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Intelligent Modularized Reconfigurable Mechanisms for Robots:Development and Experiment

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Chinese Journal of Mechanical Engineering 2020年第5期33卷 88-100页

作者： Wenfu Xu liang han Xin Wang han Yuan Bin liang School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhen 518055China Department of Automation Tsinghua UniversityBeijing 100084China

With the development of intelligent flexible manufacturing,traditional industrial manipulators with a single configuration are difficult to meet a variety of *** robots have developed rapidly which could change their configurations and end effectors for different *** reconfigurable connecting mechanism(RCM)is a core component of reconfigurable *** this paper,two types of intelligent modularized RCMs with light weight,high payload,and large pose(position and attitude)error tolerance are *** is driven by shape memory alloy(SMA)and recovery *** is locked by steel balls and *** other is driven by electromagnetic coil and locked by permanent magnet and *** locking principle,mechanical system and control system of the two RCMs are detailed *** of them meet the requirements of high precision and high payload in the industrial ***,the developed RCMs are respectively integrated to a practical robot and *** experiment results verified the performance of the two RCMs.

关键词： Reconfigurable connecting mechanisms Shape memory alloy Electromagnetic Reconfigurable manipulator

Convergent Usage of Amino Acids in Human Cancers as A Reversed Process of Tissue Development

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 147-162页

作者： Yikai Luo han liang Graduate Program in Quantitative and Computational Biosciences Baylor College of MedicineHoustonTX 77030USA Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Systems Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Genome-and transcriptome-wide amino acid usage preference across different species is a well-studied phenomenon in molecular evolution,but its characteristics and implication in cancer evolution and therapy remain largely ***,we analyzed large-scale transcriptome/proteome profiles,such as The Cancer Genome Atlas(TCGA),the Genotype-Tissue Expression(GTEx),and the Clinical Proteomic Tumor Analysis Consortium(CPTAC),and found that compared to normal tissues,different cancer types showed a convergent pattern toward using biosynthetically low-cost amino *** a pattern can be accurately captured by a single index based on the average biosynthetic energy cost of amino acids,termed energy cost per amino acid(ECPA).With this index,we further compared the trends of amino acid usage and the contributing genes in cancer and tissue development,and revealed their reversed ***,focusing on the liver,a tissue with a dramatic increase in ECPA during development,we found that ECPA represents a powerful biomarker that could distinguish liver tumors from normal liver samples consistently across 11 independent patient cohorts and outperforms any index based on single *** study reveals an important principle underlying cancer evolution and suggests the global amino acid usage as a system-level biomarker for cancer diagnosis.

关键词： Amino acid usage Tissue development Biosynthetic energy Diagnostic biomarker

Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2306-2325页

作者： liang han Chen Jiang Jiangsu Key Laboratory of Neuropsychiatric Diseases Research College of Pharmaceutical SciencesSoochow UniversitySuzhou 215123China Key Laboratory of Smart Drug Delivery Ministry of EducationState Key Laboratory of Medical NeurobiologyDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 200032China

Bloode-brain barrier(BBB)strictly controls matter exchange between blood and brain,and severely limits brain penetration of systemically administered drugs,resulting in ineffective drug therapy of brain ***,during the onset and progression of brain diseases,BBB alterations evolve *** this review,we focus on nanoscale brain-targeting drug delivery strategies designed based on BBB evolutions and related applications in various brain diseases including Alzheimer’s disease,Parkinson’s disease,epilepsy,stroke,traumatic brain injury and brain *** advances on optimization of small molecules for BBB crossing and non-systemic administration routes(e.g.,intranasal treatment)for BBB bypassing are not included in this review.

关键词： Blood-brain barrier Brain diseases Brain-targeting Drug delivery systems Nanoparticles

Neutral electrolyte aluminum air battery with open configuration

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Rare Metals 2006年第z1期25卷 360-363页

作者： han Bin liang Guangchuan Institute of Power Source and Ecomaterials Science Hebei University of Technology Tianjin 300130 China Institute of Power Source and Ecomaterials Science Hebei University of Technology Tianjin 300130 China

A kind of new long life aluminum air batteries with open configuration was developed, using aluminum alloy doped with Ga, In, Sn, Bi, Pb and Mn as anode, NaCl solution as electrolyte and air electrode as cathode. The polarization curves of aluminum electrode and air electrode were tested. And the cell′s performance was tested to calculate the utilization of aluminum electrode and the energy density. It is shown that, in the 3.5% NaCl solution, the cell can discharge at 0.29 A for 140 h with the working voltage keeping over 1.1 V. The utilization ratio of aluminum anode is over 44%, and the life of battery is longer than 2400 h.

关键词： aluminum air battery neutral electrolyte open configuration cell performance

Divalent anion intercalation and etching-hydrolysis strategies to construct ultra-stable electrodes for seawater splitting

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Science China Chemistry 2024年第2期67卷 687-695页

作者： Jiajia Lu Yang Liu han-Pu liang Key Laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao266101China Henan Provincial Key Laboratory of Nanocomposites and Applications Institute of Nano-Structured Functional MaterialsHuanghe Science and Technology CollegeZhengzhou450006China School of Materials Science and Engineering Henan Normal UniversityXinxiang453007China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Shandong Energy Institute Qingdao266101China

