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Efficacy of interleukin-17 inhibitors on radiographic progression in psoriatic arthritis:A systematic review and meta-analysis

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Chinese Medical Journal 2024年第4期137卷 473-475页

作者： han-Lei jiang Yu Du Qiang Tong Sheng-Ming Dai Department of Rheumatology and Immunology Shanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200233China

To the Editor:Psoriatic arthritis(PsA)is a highly heterogeneous inflammatory *** occurs in up to 30%of patients with psoriasis and can have severe impacts on peripheral joints,spine,tendon insertions,and fingers. ^([1])Radiographic progression is currently the preferred method for assessing structural damage of PsA. ^([2])Biologic treatment options for PsA include tumor necrosis factor-αinhibitors(TNFi),interleukin-12/23 inhibitors,and interleukin-17(IL-17)*** therapeutic effects of IL-17 inhibitors on structural damage were not consistent over multiple ***,a systematic review and meta-analysis of the available randomized controlled trials(RCTs)was conducted to quantify the overall effect of IL-17 inhibitors on structural damage in *** study was registered with PROSPERO(***42022301774).

关键词： damage analysis inhibitors

The acceptance of traditional Chinese medicine among patients with Parkinson's disease:A hospital survey

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Journal of Integrative Medicine 2024年第2期22卷 180-187页

作者： Peng Wang Jing Hong Zhu-qian Tang Bi-zhen Gong Xiao-rong Qi han jiang Bo Pan Qi Chen Postgraduate School Medical School of Chinese People’s Liberation ArmyBeijing 100853China Senior Department of Traditional Chinese Medicine the Sixth Medical Center of PLA General HospitalBeijing 100853China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Integrative Oncology the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Dermatology the First Clinical Medical CollegeAnhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

Objective:The efficacy of medications for Parkinson’s disease(PD)tend to decline over time,which has a serious impact on patients’health and quality of *** some extent,traditional Chinese medicine(TCM)can resolve the distressing problem of ineffective dopaminergic medication in PD *** purpose of this study was to investigate the attitude,acceptance,and independent predictors of TCM in PD patients admitted to the outpatient department of a tertiary ***:A cross-sectional study of PD patients was conducted in the outpatient department of a large tertiary hospital in Beijing from March 2022 to June 2023.A self-report questionnaire was developed to investigate PD patients’attitudes and acceptance of TCM based on the *** logistic regression analyses were also performed to further clarify the independent predictors influencing patients’adoption of TCM ***:A total of 397 patients completed the questionnaire,of which 78.09%were willing to be treated with TCM and 21.91%indicated that they were not willing to use *** logistic regression analysis showed that several parameters were correlated with a patient’s willingness to include TCM in their therapeutic *** included education level of a bachelor’s degree(odds ratio[OR)=8.554;95%confidence interval[CI]:4.112–17.794;P<0.001,vs junior high school education),living in an urban setting(OR=8.022;95%CI:4.577–14.060;P<0.001,vs rural),having other underlying diseases(OR=5.126;95%CI:3.078–8.537;P<0.001,vs none),having previously used TCM(OR=3.083;95%CI:1.852–5.134;P<0.001,vs not used),believing that TCM therapy is safe(OR=3.530;95%CI:1.446–8.616;P=0.006,vs not thought),believing that TCM therapy is effective(OR=3.859;95%CI:1.482–10.047;P=0.006,vs not understood),and being willing to discuss ongoing TCM therapy with an attending physician(OR=62.468;95%CI:30.350–128.574;P<0.001,vs not informed).Conclusion:This study initially investigated the acceptance

关键词： Parkinson's disease Traditional Chinese medicine Cross-sectional study

各向异性界面动力学对深胞晶生长形态稳定性的影响

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物理学报 2024年第11期73卷 325-335页

作者：孙思杰蒋晗桂林电子科技大学数学与计算科学学院桂林541004

本文采用匹配渐近法和多重变量法,基于深胞晶生长的定常解,在考虑了各向异性界面动力学后,导出胞晶界面扰动振幅变化率满足的色散关系式及界面形态满足的量子化条件,研究在各向异性界面动力学的影响下定向凝固过程中深胞晶生长界面形态... 详细信息

本文采用匹配渐近法和多重变量法,基于深胞晶生长的定常解,在考虑了各向异性界面动力学后,导出胞晶界面扰动振幅变化率满足的色散关系式及界面形态满足的量子化条件,研究在各向异性界面动力学的影响下定向凝固过程中深胞晶生长界面形态的稳定性.结果表明,考虑了各向异性界面动力学的深胞晶体生长的定向凝固系统包含两种整体不稳定机制:整体振荡不稳定机制和低频不稳定机制.通过稳定性分析发现,低阶近似下各向异性界面动力学对整体振荡不稳定机制有着显著影响,随着各向异性界面动力学参数的增大,中性模式产生强振荡的枝晶结构的整体振荡不稳定区域减小.同时,界面动力学各向异性参数对系统整体波动不稳定性的影响随着界面动力学参数的增大而增大.

