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Roots extracts of Adenophora triphylla *** improve obesity in 3T3-L1 adipocytes and high-fat diet-induced obese mice

Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 879-886页

作者： Dong-Ryung Lee Young-Sil Lee Bong-Keun Choi Hae jin Lee Sung-Bum Park Tack-Man Kim han jin oh Seung Hwan Yang Joo-Won Suh NutraPham Tech Center for Nutraceutical and Pharmaceutical Materials Myongji University Interdisciplinary Program of Biomodulation Myongji University DONG IL Pharmtec Department of Family Medicine.VIEVIS NAMUH Hospital

Objective:To investigate the anti-obesity activity and the action mechanism of the roots of Adenophora triphylla *** extract(ATE) in high-fat diet(HFD)-induced obese mice and 3T3-LI ***:The roots of Ademption triphylla were extracted with 70%*** demonstrate the compounds,linoleic acid was analyzed by using gas chromatography:and the anti-obesity effects and possible mechanisms of ATE were examined in 3T3-L1 adipocytes and HFD-induced obese ***:Treatment with ATE inhibited the lipid accumulation without cytotoxicity in 3T3-L1 ***,200 and 400 mg/kg ATE treatment significantly decreased the body weight gain,white adipose tissues(WATs) weight and plasma triglyceride level,while 100 and 200 mg/kg ATE treatment increased the plasma high-density lipoprotein cholesterol level in the HFD-induced obese mice,as compared with the HFD *** with 200 and 400 mg/kg ATE also lowered the size of adipocytes in adipose tissue and reduced the lipid accumulation in *** treatment showed significantly lower expression level of adipogenesis-relatcd proteins,such as peroxisome proliferator-activated receptor y,fatty acid binding protein(aP2),fatty acid synthase in 3T3-L1 adipocytes;and furthermore,decreased peroxisome proliferatoractivated receptor γ,aP2,fatty acid synthase,sterol regulatory element binding protein-1c,and lipoprotein lipase mRNA expression levels in WAT of the HFD-induced obese ***:These results suggested that the ATE has an anti-obesity effect,which may be elicited by regulating the expression of adipogenesis and lipogenesis-related genes and proteins in adipocytes and WAT of the HFD-induced obese mice.

关键词： Roots of Adenophora triphylla var. japonica extrac

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Stimbiotic supplementation modulated intestinal inflammatory response and improved broilers performance in an experimentally-induced necrotic enteritis infection model

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Journal of Animal Science and Biotechnology 2023年第1期14卷 322-338页

作者： Ji Hwan Lee Byongkon Lee Xavière Rousseau Gilson A.Gomes han jin oh Yong Ju Kim Se Yeon Chang Jae Woo An Young Bin Go Dong Cheol Song Hyun Ah Cho jin Ho Cho Department of Animal Science Chungbuk National UniversityCheongju 28644South Korea. Cherrybro Co. Ltd.Jincheon‑Gun 27820South Korea. AB Vista MarlboroughWiltshireUK.

Background:Two experiments were conducted to establish an optimal NE challenge model and evaluate the efficacy of stimbiotic(STB)supplementation in necrotic enteritis(NE)challenged *** Exp.1,a total of 120 Arbor Acres(AA)broilers(45.0±0.21 g)were randomly assigned to 6 treatments in a 3×2 factorial *** treatments included non-challenge(0),×10 the recommended dose(×10)or×20 the recommended dose(×20)by the *** perfringens(CP)treatments were non-challenge(No)or 3 mL of 2.2×10^(7)CFU CP challenge(Yes).In Exp.2,a total of 72 AA broilers(40.17±0.27 g)were randomly assigned to 6 treatments in a 3×2 factorial *** treatments included non-additive(CON),100 mg/kg STB(STB)and 100 mg/kg STB on top of a typical commercial blend including an essential oil,probiotics,and enzyme(CB).Challenge treatments included non-NE challenge(No)and NE challenge(Yes)as established in ***:In Exp.1,CP and vaccine challenge decreased(Phanced(P<0.05)growth performance,intestinal microbiota,and blood profiles by stimulating ileal morphology(VH and VH:CD)and propionate production in the cecum,and there were no differences in measured variables between STB and CB supplemented

关键词： Broiler chicken Clostridium perfringens Necrotic enteritis Xylanse Xylooligosaccharide