Developing stable electrodes for seawater splitting remains a great challenge due to the detachment of catalysts at a large operating current and severe anode corrosion caused by ***,divalent anion intercalation and etching-hydrolysis strategies are deployed to synthesize the ultra-stable anode,dendritic Fe(OH)_(3) grown on Ni(SO_4)_(0.3)(OH)_(1.4)–Ni(OH)_(2).Experimental results reveal that the anode exhibits good activity and excellent stability in alkaline simulated *** 500 h,the current density operated at 1.72 V remains 99.5%,about 210 m A cm^(-2).The outstanding stability originates from the etchinghydrolysis strategy,which strengthens the interaction between the catalyst and the carrier and retards thus the detachment of catalysts at a large current ***,theoretical simulations confirm that the intercalated divalent anions,such as SO_4^(2-) and CO_(3)^(2-),can weaken the adsorption strength of chlorine on the surface of catalysts and hinder the coupling and hybridization between chlorine and nickel,which slows down the anode corrosion and improves catalytic ***,the twoelectrode system shows the remarkable 95.1% energy efficiency at 2,000 A m-2and outstanding stability in 6 mol L^(-1) KOH +seawater at 80 ℃.

关键词： seawater splitting stability divalent anion intercalation etching-hydrolysis

Current status of lymph node dissection in gastric cancer

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Chinese Journal of Cancer Research 2021年第2期33卷 193-202页

作者： Bin Ke han liang Department of Gastric Cancer Tianjin Medical University Cancer Institute and HospitalTianjin Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerNational Clinical Research Center for CancerTianjin 300060China

Gastrectomy with lymph node(LN)dissection has been regarded as the standard surgery for gastric cancer(GC),however,the rational extent of lymphadenectomy remains *** gastrectomy with extended lymphadenectomy beyond D2 is classified as a non-standard gastrectomy,its clinical significance has been evaluated in many *** hard evidence is lacking,D2 plus superior mesenteric vein(No.14 v)LN dissection is recommended when harbor metastasis to No.6 nodes is suspected in the lower stomach,and dissection of splenic hilar(No.10)LN can be performed for advanced GC invading the greater curvature of the upper stomach,and D2 plus posterior surface of the pancreatic head(No.13)LN dissection may be an option in a potentially curative gastrectomy for cancer invading the *** D2+para-aortic nodal dissection(PAND)was not routinely recommended for advanced GC patients,but therapeutic D2 plus PAND may offer a chance of cure in selected patients,preoperative chemotherapy was considered as the standard treatment for GC with para-aortic node *** has been no consensus on the extent of lymphadenectomy for the adenocarcinoma of the esophagogastric junction(AEG)so *** length of esophageal invasion can be used as a reference point for mediastinal LN metastases,and the distance from the esophagogastric junction to the distal end of the tumor is essential for determining the optimal extent of *** quality of lymphadenectomy may influence prognosis in GC *** hospital volume and surgeon volume were important factors for the quality of radical *** of GC surgery may be needed to improve prognosis.

关键词： Gastric cancer lymphadenectomy lymph node prognosis

Quantile Regression of Ultra-high Dimensional Partially Linear Varying-coefficient Model with Missing Observations

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Acta Mathematica Sinica,English Series 2023年第9期39卷 1701-1726页

作者： Bao Hua Wang han Ying liang School of Mathematical Sciences Tongji UniversityShanghai200092P.R.China

In this paper,we focus on the partially linear varying-coefficient quantile regression with missing observations under ultra-high dimension,where the missing observations include either responses or covariates or the responses and part of the covariates are missing at random,and the ultra-high dimension implies that the dimension of parameter is much larger than sample *** on the B-spline method for the varying coefficient functions,we study the consistency of the oracle estimator which is obtained only using active covariates whose coefficients are *** the same time,we discuss the asymptotic normality of the oracle estimator for the linear *** that the active covariates are unknown in practice,non-convex penalized estimator is investigated for simultaneous variable selection and estimation,whose oracle property is also *** sample behavior of the proposed methods is investigated via simulations and real data analysis.

关键词： Missing observation oracle property partially linear varying-coefficient model quantile regression ultra-high dimension

Empirical Likelihood of Quantile Difference with Missing Response When High-dimensional Covariates Are Present

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Acta Mathematica Sinica,English Series 2021年第12期37卷 1803-1825页

作者： Cui Juan KONG han Ying liang School of Mathematical Sciences Tongji UniversityShanghai 200092P.R.China

We,in this paper,investigate two-sample quantile difference by empirical likelihood method when the responses with high-dimensional covariates of the two populations are missing at *** particular,based on sufficient dimension reduction technique,we construct three empirical log-likelihood ratios for the quantile difference between two samples by using inverse probability weighting imputation,regression imputation as well as augmented inverse probability weighting imputation,respectively,and prove their asymptotic *** the same time,we give a test to check whether two populations have the same distribution.A simulation study is carried out to investigate finite sample behavior of the proposed methods too.

关键词： Empirical likelihood high-dimensional missing at random sufficient dimension reduction two-sample quantile difference

Square-mean Almost Automorphic Solutions to Some Stochastic Evolution Equations I: Autonomous Case

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Acta Mathematicae Applicatae Sinica 2015年第3期31卷 577-590页

作者： Xi-liang LI Yu-liang han Bai-feng LIU School of Mathematics and Information Science Shandong Institute of Business and Technology

This paper concerns the square-mean almost automorphic solutions to a class of abstract semilinear functional integro-differential stochastic evolution equations in real separable Hilbert spaces. Under some suitable assumptions, the existence, uniqueness and asymptotic stability of the square-mean almost automorphic mild solution to some stochastic differential equations are established. As an application, we analyze the almost automorphic mild solution to some stochastic partial functional differential equation which turns out to be in good agreement with our abstract results.

关键词： square-mean almost automorphy integro-differential equations stochastic evolution equations.