关键词：深胞晶生长界面动力学稳定性

Effect of wire diameter compression ratio on drawing deformation of micro copper wire

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2605-2618页

作者： Tao HUANG han-jiang WU Ke-xing SONG Yan-min ZhanG Yan-jun ZHOU Shao-lin LI School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Henan Key Laboratory of Advanced Conductor Materials Institute of MaterialsHenan Academy of SciencesZhengzhou 450000China

A crystal plasticity finite element model was developed for the drawing deformation of pure copper micro wire,based on rate-dependent crystal plasticity *** impact of wire diameter compression ratio on the micro-mechanical deformation behavior during the wire drawing process was *** indicate that the internal deformation and slip of the drawn wire are unevenly distributed,forming distinct slip and non-slip ***,horizontal strain concentration bands develop within the drawn *** the wire diameter compression ratio increases,the strength of the slip systems and the extent of slip zones inside the deformation zone also ***,the fluctuating stress state,induced by contact pressure and frictional stress,results in a rough and uneven wire surface and diminishes the stability of the drawing process.

关键词： micro copper wire drawing deformation crystal plasticity finite element slip mode

Slc43a2^(+)T cell metastasis from spleen to brain in RGNNV infected teleost

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Science China(Life Sciences) 2024年第4期67卷 733-744页

作者： Qing Wang Yali Liu Minlin Zhang Min Yang Jiantao Liang Xiaoling Zuo Shaowen Wang Xianze Jia Huihong Zhao han jiang Qiang Lin Qiwei Qin College of Marine Sciences South China Agricultural UniversityGuangzhou 510642China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Nansha-South China Agricultural University Fishery Research Institute Guangzhou 511457China Joint University Laboratory of Guangdong Province Hong Kong and Marco Region on Marine Bioresource Conservation and ExploitationGuangzhou 510642China University of Chinese Academy of Sciences Beijing 100101China

The origin of T cells in the teleost's brain is *** viewing the central nervous system(CNS)as immune privileged has been widely accepted,previous studies suggest that T cells residing in the thymus but not in the spleen of the teleost play an essential role in communicating with the peripheral ***,we identified nine T cell subpopulations in the thymus and spleen of orange-spotted grouper(Epinephelus coioices)through single-cell RNA-sequencing *** viral CNS infection with red-spotted grouper nervous necrosis virus(RGNNV),the number of slc43a2^(+)T cells synchronously increased in the spleen and *** the infection tests in asplenic zebrafish(tlx1^▲zebrafish model),no increase in the number of slc43a2^(+)T cells was observed in the ***-cell transcriptomic analysis indicated that slc43a2^(+)T cells mature and functionally differentiate within the spleen and then migrate into the brain to trigger an immune *** study suggests a novel route for T cell migration from the spleen to the brain during viral infection in fish.

关键词： central nervous system slc43a2^(+)T cell RGNNV T cell migration teleost

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从示辱到自新:清代收充警迹考论

四川大学学报（哲学社会科学版） 2024年第2期 173-181,218页

作者：姜翰吉林大学法学院长春130012

清代“收充警迹”制度源自元、明两朝,出发点在于解决刺字刑碍人向善问题,核心措施包括纳入册籍与以盗捕盗。清初实践延续了明代警迹制度双轨制的做法,贼犯可以通过改过或者获盗的方式除籍、起字。伴随相关条例的纂修,至道光年间,清廷... 详细信息

清代“收充警迹”制度源自元、明两朝,出发点在于解决刺字刑碍人向善问题,核心措施包括纳入册籍与以盗捕盗。清初实践延续了明代警迹制度双轨制的做法,贼犯可以通过改过或者获盗的方式除籍、起字。伴随相关条例的纂修,至道光年间,清廷确立了改过同时获盗的单轨制方案,大大提高了盗贼“起除刺字”的门槛。但条例的确立未能杜绝实践中双轨制的适用,反映了制度变迁过程中路径依赖的影响,也展现了地方刑罚执行的多元面向。收充警迹的缺陷与弊端,伴随刺字刑的衰落愈加严重,最终反而导致了“自新无路”的局面。伴随旧有刑罚的失灵,地方实用主义与治理导向进一步加剧了刑罚地方化与重刑化,但单纯对旧有刑罚的强化策略不过是饮鸩止渴,只有进行根本性变革,重构旧有刑罚模式,方能走出困局。

