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N^(6)-methyladenosine(m^(6)A)RNA modification in tumor immunity

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Cancer Biology & Medicine 2022年第4期19卷 385-397页

作者： Siyi Zheng hui han Shuibin Lin Center for Translational Medicine Precision Medicine InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Otolaryngology Center for Translational MedicinePrecision Medicine InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Growing evidence supports that cancer progression is closely associated with the tumor microenvironment and immune ***,recent studies have revealed the crucial roles of epigenetic regulators in shaping the tumor microenvironment and restoring immune recognition.N^(6)-methyladenosine(m^(6)A)modification,the most prevalent epigenetic modification of mammalian mRNAs,has essential functions in regulating the processing and metabolism of its targeted RNAs,and therefore affects various biological processes including tumorigenesis and *** studies have demonstrated the critical functions and molecular mechanisms underlying abnormal m^(6)A modification in the regulation of tumor *** this review,we summarize recent research progress in the potential roles of m^(6)A modification in tumor immunoregulation,with a special focus on the anti-tumor processes of immune cells and involvement in immune-associated molecules and ***,we review current knowledge regarding the close correlation between m6A-related risk signatures and the tumor immune microenvironment landscape,and we discuss the prognostic value and therapeutic efficacy of m^(6)A regulators in a variety of cancer types.

关键词： N^(6)-methyladenosine(m^(6)A)modification immune evasion tumor microenvironment(TME) tumor immunology immune cells

Numerical Study of Heat Transfer Characteristic for Subcooled Falling Film outside the Shaped Tubes under Rolling Motion

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Journal of Thermal Science 2023年第3期32卷 922-932页

作者： han hui WANG Junqi WANG Shaowei LI Yuxing Provincial Key Laboratory of Oil and Gas Storage and Transportation Safety in Shandong Province China University of Petroleum(Huadong)Qingdao 266580China

The heat transfer performance of spiral wound heat exchanger used in the floating liquefied natural gas(FLNG)may be significantly affected by the sloshing *** this paper,a three-dimensional numerical model combined with the dynamic mesh technology is conducted to study subcooled falling film heat transfer under static and sloshing *** three-dimensional velocity distribution of the liquid film on the shell side is *** effects of cross-section shape of heat exchange tubes,Reynolds numbers and sloshing parameters on heat transfer characteristics are *** results indicate that the heat transfer performance of the egg-shaped tube is superior to that of the elliptical and circular tube under both static and sloshing conditions due to significant heat transfer improvement in the lower half of the *** heat transfer coefficients of three different kinds of tubes decrease under sloshing *** the rolling amplitude is 6°,the average heat transfer coefficients of the circular tube,elliptical tube and egg-shaped tube are reduced by 2.1%,3.7%and 4.9%*** the current sloshing parameters,increasing the rolling amplitude,the heat transfer coefficients of three different tubes are slightly increased,while the sloshing period has little effect on heat *** egg-shaped tube and elliptical tube are greatly affected by sloshing motion at the low Reynolds number,while the effect is relatively small at the high Reynolds number.

关键词： falling film flow sloshing condition spiral wound heat exchanger floating liquefied natural gas

Experimental Study on Thermal Performance of FLNG Spiral Wound Heat Exchanger under Sloshing Conditions

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Journal of Thermal Science 2019年第5期28卷 1042-1053页

作者： YAN Yan SUN Chongzheng han hui LI Yuxing College of Pipeline and Civil Engineering/Shandong Provincial Key Laboratory of Oil & Gas Storage and Transportation Safety/Qingdao Key Laboratory of Circle Sea Oil & Gas Storage and Transportation Technology China University of Petroleum

The FLNG spiral wound heat exchanger(SWHE) is affected by the sea conditions, which leads to more complex flow process and decrease the heat transfer performance of the heat exchanger. In order to study the thermal performance of FLNG SWHE under heaving and swaying conditions, the experimental devices of FLNG SWHE and six-DOF(degree of freedom) sloshing platform were built. The effects of heaving and swaying motions on the pressure drop and heat transfer characteristics were analyzed at different sloshing amplitudes. The results showed that the heaving and swaying motions can cause the temperature rise and pressure fluctuation of SWHE, especially for swaying. The effect of sloshing on the heat transfer performance at the top of SWHE was greater than bottom. The pressure fluctuation percentage was within 7% and the amount of temperature change was less than 2℃, under the sloshing displacement among 120–255 mm.