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Phytogenic feed additives alleviate pathogenic Escherichia coli-induced intestinal damage through improving barrier integrity and inhibiting inflammation in weaned pigs

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Journal of Animal Science and Biotechnology 2023年第1期14卷 295-306页

作者： Se Yeon Chang Min Ho Song Ji Hwan Lee han jin oh Yong Ju Kim Jae Woo An Young Bin Go Dong Cheol Song Hyun AhCho Seung Yeol Cho Dong Jun Kim Mi Suk Kim Hyeun Bum Kim jin Ho Cho Department of Animal Science Chungbuk National UniversityCheongju 28644South Korea. Division of Animal and Dairy Science Chungnam National UniversityDaejeon 34134South Korea. Eugene-Bio Suwon 16675South Korea. Department of Animal Resources Science Dankook UniversityCheonan 31116South Korea.

Background:This study was conducted to investigate the effects of each phytogenic feed additive(PFA;PFA1,bitter citrus extract;PFA2,a microencapsulated blend of thymol and carvacrol;PFA3,a mixture of bitter citrus extract,thymol,and carvacrol;PFA4,a premixture of grape seed,grape marc extract,green tea,and hops;PFA5,fenugreek seed powder)on the growth performance,nutrient digestibility,intestinal morphology,and immune response in weaned pigs infected with Escherichia coli(***).Results:A total of 634-week-old weaned pigs were placed in individual metabolic cages and assigned to seven treatment *** seven treatments were as follows:1)NC;basal diet without *** challenge,2)PC;basal diet with *** challenge,3)T1;PC+0.04%PFA1,4)T2;PC+0.01%PFA2,5)T3;PC+0.10%PFA3,6)T4;PC+0.04%PFA4,7)T5;PC+0.10%*** experiments lasted in 21 d,including 7 d before and 14 d after the first *** *** the *** challenge treatments,all pigs were orally inoculated by dividing a total of 10 mL of *** F18 for 3 consecutive *** PFA-added groups significantly increased(P<0.05)average daily gain and feed efficiency and decreased(P<0.05)the fecal score at d 0 to 14 post-inoculation(PI).Tumor necrosis factorαwas significantly lower(P<0.05)in the PFA-added groups except for T1 in d 14 PI compared to the PC *** T3 had a higher(P<0.05)immunoglobulin G and immunoglobulin A concentration compared to the PC treatment at d 7 ***,T3 showed significantly higher(P<0.05)villus height:crypt depth and claudin 1 expression in ileal mucosa,and significantly downregulated(P<0.05)the expression of calprotectin compared to the PC ***:Supplementation of PFA in weaned pigs challenged with *** alleviated the negative effects of *** and improved growth *** them,the mixed additive of bitter citrus extract,thymol,and carvacrol showed the most effective results,improving immune response,intestinal morphology,and expression of tight junction

关键词： Barrier integrity Escherichia coli Immunity Phytogenic feed additive Post-weaning diarrhea Weaned pigs

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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue jin Yusong Yuan Bo Ma Wenyong Xie Na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu Yang Xiuxiu jin jingyang Liu Weiping Wang Xiaoli Zhang jinfeng han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

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Nonlinear dynamics of curved IPMC actuators undergoing electrically driven large deformations

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International Journal of Smart and Nano Materials 2012年第3期3卷 214-225页

作者： jin-han Jeon Choonghee Jo Il-Kwon oh School of Mechanical Aerospace and Systems EngineeringKorea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon 305-701Republic of Korea

The nonlinear dynamics of curved ionic polymer-metal composite(IPMC)actuators having large tip displacement and periodical jumping locomotion was investigated *** snap-through phenomena,the actuator generates much larger tip displacement and shows abrupt jumps in the transitions of upswings and downswings with low input *** curved IPMC cantilever actuators having two different constant curvatures of 0.01 mm^(−1) and 0.02 mm^(−1) were fabricated through thermal treatment from flat IPMCs,simultaneously with no residual ***-fabricated IPMC actuators were tested to evaluate the effect of initial curvature under static and dynamic electrical *** the case of the flat IPMC actuator,asymmetric characteristics in step and harmonic responses were investigated in the curved IPMC ***,at relatively higher input voltage,snap-through phenomena were observed with much larger transverse displacements and periodical abrupt jumps of the instant *** revealed jumping movements between the multiple equilibrium *** results show that optimum curvatures for better bending performance of curved cantilever IPMCs exist and that this snap-through mechanism could be applied to IPMC actuators by considering their soft and flexible properties and the geometric structures.