关键词：起除刺字收充警迹以盗捕盗

民国学人关于中小学图书馆的论述及其当代启示

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图书馆杂志 2024年第5期43卷 52-60页

作者：姜晗南京大学信息管理学院

民国时期(1912—1949),中小学图书馆伴随教育的现代化和图书馆事业的兴盛而产生、发展。许多民国学人注意到了中小学图书馆的重要性及中小学图书馆实践过程中暴露的问题,并对其展开了论述。民国时期多有质疑中小学是否需要图书馆的声音... 详细信息

民国时期(1912—1949),中小学图书馆伴随教育的现代化和图书馆事业的兴盛而产生、发展。许多民国学人注意到了中小学图书馆的重要性及中小学图书馆实践过程中暴露的问题,并对其展开了论述。民国时期多有质疑中小学是否需要图书馆的声音,对此,民国学人从教育与图书馆、中小学校与图书馆、学校师生与图书馆3个方面展开,一一论证了创设中小学图书馆的必要性。面对中小学图书馆建设中的经费、建筑设备、组织、图书、服务与阅读指导问题,民国学人从现实出发论述了各个问题的解决办法。文章梳理、归纳民国学人论述中的观点、经验、建议,从中发现具有启发性的观点,并阐发对当代中小学图书馆发展的启示及对其建设的思考。

关键词：中小学图书馆民国时期民国学人中小学校

清代地方法律治理中的国家与社会:以慈善组织为中心的考察

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西南大学学报（社会科学版） 2024年第2期50卷 264-276页

作者：姜翰吉林大学法学院吉林长春130012

清代慈善组织数量众多、分布广泛,不仅发挥了施善的作用,也深深嵌入到地方法律治理之中。以养济院为代表的官办慈善组织,逐步打破原籍地收养主义,将军流人犯之年老、笃疾者纳入收养范围。各类民办慈善组织,则在治安维持与盗贼缉捕、司... 详细信息

清代慈善组织数量众多、分布广泛,不仅发挥了施善的作用,也深深嵌入到地方法律治理之中。以养济院为代表的官办慈善组织,逐步打破原籍地收养主义,将军流人犯之年老、笃疾者纳入收养范围。各类民办慈善组织,则在治安维持与盗贼缉捕、司法审判与刑罚执行、命案检验与尸体管控等领域发挥了重要作用。官办与民办慈善组织的创设与运转,均是官民互动的结果,展现了官民合作模式的动态演变,反映出国家与社会之间关系的多面性与复杂性。从地方法律治理出发,慈善组织被定位为发挥政府法律治理职能的延伸机构,带有明显的官方主导色彩。

关键词：慈善组织法律治理第三领域刑罚执行

富氢环境下镍钛形状记忆合金弹簧变形行为的实验和理论研究

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力学学报 2024年第2期56卷 422-432页

作者：姜晗于超康国政西南交通大学力学与航空航天学院成都610031

镍钛形状记忆合金器件在某些特定服役环境下不可避免地与氢接触,导致其力学性能发生改变.实验研究方面,通过对两种构型(弹簧指数为8.5和11.7)的镍钛合金弹簧进行异位电解充氢,随后对充氢和未充氢镍钛合金弹簧进行不同幅值的拉伸-卸载实... 详细信息

镍钛形状记忆合金器件在某些特定服役环境下不可避免地与氢接触,导致其力学性能发生改变.实验研究方面,通过对两种构型(弹簧指数为8.5和11.7)的镍钛合金弹簧进行异位电解充氢,随后对充氢和未充氢镍钛合金弹簧进行不同幅值的拉伸-卸载实验,揭示了氢对超弹性镍钛合金弹簧变形行为的影响.结果表明,氢会显著影响弹簧的相变硬化行为,并且使马氏体相变临界力下降地更为迅速.理论研究方面,基于实验结果,在不可逆热力学框架下构建了镍钛形状记忆合金力-扩散耦合本构模型.在该本构模型中,考虑了与弹性,马氏体相变和氢致膨胀相关的应变和氢浓度场对马氏体相变的影响.通过建立的Helmholtz自由能推导出相变行为的热力学驱动力.基于质量守恒定律和Fick定律,得到氢浓度场的演化方程.为了准确地描述充氢和未充氢镍钛合金弹簧的变形行为,在建立的本构模型基础上,进一步发展了描述弹簧力-扩散耦合变形行为并考虑其扭转、弯曲变形模式的半解析模型.通过与实验结果的对比,可以发现,提出的半解析理论模型能够很好地预测富氢环境下超弹性镍钛合金弹簧的变形行为.

关键词：镍钛形状记忆合金弹簧富氢环境力-扩散耦合半解析模型