关键词： spiral wound heat exchanger FLNG experimental sloshing

A Semantic Retrieval Model Based on Domain Ontology of Orchard Disease and Pests

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Chinese Journal of Electronics 2016年第3期25卷 460-466页

作者： HOU Jiajia LI Dongmei QIU Chengjing han hui School of Information Science and Technology Beijing Forestry University School of Information Renmin University of China School of Computer Science and Information Technology Northeast Normal University

Ontology-based semantic retrieval can improve the efficiency of information retrieval. This paper proposes a semantic retrieval model based on domain ontology of orchard disease and pests. According to Forestry Thesaurus, we semi-automatically construct a domain ontology and repair ontology inconsistency to ensure the accuracy and uniqueness of the domain knowledge. A concept similarity algorithm is proposed and applied to calculate sentence similarity. We present a synthetic sentence similarity algorithm, which is a combination of the traditional sentence similarity algorithm and the weighted sentence similarity algorithm. Compared with other related methods through experiments, our retrieval model has higher accuracy in semantic retrieval.

关键词： Orchard pests and diseases Thesaurus Ontology Inconsistency detection Concept similarity Sentence similarity

Prevalence of Falls Among the Rural Elderly-Three PLADs of Western China, 2017–2018

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China CDC weekly 2020年第46期2卷 877-880页

作者： Tong Xu hui han National Center for Women and Children’s Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?As population aging becomes serious in China,the elderly health problems stand out *** of falls of the elderly has become an important subject in China’s public health.

关键词： Rural Elderly elderly

Two-Week Prevalence of Disease Among the Rural Elderly--6 Provinces,China,2018−2019

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China CDC weekly 2020年第38期2卷 736-739页

作者： Tong Xu hui han National Center for Women and Children’s Health Chinese Center for Disease Control and PreventionBeijingChina.

What is already known about this topic?As population aging becomes serious in China,the elderly health problems stand out *** 2-week prevalence of the elderly is rising year by year,but it has been rarely studied for the rural seniors in the central and western *** is added by this report?The 2-week prevalence rate of rural elderly in the central and western China is 28.5%,and it varies among different ethnic *** top prevalence is chronic diseases,and the severity of diseases is higher in female and high age group(80-year-old and over)*** are the implications for public health practice?Considering the health status,health awareness and ethnic differences of the elderly in the central and western China,medical and health resources should be rationally allocated to prevent and treat chronic diseases and support differentiated health *** is of great significance for the development of health service plan.

关键词： prevalence diseases Rural

A study of the evolution of nanoparticle dynamics in a homogeneous isotropic turbulence flow via a DNS-TEMOM method

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Journal of Hydrodynamics 2020年第6期32卷 1091-1099页

作者： Hong-ye Ma Ming-zhou Yu han-hui Jin College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou310018China Institute of Fluid Engineering Zhejiang UniversityHangzhou310027China

In this article,a coupling of the direct numerical simulation(DNS)and the population balance modeling(PBM)is implemented to study the effect of turbulence on nanoparticle dynamics in homogenous isotropic turbulence(HIT).The DNS is implemented based on a pseudo-spectral method and the PBM is implemented using the Taylor-series expansion method of *** result verifies that coagulation due to turbulent shear force has a bigger impact on the evolution of number concentration,polydispersity,and average diameter of nanoparticles than Brownian coagulation in the *** Reynolds number plays an important role in determining the number concentration,polydispersity,and average diameter of nanoparticles,and these quantities change more rapidly with an increase of Reynolds *** is also found that the initial geometric standard deviation slows down the evolution of particle dynamics,but almost has no influence on the polydispersity of nanoparticles.

关键词： nanoparticle dynamics Turbulence pseudo-spectral method Taylor-series expansion method of moments

Net Voltage and Phenomenon of Resonance Induced by Chaotic Signal for a Superconducting Junctions Device

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Communications in Theoretical Physics 2006年第4X期46卷 647-650页

作者： LI Jing-hui han Yin-Xia Department of Physics Ningbo University Ningbo 315211 China

The effects of a quenched chaotic signal on the over-damped motion of the electron pairs of a superconducting junctions device are studied. It is shown that the chaotic signal can induce the net voltage and the phenom... 详细信息

关键词： superconducting junction electron pairs noise

Resonance, Multi-resonance, and Reverse-resonance Induced by Multiplicative Dichotomous Noise

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Communications in Theoretical Physics 2007年第4X期48卷 605-609页

作者： LI Jing-hui han Yin-Xia Faculty of Science Ningbo University Ningbo 315211 China

A constant-potential system driven by multiplicative dichotomous noise and subject to an input oscillatory signal is investigated. Two phenomena of stochastic resonance are observed. One is the response as a function of the noise＇s parameters; the other is that as a function of the input signal frequency. A phenomenon of multi-resonance （there are three or four peaks） is found for the response as a function of a parameter of the noise. A phenomenon of reverse-resonance is found, for which the response of the system to the signal can be weakened by the presence of the noise （there is an optimal minimum）. These results help in studies of the systems with multiplicative dichotomous noise, such as the semiconductor, the proteins motor, the chemical reaction, and so on.

关键词： stochastic resonance dichotomous noise