8 days(1.1-3.0 days/℃)and the date of leaf senescence was delayed by 14-19 days(5.0-7.3 days/℃)under elevated air ***,the cumulative degree days(CDD)of leaf unfolding were not significantly changed by experimental warming,which suggest the applicability of a constant CDD value to estimate the change in spring leaf phe-nology under 3℃ *** ranges of advancement and temperature sensitivity in spring phenology and delayed autumn phe-nology and proposed temperature parameters from this study might be applied to predict future phenological change.

关键词： climate change cumulative degree days experimental warming leaf senescence leaf unfolding

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Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model

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World Journal of Gastroenterology 2014年第42期20卷 15703-15714页

作者： Hyeong-Geug Kim Jung-Min Kim Jong-Min han Jin-Seok Lee Min-Kyung Choi Dong-Soo Lee Yeon-Hwa Park Chang-Gue son Liver and immunology research center Daejeon Oriental Hospital of Oriental Medical Collage of Daejeon University NAR center Inc. Daejeon Oriental Hospital of Oriental Medical Collage of Daejeon University Department of Internal Medicine Daejeon St.Mary’s Hospital The Catholic University of Korea

AIM: To evaluate protective effects of Chunggan extract (CGX), a traditional herbal formula, under 4 wk of alcohol consumption-induced liver injury.

关键词： Alcohol abuse Liver injury Traditional Chinese Medicine Fibrogenic cytokines Hepato stellate cell

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Approaching 18% efficiency of ternary organic photovoltaics with wide bandgap polymer donor and well compatible Y6 : Y6-1O as acceptor

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National Science Review 2021年第8期8卷 20-29页

作者： Xiaoling Ma Anping Zeng Jinhua Gao Zhenghao Hu Chunyu Xu Jae Hoon son Sang Young Jeong Caixia Zhang Mengyang Li Kai Wang He Yan Zaifei Ma Yongsheng Wang han Young Woo Fujun Zhang Key Laboratory of Luminescence and Optical Information Ministry of EducationBeijing Jiaotong University Organic Optoelectronic Materials Laboratory Department of ChemistryCollege of ScienceKorea University Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of Technology Department of Chemistry The Hong Kong University of Science and Technology Center for Advanced Low-Dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua University

A series of ternary organic photovoltaics(OPVs) are fabricated with one wide bandgap polymer D18-Cl as donor, and well compatible Y6 and Y6-1O as acceptor. The open-circuit-voltage(V)of ternary OPVs is monotonously increased along with the incorporation of Y6-1O, indicating that the alloy state should be formed between Y6 and Y6-1O due to their excellent compatibility. The energy loss can be minimized by incorporating Y6-1 O, leading to the VOC improvement of ternary OPVs. By finely adjusting the Y6-1O content, a power conversion efficiency of 17.91% is achieved in the optimal ternary OPVs with 30 wt% Y6-1O in acceptors, resulting from synchronously improved short-circuit-current density(JSC) of 25.87 mA cm, fill factor(FF) of 76.92% and VOC of 0.900 V in comparison with those of D18-Cl : Y6 binary OPVs. The JSC and FF improvement of ternary OPVs should be ascribed to comprehensively optimal photon harvesting, exciton dissociation and charge transport in ternary active layers. The more efficient charge separation and transport process in ternary active layers can be confirmed by the magnetophotocurrent and impedance spectroscopy experimental results, respectively. This work provides new insight into constructing highly efficient ternary OPVs with well compatible Y6 and its derivative as acceptor.

关键词： organic photovoltaics power conversion efficiency ternary strategy photon harvesting morphology regulation

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BREAKING THE PHASE AMBIGUITIES ARISING FROM ANOMALOUS SCATTERING TECHNIQUE BY THE DIRECT METHODAPPLIED TO A KNOWN PROTEIN STRUCTURE

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Chinese Physics Letters 1985年第1期2卷 13-14页

作者： FAN Hai-fu GU Yuan-xin han Fu-son Institute of Physics Academia SinicaBeijing

The method proposed by Fan et *** been applied to the discrimination of the doublets arising from the experimental OAS(one-wave-length anomalous scattering)data of the Hg-derivative of *** result was obtained which sh... 详细信息

关键词： derivative method wave

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Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome

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World Journal of Gastroenterology 2009年第15期15卷 1869-1875页

作者： Jun Seok Lee Sang Heum Kim Dae Won Jun Jee Hye han Eun Chul Jang Ji Young Park Byung Kwan son Seong Hwan Kim Yoon Ju Jo Young Sook Park Yong Soo Kim Department of Internal Medicine Eulji University School of Medicine Department of Radiology Eulji University School of Medicine Department of Family Medicine Eulji University School of Medicine Department of Occupational and Environmental Medicine College of MedicineSoonchunhyang University Department of Radiology Hanyang University School of Medicine

AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and *** pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(Phan in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(Psonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal *** pancreas also showed a strong correlation with metabolic syndrome.

关键词： Fatty pancreas Metabolic syndrome Insulin resistance

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