关键词： ionic polymer-metal composite snap-through dynamics thermal treatment actuator

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Effect of Al coating conditions on laser weldability of Al coated steel sheet

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中国有色金属学会会刊：英文版 2009年第4期19卷 946-951页

作者： Jung-han LEE Jong-Do KIM jin-Seok oh Seo-Jeong PARK Graduate School Korea Marine University Division of Marine Engineering System Korea Marine University Welding Research Center

Al coated steel sheets with excellent heat resistance,thermal reflection,and corrosion resistance are widely used in various *** laser weldability of the Al coated steel sheet for full penetration welding was *** phenomenon caused by intermixed aluminum and behavior of aluminum in the weld were *** coated steel sheets that have various thickness and coating mass were prepared for laser *** effects of parameters such as welding conditions and Al coating conditions were *** content mixed in the weld after laser welding was evaluated,and then a correlation between the mixed Al and mechanical properties was *** results show that the Al-rich zones which have Fe-Al intermetallic compounds are found in the *** intermetallic compounds cause the decreased strength of the weld.

关键词：铝合金焊接钢板焊接激光焊接 Al涂层金属间化合物涂层钢板涂层质量焊接条件

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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu jin Xin Lu Bing-Chun Yan han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

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Acoustic radiation force impulse elastography for hepatocellular carcinoma-associated radiofrequency ablation

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World Journal of Gastroenterology 2011年第14期17卷 1874-1878页

作者： Hee-jin Kwon Myong-jin Kang jin-han Cho Jong-Young oh Kyung-jin Nam Sang-Yeong han Sung Wook Lee Department of Radiology Dong-A University HospitalDongdaesindong 3gaSeo-guPusan 602-715South Korea Department of Internal Medicine Dong-A University HospitalDongdaesindong 3gaSeo-guPusan 602-715South Korea

AIM:To evaluate the potential usefulness of acoustic radiation force impulse (ARFI) images for evaluation of hepatocellular carcinomas (HCC)-associated radiofrequency ablation. METHODS:From January 2010 to June 2010,a total of 38 patients with HCC including recurred HCCs after RFA underwent ARFI elastography. The brightness of tumor was checked and the shear wave velocity was measure-d for the-quantification of stiffne-ss. According to theb-rightne-ss,the-tumors we-re-classifie-d as b-righte-r,samecolor and darker compared with adjacent parenchyma. Using the same methods,8 patients with recurred HCCs after RFA state were evaluated about the brightness compared with adjacent RFA ablation area. RESULTS:In the 38 patients with HCCs,20 (52.6%)were brighter than surrounding cirrhotic parenchyma. Another 13 (34.2%) were darker. The others (5 cases,13.2%) were seen as the same color as the adjacent liver parenchyma. Post-RFA lesions were darker than previous tumor and surrounding parenchyma in all 38 cases. However,recurred HCCs were brighter than the treated site in all 8 cases. CONCLUSION:Using ARFI technique is helpful for differential diagnosis in order to detect recurred HCCs more easily in patients with confusing status.

关键词： Hepatocellular carcinoma Elastography Radiofrequency ablation

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Actinomycosis of the appendix mimicking appendiceal tumor:A case report

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World Journal of Gastroenterology 2010年第3期16卷 395-397页

作者： Sang-Yun Lee Hee-jin Kwon jin-han Cho Jong-Young oh Kyung-jin Nam jin-Hwa Lee Seong-Kuk Yoon Myong-jin Kang jin-Sook Jeong Department of Radiology Dong-A University Hospital Department of Pathology Dong-A University Hospital

Actinomycosis is an uncommon chronic infectious disease. Common sites of involvement include the cervicofacial, thoracic and abdominopelvic regions. In abdominopelvic actinomycosis, the ileocecal region, including the appendix, is the most commonly involved site. In some reports, limited appendiceal actinomycosis has revealed a thickened appendiceal wall with peri-appendiceal inflammation as acute appendicitis or perforated appendicitis. We experienced pathologically confirmed intraluminal limited appendiceal actinomycosis without peri-appendiceal infiltration. Here, we report the computed tomography and ultrasound findings.

关键词： Actinomyces Actinomycosis Appendiceal neoplasms Appendicitis

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